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Stefan Brocke, MD, PhDAssociate Professor of Immunology
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My laboratory studies the cellular and molecular mechanisms of brain injury in inflammatory and inflammation-associated disorders of the central nervous system. For this purpose, we focus on:
vascular triggers leading to the invasion of pathogenic lymphocytes into the normal and inflamed brain,
regulation of inflammatory and anti-inflammatory processes at the level of cell surface molecules, and
cellular mechanisms regulating injury or survival/regeneration of neurons in areas affected by inflammation.
Not Accepting Lab Rotation Students at this time
Lab Rotation Projects Expression and function of lymphocyte recruitment signals at the blood-CNS barrier.
Journal Articles
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Editorial: Cyclic Nucleotide Phosphodiesterases (PDEs) in Immune Regulation and Inflammation.
Frontiers in pharmacology 2022 Jun;13950480
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Treatment of Experimental Autoimmune Encephalomyelitis with an Inhibitor of Phosphodiesterase-8 (PDE8)
Cells 2022 Feb;11,(4):
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Immunity to Respiratory Infection Is Reinforced Through Early Proliferation of Lymphoid TRM Cells and Prompt Arrival of Effector CD8 T Cells in the Lungs.
Frontiers in immunology 2019 Jan;101370
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PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex.
Cellular signalling 2017 Aug;4062-72
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Differential Expression and Function of PDE8 and PDE4 in Effector T cells: Implications for PDE8 as a Drug Target in Inflammation.
Frontiers in pharmacology 2016 Jan;7259
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Inhibition of breast cancer cell migration by activation of cAMP signaling.
Breast cancer research and treatment 2015 May;152(1):17-28
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DPP4-directed therapeutic strategies for MERS-CoV.
The Lancet. Infectious diseases 2014 Feb;14(2):100-1
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Expression of phosphodiesterase 6 (PDE6) in human breast cancer cells.
SpringerPlus 2013 Dec;2680
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Regulatory T-cells and cAMP suppress effector T-cells independently of PKA-CREM/ICER: a potential role for Epac.
The Biochemical journal 2013 Dec;456(3):463-73
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Peroxisome proliferator-activated receptor gamma is required for CD4+ T cell-mediated lymphopenia-associated autoimmunity.
Journal of immunology (Baltimore, Md. : 1950) 2011 Oct;187(8):4161-9
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Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase.
International immunology 2011 Feb;23(2):119-28
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Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: investigations in DP IV/CD26-knockout mice.
Clinical chemistry and laboratory medicine : CCLM / FESCC 2009 Jan;47(3):268-74
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Prophylactic and therapeutic suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor.
Clinical immunology (Orlando, Fla.) 2008 Oct;129(1):69-79
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Geranylgeranylation but not GTP loading determines rho migratory function in T cells.
Journal of immunology (Baltimore, Md. : 1950) 2007 Nov;179(9):6024-32
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TGF-beta1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26.
Journal of immunology (Baltimore, Md. : 1950) 2007 Apr;178(7):4632-40
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Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation.
International immunopharmacology 2006 Dec;6(13-14):1935-42
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Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes.
Biochemical and biophysical research communications 2006 Jun;345(2):713-9
Conference Papers
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Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses.
Annals of the New York Academy of Sciences 2007 Sep;1110402-9
Letters
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The differential roles of zinc in immune responses and their potential implications in antiviral immunity against SARS-CoV-2.
Clinical nutrition 10.1016/j.clnu.2020.12.005 *corresponding author 2021 Feb;
Reviews
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The Role of PDE8 in T Cell Recruitment and Function in Inflammation.
Frontiers in Cell and Developmental Biology 2021 Apr;9636778
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DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: implications for experimental encephalomyelitis and multiple sclerosis.
Frontiers in bioscience : a journal and virtual library 2008 Jan;13(6):2356-63
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The role of PDE8 in leukocyte recruitment and function in inflammation
Frontiers in Cell and Developmental Biology