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Stefan Brocke, MD, PhDAssociate Professor of Immunology
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My laboratory studies the cellular and molecular mechanisms of brain injury in inflammatory and inflammation-associated disorders of the central nervous system. For this purpose, we focus on:
vascular triggers leading to the invasion of pathogenic lymphocytes into the normal and inflamed brain,
regulation of inflammatory and anti-inflammatory processes at the level of cell surface molecules, and
cellular mechanisms regulating injury or survival/regeneration of neurons in areas affected by inflammation.
Not Accepting Lab Rotation Students at this time
Lab Rotation Projects Expression and function of lymphocyte recruitment signals at the blood-CNS barrier.
Journal Articles
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Editorial: Cyclic Nucleotide Phosphodiesterases (PDEs) in Immune Regulation and Inflammation.
Frontiers in pharmacology 2022 Jun;13950480
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Treatment of Experimental Autoimmune Encephalomyelitis with an Inhibitor of Phosphodiesterase-8 (PDE8)
Cells 2022 Feb;11,(4):
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Immunity to Respiratory Infection Is Reinforced Through Early Proliferation of Lymphoid TRM Cells and Prompt Arrival of Effector CD8 T Cells in the Lungs.
Frontiers in immunology 2019 Jan;101370
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PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex.
Cellular signalling 2017 Aug;4062-72
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Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation.
Frontiers in pharmacology 2016 Jan;7259
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Inhibition of breast cancer cell migration by activation of cAMP signaling.
Breast cancer research and treatment 2015 May;152(1):17-28
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DPP4-directed therapeutic strategies for MERS-CoV.
The Lancet. Infectious diseases 2014 Feb;14(2):100-1
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Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells.
SpringerPlus 2013 Dec;2680
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Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac.
The Biochemical journal 2013 Dec;456(3):463-73
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Peroxisome proliferator-activated receptor gamma is required for CD4+ T cell-mediated lymphopenia-associated autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2011 Oct;187(8):4161-9
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Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase.
International immunology 2011 Feb;23(2):119-28
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Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2009 Jan;47(3):268-74
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Prophylactic and therapeutic suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor.
Clinical immunology (Orlando, Fla.) 2008 Oct;129(1):69-79
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Geranylgeranylation but not GTP loading determines rho migratory function in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov;179(9):6024-32
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TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26.
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr;178(7):4632-40
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Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.
International immunopharmacology 2006 Dec;6(13-14):1935-42
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Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes.
Biochemical and biophysical research communications 2006 Jun;345(2):713-9
Conference Papers
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Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses.
Annals of the New York Academy of Sciences 2007 Sep;1110402-9
Letters
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The differential roles of zinc in immune responses and their potential implications in antiviral immunity against SARS-CoV-2.
Clinical nutrition 10.1016/j.clnu.2020.12.005 *corresponding author 2021 Feb;
Reviews
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The Role of PDE8 in T Cell Recruitment and Function in Inflammation.
Frontiers in Cell and Developmental Biology 2021 Apr;9636778
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DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis.
Frontiers in bioscience : a journal and virtual library 2008 Jan;13(6):2356-63
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Kelly MP, Nikolaev VO, Gobejishvili L, Lugnier C, Hesslinger C, Nickolaus P,
Kass DA, De Vasconcelos WP, Fischmeister R, Brocke S, Epstein PM, Piazza GA, Keeton AB, Zhou
G, Abdel-Halim M, Abadi AH, Baillie GS, Giembycz M, Bolger G, Snyder G, Tasken K, Saidu NEB,
Schmidt M, Zaccolo M, Schermuly RT, Ke H, Cote RH, Jouabadi SM, Roks AJM, Cyclic nucleotide
phosphodiesterases as drug targets, Pharmacological Reviews (2025), doi: https://doi.org/10.1016/
j.pharmr.2025.100042.
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The role of PDE8 in leukocyte recruitment and function in inflammation
Frontiers in Cell and Developmental Biology