Photo of Lakshmi Sreedharan Nair, MPhil, PhD, FNAI

Lakshmi Sreedharan Nair, MPhil, PhD, FNAI

Associate Professor of Orthopedic Surgery
Program Director, Skeletal Biology and Regeneration Graduate Program
Academic Office Location:
263 Farmington Avenue, Room E7041, MC 3711
MC 3711
United States
Farmington, CT 06030-06030-MC3711
Phone: 860-679-7190
Fax: 860-679-1553
Email: nair@uchc.edu
Website(s):

Skeletal Biology and Regeneration Graduate Program

Connecticut Convergence Institute
Education
DegreeInstitutionMajor
BScKerala UniversityChemistry
MScKerala UniversityAnalytical Chemistry
MPhilKerala UniversityChemistry
PhDSree Chitra Tirunal Institute for Medical Science and Technology (SCTIMST)Polymer Chemistry

Post-Graduate Training
TrainingInstitutionSpecialty
FellowshipSCTIMSTJunior Research Fellow
FellowshipInternational Society for Artificial OrgansYoung Scientist Award Regional Science Fellowship (India, Middle East & Africa)
FellowshipSCTIMSTSenior Research Fellow
PostdoctoralDrexel UniversityPost Doctoral Fellow, Department of Chemical Engineering

Awards
Name of Award/HonorAwarding Organization
Selected as the Core Member of NIH Special Emphasis Panel (SEP) Musculoskeletal, oethopedic, Oral, Rheoumatology, Rehab, skin, National Institutes of HealthNIH
Inducted as the fellowSociety of Biomaterials and Artificial Organs
Faculty Recognition awardGroup on Women in Medicine and Science
FinalistResearch Innovation and Leadership Award, Women of Innovation, Connecticut
“Women of Innovation Finalist” Entrepreneurial Innovation and LeadershipCT Technology Council
Tech Brief Initial AwardNational Aeronautics and Space Administration
Injectable lactoferrin gel as a macromolecular delivery vehicle- THE BEST POSTER AWARDCRC symposium
Very Good Poster Presentation AwardIUPAC International Symposium
Prof. Anantharaman Prize Merit Certificate,National Scholarships SchemeUniversity Topper in M.Sc.
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Advanced biomaterials for complex tissue regeneration AICHE annual meetingProfessional/Scientific OrganizationSymposium organizer and ChairExternalNational20202020
Indo-UK virtual conference on Current Innovations and the future of therapeutic developmentsProfessional/Scientific OrganizationSession chair,ExternalInternational20202020
National Conference Program organizing Committee Society for Biomaterialsmember, program organizing committeeExternalNational20202021
PRMRP PRE-MSH-2 Online Panel: Scientist review panelStudy SectionreviewerExternalNational20202020
DMRPD RESTORE panel (CDMRP): Scientist review panelStudy SectionreviewerExternalNational20202020
International Conference Program organizing Committee, Society for BiomaterialsProfessional/Scientific Organizationprogram committee memberExternalInternational20192020
Session co-Chair, Biotherapeutics I, International Conference on Biomaterial-Based Therapeutic Engineering and Regenerative Medicine, BioTerm 2019, November 29thWorkshop/ConferenceInternational20192019
Symposium Organizer and chair, Regenerative Engineering, Indiana Summit, October 3-5thWorkshop/ConferenceInternational20192019
NSF Review Panel: EPSCoR RII Track I. (NSF requests that date and name of panel not be disclosed)-October 2019Study SectionExternalNational20192019
External Reviewer (international), HRC-NSFC Biomedical Research Fund, International Health Research Council of New Zealand- March 2019Study SectionExternalInternational20192019
NIAMS R15 review panel, Scientific Merit Review, National Institute of Health–March 2019Study SectionExternalNational20192019
NSF Review Panel: Engineering Research Center Preproposal: (NSF requests that date and name of panel not be disclosed) –February, 2019Study SectionExternalNational20192019
Member, National Academy of Inventors Fellows Advisory Committeefellow selection committee memberExternalInternational20182020
Principal Editor, Journal of Materials ResearchProfessional/Scientific JournalPrincipal Editor of a peer reviewed journalExternalInternational2017
Deputy Director, The Cato T. Laurencin Institute for Regenerative EngineeringOtherDeputy DirectorUConn HealthUniversity2017
Regenerative Engineering SocietySecretaryExternalInternational20162020
Uconn Chapter of National Academy of InventorsVice PresidentOtherState2016
Managing editor, Journal of Regenerative Engineering and Translational MedicineProfessional/Scientific JournalManaging Editor of a peer reviewed journalExternalInternational2016
Society for Biomaterials and Artificial Organs, IndiaProfessional/Scientific JournalUS-chapter PresidentExternalNational20122021
Graduate Program, Application Review CommitteeAdvisory CommitteeMemberUConn HealthLocal2011
Journal of Biomaterials and Tissue EngineeringEditorial BoardAssociate EditorExternalNational2010
NIH Peer Review Committee: Musculoskeletal Tissue Engineering Advisory CommitteeCommittee MemberUConn HealthNational2009
Nanostructures for Therapeutic Applications - Special Edition of the Journal of Current Bioactive CompoundsEditorial BoardMemberExternalNational20092009
Society for Biomaterials, Orthopaedic Biomaterials Special Interest GroupProfessional/Scientific OrganizationChairExternalNational20092011
Society for Biomaterials, Surface Modification and Characterization Of orthopaedic and dental implantsProfessional/Scientific OrganizationSymposium chair & OrganizerExternalNational2009
MD/Ph.D recruitment interview committeeEducation CommitteeMemberUConn HealthLocal20092019
Symposium on Regenerative EngineeringOtherCo-OrganizerUConn HealthLocal2009
Journal of Biomedical Nanotechnology Editorial BoardEditorial BoardExternalNational2007
NSF review panel, Biomedical Engineering Advisory CommitteePanel memberExternalNational2007
Society for Biomaterials, Orthopaedic Biomaterials Special Interest GroupProfessional/Scientific OrganizationProgram ChairExternalNational20072009
Journal of Biomedical NanotechnologyProfessional/Scientific JournalEditorial Board MemberExternalNational2006
Society for BiomaterialsProfessional/Scientific OrganizationMemberExternalNational2004
Society for Biomaterials, Abstract Review CommitteeProfessional/Scientific OrganizationMemberExternalNational20042011
Society for Biomaterials and ArtificialProfessional/Scientific OrganizationMemberExternalNational2000
Acta BiomaterialiaProfessional/Scientific JournalReviewerExternalNational
BiomaterialsProfessional/Scientific JournalReviewerExternalNational
BiomacromoleculesProfessional/Scientific JournalReviewerExternalNational
Cell and Tissue BankingProfessional/Scientific JournalReviewerExternalNational
International Journal of BiomaterialsProfessional/Scientific JournalReviewerExternalInternational
International Journal of Biological MacromoleculesProfessional/Scientific JournalReviewerExternalInternational
International NanolettersProfessional/Scientific JournalReviewerExternalInternational
Journal of Biomedical Materials Research, Applied BiomaterialsProfessional/Scientific JournalReviewerExternalNational
Journal of Biomedical Materials Research, part AProfessional/Scientific JournalReviewerExternalNational
Journal of Bioactive and compatible PolymersProfessional/Scientific JournalReviewerExternalNational
Journal of Biomaterial Science Polymer EditionProfessional/Scientific JournalReviewerExternalNational
Journal of Controlled ReleaseProfessional/Scientific JournalReviewerExternalNational
Journal of Applied Polymer ScienceProfessional/Scientific JournalReviewerExternalNational
Journal of Heat TransferProfessional/Scientific JournalReviewerExternalNational
Journal of theoretical biologyProfessional/Scientific JournalReviewerExternalNational
Journal of Atherosclerosis and ThrombosisProfessional/Scientific JournalReviewerExternalNational
Journal of Biomaterials and NanobiotechnologyProfessional/Scientific JournalReviewerExternalRegional
Journal of Biomaterials and Tissue EngineeringProfessional/Scientific JournalReviewerExternalNational
Pharmaceutical researchProfessional/Scientific JournalReviewerExternalNational
Tissue EngineeringProfessional/Scientific JournalReviewerExternalNational
NIAMS SBIR review panel, Scientific Merit Review, National Institute of HealthStudy SectionStudy session memberExternalNational2023
In Vitro ModelsEditorial BoardEditorial Board memberInternational

Our research program is directed at understanding how cells interact with biomaterials and how to appropriately modulate the cell-biomaterial interactions for developing novel biomaterial based therapies. Our ultimate goal is to restore, maintain or improve tissue and/organ functions by modulating the host tissue microenvironment using biologically active biomaterials. Current studies focus on the design and development of regenerative biomaterials to favorably modulate the responses of a variety of cell types involved in tissue regeneration and repair. Formulating biologically active biomaterial requires a thorough understanding of the cellular responses to these materials in vitro and in vivo. Additional studies focus on the identification of sensitive markers as indices of cell-substrate interactions to gain insights into the molecular basis of cell-biomaterial interactions. Our ability to modulate the unfriendly milieu at the wound site by attenuating inflammation, controlling cellular immune responses and signal transduction pathways will significantly enhance the regenerative process in adult tissue. The objective is to identify unique biologically active molecules and develop biomaterial constructs as artificial tissue microenvironment that can favorably modulate cell responses to promote tissue regeneration and/ repair. Specific work includes rational design and/ identification of biologically active molecules that can favorably interact with cells involved in healing via multiple signaling pathways, design and development of biomaterial constructs for tissue engineering and on evaluating the biological activity of the three dimensional bio-molecular constructs using in vitro and in vivo models.

Not Accepting Lab Rotation Students at this time

Journal Articles

Books

  • Laurencin CT, Nair LS (Eds.) Nanotechnology and Tissue Engineering: The Scaffold 2007 Jan;

Book Chapters

  • Platelet Rich Plasma for the Treatment of Osteoarthritis Pain.
    Nair LS. Platelet Rich Plasma in Medicine: Basic Aspects and Clinical Applications 2020 Sep;
  • In vivo Biodegradation.
    Nair LS. Handbook on Biomaterials, Montavani D, Montano-Machado (Eds), Wiley 2019 Mar;
  • Hydrogel-nanoparticle composite for drug delivery applications
    Arianna G, Suhail S, Nair LS*. Drug Delivery Nanosystems for Biomedical Applications. 2018 Nov;
  • Matrix chemistry controlling stem cell behavior.
    Klecker C, Nair LS. Biology and Engineering of stem cell niches; Jeffrey Karp and Ajay Kumar (Eds); Elsevier, 2017 Nov;
  • Polymers and Composites for Orthopaedic Applications.
    Gohil SV, Suhail S, Rose J, Vella T, Nair LS*. Materials for Bone Disorder, Bose S and Bhandopadya A (Eds). 2017 Sep;
  • Drug loaded nanofiber matrices as diabetic wound dressing
    Gionfriddo W, Nair LS Nanotechnology and Nanomedicine in Diabetes 2012 Jan;325-344
  • Host Response to Biomaterials and its Implications in regenerative Engineering
    Nair LS Regenerative Engineering 2012 Jan;
  • Injectable in situ gelling hydrogels as Biomaterials
    Singh H, Nair LS Handbook of Integrated Biomaterials for Medical Applications 2012 Jan;359-396
  • Calcium phosphate based ceramics for biomedical applications
    Lv Q, Lo KWWH, Nair LS, Laurencin CT Biodegradable Polymers in Clinical Use and Clincal Development 2011 Jan;497-518
  • Biomimetic matrices for integrin mediated cell adhesiontions
    Ashe KM, Lee DA, Lo WH, Nair LS, Laurencin CT Biologically Responsive Hybrid Biomaterials 2010 Jan;247-284
  • Nanotechnology for Inducing Angiogenesis
    Kumbar SG, James R, Nair LS, Laurencin CT Micro and Nanoengineering of the Cell Microenvironment: Technologies and Applications 2008 Jan;317-339
  • Osteoarthritic pain and current therapeutic strategies.
    Orozco Morato E, Kishnan D, Nair LS*. Kumar A, Singh S, Singh P (Eds), Emerging materials and technologies for bone repair and regeneration. Taylor and Francis, Oct (2023)

Abstracts

  • Synthesis, characterization and in vitro degradation of L-alanine co-substituted polyphosphazenes
    Singh A, Krogman N, Swaminathan S, Nair LS, Sturgeon, Brown PW, Laurencin CT Polymer Preprints 2005 Jan;

Book Sections

  • Polyphosphazenes
    Nair LS, Khan YM, Laurencin CT An Introduction to Biomaterials and Their Applications 2010 Jan;
  • Biodegradable Polyphosphazene Blends for Biomedical Applications
    Deng M, Nair LS, Krogman NR, Allcock HR, Laurencin CT Polyphosphazenes for Biomedical Applications 2009 Jan;139-154
  • Biomimetric matrices for Integrin-mediated cell adhesion
    Ashe KM, Lee DA, Lo KW-H, Nair LS, Laurencin CT Biologically-Responsive Hybrid Biomaterials 2009 Jan;
  • Injectable Hydrogels as Biomaterials
    Nair LS, Laurencin CT, Tandon M Advanced Materials 2009 Jan;
  • Cell behavior toward nanostructured surfaces
    Kumbar SG, Kofron MD, Nair LS, Laurencin CT Biomedical Nanostructures 2008 Jan;261-295
  • Cell behavior towards nanostructured surfaces
    Kumbar SG, Kofron MD, Nair LS, Laurencin CT Biomedical Nanostructures 2007 Jan;261-287
  • Nanostructures for regenerative medicine
    Nukuvarapu SP, Kumbar SG, Nair LS, Laurencin CT Biomedical Nanostructures 2007 Jan;261-287
  • Nanotechnology and tissue engineering: the scaffold based approach
    Nair L, Bhatacharyya S, Laurencin CT Nanotechnologies for Life Sciences, Vol: 8, Nanotechnologies for Tissue, Cell and Organ Engineering 2006 Jan;
  • Polyphosphazenes
    Nair LS, Khan Y, Laurencin CT Introduction to Biomaterials 2006 Jan;273-290
  • Polyphosphazenes as novel biomaterials
    Nair LS, Lee D, Laurencin CT Handbook of Biodegradable polymeric materials and their applications 2006 Jan;277-306
  • Polyphosphazene nanofibers for biomedical applications: Preliminary studies. Nanoengineered nanofibrous materialsility
    Laurencin CT, Nair LS Nanoengineered Nanofibrous Materials Series: Nato Science Series II, Mathematics, Physics and Chemistry 2004 Jan;281-300
  • Grafting poly(ethylene glycol) onto plasticized poly(vinyl chloride) reduces cellular adhesion
    Lakshmi S, Jayakrishnan A Macromolecules: New Frontiers 1998 Jan;613

Conference Papers

  • Bioactive lactoferrin based polymeric nanofibers for bone tissue engineering
    James E, Nair LS 2012 Jan;
  • Biofunctional injectable hydrogels for orthopaedic applications
    Nair LS 2012 Jan;
  • Characterization of recombinant Lactoferrin gel as an injectable gel
    Amini AA, Nair LS 2012 Jan;
  • Development and evaluation of the bioactivity of injectable bovine lactoferrin gel for bone regeneration
    Cui Z, Nair LS 2012 Jan;
  • Evaluation of the bioactivity and biodegradability of lactoferrin based biomaterials
    Amini AA, Cui Z, Nair LS 2012 Jan;
  • Injectable Lactoferrin as an ostoegenic biomaterial
    Amini AA, Nair LS 2012 Jan;
  • Biological effects of recombinant human lactoferrin
    Amini AA, Nair LS 2011 Jan;
  • Composite PDLA/PCL Nanofiber Injectable Chitosan Gel Scaffold for Osteochondral Regeneration
    Cui Z, Wright LD, Freeman J, Drissi HM, Nair LS 2011 Jan;
  • Design of Anesthetic Nanoparticle based delivery systems for short term pain management
    Ulery B, Nair LS, Laurencin CT 2011 Jan;
  • Development of resveratrol loaded polymeric nanofibers and the effects of resveratrol on the late stage osteogenesis of preosteoblast cells
    Singh H, James E, Kan H, Nair LS 2011 Jan;
  • Evaluation of the Osteogenic activity of injectable bovine lactoferrin Gel
    Amini AA, Nair LS 2011 Jan;
  • Gelatin-based injectable gels for the three-dimensional culture of osteoblasts
    Amini A, Nair LS 2011 Jan;
  • Investigation of Hydrogel-Nanofiber composite for Cartilage Regeneration
    Wright LD, Cui Z, Nair LS, Freeman JW 2011 Jan;
  • Lactoferrin is a regulator of FGF expression in osteoblast-like MC3T3-E1 cells
    James E, Xiao L, Hurley MM, Nair LS 2011 Jan;
  • Composite Electrospun/Hydrogel Scaffold for Cartilage Tissue Engineering
    Wright L, Fischer K, Nair LS, Freeman J 2010 Jan;
  • Development of a Novel Biodegradable Stimuli-Sensitive Injectable Hydrogel System for Orthopeadic Applications
    Burks M, Laurencin CT, Nair LS 2010 Jan;
  • Extending the action of ropivacaine in rats with a thermogelling biodegradable matrix
    Foley PL, Nair LS, Laurencin CT, Tran C 2010 Jan;
  • Injectable lactoferrin gel as a macromolecular delivery vehicle
    Rivest S, Amini A, Hanenbaum C, Nair LS 2010 Jan;
  • Three-dimensional Polyphosphazene Nanostructured Biomimetic Scaffolds for Loadbearing Bone Regeneration
    Deng M, Kumbar SG, Nair LS, Weikel AL, Allcock HR, Laurencin CT 2010 Jan;
  • Injectable tissueengineered bone healing of a rat calvarial defect
    Stephen S, Gross B, Tholpady S, Nair LS, Ogle R, Park S 2009 Jan;
  • Osteogenic Nanostructured Titanium Surface: A potential Orthopaedic Material (Young investigator invitee)
    Saleh J, Laurencin CT, Nair LS 2009 Jan;
  • Osteoinduction of human adipose derived stem cells using composite sintered microsphere matrix
    Laurencin CT, Cushnie E, Nair LS, Khan Y 2009 Jan;
  • Composite Microsphere nanofiber scaffolds for bone tissue engineering
    Brown J, Nair LS, Laurencin CT 2008 Jan;
  • Curcumin Containing Polymeric Nanofibers: Novel Wound Dressings with Antioxidant Properties
    Merrell J, McLaughlin S, Laurencin CT, Nair LS 2008 Jan;
  • Development of a Novel Stimuli Sensitive Injectable Hydrogel system for Biomedical Applications
    Burks M, Laurencin CT, Nair LS 2008 Jan;
  • Evaluation of the Responses of Human and Rabbit Bone Marrow Derived Mesenchymal Stem Cells to Dynamic Culture Conditions in HARV Bioreactors
    Lv Q, Nair LS, Laurencin CT 2008 Jan;
  • Fabrication and in vitro evaluation of novel polyphosphazene-nano hydroxyapatite microsphere scaffolds for bone tissue engineering
    Nukavarapu SP, Kumbar SG, Krogman N, Nair LS, Allcock HR, Laurencin CT 2008 Jan;
  • Injectable thermosensitive chitosan based scaffolds for musculoskeletal tissue regeneration
    Nair LS 2008 Jan;
  • Nanostructured Titanium Surface Containing Silver Nanoparticles: A Potential Orthopaedic Biomaterial
    Nair LS, Herlihy T, Laurencin CT 2008 Jan;
  • Novel Dipeptide-Based Biodegradable Polymeric Blends for Bone Tissue Engineering:Poly[(glycine ethyl glycinato)(phenyl phenoxy)phosphazene] – Poly(lactide-co-glycolide) Miscibility and Osteocompatibility Studies
    Deng M, Nair LS, Krogman N, Allcock H, Laurencin CT 2008 Jan;
  • Thermosensitive Chitosan As A Matrix For The Controlled Delivery Of Biologically Active Molecules For Bone Repair
    Bush JR, Madhu V, Laurenicn CT, Balian G, Nair LS 2008 Jan;
  • Biodegradable Polyphosphazenes : A versatile class of biomaterials
    Nair LS, Laurencin CT 2007 Jan;
  • Nanotechnology and Orthopaedic Surgery
    Taylor E, Nair L, Laurencin CT 2007 Jan;14-15
  • One step in situ method for developing silver nanoparticle-Polymer Composites for Orthopaedic Applications
    Jupitor R, Laurencin CT, Nair LS 2007 Jan;
  • Synthesis and characterization of novel biodegradable phenyl phenoxy-based polyphosphazene blends: in vitro osteocompatibility evaluation
    Deng M, Kumbar SG, Krogman NR, Nair LS, Allcock HR, Laurencin CT 2007 Jan;
  • Development of injectable thermogelling chitosan-inorganic phosphate solution for biomedical application
    Nair LS, Bijoux C, Trevor S, Laurencin CT 2006 Jan;
  • Fabrication and biocompatibility of polyphosphazene Tubular electrospun nanofiber scaffolds for bone tissue engineering
    Bhattacharyya S, Kumbar SG, Khan YM, Nair LS, Laurencin CT 2006 Jan;
  • In vivo evaluation of novel biodegradable physiological temperature setting composites for bone tissue engineering
    Sethuraman S, El-Amin, S, Khan Y, Kwon M, Nguyen T, Nair LS, Singh A, Krogman,N, Allcock HR, Brown PW, Laurencin CT 2006 Jan;
  • Injectable, thermosetting in situ forming biodegradable hydrogels as sustained macromolecular delivery systems
    Nair LS, Trevor S, Burks MV, Laurencin CT 2006 Jan;
  • Nanohydroxyapatite incorporated polyphosphazene nanofibers for bone tissue engineering
    Bhattacharyya S, Nair LS, Singh A, Krogman NR, Brown PW, Allcock HR, Laurencin CT 2006 Jan;
  • Osteogenic Differentiation of Human Mesenchymal Stem Cells in Injectable In situ Thermogelling Chitosan Solution
    Nair LS, Trevor S, Laurencin CT 2006 Jan;
  • Physico-chemical evaluation of physiological temperature setting polymer-ceramic composites for bone tissue engineering
    Sethuraman S, Nair LS, Nguyen T, Singh A, Allcock HR, Greish Y, Brown PW, Laurencin CT 2006 Jan;
  • Biodegradable poly[bis(ethyl alanato)phosphazene]-Poly(lactide-coglycolide)blends: Miscibility and Osteocompatibility evaluations
    Nair LS, Singh A, Bender J, Sethuraman S, Greish YE, Brown PW, Allcock HR, Laurencin CT 2005 Jan;844Y9.7.1-Y 9.7.7
  • Development of biodegradable polyphosphazene-nanohydroxyapatite composite nanofibers via electrospinning
    Bhatttachyaryya S, Nair LS, Sing A, Krogman NR, Bender J, Greish YE, Brown PW, Allcock HR, Laurencin CT 2005 Jan;84591-96
  • Development of novel biodegradable amino acid ester based polyphosphazene-hydroxyapatite composites for bone tissue engineering
    Sethuranum S, Nair LS, Singh A, Bender J, Greish Y, Allcock H, Brown P, Laurencin CT 2005 Jan;845291-296
  • In Vivo Biocompatibility Evaluation of Novel Amino Acid Ester based Biodegradable Polyphosphazenes for Biomedical Applications
    Sethraman S, Nair LS, Nguyen M, Singh A, Allcock HR, Greish Y, Brown PW, Laurencin CT 2005 Jan;
  • Nanostructured Materials for Tissue Engineering and Drug Delivery
    Nair LS, Laurencin CT 2005 Jan;
  • Nanostructured Materials for Tissue Engineering and Drug Delivery
    Laurencin CT, Nair LS 2005 Jan;
  • Synthesis, characterization and in vitro degradation of L-alanine co-substituted polyphosphazenes
    Singh A, Krogman NR, Sethuraman S, Nair LS, Sturgeon JL, Brown PW, Allcock HR, Laurencin CT 2005 Jan;
  • Biodegradable polyphosphazene for biomedical applications
    Laurencin CT, Nair LS 2004 Jan;
  • Design of high strength degradable polyphosphazenes: Modulation of mechanical properties via side chain chemistry
    Sethraman S, Nguyen T, Nair LS, Singh A, Allcock HR, Greish Y, Brown PW, Laurencin CT 2004 Jan;
  • Novel amino acid ester polyphosphazene-hydroxyapatite composites for bone tissue engineering
    Sethuraman S, Nair LS, Bender JD, Singh A, Allcock HR, Greish Y, Brown PW, Laurencin CT 2004 Jan;
  • Novel biomaterial for bone tissue engineering
    Lakshmi S, Bender JD, Greish YE, Brown PW, Allcock HR, Laurencin CT 2004 Jan;
  • Polyphosphazene-hydroxyapatite scaffolds for bone tissue engineering
    Lakshmi S, Bender JD, Greish YE, Brown PW, Allcock HR, Laurencin CT 2004 Jan;
  • Preparation of biocompatible polyphosphazene nanofiber mats by electrospinning
    Lakshmi S, Bender JD, Greish YE, Brown PW, Allcock HR, Laurencin CT 2004 Jan;
  • Preparation of poly[bis (carboxylato phenoxy)phosphazene] non woven nanofiber mats by electrospinning
    Bhattacharyya S, Nair LS, Bender J, Greish YE, Brown PW, Allcock HR, Laurencin CT 2004 Jan;EXS-1157-163
  • Synthesis and evaluation of novel amino acid ester phenyl phenoxy polyphosphazene for bone tissue engineering
    Sethuraman S, Nair LS, Singh A, Bender JD, Allcock HR, Greish Y, Brown PW, Laurencin CT 2004 Jan;
  • Synthesis and Fabrication of porous nanofiber matrices of biodegradable polyphosphazenes as scaffolds for tissue engineering
    Bhattacharyya S, Lakshmi S, Bender J, Greish YE, Brown PW, Allcok HR, Laurencin CT 2004 Jan;
  • In vitro evaluation of novel glycine containing biodegradable polyphosphazenes for bone tissue engineering
    Lakshmi S, Lee DA, Bender JD, Allcock HR, Laurencin CT 2003 Jan;
  • In vitro evaluation of novel biodegradable polyphosphazenes for bone tissue engineering
    Lakshmi S, Lee DA, Bender JD, Allcock HR, Laurencin CT 2003 Jan;
  • Novel biodegradable polyphosphazenes for bone tissue engineering: An in vitro evaluation
    Lakshmi S, Lee DA, Bender JD, Allcock HR, Laurencin CT 2003 Jan;
  • Preparation of polyphosphazene mats by electrospinning
    Bhattacharyya S, Lakshmi S, Bender J Allcock HR, Laurencin CT 2003 Jan;
  • Grafting poly(ethylene glycol) onto plasticized poly(vinyl chloride) reduces cellular adhesion
    Lakshmi S, Jayakrishnan A 1998 Jan;
  • Grafting poly(ethylene glycol) onto plasticized poly(vinyl chloride) via Williamson ether synthesis: A simple novel route to improve the blood compatibility of PVC
    Lakshmi S, Jayakrishnan A 1997 Jan;
  • Inhibition of bacterial adherence on plasticized poly(vinyl chloride) by grafting poly(ethylene glycol) via Williamson ether synthesis
    Lakshmi S, Jayakrishnan A 1997 Jan;
  • Surface grafting of poly(ethylene glycol) onto poly(vinyl chloride) improves the blood compatibility of PVC
    Lakshmi S, Jayakrishnan A 1997 Jan;
  • Phase transfer catalyzed surface modification prevents plasticizer migration from plasticized poly(vinyl chloride)
    Lakshmi S, Jayakrishnan A 1996 Jan;
  • Polystyrene supported benzoic oximinodithiocarbonic anhydrides as heterogeneous photoinitiators
    Lakshmi S, Sreekumar K 1995 Jan;
  • Comprehensive evaluation of long-term dynamic mechanical behavior in a rat MIS OA model.
    Kishnan D, Orozco E, Nair LS*.
  • Intra-articular Delivery of Curcumin and Ropivacaine for Managing Osteoarthritic Pain.
    Orozco Morato E, Nair LS*.
  • Minimally invasive periarticular injections of local anesthetic provides prolonged analgesia in a rodent Osteoarthritic model
    Kishnan D, Walker J Nair LS. 2425

Letters

Other

  • Synthetic Artificial Stem Cells (SASC).
    Laurencin CT, Shah S, Nair LS, Kan H. US Pat Prov Appl 62/963,751 2020 Jan;
  • Bi-Phasic 3-Dimensional Nanofiber Scaffolds, Two parallel beam collector device methods of use
    Laurencin CT, Khan Y, Nair LS, US. Pat App No 14/302,336 2019 Nov;
  • Injectable amnion hydrogel as stem cell delivery system for osteoarthritis treatment
    Laurencin CT, Bhattacharjee M, Nair LS. Uconn ref. 18-843-PRO. 2018 Nov;
  • Multi-chamber culture system
    Laurencin CT, Barajaa M, Nair LS. UCONNCG-18071 ProvisionalSB-1 2018 Oct;
  • Review of “Biomaterials for Musculoskeletal Regeneration: Concepts” by Bikramjit Basu and “Biomaterials for Musculoskeletal Regeneration: Applications” by Bikramjit Basu and Sourabh Gosh
    Khan Y, Nair LS, J Mater Sci., 2017 Oct;
  • Mechanically competent scaffold for rotator cuff and tendon augmentation.
    Laurencin CT, Aronson MT, Nair LS, Reilly JW. US patent number: 9757132 B2 2017 Sep;
  • Lactoferrin: a biologically active molecule for bone regeneration.
    Amini, A A; Nair, L S Current medicinal chemistry 2011 Jan;18(8):1220-9
  • . Analgesic Compositions, methods of manufacture and use there of,
    Nair LS*, Kishnan D, Nieh M, Walker J. US Non-Provisional patent application PCT/US23/84547 (2023)
  • “Special Edition in Honor of Robert Langer’s 70th Birthday” in Regenerative Engineering and Translational Medicine,
    Kohn J, Green J, Nair LS (Eds) Springer-nature. Vol 1 (2022)
  • Synergistic effects of bupivacaine and kartogenin for the management of pain
    Nair LS*, Onwuka D, Orozco E, Walker J. US Patent Proc Appl 22-0608-US-PRO (2022)
  • Synergistic effects of endocannabinoids and local anesthetics
    Nair LS*, Kishnan D, Nieh M, Walker J. US Patent Proc Appl (2022)

Reviews

  • Corrosion of Metals During Use in Arthroplasty.
    Ude, Chinedu C; Dzidotor, Godwin K; Iloeje, Kamsiyochukwu; Nair, Lakshmi S; Laurencin, Cato T ACS applied bio materials 2023 Jun;6(6):2029-2042
  • Regenerative Engineering of the Rotator Cuff of the Shoulder. ACS Biomaterials Science and Engineering
    Narayanan G, Nair LS, Laurencin CT ACS Biomaterials Science and Engineering 2018 Sep;
  • Regenerative Engineering of the Rotator Cuff of the Shoulder. ACS Biomaterials Science and Engineering
    Narayanan G, Nair LS, Laurencin CT ACS Biomaterials Science and Engineering 2018 Sep;
  • Biodegradable polyphosphazene-based blends for regenerative engineering.
    Ogueri KS, Escobar Ivirico JL, Nair LS, Allcock HR, Laurencin CT. Reg Eng Trans Med 2017 Oct;
  • Biomaterials and cell based therapies for treating osteoarthritis
    Ivirico JLE, Bhattacharjee M, Kuyinu E, Nair LS, Laurencin CT. Regen Eng 2017 Oct;
  • Musculoskeletal tissue regeneration: Role of stem cells.
    Narayanan G, Bhattacharjee M, Nair LS, Laurencin CT. J Reg Eng Trans Med 2017 Oct;
  • The Quest toward limb regeneration: a regenerative engineering approach.
    Laurencin, Cato T; Nair, Lakshmi S Regenerative biomaterials 2016 Jun;3(2):123-5
  • Biomedical Applications of Biodegradable Polymers.
    Ulery, Bret D; Nair, Lakshmi S; Laurencin, Cato T Journal of polymer science. Part B, Polymer physics 2011 Jun;49(12):832-864
  • Titania nanotubes: Novel Nanostructures for improved Osseointegration
    Swami N, Cui Z, Nair LS J Heat Transfer 2011 Jan;133125
  • Chitosan: A versatile biomedical polymer
    Cui Z, Nair LS Recent Patents on Biomed Eng 2010 Jan;3127-129
  • Long-term effects of bone morphogenetic protein- based treatments in humans.
    Burks, Martin V; Nair, Lakshmi Journal of long-term effects of medical implants 2010 Jan;20(4):277-93
  • The FDA and safety--beyond the heparin crisis.
    Laurencin, Cato T; Nair, Lakshmi Nature biotechnology 2008 Jun;26(6):621-3
  • Nanofibers and nanoparticles for orthopaedic surgery applications.
    Nair, Lakshmi S; Laurencin, Cato T The Journal of bone and joint surgery. American volume 2008 Feb;90 Suppl 1128-31
  • Biodegradable polymers as biomaterials
    Nair LS, Laurencin CT Prog Polym Sci 2007 Jan;32762-798
  • Electroconductivity, a regenerative engineering approach to reverse rotator cuff muscle degeneration.
    Saveh-Shemshaki, Nikoo; Barajaa, Mohammed A; Otsuka, Takayoshi; Mirdamadi, Elnaz S; Nair, Lakshmi S; Laurencin, Cato T Regenerative biomaterials 10rbad099
Title or AbstractTypeSponsor/EventDate/YearLocation
Injectable Hydrogels for cell and drug deliveryOtherInternational Conference on Biomaterial-based therapeutic Engineering and R2019
Injectable Hydrogels for Treating Musculoskeletal Injury and Pain.OtherBrazil MRS meeting2019
. Injectable aminion membrane hydrogels for musculoskeletal regenerative engineering.TalkCIMTEC2018
Next generation nanofiber structures for regenerative engineering.TalkCIMTEC2018
Injectable systems for cell and drug delivery.OtherBioMET-20182018
Hydrogels for Regenerative Medicine in Biofabrication and 3D printing for regenerative medicineOtherBioMET-20182018
Cell Instructive Injectable Materials for Bone Regeneration, Innovations in Biomedical MaterialsTalk2012Raleigh, NC
Biofunctional Injectable Hydrogels for Cell TherapyTalkNanoBIO 20122012Kochi, India
Biomaterials for medical devices and regenerative engineeringTalkKerala State Council for Science2012Trivandrum, India
Biomaterials for Regenerative EngineeringTalkInternational Conference on recent trends in Molecular Medicine2012Alappuzha, India
Evaluation of the bioactivity and biodegradability of lactoferrin based biomaterialsTalkWorld Biomaterials Conference2012Chengdu, China
Biofunctional injectable hydrogels for orthopaedic applications. TalkInternational conference on tissue science and engineering2012Chicago, IL
Characterization of recombinant Lactoferrin gel as an injectable gelTalkTERMIS2012Houston, TX
Skin and adipose tissue engineeringOtherAnnual meeting of the biomedical engineering society2012Atlanta, GA
Bioactive lactoferrin based polymeric nanofibers for bone tissue engineeringPosterBMES2012Atlanta, Georgia
Injectable Lactoferrin as an ostoegenic biomaterialPosterOrthopaedic Research society meeting2012San Fransisco, CA
Injectable Biomaterials for Tissue Regeneration and Protein DeliveryTalkMS&T11, American Ceramic Society Meeting2011Columbus, Ohio
Lactoferrin as a regulator of FGF expression in osteoblast-like MC3T3-E1 cellsPosterAnnual Orthopaedic Research Society meeting2011Long beach, CA
Evaluation of the Osteogenic activity of injectable bovine lactoferrin GelTalkSociety for Biomaterials2011Orlando Florida
Development of resveratrol loaded polymeric nanofibers and the effects of resveratrol on the late stage osteogenesis of preosteoblast cellsTalkAnnual American Medical Association MSS/RFS research Symposium2011New Orleans
Composite PDLA/PCL Nanofiber Injectable Chitosan Gel Scaffold for Osteochondral RegenerationTalkBiomedical Engineering Society2011Hartford, CT
Design of Anesthetic Nanoparticle based delivery systems for short term pain managementTalkBiomedical Engineering Society2011Hartford, CT
Composite Electrospun/Hydrogel Scaffold for Cartilage Tissue Engineering TalkBiomedical Engineering Society Annual Meeting2011
Biological effects of recombinant human lactoferrin.TalkOrthopaedic Research society meeting2011Long beach, CA
Investigation of Hydrogel-Nanofiber composite for Cartilage RegenerationPosterBiomedical Engineering Society2011Hartford, CT
Gelatin-based injectable gels for the three-dimensional culture of osteoblastsPosterBiomedical Engineering Society2011Hartford, CT
Lactoferrin as a regulator of FGF expression in osteoblast-like MC3T3-E1 cellsPosterAnnual Orthopaedic Research Society meeting2011Long Beach, CA
Biomaterials for Skeletal Tissue RegenerationTalkThe Stem Cell Seminar Series, UCHC2011Farmington, CT
Nanostructures for Tissue RegenerationTalkNorth East Biomaterials Day2010Columbia University, New York
Composite Electrospun/Hydrogel Scaffold for Cartilage Tissue EngineeringPosterBiomedical Engineering Society Annual Meeting2010
Injectable lactoferrin gel as a macromolecular delivery vehiclePosterCRC symposium2010Yale University, New Haven
Development of a Novel Biodegradable Stimuli- Sensitive Injectable Hydrogel System for Orthopeadic ApplicationsTalkNational Medical Association2010Florida
Lactoferrin as a regulator of FGF expression in osteoblast-like MC3T3-E1 cellsTalkAnnual Orthopaedic Research Society meeting2010
Extending the action of ropivacaine in rats with a thermogelling biodegradable matrixTalkACLAM Forum2010Newport, RI
Three dimensional Polyphosphazene Nanostructured Biomimetic Scaffolds for Loadbearing Bone RegenerationTalkTERMIS2010
Osteogenic Nanostructured Titanium Surface: A potential Orthopaedic MaterialPoster6th International Key symposium on Nanomedicine2009Stockholm, Sweden
Biodegradable micro-nano scaffolds for ligament and tendon regenerationTalkWorld conference on regenerative medicine2009Leipzig, Germany
Osteoinduction of human adipose derived stem cells using composite sintered microsphere matrixTalkISSCR2009Barcelona, Spain
Injectable tissueengineered bone healing of a rat calvarial defectTalkOtolaryngology conference2009
Nanotechnology and Tissue EngineeringTalkStevens Institute2009New Jersey
Injectable Stimuli Sensitive Scaffolds for Musculoskeletal Tissue regenerationTalk3rd annual research day, New England Musculoskeletal Institute, UCHC2009Farmington, CT
Biomaterials for musculoskeletal tissue regenerationOtherSociety for Biomaterials 2009 Annual Meeting2009San Antonio, TX
Preventing implant associated infectionsOtherSociety for Biomaterials 2009 Annual Meeting2009San Antonio, TX
Invited lecture on “Nanotechnology and Tissue EngineeringTalkASME-NSF work shop2008Boston, MA
Nanostructured Titanium Surface Containing Silver Nanoparticles: A Potential Orthopaedic BiomaterialPosterWorld Biomaterials Conference2008Amsterdam, Netherlands
Injectable thermosensitive chitosan based scaffolds for musculoskeletal tissue regenerationTalkTERMIS2008CA
Curcumin Containing Polymeric Nanofibers: Novel Wound Dressings with Antioxidant PropertiesTalkWorld Biomaterials Conference2008Amsterdam, Netherlands
Evaluation of the Responses of Human and Rabbit Bone Marrow Derived Mesenchymal Stem Cells to Dynamic Culture Conditions in HARV BioreactorsTalkWorld Biomaterials Conference2008Amsterdam, Netherlands
Novel Dipeptide-Based Biodegradable Polymeric Blends for Bone Tissue Engineering:Poly[(glycine ethyl glycinato)(phenyl phenoxy)phosphazene] – Poly(lactide-co-glycolide) Miscibility and Osteocompatibility StudiesTalkWorld Biomaterials Conference2008Amsterdam, Netherlands
Composite Microsphere nanofiber scaffolds for bone tissue engineering TalkWorld Biomaterials Conference2008Amsterdam, Netherlands
Development of a Novel Stimuli Sensitive Injectable Hydrogel system for Biomedical ApplicationsTalkNational Medical Association2008
Fabrication and in vitro evaluation of novel polyphosphazene-nano hydroxyapatite microsphere scaffolds for bone tissue engineeringTalkOrthopaedic Research Society meeting2008
Thermosensitive Chitosan As A Matrix For The Controlled Delivery Of Biologically Active Molecules For Bone RepairTalkAIChE Annual meeting2008Salt Lake city, Utah
Cell-Nanomaterial InteractionTalknanoSTAR Biology & Medicine workshop, May, University of Virginia2008Charlottesville, VA
Nanotechnology and Tissue engineeringTalkCumberland University2008
Nanotechnology for Orthopaedic ApplicationsTalkAAOS Fracture Repair: Challenges and Opportunities2007Florida
One step in situ method for developing silver nanoparticle-Polymer Composites for Orthopaedic ApplicationsPosterNational Medical Association Meeting2007Hawai
Synthesis and characterization of novel biodegradable phenyl phenoxy-based polyphosphazene blends: in vitro osteocompatibility evaluationTalkBiomaterials USA Annual Meeting2007
Biodegradable Polyphosphazenes: A versatile class of biomaterialsTalkHilton Head Conference2007SC
Invited lecture on Biocompatible biomaterials for tissue repair and regenerationTalkVirginia Common Wealth University2007Virginia
Surface Modification and Characterization of Orthopaedic and Dental Implants at the Nano/Micro scale for improved osseointegrationOtherSociety for Biomaterials 2007Annual Meeting2007Chicago, IL
Surface Modification and characterization of BiomaterialsOtherSociety for Biomaterials 2007 Annual Meeting2007Chicago, IL
Injectable biodegradable hydrogels for biomedical applications TalkIndian Institute of Technology2006Kanpur, India
Musculoskeletal tissue engineering: A scaffold based approachTalkAmritha Institute of Medical Sciences and Technology2006Kerala, India
Osteogenic Differentiation of Human Mesenchymal Stem Cells in Injectable In situ Thermogelling Chitosan SolutionPosterSociety for Biomaterials USA meeting2006
Injectable, thermosetting in situ forming biodegradable hydrogels as sustained macromolecular delivery systemsPosterOrthopaedic Research Society meeting2006
Development of injectable thermogelling chitosan-inorganic phosphate solution for biomedical applicationTalkSociety for Biomaterials USA meeting2006
Nanohydroxyapatite incorporated polyphosphazene nanofibers for bone tissue engineeringTalk2006 Summer Bioengineering Conference The American Society of2006
Fabrication and biocompatibility of polyphosphazene Tubular electrospun nanofiber scaffolds for bone tissue engineeringTalkSummer Bioengineering Conference The American Society2006
Physico-chemical evaluation of physiological temperature setting polymer-ceramic composites for bone tissue engineeringTalk52nd Annual meeting of2006Chicago, Illinois
Injectable, thermosetting in situ forming biodegradable hydrogels as sustained macromolecular delivery systemsTalk52nd Annual meeting of Orthopaedic Research Society2006Chicago, IL
Surface Modification and characterization of BiomaterialsOtherSociety for Biomaterials 2006 Annual Meeting2006Pittsburgh,PA
Synthesis, characterization and in vitro degradation of L-alanine co-substituted polyphosphazenesTalkAbstracts of papers, 230th ACS National Meeting2005Washington, DC
Materials for Tissue Engineering and Drug DeliveryTalkNano Corridors Meeting with VA/NC Universities2005Danville, VA
In Vivo Biocompatibility Evaluation of Novel Amino Acid Ester based Biodegradable Polyphosphazenes for Biomedical ApplicationsTalk30th Annual Meeting of the Society for Biomaterials2005Memphis, TN
Synthesis, characterization and in vitro degradation of L-alanine co-substituted polyphosphazenes, Polymer PreprintsTalk2005
Preparation of biocompatible polyphosphazene nanofiber mats by electrospinningTalk7th World Biomaterials Conference of the Society of Biomaterials2004Sydney, Australia
Polyphosphazene-hydroxyapatite scaffolds for bone tissue engineeringTalk7th World Biomaterials Conference of the Society of Biomaterials2004Sydney, Australia
Synthesis and evaluation of novel amino acid ester phenyl phenoxy polyphosphazene for bone tissue engineeringTalkTransactions of the 5th combined meeting of the Orthopaedic research societies of Canada, USA, Japan2004
Synthesis and Fabrication of porous nanofiber matrices of biodegradable polyphosphazenes as scaffolds for tissue engineeringTalkCelebration of diversity in organic chemistry symposium at Pfizer Globel Research2004Groton, CT
Tissue EngineeringTalkSecond International Workshop on “Nanotechnology and Health Care2004Thanjavur, India
Preparation of biocompatible polyphosphazene nanofiber mats by electrospinningPoster7th World Biomaterials Conference of the Society of Biomaterials2004Sydney, Australia
Novel biomaterial for bone tissue engineeringPoster7th World Biomaterials Conference of the Society of Biomaterials2004Sydney, Australia
Novel amino acid ester polyphosphazene-hydroxyapatite composites for bone tissue engineeringTalkMaterial Research Society Fall Meeting2004Boston, MA
Design of high strength degradable polyphosphazenes: Modulation of mechanical properties via side chain chemistryTalkMaterial Research Society Fall2004Boston, MA
Polyphosphazene nanohydroxyapatite composite nanofibers as scaffolds for bone tissue engineeringTalkMaterial Research Society Fall Meeting2004Boston, MA
Biodegradable polyphosphazene for biomedical applicationsTalkNASA cell biology meeting2004Palo Alto, CA.
Nanostructured Drug Delivery and Biosensor SystemsOtherMRS Fall Meeting2004Boston, MA
In vitro evaluation of novel glycine containing biodegradable polyphosphazenes for bone tissue engineeringTalk29th Annual meeting of Society for Biomaterials2003Reno Hilton, Nevada
In vitro evaluation of novel glycine containing biodegradable polyphosphazenes for bone tissue engineeringPoster29th Annual meeting of Society for Biomaterials2003Nevada
Novel biodegradable polyphosphazenes for bone tissue engineering: An in vitro evaluationPoster29th Annual meeting of Society for Biomaterials2003Reno Hilton, Nevada
Novel biodegradable polyphosphazenes for bone tissue engineering: An in vitro evaluationTalk29th Annual meeting of Society for Biomaterials2003Reno Hilton, Nevada
Preparation of polyphosphazene mats by electrospinningTalkMaterial Research Society Fall Meeting2003Boston, MA
Grafting poly(ethylene glycol) onto plasticized poly(vinyl chloride) reduces cellular adhesionPosterIUPAC International Symposium on Advances in Polymer Science and Technology1998Chennai, India
Surface grafting of poly(ethylene glycol) onto poly(vinyl chloride) improves the blood compatibility of PVCTalk9th Kerala Science Congress1997Kerala, India
Grafting poly(ethylene glycol) onto plasticized poly(vinyl chloride) via Williamson ether synthesis: A simple novel route to improve the blood compatibility of PVCTalk11th World Congress of the International Society for Artifical1997Providence, RI
Inhibition of bacterial adherence on plasticized poly(vinyl chloride) by grafting poly(ethylene glycol) via Williamson ether synthesisTalk49th Indian Pharmaceutical Congress1997Kerala, India
Invited Lecture on Grafting poly(ethylene glycol) onto plasticized PVC via Williamson ether synthesisTalk11th World Congress of the International Society for Artifical Organs (ISAO-97)1997Providence, RI
Phase transfer catalyzed surface modification prevents plasticizer migration from plasticized poly(vinyl chloride)Talk8th Kerala Science Congress1996Kerala, India
Invited Lecture on Phase transfer catalyzed surface modification of polymersTalkAnnual Conference of Kerala Academy of Sciences1996Kerala, India
Polystyrene supported benzoic oximinodithiocarbonic anhydrides as heterogeneous photoinitiatorsTalkInternational Symposium on Macromolecules1995Kerala, India
Polystyrene supported benzoic oximinodithiocarbonic anhydrides as heterogeneous photoinitiatorsPosterInternational Symposium on Macromolecules1995Kerala, India