Lakshmi Sreedharan Nair, Ph.D., SCTIMST
Assistant Professor, Orthopaedic Surgery|
Academic Office Location: Orthopaedic Surgery University of Connecticut Health Center 263 Farmington Avenue Farmington, CT 06030 |
|
| Phone: | 860-679-7190 |
| Fax: | 860-679-1553 |
| Email: | nair@uchc.edu |
| Website(s): |
Skeletal, Craniofacial, & Oral Biology Graduate Program |
Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| Ph.D. | Sree Chitra Tirunal Institute for Medical Science and Technology (SCTIMST) | Polymer Chemistry |
| M.Phil. | Kerala University | Chemistry |
| M.Sc. | Kerala University | Analytical Chemistry |
| B.Sc. | Kerala University | Chemistry |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Fellowship | SCTIMST | Junior Research Fellow |
| Fellowship | International Society for Artificial Organs | Young Scientist Award Regional Science Fellowship (India, Middle East & Africa) |
| Fellowship | SCTIMST | Senior Research Fellow |
| Post Doctoral | Drexel University | Post Doctoral Fellow, Department of Chemical Engineering |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| “Women of Innovation Finalist” Entrepreneurial Innovation and Leadership | CT Technology Council |
| Tech Brief Initial Award | National Aeronautics and Space Administration |
| Injectable lactoferrin gel as a macromolecular delivery vehicle- THE BEST POSTER AWARD | CRC symposium |
| Very Good Poster Presentation Award | IUPAC International Symposium |
| Prof. Anantharaman Prize Merit Certificate,National Scholarships Scheme | University Topper in M.Sc. |
Our research program is directed at understanding how cells interact with biomaterials and how to appropriately modulate the cell-biomaterial interactions for developing novel biomaterial based therapies. Our ultimate goal is to restore, maintain or improve tissue and/organ functions by modulating the host tissue microenvironment using biologically active biomaterials. Current studies focus on the design and development of regenerative biomaterials to favorably modulate the responses of a variety of cell types involved in tissue regeneration and repair. Formulating biologically active biomaterial requires a thorough understanding of the cellular responses to these materials in vitro and in vivo. Additional studies focus on the identification of sensitive markers as indices of cell-substrate interactions to gain insights into the molecular basis of cell-biomaterial interactions.
Our ability to modulate the unfriendly milieu at the wound site by attenuating inflammation, controlling cellular immune responses and signal transduction pathways will significantly enhance the regenerative process in adult tissue. The objective is to identify unique biologically active molecules and develop biomaterial constructs as artificial tissue microenvironment that can favorably modulate cell responses to promote tissue regeneration and/ repair. Specific work includes rational design and/ identification of biologically active molecules that can favorably interact with cells involved in healing via multiple signaling pathways, design and development of biomaterial constructs for tissue engineering and on evaluating the biological activity of the three dimensional bio-molecular constructs using in vitro and in vivo models.
Our ability to modulate the unfriendly milieu at the wound site by attenuating inflammation, controlling cellular immune responses and signal transduction pathways will significantly enhance the regenerative process in adult tissue. The objective is to identify unique biologically active molecules and develop biomaterial constructs as artificial tissue microenvironment that can favorably modulate cell responses to promote tissue regeneration and/ repair. Specific work includes rational design and/ identification of biologically active molecules that can favorably interact with cells involved in healing via multiple signaling pathways, design and development of biomaterial constructs for tissue engineering and on evaluating the biological activity of the three dimensional bio-molecular constructs using in vitro and in vivo models.
Not accepting students for Lab Rotations at this time.
Journal Articles
-
A chitosan thermogel for delivery of ropivacaine in regional musculoskeletal anesthesia
(2013) Biomaterials 10 (34) 2539-2546
-
Evaluation of the Bioactivity of Recombinant Human Lactoferrins Toward Murine Osteoblast-Like Cells for Bone Tissue Engineering
(2013) Tissue Eng Part A
-
Hydrolysis of Ca-deficient hydroxyapatite precursors in the presence of alanine-functionalized polyphosphazene nanofibers
(2013) Ceramics International 1 (39) 519-528
-
Nano-ceramic Composite Scaffolds for Bioreactor-based Bone Engineering
(2013) Clin Orthop Relat Res
-
Enzymatically cross-linked injectable gelatin gel as osteoblast delivery vehicle
(2012) Journal of Bioactive and Compatible Polymers 4 (27) 342-355
-
Evaluation of the Bioactivity of Recombinant Human Lactoferrins towards Murine Osteoblast-like Cells for Bone Tissue Engineering
(2012) Tissue Eng Part A
-
Fabrication and Evaluation of Resveratrol Loaded Polymeric Nanofibers
(2012) Journal of Biomaterials and Tissue Engineering 3 (2) 228-235
-
Injectable hydrogels for bone and cartilage repair
(2012) Biomed Mater 2 (7) 24105
-
Injectable thermogelling chitosan for the local delivery of bone morphogenetic protein
(2012) J Mater Sci Mater Med 9 (23) 2141-9
-
Biomimetic Structures: Biological Implications of Dipeptide-Substituted Polyphosphazene–Polyester Blend Nanofiber Matrices for Load-Bearing Bone Regeneration
(2011) Advanced Functional Materials 14 (21) 2641-2651
-
Development and characterization of biodegradable nanocomposite injectables for orthopaedic applications based on polyphosphazenes
(2011) J Biomater Sci Polym Ed 6-Apr (22) 733-52
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Improved bio-implant using ultrafast laser induced self-assembled nanotexture in titanium
(2011) J Biomed Mater Res B Appl Biomater 2 (97) 299-305
-
Polyphosphazene containing vitamin substituents: synthesis, characterization and hydrolytic sensitivity
(2011) Macromolecules 6 (44) 1355-1364
-
Polyphosphazenes containing vitamin substituents. Synthesis, characterization and hydrolytic sensitivity
(2011) Macromolecules 6 (44) 1355-1364
-
Prolotherapy for tissue repair
(2011) Transl Res 3 (158) 129-131
-
Biomimetic, bioactive etheric polyphosphazene-poly(lactide-co-glycolide) blends for bone tissue engineering
(2010) J Biomed Mater Res A 1 (92) 114-25
-
Composite scaffolds: bridging nanofiber and microsphere architectures to improve bioactivity of mechanically competent constructs
(2010) J Biomed Mater Res A 4 (95) 1150-8
-
Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering
(2010) Biomaterials 18 (31) 4898-4908
-
Functionalization of chitosan/poly(lactic acid-glycolic acid) sintered microsphere scaffolds via surface heparinization for bone tissue engineering
(2010) J Biomed Mater Res A 3 (93) 1193-208
-
Hydrogen bonding in blends of polyesters with dipeptide-containing polyphosphazenes
(2010) Journal of Applied Polymer Science 1 (115) 431-437
-
Hydrolysable polylactide-Polyphosphazene block copolymers for biomedical applications: Synthesis, Characterization and composites with Poly(lactide-co-glycolic acid)
(2010) Polym Chem 9 (1) 1459-1466
-
In Situ Porous Structures: A Unique Polymer Erosion Mechanism in Biodegradable Dipeptide-based Polyphosphazene and Polyester Blends Producing Matrices for Regenerative Engineering
(2010) Adv Funct Mater 17 (20) 2743-2957
-
Injectable tissue-engineered bone repair of a rat calvarial defect
(2010) Laryngoscope 5 (120) 895-901
-
Iodine-containing radio-opaque polyphosphazenes
(2010) Polym Chem (19) 1467-1474
-
Mechanical properties and osteocompatibility of novel biodegradable alanine based polyphosphazenes: Side group effects
(2010) Acta Biomater 6 (6) 1931-7
-
Miscibility of choline-substituted polyphosphazenes with PLGA and osteoblast activity on resulting blends
(2010) Biomaterials 33 (31) 8507-15
-
Novel nanostructured scaffolds as therapeutic replacement options for rotator cuff disease
(2010) J Bone Joint Surg Am (92 Suppl 2) 170-9
-
Biodegradable polyphosphazene-nanohydroxyapatite composite nanofibers: scaffolds for bone tissue engineering
(2009) J Biomed Nanotechnol 1 (5) 69-75
-
Curcumin-loaded poly(epsilon-caprolactone) nanofibres: diabetic wound dressing with anti-oxidant and anti-inflammatory properties
(2009) Clin Exp Pharmacol Physiol 12 (36) 1149-56
-
Fabrication, characterization, and in vitro evaluation of poly(lactic acid glycolic acid)/nano-hydroxyapatite composite microsphere-based scaffolds for bone tissue engineering in rotating bioreactors
(2009) J Biomed Mater Res A 3 (91) 679-91
-
Polyphosphazenes that contain dipeptide side groups: Synthesis, characterization, and sensitivity to hydrolysis
(2009) Macromolecules 3 (42) 636-639
-
The influence of side group modification in polyphosphazenes on hydrolysis and cell adhesion of blends with PLGA
(2009) Biomaterials 17 (30) 3035-3041
-
Biologically active chitosan systems for tissue engineering and regenerative medicine
(2008) Curr Top Med Chem 4 (8) 354-64
-
Electrospun poly(lactic acid-co-glycolic acid) scaffolds for skin tissue engineering
(2008) Biomaterials 30 (29) 4100-7
-
Formation and properties of composites comprised of calcium-deficient hydroxyapatites and ethyl alanate polyphosphazenes
(2008) J Mater Sci Mater Med 9 (19) 3153-60
-
Formation of composites comprised of calcium deficient HAp and cross-linked gelatin
(2008) J Mater Sci Mater Med 10 (19) 3193-3201
-
Induction of angiogenesis in tissue-engineered scaffolds designed for bone repair: a combined gene therapy-cell transplantation approach
(2008) Proc Natl Acad Sci U S A 32 (105) 11099-104
-
Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid)
(2008) Biomaterials 3 (29) 337-49
-
Nanophasic hydroxyapatite incorporated biodegradable polyphosphazene nanofibers for bone tissue engineering
(2008) J. Biomed. Nanotechnology (45) 1-7
-
Polyphosphazene/nano-hydroxyapatite composite microsphere scaffolds for bone tissue engineering
(2008) Biomacromolecules 7 (9) 1818-25
-
Solvent/non-solvent sintering: a novel route to create porous microsphere scaffolds for tissue regeneration
(2008) J Biomed Mater Res B Appl Biomater 2 (86) 396-406
-
Synthesis and characterization of new biomedical polymers: Serine-and threonine-containing polyphosphazenes and poly(L-lactic acid) grafted copolymers
(2008) Macromolecules 21 (41) 7824-7828
-
Synthesis and characterization of novel biodegradable phenyl phenoxy polyphosphazene blends: in vitro osteocompatibility evaluation
(2008) Biomaterials (29) 337-349
-
Synthesis and Characterization of Polyphosphazene-Block-Polyester and Polyphosphazene-Block-Polycarbonate macromolecules
(2008) Macromolecules 4 (41) 1126-1130
-
Synthesis of purine and pyrimidine-containing polyphosphazenes: physical properties and hydrolytic behavior
(2008) Macromolecules 22 (41) 8467-8472
-
Apatite nano-crystalline surface modification of poly(lactide-co-glycolide) sintered microsphere scaffolds for bone tissue engineering: implications for protein adsorption
(2007) J Biomater Sci Polym Ed 9 (18) 1141-52
-
Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications
(2007) Biomacromolecules 12 (8) 3779-85
-
Human endothelial cell growth and phenotypic expression on three dimensional poly(lactide-co-glycolide) sintered microsphere scaffolds for bone tissue engineering
(2007) Biotechnol Bioeng 5 (98) 1094-102
-
Hydroxyapatite-polyphosphazene composites prepared at low temperatures
(2007) J American Ceramic Society (90) 2728-2734
-
Miscibility of bioerodible polyphosphazene/poly(lactide-co-glycolide) blends
(2007) Biomacromolecules 4 (8) 1306-12
-
Nanobiomaterial applications in orthopedics
(2007) J Orthop Res 1 (25) 11-22
-
Novel low temperature setting nanocrystalline calcium phosphate cements for bone repair: osteoblast cellular response and gene expression studies
(2007) J Biomed Mater Res A 4 (82) 884-91
-
Polyphosphazene Blends: The development of a Novel Biomedical Material
(2007) Polym Prepr (ACS Div Polym Chem) (48)
-
Silver Nanoparticles: Synthesis and Therapeutic Applications
(2007) Journal of Biomedical Nanotechnology 4 (3) 301-316
-
Structural and nanoindentation studies of stem cell-based tissue-engineered bone
(2007) J Biomech 2 (40) 399-411
-
Chitosan Composites for Tissue Engineering: Bone Tissue Engineering Scaffolds
(2006) Asian Chitin Journal (2) 1-10
-
Effect of side group chemistry on the properties of biodegradable L-alanine cosubstituted polyphosphazenes
(2006) Biomacromolecules 3 (7) 914-8
-
Electrospinning of Biodegradable Polyphosphazenes for Biomedical Applications: Fabrication of Poly[bis(ethyl alanato) phosphazene] Nanofibers
(2006) J Biomed Nanotechnol (2) 1-10
-
Formation of hydroxyapatite-polyphosphazene polymer composites at physiologic temperature
(2006) J Biomed Mater Res A 2 (77) 416-25
-
In Vitro and In Vivo Characterization of Biodegradable Poly(organophosphazenes) for Biomedical Applications
(2006) Journal of Inorganic and Organometallic Polymers and Materials 4 (16) 365-385
-
In vivo biodegradability and biocompatibility evaluation of novel alanine ester based polyphosphazenes in a rat model
(2006) J Biomed Mater Res A 4 (77) 679-87
-
Polymeric nanofibers as novel carriers for the delivery of therapeutic molecules
(2006) J Nanosci Nanotechnol 10-Sep (6) 2591-607
-
Polymers as biomaterials for tissue engineering and controlled drug delivery
(2006) Adv Biochem Eng Biotechnol (102) 47-90
-
Synthesis, characterization, and osteocompatibility evaluation of novel alanine-based polyphosphazenes
(2006) J Biomed Mater Res A 1 (76) 206-13
-
Composite formation from hydroxyapatite with sodium and potassium salts of polyphosphazene
(2005) J Mater Sci Mater Med 7 (16) 613-20
-
Low temperature formation of hydroxyapatite-poly(alkyl oxybenzoate)phosphazene composites for biomedical applications
(2005) Biomaterials 1 (26) 1-9
-
Development of novel tissue engineering scaffolds via electrospinning
(2004) Expert Opin Biol Ther 5 (4) 659-68
-
Fabrication and optimization of methylphenoxy substituted polyphosphazene nanofibers for biomedical applications
(2004) Biomacromolecules 6 (5) 2212-20
-
Biodegradable polyphosphazenes for drug delivery applications
(2003) Adv Drug Deliv Rev 4 (55) 467-82
-
Novel polyphosphazene-hydroxyapatite composites as biomaterials
(2003) IEEE Eng Med Biol Mag 5 (22) 18-26
-
Properties and performance of sulfide-substituted plasticized poly(vinyl chloride) as a biomaterial
(2003) J Biomed Mater Res B Appl Biomater 1 (65) 204-210
-
Synthesis and polymerization of new iodine-containing monomer
(2003) J Appl Polym 11 (88) 2580-2584
-
A floating-type oral dosage form for piroxicam based on hollow polycarbonate microspheres: in vitro and in vivo evaluation in rabbits
(2002) J Control Release 1-3 (79) 71-79
-
Bacterial adhesion onto azidated poly(vinyl chloride) surfaces
(2002) J Biomed Mater Res 1 (61) 26-32
-
Iodination of Plasticized Poly(Vinyl Chloride) in Aqueous
Media via Phase Transfer Catalysis
(2002) J Appl Polym Sci 3 (84) 493-499
-
Preparation and evaluation of photocrosslinkable chitosan as a drug delivery matrix
(2002) J Appl Polym Sci 8 (86) 1873
-
Synthesis, surface properties and performance of thiosulphate-substituted plasticized poly(vinyl chloride)
(2002) Biomaterials 24 (23) 4855-4862
-
Toxicity, biodegradation and elimination of polyanhydrides
(2002) Adv Drug Deliv Rev 7 (54) 933-61
-
Photocrosslinking of dithiocarbamate-substituted PVC reduces plasticizer migration
(1999) Polymer (39) 151-157
-
Immobile plasticizer in flexible PVC
(1998) Nature 6712 (396) 638
-
Migration resistant, blood-compatible plasticized polyvinyl chloride for medical and related applications
(1998) Artif Organs 3 (22) 222-229
Books
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(2007) Nanotechnology and Tissue Engineering: The Scaffold
Book Chapters
-
Drug loaded nanofiber matrices as diabetic wound dressing
(2012) Nanotechnology and Nanomedicine in Diabetes 325-344
-
Host Response to Biomaterials and its Implications in regenerative
Engineering
(2012) Regenerative Engineering
-
Injectable in situ gelling hydrogels as Biomaterials
(2012) Handbook of Integrated Biomaterials for Medical Applications 359-396
-
Calcium phosphate based ceramics for biomedical applications
(2011) Biodegradable Polymers in Clinical Use and Clincal Development 497-518
-
Biomimetic matrices for integrin mediated cell adhesiontions
(2010) Biologically Responsive Hybrid Biomaterials 247-284
-
Nanotechnology for Inducing Angiogenesis
(2008) Micro and Nanoengineering of the Cell Microenvironment: Technologies and Applications 317-339
Abstracts
-
Synthesis, characterization and in vitro degradation of L-alanine co-substituted polyphosphazenes
(2005) Polymer Preprints
Book Sections
-
Polyphosphazenes
(2010) An Introduction to Biomaterials and Their Applications
-
Biodegradable Polyphosphazene Blends for Biomedical Applications
(2009) Polyphosphazenes for Biomedical Applications 139-154
-
Biomimetric matrices for Integrin-mediated cell adhesion
(2009) Biologically-Responsive Hybrid Biomaterials
-
Injectable Hydrogels as Biomaterials
(2009) Advanced Materials
-
Cell behavior toward nanostructured surfaces
(2008) Biomedical Nanostructures 261-295
-
Cell behavior towards nanostructured surfaces
(2007) Biomedical Nanostructures 261-287
-
Nanostructures for regenerative medicine
(2007) Biomedical Nanostructures 261-287
-
Nanotechnology and tissue engineering: the scaffold based approach
(2006) Nanotechnologies for Life Sciences, Vol: 8, Nanotechnologies for Tissue, Cell and Organ Engineering
-
Polyphosphazenes
(2006) Introduction to Biomaterials 273-290
-
Polyphosphazenes as novel biomaterials
(2006) Handbook of Biodegradable polymeric materials and their applications 277-306
-
Polyphosphazene nanofibers for biomedical applications:
Preliminary studies. Nanoengineered nanofibrous materialsility
(2004) Nanoengineered Nanofibrous Materials Series: Nato Science Series II, Mathematics, Physics and Chemistry 281-300
-
Grafting poly(ethylene glycol) onto plasticized poly(vinyl
chloride) reduces cellular adhesion
(1998) Macromolecules: New Frontiers 613
Conference Papers
-
Bioactive lactoferrin based polymeric nanofibers for bone tissue engineering
(2012)
-
Biofunctional injectable hydrogels for orthopaedic applications
(2012)
-
Characterization of recombinant Lactoferrin gel as an injectable
gel
(2012)
-
Development and evaluation of the bioactivity of injectable bovine lactoferrin gel for bone regeneration
(2012)
-
Evaluation of the bioactivity and biodegradability of
lactoferrin based biomaterials
(2012)
-
Injectable Lactoferrin as an ostoegenic biomaterial
(2012)
-
Biological effects of recombinant human lactoferrin
(2011)
-
Composite PDLA/PCL Nanofiber Injectable Chitosan Gel Scaffold for Osteochondral Regeneration
(2011)
-
Design of Anesthetic Nanoparticle based delivery systems for short term pain management
(2011)
-
Development of resveratrol loaded polymeric nanofibers and the effects of resveratrol on the late stage osteogenesis of preosteoblast cells
(2011)
-
Evaluation of the Osteogenic activity of injectable bovine
lactoferrin Gel
(2011)
-
Gelatin-based injectable gels for the three-dimensional culture of
osteoblasts
(2011)
-
Investigation of Hydrogel-Nanofiber composite for Cartilage Regeneration
(2011)
-
Lactoferrin is a regulator of FGF expression in osteoblast-like MC3T3-E1 cells
(2011)
-
Composite Electrospun/Hydrogel Scaffold for Cartilage Tissue Engineering
(2010)
-
Development of a Novel Biodegradable Stimuli-Sensitive Injectable Hydrogel System for Orthopeadic Applications
(2010)
-
Extending the action of ropivacaine in rats with a thermogelling biodegradable matrix
(2010)
-
Injectable lactoferrin gel as a macromolecular delivery vehicle
(2010)
-
Three-dimensional Polyphosphazene Nanostructured Biomimetic Scaffolds for Loadbearing Bone Regeneration
(2010)
-
Injectable tissueengineered bone healing of a rat calvarial defect
(2009)
-
Osteogenic Nanostructured Titanium Surface: A potential Orthopaedic Material (Young investigator invitee)
(2009)
-
Osteoinduction of human adipose derived stem cells using composite sintered microsphere matrix
(2009)
-
Composite Microsphere nanofiber scaffolds for bone tissue engineering
(2008)
-
Curcumin Containing Polymeric Nanofibers: Novel Wound Dressings with Antioxidant Properties
(2008)
-
Development of a Novel Stimuli Sensitive Injectable Hydrogel system for Biomedical Applications
(2008)
-
Evaluation of the Responses of Human and Rabbit Bone Marrow Derived Mesenchymal Stem Cells to Dynamic Culture Conditions in HARV Bioreactors
(2008)
-
Fabrication and in vitro evaluation of novel polyphosphazene-nano hydroxyapatite microsphere scaffolds for bone tissue engineering
(2008)
-
Injectable thermosensitive chitosan based scaffolds for musculoskeletal tissue regeneration
(2008)
-
Nanostructured Titanium Surface Containing Silver Nanoparticles: A Potential Orthopaedic Biomaterial
(2008)
-
Novel Dipeptide-Based Biodegradable Polymeric Blends for Bone Tissue Engineering:Poly[(glycine ethyl glycinato)(phenyl phenoxy)phosphazene] – Poly(lactide-co-glycolide) Miscibility and
Osteocompatibility Studies
(2008)
-
Thermosensitive Chitosan As A Matrix For The Controlled Delivery Of Biologically Active Molecules For Bone Repair
(2008)
-
Biodegradable Polyphosphazenes : A versatile class of
biomaterials
(2007)
-
Nanotechnology and Orthopaedic Surgery
(2007) (1) 4-15
-
One step in situ method for developing silver nanoparticle-Polymer Composites for Orthopaedic Applications
(2007)
-
Synthesis and characterization of novel biodegradable phenyl phenoxy-based polyphosphazene blends: in vitro osteocompatibility evaluation
(2007)
-
Development of injectable thermogelling chitosan-inorganic phosphate solution for biomedical application
(2006)
-
Fabrication and biocompatibility of polyphosphazene Tubular electrospun nanofiber scaffolds for bone tissue engineering
(2006)
-
In vivo evaluation of novel biodegradable physiological temperature setting composites for bone tissue engineering
(2006)
-
Injectable, thermosetting in situ forming biodegradable hydrogels as sustained macromolecular delivery systems
(2006)
-
Nanohydroxyapatite incorporated polyphosphazene nanofibers for bone tissue engineering
(2006)
-
Osteogenic Differentiation of Human Mesenchymal Stem Cells in Injectable In situ Thermogelling Chitosan Solution
(2006)
-
Physico-chemical evaluation of physiological temperature setting
polymer-ceramic composites for bone tissue engineering
(2006)
-
Biodegradable poly[bis(ethyl alanato)phosphazene]-Poly(lactide-coglycolide)blends: Miscibility and Osteocompatibility evaluations
(2005) (844) Y9.7.1-Y 9.7.7
-
Development of biodegradable polyphosphazene-nanohydroxyapatite composite nanofibers via electrospinning
(2005) (845) 91-96
-
Development of novel biodegradable amino acid ester based polyphosphazene-hydroxyapatite composites for bone tissue engineering
(2005) (845) 291-296
-
In Vivo Biocompatibility Evaluation of Novel Amino Acid Ester based
Biodegradable Polyphosphazenes for Biomedical Applications
(2005)
-
Nanostructured Materials for Tissue Engineering and Drug Delivery
(2005)
-
Nanostructured Materials for Tissue Engineering and Drug
Delivery
(2005)
-
Synthesis, characterization and in vitro degradation of L-alanine
co-substituted polyphosphazenes
(2005)
-
Biodegradable polyphosphazene for biomedical applications
(2004)
-
Design of high strength degradable polyphosphazenes: Modulation of
mechanical properties via side chain chemistry
(2004)
-
Novel amino acid ester polyphosphazene-hydroxyapatite composites
for bone tissue engineering
(2004)
-
Novel biomaterial for bone tissue engineering
(2004)
-
Polyphosphazene nanohydroxyapatite composite nanofibers as scaffolds for bone tissue engineering
(2004)
-
Polyphosphazene-hydroxyapatite scaffolds for bone tissue engineering
(2004)
-
Preparation of biocompatible polyphosphazene nanofiber mats by
electrospinning
(2004)
-
Preparation of poly[bis (carboxylato phenoxy)phosphazene] non woven nanofiber mats by electrospinning
(2004) (EXS-1) 157-163
-
Synthesis and evaluation of novel amino acid ester phenyl phenoxy
polyphosphazene for bone tissue engineering
(2004)
-
Synthesis and Fabrication of porous nanofiber matrices of
biodegradable polyphosphazenes as scaffolds for tissue engineering
(2004)
-
In vitro evaluation of novel glycine containing biodegradable polyphosphazenes for bone tissue engineering
(2003)
-
In vitro evaluation of
novel biodegradable polyphosphazenes for bone tissue engineering
(2003)
-
Novel biodegradable polyphosphazenes for bone tissue engineering: An in vitro evaluation
(2003)
-
Preparation of polyphosphazene mats by electrospinning
(2003)
-
Grafting poly(ethylene glycol) onto plasticized poly(vinyl
chloride) reduces cellular adhesion
(1998)
-
Grafting poly(ethylene glycol) onto plasticized poly(vinyl
chloride) via Williamson ether synthesis: A simple novel route to improve the blood compatibility of PVC
(1997)
-
Inhibition of bacterial adherence on plasticized poly(vinyl
chloride) by grafting poly(ethylene glycol) via Williamson ether synthesis
(1997)
-
Surface grafting of poly(ethylene glycol) onto poly(vinyl chloride) improves the blood compatibility of PVC
(1997)
-
Phase transfer catalyzed surface modification prevents plasticizer migration from plasticized poly(vinyl chloride)
(1996)
-
Polystyrene supported benzoic oximinodithiocarbonic anhydrides as heterogeneous photoinitiators
(1995)
Letters
-
The formation of an apatite coating on carboxylated polyphosphazenes via a biomimetic process
(2007) Materials Letters 17 (61) 3692-3695
Other
-
Lactoferrin: a biologically active molecule for bone regeneration
(2011) Curr Med Chem 8 (18) 1220-9
Reviews
-
Biomedical Applications of Biodegradable Polymers
(2011) J Polym Sci B Polym Phys 12 (49) 832-864
-
Titania nanotubes: Novel Nanostructures for improved Osseointegration
(2011) J Heat Transfer (133) 125
-
Chitosan: A versatile biomedical polymer
(2010) Recent Patents on Biomed Eng (3) 127-129
-
Long-term effects of bone morphogenetic protein- based treatments in humans
(2010) J Long Term Eff Med Implants 4 (20) 277-293
-
Nanofibers and nanoparticles for orthopaedic surgery applications
(2008) J Bone Joint Surg Am (90 Suppl 1) 128-31
-
The FDA and safety--beyond the heparin crisis
(2008) Nat Biotechnol 6 (26) 621-3
-
Biodegradable polymers as biomaterials
(2007) Prog Polym Sci (32) 762-798
| Title or Abstract | Sponsor/Event | Date/Year | Location |
|---|---|---|---|
| Cell Instructive Injectable Materials for Bone Regeneration, Innovations in Biomedical Materials | 2012 | Raleigh, NC | |
| Biofunctional Injectable Hydrogels for Cell Therapy | NanoBIO 2012 | 2012 | Kochi, India |
| Biomaterials for medical devices and regenerative engineering | Kerala State Council for Science | 2012 | Trivandrum, India |
| Biomaterials for Regenerative Engineering | International Conference on recent trends in Molecular Medicine | 2012 | Alappuzha, India |
| Evaluation of the bioactivity and biodegradability of lactoferrin based biomaterials | World Biomaterials Conference | 2012 | Chengdu, China |
| Biofunctional injectable hydrogels for orthopaedic applications. | International conference on tissue science and engineering | 2012 | Chicago, IL |
| Characterization of recombinant Lactoferrin gel as an injectable gel | TERMIS | 2012 | Houston, TX |
| Skin and adipose tissue engineering | Annual meeting of the biomedical engineering society | 2012 | Atlanta, GA |
| Bioactive lactoferrin based polymeric nanofibers for bone tissue engineering | BMES | 2012 | Atlanta, Georgia |
| Injectable Lactoferrin as an ostoegenic biomaterial | Orthopaedic Research society meeting | 2012 | San Fransisco, CA |
| Injectable Biomaterials for Tissue Regeneration and Protein Delivery | MS&T11, American Ceramic Society Meeting | 2011 | Columbus, Ohio |
| Lactoferrin as a regulator of FGF expression in osteoblast-like MC3T3-E1 cells | Annual Orthopaedic Research Society meeting | 2011 | Long beach, CA |
| Evaluation of the Osteogenic activity of injectable bovine lactoferrin Gel | Society for Biomaterials | 2011 | Orlando Florida |
| Development of resveratrol loaded polymeric nanofibers and the effects of resveratrol on the late stage osteogenesis of preosteoblast cells | Annual American Medical Association MSS/RFS research Symposium | 2011 | New Orleans |
| Composite PDLA/PCL Nanofiber Injectable Chitosan Gel Scaffold for Osteochondral Regeneration | Biomedical Engineering Society | 2011 | Hartford, CT |
| Design of Anesthetic Nanoparticle based delivery systems for short term pain management | Biomedical Engineering Society | 2011 | Hartford, CT |
| Composite Electrospun/Hydrogel Scaffold for Cartilage Tissue Engineering | Biomedical Engineering Society Annual Meeting | 2011 | |
| Biological effects of recombinant human lactoferrin. | Orthopaedic Research society meeting | 2011 | Long beach, CA |
| Investigation of Hydrogel-Nanofiber composite for Cartilage Regeneration | Biomedical Engineering Society | 2011 | Hartford, CT |
| Gelatin-based injectable gels for the three-dimensional culture of osteoblasts | Biomedical Engineering Society | 2011 | Hartford, CT |
| Lactoferrin as a regulator of FGF expression in osteoblast-like MC3T3-E1 cells | Annual Orthopaedic Research Society meeting | 2011 | Long Beach, CA |
| Biomaterials for Skeletal Tissue Regeneration | The Stem Cell Seminar Series, UCHC | 2011 | Farmington, CT |
| Nanostructures for Tissue Regeneration | North East Biomaterials Day | 2010 | Columbia University, New York |
| Composite Electrospun/Hydrogel Scaffold for Cartilage Tissue Engineering | Biomedical Engineering Society Annual Meeting | 2010 | |
| Injectable lactoferrin gel as a macromolecular delivery vehicle | CRC symposium | 2010 | Yale University, New Haven |
| Development of a Novel Biodegradable Stimuli- Sensitive Injectable Hydrogel System for Orthopeadic Applications | National Medical Association | 2010 | Florida |
| Lactoferrin as a regulator of FGF expression in osteoblast-like MC3T3-E1 cells | Annual Orthopaedic Research Society meeting | 2010 | |
| Extending the action of ropivacaine in rats with a thermogelling biodegradable matrix | ACLAM Forum | 2010 | Newport, RI |
| Three dimensional Polyphosphazene Nanostructured Biomimetic Scaffolds for Loadbearing Bone Regeneration | TERMIS | 2010 | |
| Osteogenic Nanostructured Titanium Surface: A potential Orthopaedic Material | 6th International Key symposium on Nanomedicine | 2009 | Stockholm, Sweden |
| Biodegradable micro-nano scaffolds for ligament and tendon regeneration | World conference on regenerative medicine | 2009 | Leipzig, Germany |
| Osteoinduction of human adipose derived stem cells using composite sintered microsphere matrix | ISSCR | 2009 | Barcelona, Spain |
| Injectable tissueengineered bone healing of a rat calvarial defect | Otolaryngology conference | 2009 | |
| Nanotechnology and Tissue Engineering | Stevens Institute | 2009 | New Jersey |
| Injectable Stimuli Sensitive Scaffolds for Musculoskeletal Tissue regeneration | 3rd annual research day, New England Musculoskeletal Institute, UCHC | 2009 | Farmington, CT |
| Biomaterials for musculoskeletal tissue regeneration | Society for Biomaterials 2009 Annual Meeting | 2009 | San Antonio, TX |
| Preventing implant associated infections | Society for Biomaterials 2009 Annual Meeting | 2009 | San Antonio, TX |
| Invited lecture on “Nanotechnology and Tissue Engineering | ASME-NSF work shop | 2008 | Boston, MA |
| Nanostructured Titanium Surface Containing Silver Nanoparticles: A Potential Orthopaedic Biomaterial | World Biomaterials Conference | 2008 | Amsterdam, Netherlands |
| Injectable thermosensitive chitosan based scaffolds for musculoskeletal tissue regeneration | TERMIS | 2008 | CA |
| Curcumin Containing Polymeric Nanofibers: Novel Wound Dressings with Antioxidant Properties | World Biomaterials Conference | 2008 | Amsterdam, Netherlands |
| Evaluation of the Responses of Human and Rabbit Bone Marrow Derived Mesenchymal Stem Cells to Dynamic Culture Conditions in HARV Bioreactors | World Biomaterials Conference | 2008 | Amsterdam, Netherlands |
| Novel Dipeptide-Based Biodegradable Polymeric Blends for Bone Tissue Engineering:Poly[(glycine ethyl glycinato)(phenyl phenoxy)phosphazene] – Poly(lactide-co-glycolide) Miscibility and Osteocompatibility Studies | World Biomaterials Conference | 2008 | Amsterdam, Netherlands |
| Composite Microsphere nanofiber scaffolds for bone tissue engineering | World Biomaterials Conference | 2008 | Amsterdam, Netherlands |
| Development of a Novel Stimuli Sensitive Injectable Hydrogel system for Biomedical Applications | National Medical Association | 2008 | |
| Fabrication and in vitro evaluation of novel polyphosphazene-nano hydroxyapatite microsphere scaffolds for bone tissue engineering | Orthopaedic Research Society meeting | 2008 | |
| Thermosensitive Chitosan As A Matrix For The Controlled Delivery Of Biologically Active Molecules For Bone Repair | AIChE Annual meeting | 2008 | Salt Lake city, Utah |
| Cell-Nanomaterial Interaction | nanoSTAR Biology & Medicine workshop, May, University of Virginia | 2008 | Charlottesville, VA |
| Nanotechnology and Tissue engineering | Cumberland University | 2008 | |
| Nanotechnology for Orthopaedic Applications | AAOS Fracture Repair: Challenges and Opportunities | 2007 | Florida |
| One step in situ method for developing silver nanoparticle-Polymer Composites for Orthopaedic Applications | National Medical Association Meeting | 2007 | Hawai |
| Synthesis and characterization of novel biodegradable phenyl phenoxy-based polyphosphazene blends: in vitro osteocompatibility evaluation | Biomaterials USA Annual Meeting | 2007 | |
| Biodegradable Polyphosphazenes: A versatile class of biomaterials | Hilton Head Conference | 2007 | SC |
| Invited lecture on Biocompatible biomaterials for tissue repair and regeneration | Virginia Common Wealth University | 2007 | Virginia |
| Surface Modification and Characterization of Orthopaedic and Dental Implants at the Nano/Micro scale for improved osseointegration | Society for Biomaterials 2007Annual Meeting | 2007 | Chicago, IL |
| Surface Modification and characterization of Biomaterials | Society for Biomaterials 2007 Annual Meeting | 2007 | Chicago, IL |
| Injectable biodegradable hydrogels for biomedical applications | Indian Institute of Technology | 2006 | Kanpur, India |
| Musculoskeletal tissue engineering: A scaffold based approach | Amritha Institute of Medical Sciences and Technology | 2006 | Kerala, India |
| Osteogenic Differentiation of Human Mesenchymal Stem Cells in Injectable In situ Thermogelling Chitosan Solution | Society for Biomaterials USA meeting | 2006 | |
| Injectable, thermosetting in situ forming biodegradable hydrogels as sustained macromolecular delivery systems | Orthopaedic Research Society meeting | 2006 | |
| Development of injectable thermogelling chitosan-inorganic phosphate solution for biomedical application | Society for Biomaterials USA meeting | 2006 | |
| Nanohydroxyapatite incorporated polyphosphazene nanofibers for bone tissue engineering | 2006 Summer Bioengineering Conference The American Society of | 2006 | |
| Fabrication and biocompatibility of polyphosphazene Tubular electrospun nanofiber scaffolds for bone tissue engineering | Summer Bioengineering Conference The American Society | 2006 | |
| Physico-chemical evaluation of physiological temperature setting polymer-ceramic composites for bone tissue engineering | 52nd Annual meeting of | 2006 | Chicago, Illinois |
| Injectable, thermosetting in situ forming biodegradable hydrogels as sustained macromolecular delivery systems | 52nd Annual meeting of Orthopaedic Research Society | 2006 | Chicago, IL |
| Surface Modification and characterization of Biomaterials | Society for Biomaterials 2006 Annual Meeting | 2006 | Pittsburgh,PA |
| Synthesis, characterization and in vitro degradation of L-alanine co-substituted polyphosphazenes | Abstracts of papers, 230th ACS National Meeting | 2005 | Washington, DC |
| Materials for Tissue Engineering and Drug Delivery | Nano Corridors Meeting with VA/NC Universities | 2005 | Danville, VA |
| In Vivo Biocompatibility Evaluation of Novel Amino Acid Ester based Biodegradable Polyphosphazenes for Biomedical Applications | 30th Annual Meeting of the Society for Biomaterials | 2005 | Memphis, TN |
| Synthesis, characterization and in vitro degradation of L-alanine co-substituted polyphosphazenes, Polymer Preprints | 2005 | ||
| Preparation of biocompatible polyphosphazene nanofiber mats by electrospinning | 7th World Biomaterials Conference of the Society of Biomaterials | 2004 | Sydney, Australia |
| Polyphosphazene-hydroxyapatite scaffolds for bone tissue engineering | 7th World Biomaterials Conference of the Society of Biomaterials | 2004 | Sydney, Australia |
| Synthesis and evaluation of novel amino acid ester phenyl phenoxy polyphosphazene for bone tissue engineering | Transactions of the 5th combined meeting of the Orthopaedic research societies of Canada, USA, Japan | 2004 | |
| Synthesis and Fabrication of porous nanofiber matrices of biodegradable polyphosphazenes as scaffolds for tissue engineering | Celebration of diversity in organic chemistry symposium at Pfizer Globel Research | 2004 | Groton, CT |
| Tissue Engineering | Second International Workshop on “Nanotechnology and Health Care | 2004 | Thanjavur, India |
| Preparation of biocompatible polyphosphazene nanofiber mats by electrospinning | 7th World Biomaterials Conference of the Society of Biomaterials | 2004 | Sydney, Australia |
| Novel biomaterial for bone tissue engineering | 7th World Biomaterials Conference of the Society of Biomaterials | 2004 | Sydney, Australia |
| Novel amino acid ester polyphosphazene-hydroxyapatite composites for bone tissue engineering | Material Research Society Fall Meeting | 2004 | Boston, MA |
| Design of high strength degradable polyphosphazenes: Modulation of mechanical properties via side chain chemistry | Material Research Society Fall | 2004 | Boston, MA |
| Polyphosphazene nanohydroxyapatite composite nanofibers as scaffolds for bone tissue engineering | Material Research Society Fall Meeting | 2004 | Boston, MA |
| Biodegradable polyphosphazene for biomedical applications | NASA cell biology meeting | 2004 | Palo Alto, CA. |
| Nanostructured Drug Delivery and Biosensor Systems | MRS Fall Meeting | 2004 | Boston, MA |
| In vitro evaluation of novel glycine containing biodegradable polyphosphazenes for bone tissue engineering | 29th Annual meeting of Society for Biomaterials | 2003 | Reno Hilton, Nevada |
| In vitro evaluation of novel glycine containing biodegradable polyphosphazenes for bone tissue engineering | 29th Annual meeting of Society for Biomaterials | 2003 | Nevada |
| Novel biodegradable polyphosphazenes for bone tissue engineering: An in vitro evaluation | 29th Annual meeting of Society for Biomaterials | 2003 | Reno Hilton, Nevada |
| Novel biodegradable polyphosphazenes for bone tissue engineering: An in vitro evaluation | 29th Annual meeting of Society for Biomaterials | 2003 | Reno Hilton, Nevada |
| Preparation of polyphosphazene mats by electrospinning | Material Research Society Fall Meeting | 2003 | Boston, MA |
| Grafting poly(ethylene glycol) onto plasticized poly(vinyl chloride) reduces cellular adhesion | IUPAC International Symposium on Advances in Polymer Science and Technology | 1998 | Chennai, India |
| Surface grafting of poly(ethylene glycol) onto poly(vinyl chloride) improves the blood compatibility of PVC | 9th Kerala Science Congress | 1997 | Kerala, India |
| Grafting poly(ethylene glycol) onto plasticized poly(vinyl chloride) via Williamson ether synthesis: A simple novel route to improve the blood compatibility of PVC | 11th World Congress of the International Society for Artifical | 1997 | Providence, RI |
| Inhibition of bacterial adherence on plasticized poly(vinyl chloride) by grafting poly(ethylene glycol) via Williamson ether synthesis | 49th Indian Pharmaceutical Congress | 1997 | Kerala, India |
| Invited Lecture on Grafting poly(ethylene glycol) onto plasticized PVC via Williamson ether synthesis | 11th World Congress of the International Society for Artifical Organs (ISAO-97) | 1997 | Providence, RI |
| Phase transfer catalyzed surface modification prevents plasticizer migration from plasticized poly(vinyl chloride) | 8th Kerala Science Congress | 1996 | Kerala, India |
| Invited Lecture on Phase transfer catalyzed surface modification of polymers | Annual Conference of Kerala Academy of Sciences | 1996 | Kerala, India |
| Polystyrene supported benzoic oximinodithiocarbonic anhydrides as heterogeneous photoinitiators | International Symposium on Macromolecules | 1995 | Kerala, India |
| Polystyrene supported benzoic oximinodithiocarbonic anhydrides as heterogeneous photoinitiators | International Symposium on Macromolecules | 1995 | Kerala, India |