Photo of Laurinda A. Jaffe, Ph.D.

Laurinda A. Jaffe, Ph.D.

Professor and Chair, Department of Cell Biology
Academic Office Location:
Cell Biology, E-6029
UConn Health
263 Farmington Avenue
Farmington, CT 06030
Phone: 860-679-2661
Fax: 860-679-1269
Email: ljaffe@uchc.edu
Website(s):

Jaffe Lab Page

Cell Biology Graduate Program

Genetics & Developmental Biology Graduate Program

Education
DegreeInstitutionMajor
B.S.Purdue UniversityBiology
Ph.D.University of California, Los AngelesBiology

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralMarine Biological Laboratory, Woods HoleCell Biology
PostdoctoralUniversity of California, San DiegoCell Biology

Awards
Name of Award/HonorAwarding Organization
Invited to serve on the scientific advisory board for the Laboratory of Developmental BiologySorbone University/CNRS
UConn Health Dean's Award for Excellence in Research MentoringUConn Health
Frontiers in Reproduction Pioneer AwardFrontiers in Reproduction Program (NICHD, MBL, and Burroughs Wellcome)
MERIT Award, 2014 (extension to April 2024 approved)NIH/NICHD
FellowAAAS
Human Frontier Science Program Award 2000-2004Human Frontier Science Program
Faculty Award for Women 1991-1997National Science Foundation
Loeser Award for Outstanding TeachingUniversity of Connecticut Health Center
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Developmental BiologyEditorial BoardEditorial Board MemberExternalNational2018
5th International Oocyte MeetingWorkshop/ConferenceCo-OrganizerExternalInternational20182019
Max Planck Institute for Multidisciplinary SciencesAdvisory CommitteeScientific Advisory Board MemberExternalInternational2018
2012 Cold Spring Harbor meeting on Germ Cells Workshop/ConferenceOrganizerExternalNational20122012
2011 American Society for Cell Biology minisymposiumWorkshop/ConferenceOrganizerExternalNational20112011
NICHD Board of scientific counselorsAdvisory CommitteeMemberExternalNational20112016
Department of Cell BiologyEducation CommitteeInterim ChairUConn HealthUniversity20062011
Cellular, Molecular, and Integrative Reproduction, NIH study section Study SectionMemberExternalNational20062012
Department of Cell BiologyEducation CommitteeVice ChairUConn HealthUniversity20032006
Cell Development and Function, NIH study sectionStudy SectionMemberExternalNational19982002
Developmental Biology Professional/Scientific JournalEditorExternalNational19952007
Developmental Biology Professional/Scientific JournalAssociate EditorExternalNational19861995
Department of Cell BiologyEducation CommitteeChairUConn HealthUniversity
Advanced Research Training Courses Advisory Committee, Marine Biological Lab (Woods Hole)Education CommitteeMemberExternalUniversity
Research CouncilResearch CommitteeMemberUConn HealthUniversity
Richard D. Berlin Memorial Lecture SeriesResearch CommitteeMember and ChairpersonUConn HealthUniversity
Sorbonne Universite/CNRSAdvisory CommitteeScientific Advisory Board MemberExternalInternational
Post bac program advisory committeeAdvisory CommitteeMemberUConn HealthUniversity

My lab's research concerns the physiological mechanisms that regulate the oocyte cell cycle and fertilization. Currently, our studies are focused on meiotic regulation in the ovarian follicle. We are investigating how the ovarian follicle functions as a coordinated system in which events in the somatic cells surrounding the oocyte regulate its meiotic progression.


 

Not accepting students for Lab Rotations at this time

Journal Articles

Book Chapters

  • Preparing for fertilization: Intercellular signals for oocyte maturation
    Shuhaibar, L.C., Carroll, D.J., and Jaffe, L.A. Reproductive and Developmental Strategies 2018 Jan;535-548
  • Preparing for fertilization: Intercellular signals for oocyte maturation, Chapter 25
    Shuhaibar, L.C., Carroll, D.J., and Jaffe, L.A. Reproductive and Developmental Strategies 2018 Jan;535-548
  • Initiation of the meiotic prophase-to-metaphase transition in mammalian oocytes
    Jaffe LA, Norris RP Oogenesis -- The Universal Process 2010 Jan;181-197
  • Egg membranes during fertilization
    Jaffe LA Molecular Biology of Membrane Transport Disorders 1996 Jan;367-378
  • Egg activation at fertilization: structural changes in the endoplasmic reticulum
    Jaffe LA, Terasaki M Meiosis II: Contemporary Approaches to the Study of Meiosis 1993 Jan;167-174
  • Receptors, G-proteins, and activation of the amphibian egg
    Kline D, Kado RT, Kopf GS, Jaffe LA Mechanisms of Fertilization, NATO ASI Series, volume H45 1990 Jan;529-541
  • G proteins and the regulation of oocyte maturation and fertilization
    Turner PR, Jaffe LA The Cell Biology of Fertilization 1989 Jan;297-318
  • Receptors, G-proteins, and egg activation
    Jaffe LA Mechanisms of Egg Activation 1989 Jan;151-155
  • Polyspermy prevention mechanisms
    Jaffe LA, Gould M Biology of Fertilization vol 3 1985 Jan;223 250
  • Control of cell fusion at fertilization by membrane potential
    Gould-Somero M, Jaffe LA Cell Fusion: Gene Transfer and Transformation 1984 Jan;27-38
  • Fertilization potentials from eggs of the marine worms Chaetopterus and Saccoglossus
    Jaffe LA The Physiology of Excitable Cells 1983 Jan;211-218

Other

  • A new combination therapy for the treatment of FGFR3-related skeletal disease.
    Legeai-Mallet L., Shuhaibar L.C., and Jaffe LA. Patent application submitted to the European Patent Office, June 2020. Institut national de la sante et de la recherche medicale (France) and University of Connecticut, Assignees.

Reviews

Title or AbstractTypeSponsor/EventDate/YearLocation
Physiology of fertilizationLecture2022National Academy of Sciences, Physiology and Pharmacology section meeting
Regulation of bone growth by the NPR2 guanylyl cyclaseOtherUniversity of Paris2019Paris, France
Gonadotropin-induced calcium dynamics in intact mouse follicles.PosterGordon Research Conference on Fertilization & the Activation of Development2019New Hampshire
Intercellular communication between the luteinizing hormone receptor and the NPR2 guanylyl cyclase in mouse ovarian follicles.OtherGordon Research Conference on Fertilization & the Activation of Development2019New Hampshire
Luteinizing hormone receptor and NPR2 guanylyl cyclase communication in mouse ovarian follicles.PosterASCB/EMBO Cell Biology Meeting2019Washington DC
Regulation of mammalian oocyte meiosis by intercellular communication within the ovarian follicleOtherSociety for the Study of Reproduction Meeting2018New Orleans, LA
Illuminating cellular communication: Imaging cyclic GMP signaling within intact tissuesOtherEuropean Molecular Biology Laboratory2018Heidelberg, Germany
Regulation of mammalian oocyte meiosis by intercellular communication within the ovarian follicleOther117th International Titisee Conference2018Titisee, Germany
Illuminating cellular communication: Imaging cyclic GMP signaling within intact tissuesOtherUniversity of Hamburg2018Hamburg, Germany
Frontiers in Reproduction: How the ovarian follicle controls meiotic progression in the oocyteOther2017Marine Biological Laboratory, Woods Hole MA
Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in ovarian folliclesOther8th International Conference on cGMP2017Germany
Regulation of mammalian oocyte meiosis by intercellular communication within the ovarian follicleOtherGordon Conference2017New Hampshire
Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in ovarian folliclesOther2016University of Pittsburgh
A conserved cGMP signaling pathway that controls development of both oocytes and bonesOther2016University of Minnesota
Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in ovarian folliclesOther2015University of Washington, Seattle WA
Luteinizing hormone signaling rapidly reduces cyclic GMP levels in mammalian ovarian follicles by dephospho rylation of NPR2 and phosphorylation of PDE5, leading to meiotic resumptionOther2015Japan