Rashmi Bansal, Ph.D.

Professor of Neuroscience
Academic Office Location:
Neuroscience
University of Connecticut Health Center
263 Farmington Avenue
Farmington, CT 06030-3401
Phone: 860-679-1133
Fax: 860-679-8140
Website(s): Cell Biology Graduate Program
Neuroscience Graduate Program

Education
DegreeInstitutionMajor
Ph.D.Central Drug Research InstituteNeuroscience
M.S.Lucknow UniversityBiochemistry
B.S.Lucknow UniversityBiology
Developmental, cellular and molecular biology of Oligodendrocytes, the cells that synthesize myelin membrane in the central nervous system; growth factor regulation of development and function and its relationship to neurodegenerative disease, including Multiple Sclerosis.Current research is focused on investigation of basic mechanisms of cell biology in a developmental context. (oligodendrocyte developmental lineage is the model system)--Molecular mechanisms of regulation of differentiation by growth factor receptors, including the application of transgenic mouse models, cell culture and transfection systems. --Membrane biogenesis and function, including the role of glycosphingolipid-cholesterol microdomains (rafts) and signal transduction. --The relationship of these to Multiple Sclerosis
Accepting students for Lab Rotations for Fall '14, Spring '15

Journal Articles

Book Chapters

  • Functional Dynamics of Myelin Lipids
    Fewou SN, Jackman N, van Meer G, Bansal R, Pfeiffer SE (2009) Handbook of Neurochemistry and Molecular Neurobiology
  • NEPHGE and pI strip proteomic two-dimensional gel electrophoretic mapping of lipid-rich membranes
    Pfeiffer SE, Yamaguchi Y, Marta, CB, Bansal R, Taylor CM (2005) The Proteomics Protocols Handbook
  • The Transport, Assembly, and Function of Myelin Lipids
    Taylor CM, Marta CB, Bansal R, Pfeiffer SE (2003) Myelin and its Diseases 57-80
  • Mechanisms of myelin membrane biogenesis by oligodendrocytes.
    Krüger WH, Madision DL, Kim T, Yamaguchi Y, Bouverat B, Bansal R, Pfeiffer SE (1998) Frontiers of Neural Development
  • Regulation of oligodendrocyte differentiation by fibroblast growth factors
    Bansal R, Pfeiffer SE (1997) Brain Plasticity: Development and Aging
  • Oligodendrocyte progenitor development: Reversible inhibition by a monoclonal antibody reacting with galactocerebroside and sulfatide
    Bansal R, Gard AL, Warrington AE, Gonye G, Avossa D, Pfeiffer SE (1990) Differentiation and Function of Glia 159-168
  • Regulation of oligodendrocyte progenitor development: antibody perturbation studies
    Pfeiffer SE, Bansal R, Gard AL (1990) Cellular and Molecular Biology of Myelination, NATO ASI Series 19-31
  • Trophic regulation of myelinogenesis
    Gard AL, Bansal R, Pfeiffer SE (1989) Trophic Factors in the Nervous System 247-261
  • Oligodendrocyte differentiation: Quantitative studies in primary cultures of dissociated fetal rat brain
    Bansal R, Barbarese E, Bhat S, Carson J, Edgar A, Friederich V, Macklin W, Pfeiffer SE, Singh H, Woodiel F (1986) Glial-Neuronal Communication in Development and Regeneration, 737-754
  • Regulation of early myelinogenesis in primary cultures of dissociated rat brain
    Barbarese E, Bhat S, Bansal R, Carson J, Edgar A, Pfeiffer SE, Singh H, Woodiel F (1983) Neuroscience Approached Through Cell Culture. Vol. II. 167-176

Conference Papers

Reviews

Title or AbstractTypeSponsor/EventDate/YearLocation
Membrane Domains in CNS Physiology and Pathology Talk4th Special International Society for Neurochemistry2010Sicily, Italy.
Signaling to and by myelin forming cellsTalkGordon Research Conference on Myelin Biology2004 Barga, Italy
Positive and negative regulators of oligodendrocyte terminal differentiationTalkDepartment of Neuroscience, Case Western Reserve University 2003Cleveland, OH
Sulfated Galactsylceramide regulates oligodendrocyte differentiation and myelin-axolemmal interactionTalkSecond Charleston Ceramide Conference2003 Como, Italy
Regulation of Oligodendrocyte Terminal Differentiation: Analysis of Genetically Modified MiceTalkDepartment of Neuroscience, University of Connecticut Health Center2003Farmington, CT
Role of glycosphingolipids in oligodendrocyte differentiation and myelin biogenesisTalkGordon Research Conference on Glycolipid and Sphingolipid Biology 2002Ventura, CA
Fibroblast growth factor receptor-3 null mice exhibit a delay in the development of oligodendrocytes and myelinationTalkAmerican Society for Neurochemistry2002West Palm Beach, Florida
Syndecan-3 and perlican are differentially synthesized by progenitor and mature oligodendrocyte and accumulates in the ECMTalkInternational Society for Neurochemistry Satellite Meeting on Myelin Biology 2001Colonia, Uraguay
Is sulfatide the glycosphingolipid molecule responsible for negatively regulating oligodendrocyte differentiation and normal myelin formationTalkInternational Society for Neurochemistry Satellite Meeting on Glycosphingolipids 2001Iguazu, Argentina
FGF receptors in oligodendrocyte developmentTalkDepartment of Biological Sciences, Tata Institute of Fundamental Research2001Mumbai, India
FGF receptor function in oligodendrocyte developmentTalkGordon Research Conference on Myelin Biology2000Barga, Italy
Negative regulation of oligodendrocyte differentiation by galactosphingolipidsTalkGordon Research Conference on Glycolipid and Sphingolipid Biology 2000Barga, Italy
FGFs in development and diseaseTalkDepartment of Neuroscience, University of Connecticut Health Center2000Farmington, CT
Regulation of oligodendrocyte differentiation and myelin biogenesisTalkUniversity of Cambridge 1999Cambridge, UK
Re-programming of differentiation fate: FGF-2 converts mature oligodendrocytes to a novel dedifferentiated stageTalkKing's College 1999London, UK.
Demyelinating diseases and mice mutants of myelin genesTalkInternational Society for Pharmacology 1999New Delhi, India
Negative regulation of oligodendrocyte differentiation by galactolipidsTalkInternational Society for Neurochemistry Satellite Meeting on Myelin Biology 1999Ruegen, Germany
Developmental and ligand-mediated regulation of FGF- receptors and co-receptors during oligodendrocyte differentiation and de-differentiationTalkConference of Indian Academy of Neuroscience and National Symposium on Signal Transduction 1998New Delhi, India
Regulation of oligodendrocyte development by Fibroblast growth factors: Lineage stage-specific modulation of receptor expressionTalkInternational Society for Developmental Neuroscience1998Vancouver, Canada
FGF receptor and Co-receptor expression and regulation in the oligodendrocyte lineageTalkPenn State College of Medicine 1998Hershey, PA
Importance of glycolipids in oligodendrocyte membrane biogenesis and maintenance: Protein lipid interactionsTalkInternational Society for Neurochemistry1997Boston, MA
Altered oligodendrocyte differentiation in mice lacking Galactocerebroside and SulfatideTalkInterntational Society for Neurochemistry Satellite Meeting1997Mystic, CT
Regulation of cell differentiation by environmental factorsTalkEighth Medical Symposium 1997Ross University School of Medicine, Dominica
Requirement of cell surface heparan sulfate for response of oligodendrocyte progenitors to FGFTalkBoeringer Ingleheim1997Ridgefield, CT
Oligodendrocyte development and regulation by growth factorsTalkHopital de la Salpetriere 1996Paris, France
Regulation of oligodendrocyte development by FGFTalkGordon Research Conference on Myelin 1996Barga, Italy
FGF-2 stimulates mature oligodendrocyte process outgrowthTalkAmerican Society for Neurochemistry1996Philadelphia, PA
Changing repertoire of FGF receptors and putative co-receptors during oligodendrocyte development: Regulation by ligandTalkInternational Society for Neurochemistry Myelin Satellite 1995Okazaki, Japan
Role of sulfatide in oligodendrocyte development and myelin biogenesisTalkInternational Society for Neurochemistry1995Kyoto, Japan
FGF Co-receptor, Syndecan-3 is expressed and required for Oligodendrocyte progenitor proliferationTalkGordon Research Conference on Myelin 1994Ventura, CA
Oligodendrocyte developmental regulation: Growth factors and cell surface moleculesTalkElba International Neuroscience Program Summer School1993Elba, Italy
N-Syndecan is developmentally regulated during oligodendrocyte differentiation, and may act as a putative low affinity bFGF receptor on Pro-oligodendroblastsTalkInternational Society for Neurochemistry Myelin Satellite1993La Londe, France
Sulfatide synthesis is not a pre-requisite for oligodendrocyte lineage progressionTalkInternational Society for Neurochemistry1993Montpellier, France
Analysis of the oligodendrocyte cell lineage in culture and in vivoTalkNew York Friends of Myelin Group 1992Hunter Collage, NY, NY
POA, a developmental antigen expressed by A007/O4 positive oligodendrocyte progenitors prior to the appearance of sulfatideTalkInternational Society for Neurochemistry Myelin Satellite 1991Fiji Islands
Regulation of gene expression in mature oligodendrocytes by the specialized myelin-like membrane environmentTalkKroc-UConn Symposium. UConn Health Center1990Farmington, CT
Myelinogenesis: perturbation by antibodies to oligodendrocyte lineage cell surface componentsTalkSymposium on "Differentiation and Function of Glia"1989Rome, Italy