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Granulosa Cells Alone, Without Theca Cells, Can Mediate LH-induced Oocyte Meiotic Resumption.
Norris, Rachael P; Jaffe, Laurinda A Endocrinology 2024 Jan;165(3):
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Luteinizing hormone stimulates ingression of mural granulosa cells within the mouse preovulatory follicle.
Owen, Corie M; Jaffe, Laurinda A Biology of reproduction 2023 Oct;
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Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase.
Egbert, Jeremy R*; Silbern, Ivan; Uliasz, Tracy F; Lowther, Katie M; Yee, Siu-Pok; Urlaub, Henning*; Jaffe, Laurinda A* Biology of reproduction 2023 Sep;
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Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases.
Egbert, Jeremy R*; Uliasz, Tracy F; Lowther, Katie M; Kaback, Deborah; Wagner, Brandon M; Healy, Chastity L; O'Connell, Timothy D; Potter, Lincoln R; Jaffe, Laurinda A*; Yee, Siu-Pok* Frontiers in molecular neuroscience 2022 Oct;151007026
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Endowed Chairs and Professorships: A New Frontier in Gender Equity.
Thorndyke, Luanne E; Milner, Robert J; Jaffe, Laurinda A Academic medicine : journal of the Association of American Medical Colleges 2022 Jun;
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Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth.
Shuhaibar, Leia C; Kaci, Nabil; Egbert, Jeremy R; Horville, Thibault; Loisay, Léa; Vigone, Giulia; Uliasz, Tracy F; Dambroise, Emilie; Swingle, Mark R; Honkanen, Richard E; Biosse Duplan, Martin; Jaffe, Laurinda A; Legeai-Mallet, Laurence JCI insight 2021 May;6(9):e141426
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Kisspeptin-54 injection induces a physiological LH surge and ovulation in mice.
Owen, Corie M; Zhou, Xiang; Bernard, Daniel J; Jaffe, Laurinda A Biology of reproduction 2021 Apr;
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Cyclic AMP links luteinizing hormone signaling to dephosphorylation and inactivation of the NPR2 guanylyl cyclase in ovarian follicles.
Egbert, Jeremy R; Robinson, Jerid W; Uliasz, Tracy F; Potter, Lincoln R; Jaffe, Laurinda A Biology of reproduction 2021 Feb;104(5):939-941
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Cellular heterogeneity of the LH receptor and its significance for cyclic GMP signaling in mouse preovulatory follicles.
Baena, Valentina; Owen, Corie M; Uliasz, Tracy F; Lowther, Katie M; Yee, Siu-Pok; Terasaki, Mark; Egbert, Jeremy R; Jaffe, Laurinda A Endocrinology 2020 May;161(7)bgaa074
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Follicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles.
Egbert, Jeremy R; Fahey, Paul G; Reimer, Jacob; Owen, Corie M; Evsikov, Alexei V; Nikolaev, Viacheslav O; Griesbeck, Oliver; Ray, Russell S; Tolias, Andreas S; Jaffe, Laurinda A Biology of Reproduction 2019 Aug;101(2)433-444
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The fast block to polyspermy: New insight into a century-old problem.
Jaffe, Laurinda A The Journal of General Physiology 2018 Aug;1501233-1234
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Multiple cAMP phosphodiesterases act together to prevent premature oocyte meiosis and ovulation.
Vigone, Giulia; Shuhaibar, Leia C; Egbert, Jeremy R; Uliasz, Tracy F; Movsesian, Matthew A; Jaffe, Laurinda A Endocrinology 2018 Mar;1592142-2152
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Luteinizing hormone signaling phosphorylates and activates the cyclic GMP phosphodiesterase PDE5 in mouse ovarian follicles, contributing an additional component to the hormonally induced decrease in cyclic GMP that reinitiates meiosis.
Egbert, Jeremy R; Yee, Siu-Pok; Jaffe, Laurinda A Developmental biology 2018 Mar;435(1):6-14
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Shedding light on spawning in jellyfish.
Jaffe, Laurinda A eLife 2018 Jan;7e34258
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Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor.
Shuhaibar, Leia C; Robinson, Jerid W; Vigone, Giulia; Shuhaibar, Ninna P; Egbert, Jeremy R; Baena, Valentina; Uliasz, Tracy F; Kaback, Deborah; Yee, Siu-Pok; Feil, Robert; Fisher, Melanie C; Dealy, Caroline N; Potter, Lincoln R; Jaffe, Laurinda A eLife 2017 Dec;6
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Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B.
Robinson, Jerid W; Egbert, Jeremy R; Davydova, Julia; Schmidt, Hannes; Jaffe, Laurinda A; Potter, Lincoln R Cellular signalling 2017 Sep;40222-229
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Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle.
Jaffe, Laurinda; Egbert, Jeremy R Annual review of physiology 2017 Jan;79237-260
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Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis.
Egbert, Jeremy R; Uliasz, Tracy F; Shuhaibar, Leia C; Geerts, Andreas; Wunder, Frank; Kleiman, Robin J; Humphrey, John M; Lampe, Paul D; Artemyev, Nikolai O; Rybalkin, Sergei D; Beavo, Joseph A; Movsesian, Matthew A; Jaffe, Laurinda A Biology of reproduction 2016 May;94(5):110
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Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.
Shuhaibar, Leia C; Egbert, Jeremy R; Edmund, Aaron B; Uliasz, Tracy F; Dickey, Deborah M; Yee, Siu-Pok; Potter, Lincoln R; Jaffe, Laurinda A Developmental biology 2015 Oct;409194-201
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Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.
Shuhaibar, Leia C; Egbert, Jeremy R; Norris, Rachael P; Lampe, Paul D; Nikolaev, Viacheslav O; Thunemann, Martin; Wen, Lai; Feil, Robert; Jaffe, Laurinda A Proceedings of the National Academy of Sciences of the United States of America 2015 Mar;112(17):5527-32
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Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.
Egbert, Jeremy R; Shuhaibar, Leia C; Edmund, Aaron B; Van Helden, Dusty A; Robinson, Jerid W; Uliasz, Tracy F; Baena, Valentina; Geerts, Andreas; Wunder, Frank; Potter, Lincoln R; Jaffe, Laurinda A Development (Cambridge, England) 2014 Sep;141(18):3594-604
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Hormonal coordination of natriuretic peptide type C and natriuretic peptide receptor 3 expression in mouse granulosa cells.
Lee, Kyung-Bon; Zhang, Meijia; Sugiura, Koji; Wigglesworth, Karen; Uliasz, Tracy; Jaffe, Laurinda A; Eppig, John J Biology of reproduction 2013 Feb;88(2):42
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Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes resumption of meiosis in oocytes.
Robinson, Jerid W; Zhang, Meijia; Shuhaibar, Leia C; Norris, Rachael P; Geerts, Andreas; Wunder, Frank; Eppig, John J; Potter, Lincoln R; Jaffe, Laurinda A Developmental biology 2012 Jun;366(2):308-16
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Voltage sensitive phosphoinositide phosphatases of Xenopus: their tissue distribution and voltage dependence.
Ratzan, William J; Evsikov, Alexei V; Okamura, Yasushi; Jaffe, Laurinda A Journal of cellular physiology 2011 Nov;226(11):2740-6
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Epidermal growth factor receptor kinase activity is required for gap junction closure and for part of the decrease in ovarian follicle cGMP in response to LH.
Norris, Rachael P; Freudzon, Marina; Nikolaev, Viacheslav O; Jaffe, Laurinda A Reproduction (Cambridge, England) 2010 Nov;140(5):655-62
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Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte.
Norris, Rachael P; Ratzan, William J; Freudzon, Marina; Mehlmann, Lisa M; Krall, Judith; Movsesian, Matthew A; Wang, Huanchen; Ke, Hengming; Nikolaev, Viacheslav O; Jaffe, Laurinda A Development (Cambridge, England) 2009 Jun;136(11):1869-78
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Luteinizing hormone causes MAP kinase-dependent phosphorylation and closure of connexin 43 gap junctions in mouse ovarian follicles: one of two paths to meiotic resumption.
Norris, Rachael P; Freudzon, Marina; Mehlmann, Lisa M; Cowan, Ann E; Simon, Alexander M; Paul, David L; Lampe, Paul D; Jaffe, Laurinda A Development (Cambridge, England) 2008 Oct;135(19):3229-38
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A G(s)-linked receptor maintains meiotic arrest in mouse oocytes, but luteinizing hormone does not cause meiotic resumption by terminating receptor-G(s) signaling.
Norris, Rachael P; Freudzon, Leon; Freudzon, Marina; Hand, Arthur R; Mehlmann, Lisa M; Jaffe, Laurinda A Developmental biology 2007 Oct;310(2):240-9
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Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte.
Mehlmann, Lisa M; Kalinowski, Rebecca R; Ross, Lavinia F; Parlow, Albert F; Hewlett, Erik L; Jaffe, Laurinda A Developmental biology 2006 Nov;299(2):345-55
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Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein.
Freudzon, Leon; Norris, Rachael P; Hand, Arthur R; Tanaka, Shigeru; Saeki, Yoshinaga; Jones, Teresa L Z; Rasenick, Mark M; Berlot, Catherine H; Mehlmann, Lisa M; Jaffe, Laurinda A The Journal of cell biology 2005 Oct;171(2):255-65
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SH2 domain-mediated activation of an SRC family kinase is not required to initiate Ca2+ release at fertilization in mouse eggs.
Mehlmann, Lisa M; Jaffe, Laurinda A Reproduction (Cambridge, England) 2005 May;129(5):557-64
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The Gs-linked receptor GPR3 maintains meiotic arrest in mammalian oocytes.
Mehlmann, Lisa M; Saeki, Yoshinaga; Tanaka, Shigeru; Brennan, Thomas J; Evsikov, Alexei V; Pendola, Frank L; Knowles, Barbara B; Eppig, John J; Jaffe, Laurinda A Science (New York, N.Y.) 2004 Dec;306(5703):1947-50
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Maintenance of meiotic prophase arrest in vertebrate oocytes by a Gs protein-mediated pathway.
Kalinowski, Rebecca R; Berlot, Catherine H; Jones, Teresa L Z; Ross, Lavinia F; Jaffe, Laurinda A; Mehlmann, Lisa M Developmental biology 2004 Mar;267(1):1-13
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Function of a sea urchin egg Src family kinase in initiating Ca2+ release at fertilization.
Giusti, Andrew F; O'Neill, Forest J; Yamasu, Kyo; Foltz, Kathy R; Jaffe, Laurinda A Developmental biology 2003 Apr;256(2):367-78
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A receptor linked to a Gi-family G-protein functions in initiating oocyte maturation in starfish but not frogs.
Kalinowski, Rebecca R; Jaffe, Laurinda A; Foltz, Kathy R; Giusti, Andrew F Developmental biology 2003 Jan;253(1):139-49
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Meiotic arrest in the mouse follicle maintained by a Gs protein in the oocyte.
Mehlmann, Lisa M; Jones, Teresa L Z; Jaffe, Laurinda A Science (New York, N.Y.) 2002 Aug;297(5585):1343-5
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Evidence that phospholipase C from the sperm is not responsible for initiating Ca(2+) release at fertilization in mouse eggs.
Mehlmann, L M; Chattopadhyay, A; Carpenter, G; Jaffe, L A Developmental biology 2001 Aug;236(2):492-501
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Sperm extract injection into ascidian eggs signals Ca(2+) release by the same pathway as fertilization.
Runft, L L; Jaffe, L A Development (Cambridge, England) 2000 Aug;127(15):3227-36
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Evidence that fertilization activates starfish eggs by sequential activation of a Src-like kinase and phospholipase cgamma.
Giusti, A F; Xu, W; Hinkle, B; Terasaki, M; Jaffe, L A The Journal of biological chemistry 2000 Jun;275(22):16788-94
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Calcium release at fertilization of Xenopus eggs requires type I IP(3) receptors, but not SH2 domain-mediated activation of PLCgamma or G(q)-mediated activation of PLCbeta.
Runft, L L; Watras, J; Jaffe, L A Developmental biology 1999 Oct;214(2):399-411
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Identification of PLCgamma-dependent and -independent events during fertilization of sea urchin eggs.
Carroll, D J; Albay, D T; Terasaki, M; Jaffe, L A; Foltz, K R Developmental biology 1999 Feb;206(2):232-47
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SH2 domain-mediated activation of phospholipase Cgamma is not required to initiate Ca2+ release at fertilization of mouse eggs.
Mehlmann, L M; Carpenter, G; Rhee, S G; Jaffe, L A Developmental biology 1998 Nov;203(1):221-32
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Evidence that Gq family G proteins do not function in mouse egg activation at fertilization.
Williams, C J; Mehlmann, L M; Jaffe, L A; Kopf, G S; Schultz, R M Developmental biology 1998 Jun;198(1):116-27
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Calcium release at fertilisation in starfish eggs is mediated by phospholipase Cγ
Carroll D.J., Ramarao C.S., Mehlmann L.M., Roche S., Terasaki M., Jaffe L.A. Zygote 1998 Jan;6(1 SUPPL.):
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Calcium release at fertilization in starfish eggs is mediated by phospholipase Cgamma.
Carroll, D J; Ramarao, C S; Mehlmann, L M; Roche, S; Terasaki, M; Jaffe, L A The Journal of cell biology 1997 Sep;138(6):1303-11
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Structural change of the endoplasmic reticulum during fertilization: evidence for loss of membrane continuity using the green fluorescent protein.
Terasaki, M; Jaffe, L A; Hunnicutt, G R; Hammer, J A Developmental biology 1996 Nov;179(2):320-8
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Increased expression of alphaq family G-proteins during oocyte maturation and early development of Xenopus laevis.
Gallo, C J; Jones, T L; Aragay, A M; Jaffe, L A Developmental biology 1996 Jul;177(1):300-8
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Proteases stimulate fertilization-like responses in starfish eggs.
Carroll, D J; Jaffe, L A Developmental biology 1995 Aug;170(2):690-700
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Reorganization of the endoplasmic reticulum during meiotic maturation of the mouse oocyte.
Mehlmann, L M; Terasaki, M; Jaffe, L A; Kline, D Developmental biology 1995 Aug;170(2):607-15
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Stimulation of Xenopus oocyte maturation by inhibition of the G-protein alpha S subunit, a component of the plasma membrane and yolk platelet membranes.
Gallo, C J; Hand, A R; Jones, T L; Jaffe, L A The Journal of cell biology 1995 Jul;130(2):275-84
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Structural changes in the endoplasmic reticulum of starfish oocytes during meiotic maturation and fertilization.
Jaffe, L A; Terasaki, M Developmental biology 1994 Aug;164(2):579-87
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Evidence for both tyrosine kinase and G-protein-coupled pathways leading to starfish egg activation.
Shilling, F M; Carroll, D J; Muslin, A J; Escobedo, J A; Williams, L T; Jaffe, L A Developmental biology 1994 Apr;162(2):590-9
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Oocyte maturation in starfish is mediated by the beta gamma-subunit complex of a G-protein.
Jaffe, L A; Gallo, C J; Lee, R H; Ho, Y K; Jones, T L The Journal of cell biology 1993 May;121(4):775-83
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Structural changes of the endoplasmic reticulum of sea urchin eggs during fertilization.
Jaffe, L A; Terasaki, M Developmental biology 1993 Apr;156(2):566-73
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Organization of the sea urchin egg endoplasmic reticulum and its reorganization at fertilization.
Terasaki, M; Jaffe, L A The Journal of cell biology 1991 Sep;114(5):929-40
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Evidence for the involvement of a pertussis toxin-insensitive G-protein in egg activation of the frog, Xenopus laevis.
Kline, D; Kopf, G S; Muncy, L F; Jaffe, L A Developmental biology 1991 Feb;143(2):218-29
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Development of calcium release mechanisms during starfish oocyte maturation.
Chiba, K; Kado, R T; Jaffe, L A Developmental biology 1990 Aug;140(2):300-6
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Activation by serotonin of starfish eggs expressing the rat serotonin 1c receptor.
Shilling, F; Mandel, G; Jaffe, L A Cell regulation 1990 May;1(6):465-9
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Evidence that the voltage-dependent component in the fertilization process is contributed by the sperm.
Iwao, Y; Jaffe, L A Developmental biology 1989 Aug;134(2):446-51
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Pertussis toxin inhibits 1-methyladenine-induced maturation in starfish oocytes.
Shilling, F; Chiba, K; Hoshi, M; Kishimoto, T; Jaffe, L A Developmental biology 1989 Jun;133(2):605-8
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Fertilization events induced by neurotransmitters after injection of mRNA in Xenopus eggs.
Kline, D; Simoncini, L; Mandel, G; Maue, R A; Kado, R T; Jaffe, L A Science (New York, N.Y.) 1988 Jul;241(4864):464-7
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A cholera toxin-sensitive G-protein stimulates exocytosis in sea urchin eggs.
Turner, P R; Jaffe, L A; Primakoff, P Developmental biology 1987 Apr;120(2):577-83
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A calcium-activated sodium conductance produces a long-duration action potential in the egg of a nemertean worm.
Jaffe, L A; Kado, R T; Kline, D The Journal of physiology 1986 Dec;381263-78
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A calcium-activated sodium conductance contributes to the fertilization potential in the egg of the nemertean worm Cerebratulus lacteus.
Kline, D; Jaffe, L A; Kado, R T Developmental biology 1986 Sep;117(1):184-93
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Regulation of cortical vesicle exocytosis in sea urchin eggs by inositol 1,4,5-trisphosphate and GTP-binding protein.
Turner, P R; Jaffe, L A; Fein, A The Journal of cell biology 1986 Jan;102(1):70-6
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Propagating potassium and chloride conductances during activation and fertilization of the egg of the frog, Rana pipiens.
Jaffe, L A; Kado, R T; Muncy, L The Journal of physiology 1985 Nov;368227-42
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Fertilization potential and polyspermy prevention in the egg of the nemertean, Cerebratulus lacteus.
Kline, D; Jaffe, L A; Tucker, R P The Journal of experimental zoology 1985 Oct;236(1):45-52
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Fertilization-induced ionic conductances in eggs of the frog, Rana pipiens.
Jaffe, L A; Schlichter, L C The Journal of physiology 1985 Jan;358299-319
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Fertilization increases the polyphosphoinositide content of sea urchin eggs.
Turner, P R; Sheetz, M P; Jaffe, L A Nature 1984 Jan;310(5976):414-5
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Studies of the voltage-dependent polyspermy block using cross-species fertilization of amphibians.
Jaffe, L A; Cross, N L; Picheral, B Developmental biology 1983 Aug;98(2):319-26
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Absence of an electrical polyspermy block in the mouse.
Jaffe, L A; Sharp, A P; Wolf, D P Developmental biology 1983 Apr;96(2):317-23
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Studies of the mechanism of the electrical polyspermy block using voltage clamp during cross-species fertilization.
Jaffe, L A; Gould-Somero, M; Holland, L Z The Journal of cell biology 1982 Mar;92(3):616-21
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Localization of electrical excitability in the early embryo of Dentalium.
Jaffe, L A; Guerrier, P Developmental biology 1981 Apr;83(2):370-3
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Actin, microvilli, and the fertilization cone of sea urchin eggs.
Tilney, L G; Jaffe, L A The Journal of cell biology 1980 Dec;87(3 Pt 1):771-82
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Electrical polyspermy block in sea urchins: Nicotine and low sodium experiments
Jaffe LA Develop Growth Differ 1980 Jan;22(3 Pt 2):503-507
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Electrically mediated fast polyspermy block in eggs of the marine worm, Urechis caupo.
Gould-Somero, M; Jaffe, L A; Holland, L Z The Journal of cell biology 1979 Aug;82(2):426-40
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Ionic mechanism of the fertilization potential of the marine worm, Urechis caupo (Echiura).
Jaffe, L A; Gould-Somero, M; Holland, L The Journal of general physiology 1979 Apr;73(4):469-92
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The time course of cortical vesicle fusion in sea urchin eggs observed as membrane capacitance changes.
Jaffe, L A; Hagiwara, S; Kado, R T Developmental biology 1978 Nov;67(1):243-8
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Membrane potential of the unfertilized sea urchin egg.
Jaffe, L A; Robinson, K R Developmental biology 1978 Jan;62(1):215-28
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Fast block to polyspermy in sea urchin eggs is electrically mediated.
Jaffe, L A Nature 1976 May;261(5555):68-71
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Calcium accumulations within the growing tips of pollen tubes.
Jaffe, L A; Weisenseel, M H; Jaffe, L F The Journal of cell biology 1975 Nov;67(2PT.1):488-92