Photo of Anne M. Delany, Ph.D.

Anne M. Delany, Ph.D.

Professor, Medicine
Academic Office Location:
Center for Molecular Oncology
Department of Medicine
Uconn Health
263 Farmington Ave
Farmington, CT 06030-3101
Phone: 860-679-8730
860-679-8736
Fax: 860-679-7639
Email: adelany@uchc.edu
Website(s):

Cell Biology Graduate Program

Skeletal Biology and Regeneration Graduate Program

Curriculum Vitae:

Regulation of osteoblast gene expression by microRNAs; Molecular mechanisms controlling bone remodeling.

Education
DegreeInstitutionMajor
B.S.Roger Williams CollegeChemistry
Ph.D.Dartmouth Medical SchoolBiochemistry

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralDartmouth Medical SchoolBiochemistry (Constance Brinckerhoff, PhD)
PostdoctoralSaint Francis Hospital & Medical CenterPostdoctoral Fellow, Bone Biology (Ernesto Canalis, MD)

Awards
Name of Award/HonorAwarding Organization
Young Investigator AwardAmerican Society for Bone and Mineral Research

l am very interested in mentoring and I am committed to the success of my graduate students. Recognizing that each student is different, I enjoy learning about my students and finding ways to help them build on their strengths and work on skills needing improvement.

Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Skeletal Biology Structure and Regeneration (SBSR) study section/NIHStudy Sectionad hoc committee memberExternalNational2023
MD/PhD Admissions CommitteeAdvisory Committeecommittee memberUConn HealthUniversity2023
Skeletal Biology Development and Disease (SBDD) Study SectionStudy Sectionad hoc committee memberExternalNational2022
Vidi-programme NWO/ZonMw / Dutch Research CouncilStudy Sectionad hoc committee memberExternalInternational2022
MD/PhD Executive CommitteeAdvisory Committeecommittee memberUConn HealthUniversity2022
Member Conflict: Skeletal and Dental Biology and Tissue Engineering SEP/ NIHStudy SectionCommittee ChairExternalNational2021
Graduate School Diversity, Equity and Inclusion CommitteeAdvisory Committeecommittee memberUConn HealthUniversity2021
Skeletal Biology and Regeneration Recruitment CommitteeAdvisory CommitteeChairUConn HealthUniversity20202022
Graduate Programs CommitteeAdvisory CommitteeChairUConn HealthUniversity20202022
Education CouncilAdvisory Committeecommittee memberUConn HealthUniversity20202022
Academic Advancement CommitteeAdvisory Committeecommittee memberUConn HealthUniversity20202024
Graduate Faculty CouncilAdvisory CommitteememberUConn HealthUniversity20192020
Institutional Animal Care and Use CommitteeAdvisory CommitteememberUConn HealthLocal2018
Graduate Programs CommitteeAdvisory Committeevice chairUConn HealthLocal20182020
microCT Core Advisory CommitteeAdvisory CommitteeUConn HealthUniversity2018
Skeletal Biology and Regeneration ProgramAdvisory CommitteedirectorUConn HealthLocal20162018
Skeletal Biology Structure and Regeneration (SBSR) Study SectionStudy SectionMemberExternalNational20152019
Society for OsteobiologyProfessional/Scientific OrganizationmemberExternalInternational2015
Skeletal Biology and Regeneration ProgramAdvisory Committeeassociate directorUConn HealthLocal20142016
Skeletal Biology and Regeneration Program Executive CommitteeAdvisory CommitteememberUConn HealthLocal20142020
Abstract Review Committee American Society for Bone and Mineral Research Professional/Scientific OrganizationmemberExternalInternational20132013
Abstract Review Committee Member American Society for Bone and Mineral Research Professional/Scientific OrganizationmemberExternalInternational20112011
Skeletal Craniofacial Oral Biology Graduate Program, Preliminary Exam Review Committee Advisory CommitteememberUConn HealthUniversity20112011
Skeletal Craniofacial Oral Biology Graduate Program: Preliminary Exam Review CommitteeProfessional/Scientific OrganizationMemberExternalNational2011
Curriculum Policy Subcommittee Advisory CommitteeVice ChairUConn HealthUniversity2010
Endocrine SocietyProfessional/Scientific OrganizationMemberExternalNational2010
Curriculum Policy SubcommitteeProfessional/Scientific OrganizationVice ChairExternalNational2010
Science Policy Committee American Society for Bone and Mineral Research Professional/Scientific OrganizationmemberExternalInternational20082011
Molecular Core Advisory Committee Advisory CommitteeMemberUConn HealthUniversity2008
International Bone and Cancer SocietyProfessional/Scientific OrganizationMemberExternalInternational2008
American Society for Bone and Mineral Research: Science Policy CommitteeProfessional/Scientific OrganizationMemberExternalNational20082011
Molecular Core Advisory CommitteeProfessional/Scientific OrganizationMemberExternalNational20082013
Faculty Search Committee, Center for Molecular MedicineProfessional/Scientific OrganizationMemberExternalNational20082009
Biomedical Sciences Graduate Admissions CommitteeProfessional/Scientific OrganizationApplication reviews, interviewsExternalNational20072011
Abstract Review Committee Member American Society for Bone and Mineral Research Professional/Scientific OrganizationmemberExternalInternational20042004
American Society for Bone and Mineral Research: Abstract Review CommitteeProfessional/Scientific OrganizationMemberExternalNational2004
Current Rheumatology ReviewsEditorial BoardMemberExternalNational2004
Pilot & Feasibility Core UCHC Musculoskeletal Core Center GrantProfessional/Scientific OrganizationCo-DirectorExternalUniversity20022004
American Society for Matrix BiologyProfessional/Scientific OrganizationMemberExternalNational2000
Arthritis Research and TherapyProfessional/Scientific JournalMemberExternalNational19992009
American Society for MicrobiologyProfessional/Scientific OrganizationMemberExternalNational19952004
American Society for Bone and Mineral ResearchProfessional/Scientific OrganizationmemberExternalInternational1993

My laboratory is focused on understanding how microRNAs (miRNAs), which are a class of small non-coding RNAs, regulate gene expression in bone cells. Osteoblasts are the cells responsible for bone formation, and we are interested in determining the molecular mechanisms by which miRNAs control the differentiation and function of these cells. In the osteoblast lineage, we are currently studying the function and regulation of miR-433-3p. In collaboration with Dr. Sun-Kyeong Lee (Center on Aging) we are also investigating how the miR-29-3p family of miRNAs regulates the commitment and function of bone-resorbing osteoclasts.


We utilize in vitro studies to identify specific mRNAs and signaling pathways regulated by miRNAs. We follow up on these observations by examining the skeletal phenotype of mouse models in which the expression of either miR-29 or miR-433 is inhibited in a lineage-restricted manner. These mouse models are also useful for determining how miRNAs affect the response of the skeleton to intermittently administered parathyroid hormone (PTH), which is a bone anabolic therapy, or to exogenous glucocorticoids, which can cause bone loss.


In additional collaborative studies with Dr. Archana Sanjay (Department of Orthopedics), we are investigating how miRNAs regulate the process of fracture repair in young vs aged mice and in healthy vs diabetic mice.

Accepting Lab Rotation Students: Summer 2022, Fall 2022, and Spring 2023


Potential Lab Rotation Projects
1. Wnt signaling promotes commitment to the osteoblast lineage and is important for osteoblast function. miR-433 dampens Wnt signaling and we are interested in identifying components of the Wnt pathway that are targeted by miR-433.


2. A common progenitor gives rise to osteoclasts, macrophages and dendritic cells. Since miR-29 promotes osteoclast commitment in vitro, we are interested in determining whether progenitor cells from mice expressing a miR-29 inhibitor are more likely to differentiate towards the macrophage fate and whether RNAs important for macrophage commitment are targeted by miR-29.


3. Intermittent administration of PTH is a clinically relevant bone anabolic therapy. miR-433 targets Creb1, which is a transcription factor critical for signaling down stream of PTH receptor activation. We are interested in determining whether mice expressing a miR-433 inhibitor in bone are more responsive to intermittent PTH therapy.

Journal Articles

Book Chapters

  • Cytokines and Growth Factors in Arthritic Diseases: Mechanisms of Cell Proliferation and Matrix Degradation in Rheumatoid Arthritis
    Brinckerhoff C.E., Delany A.M. Cytokines in Inflammation
  • Growth Factors and Bone
    Delany A.M., Canalis E. Growth Factors and Cytokines in Health and Disease
  • Measuring Transcription of Matrix Metalloproteinases: Run-On vs. hnRNA
    Delany A.M. Matrix Metalloproteinase Protocols
  • miRNAs in bone repair
    Franceschetti T, Delany AM miRNA in Regenerative Medicine 653-683
  • The Cellular and Molecular Basis of Glucocorticoid Actions in Bone
    Delany, A.M., Pereira, R.M.R., Pereira, R.C., Canalis, E. Frontiers of Hormone Research: Glucocorticoid Induced Osteoporosis 2-12

Abstracts

  • . Inhibition of miR-29 activity in the myeloid lineage by expression of a miR-29 tough decoy enhances trabecular bone volume in male mice.
    Shin B, Delany AM*, Lee SK* *co-corresponding authors J Bone Miner Res 34(Suppl 1,):
  • A crucial role for microRNA-433-3p in endochondral ossification: Suppression of miR-433-3p in the osteochondral lineage alters growth plate morphology and bone growth
    Prachi Thakore, Sangita Karki, Anne Delany J Bone Miner Res 38
  • Aberrant In Vitro Differentiation of Marrow Stromal Cells from Osteonectin-Null Mice Correlates with Osteopenic Phenotype In Vivo
    Delany, A.M., Kalajzic, I., Canalis, E. J. Bone Mineral Res. 15(1):S344
  • Absence of Mineral Maturation in the Osteonectin-Null Mouse: An Age Dependent Study
    Boskey, A.L., Paschalis, E.P., Canalis, E., Amling, M., Delany, A.M. J. Bone Mineral Res. 15(1):S205
  • Absence of Mineral Maturation in the Osteonectin-Null Mouse: An Age Dependent Study
    Boskey, A.L., Paschalis, E.P., Canalis, E., Amling, M., Delany, A.M. J. Bone Mineral Res. 15(1):S04
  • Alternative Splicing, Polyadenylation, and MicroRNAs Targeting Insulin-Like Growth Factor-1 in Osteoblasts
    Smith S., Kessler C.B., Rosen C., Delany A.M. J Bone Miner Res. 27(1):S94
  • Analysis of the 3' Untranslated Region of the IGF-I Gene: Implications for mRNA Stability and Serum IGF-I Levels
    Delany, A., Demambro, .V, Kawai, M., Delahunty, K., Graber, J., Kessler, C., Beamer, W., Rosen, C. J. Bone Mineral Res. 24(1):S134
  • Basic Fibroblast Growth Factor (bFGF) Down-Regulates Osteonectin Expression in Osteoblasts by Transcriptional Mechanisms
    Delany, A.M., Canalis, E. J. Bone Mineral Res. 11(1):S403
  • CAAT Enhancer Binding Proteins Mediate Down Regulation of Insulin-Like Growth Factor I by Cortisol in Osteoblasts
    Delany, A.M., Durant, D., Canalis, E. J. Bone Mineral Res. 14(1):S234
  • Collagenase and its Activator: Members of a New Supergene Family of Metalloproteinases Which Induce an Oncogene Induced mRNA
    Fini, M.E., Plucinska, I.M., Beeman, A.M., Brinckerhoff, C.E. Arthritis Rheum. 30S16
  • Cortisol Increases the Number of Cells of the Osteoblastic Lineage, but Precludes their Differentiation into Functional Osteoblasts
    Pereira, R.M.R., Delany, A.M., Canalis, E. J. Bone Mineral Res. 15(1):S275
  • Cortisol Prevents the Differentiation of Stromal Cells into Mature Osteoblasts
    Pereira, R.C., Delany, A.M., Canalis, E. J. Bone Mineral Res. 15(1):S240
  • Disparate regulation of EGF-induced metalloproteinase expression and proliferation in fibroblasts
    Delany A.M., Brinckerhoff C.E. Arthritis Rheum 31S93
  • Expression of Scatter Factor by Osteoblasts and Induction by Factors Promoting Fracture Healing
    Blanquaert, F., Delany, A.M., Canalis, E. J. Bone Mineral Res. 12(1):S209
  • Fibroblast Growth Factor-2 (FGF-2) Modulates the Breast Cancer Associated Metalloproteinase, Stromelysin-3, in Osteoblasts
    Delany A.M., Canalis C. J. Bone Mineral Res 12(1):S432
  • Fibroblast Growth Factor-2 Decreases Osteonectin RNA Stability and Regulates Novel RNA Binding Proteins Associated with Its 3’-Untranslated Region
    Delany A.M., Marcy M.J., Canalis E. J. Bone Mineral Res. 14(1):S329
  • Glucocorticoids Regulate a Novel Cytosolic Protein that Binds to the Coding Region of Collagenase 3 mRNA
    Rydziel, S., Delany, A.M., Canalis, E. Bone 23(5):S553
  • Glucocorticoids Regulate Novel Cytosolic Proteins Binding to the 3’ Untranslated Region of Collagenase 3 mRNA
    Rydziel S., Delany A.M., Canalis E. J. Bone Mineral Res. 14(1):S297
  • Glucocorticoids Regulate Novel Cytosolic Proteins that Bind Specifically to the 3’ Untranslated Region of Collagenase 3 mRNA
    Rydziel, S., Delany, A.M., Canalis, E. J. Bone Mineral Res. 15(1):S250
  • Increased Notch 1 in Osteonectin-Null Osteoblasts: A Potential Mechanism for Aberrant Maturation
    Kessler C., Delany A.M. J. Bone Mineral Res. 19(1):S220
  • Inhibition of miR-433-3p activity in osteoblastic cells attenuates glucocorticoid-mediated trabecular bone loss
    Pereira R., Thakore P., Karki S., Delany A.M. J Bone Miner Res
  • Inhibition of miR-433-3p activity in osteoblastic cells attenuates glucocorticoid-mediated trabecular bone loss
    Pereira R., Thakore P., Karki S., Delany A.M. J Bone Miner Res 37(S1):
  • Insulin-Like Growth Factor (IGF) I is Required for the Expression of IGF Binding Protein-5 by the Osteoblast
    Gabbitas, B., Delany, A.M., Canalis, E. J. Bone Mineral Res. 11(1):S177
  • Interaction of Prostate Cancer Cells with Disorganized Bone Matrix Provides Resistance to Radiation-Induced Death In Vitro
    Kapinas, K., Lowther, K., Kessler, C., Campagnola, P., Delany, A. J. Bone Mineral Res. 24(1):S134
  • MicroRNA (miRNA) Binding Sites in the Osteonectin 3’ Untranslated Region (UTR) Regulate Expression
    Kessler C., Delany A.M. J. Bone Mineral Res. 20(1):S207
  • miR-29 Regulates Wnt Signaling in Human Osteoblasts Through a Positive Feedback Loop
    Kapinas K., Kessler C.B., Ricks T., Gronowicz G., Delany A.M. J. Bone Mineral Res. 25(1):S65
  • Noggin Overexpression Precludes the Differentiation of Stromal Cells into Functional Osteoblasts
    Gazzerro, E., Du, Z., Econimides, A.N., Delany, A.M., E. Canalis. J. Bone Mineral Res. 16(1):S370
  • Notch 1 Constitutive Activation Induces a Shift From Osteoblastogenesis to Adipogenesis in Marrow Stromal Cells
    Gazzerro, E., Sciadone, M., Priest, L., Delany, A.M., Canalis, E. J. Bone Mineral Res. 18(1):S6
  • Osteonectin 3’ Untranslated Region Single Nucleotide Polymorphisms Differentially Regulate Gene Expression: MicroRNAs Target SNP Regions
    Kapinas K., Franceschetti T., Kessler C.B., Delany A.M. J. Bone Mineral Res. 25(1):S275
  • Osteonectin/SPARC is Critical for Anabolic Response to PTH in the Skeleton
    Kessler C., Delany A.M. J. Bone Mineral Res. 21(1):S134
  • Overexpression of CHOP, A Dominant-Negative C/EBP, Accelerates and Enhances Osteoblastic Differentiation
    Pereira R.C., Delany A.M., Canalis E. J. Bone Mineral Res. 17(1):S249
  • Overexpression of Notch 1 Receptor Intracellular Domain Inhibits Differentiation of Cells of the Osteoblastic Lineage
    Sciaudone M.P., Delany A.M., Canalis E. J. Bone Mineral Res. 17(1):S194
  • Poorly Structured Bone Matrix, Reminiscent of an “Osteoblastic” Lesion Promotes an Aggressive Gene Expression Profile in Prostate Carcinoma Cells In Vitro
    Delany, A., Lowther, K., Kapinas, K., Kessler, K., Nadiarnykh, O., Campagnola, P. Cancer Treatment Rev 42(1):S57
  • Slit-ROBO Rho GTPase activating protein 2 (SRGAP2) in osteoclasts limits inflammatory osteoclastogenesis and inhibits expression of the coupling clastokine SLIT3. J Bone
    Shin B, Kupferman J, Schmidt E, Polleux F, Delany AM*, Lee SK* co-corresponding authors J Bone Miner Res. co-corresponding authors(Suppl 1,):
  • Specific Osteoblast Cytosolic Proteins Bind and Stabilize Collagenase 3 mRNA
    Rydziel, S., Delany, A.M., Canalis, E. J. Bone Mineral Res. 17(1):S405
  • Study of Osteonectin Gene Polymorphisms in Men with Idiopathic Osteoporosis
    Delany, A.M., Shubert-Coleman, J., Bahl, R., Colvin, T.L., Powell, J., Kurland, E.S. J. Bone Mineral Res. 18(1):S129
  • The Synthetic Retinoid (4-hydroxyphenyl)Retinamide Antagonizes TGFß Induced α1(I) Collagen mRNA
    Delany, A.M., Brinckerhoff, C.E. Arthritis Rheum. 33R39
  • Transcriptional Regulation of Insulin-Like Growth Factor-I (IGF-I) by Prostaglandin E2 (PGE2) in Osteoblasts
    Pash, J.M., Delany, A.M., Canalis, E. J. Bone Mineral Res. 9(1):S124
  • Transcriptional Repression of Insulin-Like Growth Factor I by Transforming Growth Factor β1 in Rat Osteoblastic Cells
    Delany, A.M., Gabbitas, B.Y., Canalis, E. J. Bone Mineral Res. 10(1):S144
  • Transcriptional Repression of Matrix Metalloproteinase I by Insulin-Like Growth Factor I in Rat Osteoblasts
    Delany, A.M., Rydziel, S., Canalis, E. J. Bone Mineral Res. 10(1):S164
  • Wnt 1 Induces the Differentiation of Stromal Cells into Mature Osteoblasts
    Pereria, P.C., Delany, A.M., Canalis, E. J. Bone Mineral Res. 16(1):S492

Conference Papers

Notes

Reviews

Title or AbstractTypeSponsor/EventDate/YearLocation
miRNAs in bone cellsLecture2021University of Minnesota
miRNA regulation of gene expression in bone cellsLectureUConn RNA Salon2019UConn Storrs
Inhibition of miR-29 activity in the myeloid lineage by expression of a miR-29 tough decoy enhances trabecular bone volume in male micePosterASBMR2019Tampa, fl
Slit-ROBO Rho GTPase activating protein 2 (SRGAP2) in osteoclasts limits inflammatory osteoclastogenesis and inhibits expression of the coupling clastokine SLIT3.PosterASBMR2019Tampa, fl
Meet the Professor: microRNAs and BoneLectureAmerican Society for Bone and Mineral Research2018Montreal, Canada
microRNA regulation of circadian rhythm in the osteoblastic lineageTalkKeystone Symposium: Small RNA Silencing: Little Guides, Big Biology2016Keystone, CO
Meet the Professor: microRNAs and Bone HomeostasisLectureAmerican Society for Bone and Mineral Research2016Atlanta, GA
miR-29 and BoneLectureUniversity of Uppsala2014Sweden
Polyadenylation, and MicroRNAs Targeting Insulin-like Growth Factor-1 in OsteoblastsPosterAmerican Society for Bone and Mineral Research2012Minneapolis, Minnesota
miR-29 regulates osteoclastogenesisPosterAmerican Society for Bone and Mineral Research2012Minneapolis, Minnesota
Role of miR-29 in boneLectureEndocrine Society2011Boston,MA
MicroRNAs: No Small Role in Skeletal RegulationLectureEndocrine Society2011Boston, Massachusetts
miR-29 Regulates Wnt Signaling in Human Osteoblasts Through A Positive Feedback LoopTalkAmerican Society for Bone and Mineral Research2010Toronto, Canada
Bone Cartilage: Matrix Formation and MineralizationTalkAmerican Society for Bone and Mineral Research2010Toronto, Canada
Osteonectin 3’ Untranslated Region Single Nucleotide Polymorphisms Differentially Regulate Gene Expression: microRNAs Target SNP RegionsPosterAmerican Society for Bone and Mineral Research2010Toronto, Canada
Analysis of the 3' Untranslated Region of the IGF-I Gene: Implications for mRNA Stability and Serum IGF-I LevelsPosterAmerican Society for Bone and Mineral Research2009Denver, Colorado
Interaction of Prostate Cancer Cells with Disorganized Bone Matrix Provides Resistance to Radiation-Induced Death In VitroPosterAmerican Society for Bone and Mineral Research2009Denver, Colorado
Association of Prostate Cancer Cells With Disorganized Bone Matrix Provides Resistance to Radiation-Induced Death In VitroTalkInternational Meeting on Cancer Induced Bone Disease2009Arlington, Virgina
Function of Osteonectin in Bone, and its Post-transcriptional Regulation TalkAmerican Society for Matrix Biology 2008San Diego, CA
Regulation of Osteonectin/SPARC by MicroRNA-29TalkAmerican Society for Bone and Mineral Research2008Montreal, Canada
Pediatric Nephrology Seminar SeriesTalkUniversity of California2008Los Angeles, California
Special Interest Group – Bone BiologyTalkAmerican Society for Matrix Biology2008San Diego, California
Poorly Structured Bone Matrix, Reminiscent of an “Osteoblastic” Lesion Promotes an Aggressive Gene Expression Profile in Prostate Carcinoma Cells In vVtroTalkInternational Meeting on Cancer Induced Bone Disease2008Edinburgh, Scotland
Differential Regulation of Gene Expression by SNPs in the Osteonectin/SPARC 3’ Untranslated Region (UTR): A Mechanism for Modulation of Bone MassPosterAmerican Society for Bone and Mineral Research2008Montreal, Canada
Skeletal Biology Seminar SeriesTalkThe Jackson Laboratories2007Bar Harbor, Maine
microRNAs and Bone LectureAmerican Society for Bone and Mineral Research 2006Philadelphia, PA
Bone RoundsTalkColumbia University College of Physicians and Surgeons2006New York, New York
Trinity College Biology Department Seminar SeriesTalkTrinity College2006Hartford, Connecticut
Bone, Cartilage, Connective Tissue Matrix IIITalkAmerican Society for Bone and Mineral Research2006Philadelphia, Pennsylvania
“Meet the Professor” – MicroRNAs and BoneTalkAmerican Society for Bone and Mineral Research2006Philadelphia, Pennsylvania
Osteonectin/SPARC is critical for anabolic response to PTH in the skeletonPosterAmerican Society for Bone and Mineral Research2006Philadelphia, Pennsylvania
MicroRNA (miRNA) Binding Sites in the Osteonectin 3’ Untranslated Region (UTR) Regulate ExpressionTalkAmerican Society for Bone and Mineral Research2005Nashville, Tennessee
Increased Notch 1 in Osteonectin-Null Osteoblasts: A Potential Mechanism for Aberrant MaturationPosterAmerican Society for Bone and Mineral Research2004Seattle, Washington
Function and regulation of osteonectin in boneTalkHenry Ford Hospital2003Detroit, MI
State of the Art Lecture - Glucocorticoid ActionTalkAmerican Society for Bone and Mineral Research2003Minneapolis, Minnesota
Matricellular Proteins in Normal and Cancer Cell-Matrix InteractionsTalkInternational Hermelin Brain Tumor Center Symposium2003Detroit, Michigan
Study of Osteonectin Gene Polymorphisms in Men With Idiopathic OsteoporosisPosterAmerican Society for Bone and Mineral Research2003Minneapolis, Minnesota
Osteonectin in BonePanel DiscussionNational Institutes of Health2002Bethesda, MD
Osteonectin Supports Osteoblast Maturation and SurvivalTalkAmerican Society for Bone and Mineral Research2002San Antonio, Texas
Extracellular Matrix and Aging: Musculoskeletal System and SkinTalkNational Institute on Aging Workshop2002Bethesda, Maryland
Osteonectin Supports Osteoblast Maturation and SurvivalPosterAmerican Society for Bone and Mineral Research2002San Antonio, Texas
BMPs, TGF-beta, Other Growth Factors/Cytokines IITalkAmerican Society for Bone and Mineral Research2001Phoenix, Arizona
The Osteonectin-Null Mutation Compromises Osteoblast Formation and MaturationPosterAmerican Society for Bone and Mineral Research2001Toronto, Canada
Bone Cells – Osteoblasts IITalkAmerican Society for Bone and Mineral Research2000Toronto, Canada
Aberrant In Vitro Differentiation of Marrow Stromal Cells from Osteonectin-Null Mice Correlates with Osteopenic Phenotype In VivoPosterAmerican Society for Bone and Mineral Research2000Toronto, Canada
Osteonectin-Null Mice Develop Severe OsteopeniaTalkAmerican Society for Bone and Mineral Research1999
CAAT Enhancer Binding Proteins Mediate Down Regulation of Insulin-Like Growth Factor I by Cortisol in OsteoblastsPosterAmerican Society for Bone and Mineral Research1999
Fibroblast Growth Factor-2 Decreases Osteonectin RNA Stability and Regulates Novel RNA Binding Proteins Associated with its 3’-Untranslated RegionPosterAmerican Society for Bone and Mineral Research1999
Fibroblast Growth Factor-2 (FGF-2) Modulates the Breast Cancer Associated Metalloproteinase, Stromelysin-3, in OsteoblastsPosterAmerican Society for Bone and Mineral Research1997
Basic Fibroblast Growth Factor (bFGF) Down-Regulates Osteonectin Expression in Osteoblasts by Transcriptional MechanismsPosterAmerican Society for Bone and Mineral Research1996
Autocrine Suppression of Osteoblast Matrix Metalloproteinase I by Insulin-Like Growth Factor ITalkEndocrine Society1995
Transcriptional Repression of Insulin-Like Growth Factor I by Transforming Growth Factor ß1 in Rat Osteoblast CellsTalkAmerican Society for Bone and Mineral Research1995
Transcriptional Repression of Matrix Metalloproteinase I by Insulin-Like Growth Factor I in Rat Osteoblast CellsTalkAmerican Society for Bone and Mineral Research1995
Cortisol Inhibits Insulin-Like Growth Factor-I (IGF-I) Expression in Osteoblasts by Transcriptional MechanismsTalkAmerican Society for Bone and Mineral Research1994
Transcriptional Repression of the a1(I) Procollagen Gene by Cortisol in Cultured Rat OsteoblastsPosterEndocrine Society1994
Cortisol Increases Interstitial Collagenase Expression in Osteoblasts by Post-Transcriptional MechanismsPosterAmerican Society for Bone and Mineral Research1994
The Synthetic Retinoid (4-hydroxyphenyl)Retinamide Antagonizes TGFß Induced a1(I) Collagen mRNAPosterAmerican College of Rheumatology1990
Disparate Regulation of EGF-Induced Metalloproteinase Expression and Proliferation in FibroblastsPosterAmerican College of Rheumatology1988