Photo of Catherine H. Wu, Ph.D.

Catherine H. Wu, Ph.D.

Professor of Medicine
Academic Office Location:
University of Connecticut Health Center
Medicine/ Gastroenterology & Hepatology
263 Farmington Avenue
Farmington, CT 06030-1845
Phone: 860-679-3110
Fax: 860-679-3159
Website(s): Cell Biology Graduate Program
Education
DegreeInstitutionMajor
Ph.D.Brooklyn College, City University of NYBiochemistry
B.S.Brooklyn College, City University of NYChemistry

Awards
Name of Award/HonorAwarding Organization
U.S. Patent 6,525,242 Propagation of Human Hepatocytes in Non-Human AnimalsUnited States Patent and Trademark Office
Blowitz-Ridgeway Foundation ScholarAmerican Liver Foundation
U.S. Patent 5,656,609 Method of Enhancing and/or Prolonging Expression of a Gene Introduced into a CellUnited States Patent and Trademark Office
U.S. Patent 5,166,320 Carrier System and Method for Introduction of Genes into Mammalian CellsUnited States Patent and Trademark Office
2009-present: UConn School of Medicine, Histology preceptor for first year human systems course 2010-present: UConn School of Medicine, Gross Anatomy preceptor 2008-2011: Tunxis Community College, Anatomy & Physiology I & II, lecture and laboratory
Dr. Wu’s laboratory is involved in research in gene therapy of liver diseases and creating novel animal models for studying liver diseases. Dr. Wu’s laboratory has developed a protein base carrier molecule that can deliver molecular reagents such as genes and antisense DNA and RNA molecules specifically to liver cells. The original liver-specific carrier molecule has been used to deliver human albumin gene and human low density lipoprotein receptor in animals deficient in albumin or LDLR expression resulting in partially reversal of metabolic liver diseases. The novel carrier protein has also been show to be successful in delivering molecular agents for treatment of acquired liver diseases such as Hepatitis B and hepatic fibrosis. Research in this area is now focused on modifying the liver specific carrier protein to include elements that would enhance the efficiency of delivery process so that molecular agents taken into liver cells by this system can be rendered more biologically active and thus more therapeutically effective. The laboratory is in the process of characterizing a normal rat with humanized liver. We have produced a rat with normal immune system capable of hosting human liver cells in its liver. The animal has been shown to be susceptible to human hepatitis B viral infection. We are now studying the molecular regulation of human Hepatitis C virus and its structure since not much is know about either of the two areas of HCV viral genome. We will use rats with humanized liver to develop a rodent model of HCV infection and to use this model to test novel HCV therapeutics.
Not accepting students for Lab Rotations at this time.

Journal Articles

Books

  • Multiple contributors Molecular Diagnosis and Gene Therapy 1996 Jan;
  • Multiple contributors Liver Diseases: Diagnosis and Therapy Using Specific Receptors and Ligands 1991 Jan;

Book Chapters

  • Polymeric Biomaterials
    Ouyang, E.C., Wu, C.H., and Wu, G.Y. Biocompatible polymers in liver-targeted gene delivery systems 2002 Jan;975-982
  • Meth. Mole. Med. – Nonviral Vectors for Gene Therapy: Methods and Protocols
    Zhong, Bo-Hua, Wu, G.Y., and Wu, C.H. Progress Towards a Synthetic Virus: A Multicomponent System for Liver-Directed DNA Delivery 2001 Jan;
  • Progress in Gene Therapy - Basic and Clinical Frontiers
    Fukuma, T., Wu, G.Y., and Wu, C.H. Liver-selective nucleic acid targeting using the asialoglycoprotein receptor 2000 Jan;
  • Current Concepts of Gene Therapy
    Wu, G.Y. and Wu, C.H. Targeted gene delivery and expression in hepatocytes 1997 Jan;
  • Gene Therapy Protocols
    Findeis, M.A., Wu, C.H., and Wu, G.Y. Methods for Targeted Gene Trans¬fer to Liver Using DNA-Protein Complexes 1997 Jan;
  • Molecular Diagnosis and Gene Therapy
    Wu, G.Y. and Wu, C.H. Gene therapy for hepatic diseases 1997 Jan;
  • Gene Therapy and Artificial Self-Assembling Systems for Gene Transfer
    Wu, G.Y. and Wu, C.H. Progress in targeting nucleic acids to the liver 1996 Jan;
  • Treatments in Hepatology
    Wu, G.Y., and Wu, C.H. Gene therapy and liver diseases 1995 Jan;
  • Methods in Enzymol.
    Findeis, M.A., Wu, C.H. and Wu, G.Y. Ligand-based carrier systems for delivery of DNA to hepatocytes 1994 Jan;
  • Neoglycoconjugates: Preparation and Application
    Lee-Young, A., Wu, C.H., and Wu, G.Y. Delivery of polynucleotides to hepatocytes 1994 Jan;
  • The Liver: Biology and Pathology
    Wu, G.Y. and Wu, C.H. Gene therapy by targeting nucleic acids to hepatocytes 1994 Jan;
  • Extrahepatic Manifestations of Liver Diseases
    Wu, G.Y. and Wu, C.H. Advances in gene therapy for liver diseases 1993 Jan;
  • The Extracellular Matrix and Liver Disease
    Wu, C.H., Walton, C.M., and Wu, G.Y. Propeptide-mediated regulation of procollagen synthesis 1993 Jan;
  • Progress in Liver Diseases
    Makdisi, W.J., Wu, C.H., and Wu, G.Y. Methods of gene transfer into hepatocytes: Progress toward gene therapy 1992 Jan;
  • Seminars in Liver Disease
    Versland, M.R., Wu, C.H., and Wu, G.Y. Strategies for gene therapy in the liver 1992 Jan;
  • Etiology, Pathology, and Treatment of Hepatocellular Carcinoma in North America
    Keegan-Rogers, V., Wu, C.H. and Wu, G.Y. Experimental therapeutic modalities for hepatocellular carcinoma 1991 Jan;
  • Targeted Diagnosis and Therapy of Liver Diseases: Cell Surface Receptors and Liver Directed Agents
    Wu, G.Y. and Wu, C.H. Targeted delivery and expression of foreign genes in hepatocytes 1991 Jan;
  • Therapy of Genetic Diseases
    Wu, G.Y. and Wu, C.H. Delivery and expression of genes in hepatocytes 1991 Jan;

Reviews

  • Hepatic Fibrosis - A Mini Review
    Wu, CH. and Wu, GY. Chinese J Gastro 2000 Jan;580-83
Title or AbstractTypeSponsor/EventDate/YearLocation
"HCV Rat Model"Misr International University2010Cairo, Egypt
"Human Liver Cell Transplantation in Rats"Misr International University2007Cairo, Egypt
“Animal Model of HCV infection in the Immunocompetent Rat”SRMC2006Chennai, India
“Distribution and Characterization of Human Liver Cells in the Immunocompetent Rat”1st International Conference on Genetic Engineering and Biotechnology Research 2004Dokki, Cairo, Egypt
“SiRNA inhibitors of HCV replication”Orchid Research Laboratory2004Chennai, India
“Liver Cell Transplantation in the Immune-competent Rat: Distribution and Function” 3rd International Congress in Forensic Science and Molecular Medicine2003Dubronik, Croatia
“Molecular therapies for Viral Hepatitis”Chiang Mai Medical School, Dept of Medicine, Gastroenterology Division2002Chiang Mai, Thailand
“Fibrosis and therapeutic approaches”Second International Symposium on Cirrhosis and its Complications2002Shanghai, China
“Hepatic Fibrosis – Cellular Mechanisms”3rd International Meeting of Viral Hepatitis2002Tokyo, Japan
“Hepatic Fibrosis – Experimental Therapeutic Strategies”West China Medical School, Dept of Internal Medicine2002Chengdu, China
“Rodent Model for Viral Hepatitis”Second International Conference on Forensic Medicine and Gene Therapy2001Debrovnik, Croatia
“Molecular agents for viral hepatitis”Fourth Shanghai International Conference of Gastroenterology2000Shanghai, China
“Pathogenesis of liver fibrosis in portal hypertension”Indian Society of Gastroenterology/40th Annual Conference1999New Delhi, India
“Hepatic fibrosis”Sri Ramadhandran Medical College, Department of Medicine1999Calcutta, India
“Receptor mediated gene delivery in the liver”Wright State University, Dept of Biochemistry and Molecular Biology/Visiting Professor1998Wayne, OH
“A tri-component DNA carrier: Progress towards a synthetic virus”.American Association for the Study of Liver Diseases1997Chicago, IL
“Evolving Approaches to Gene Therapy for Liver Disease”American Society for the Study of Liver Diseases 1997Chicago, IL
“Transgenic Animal Models for the Study of Liver Diseases”American Association for the Study of Liver Diseases/Co-Chair-Research Workshop1997Chicago, IL
“Gene therapy for hepatitis”Shanghai Medical University, Digestive Disease Institute, Ren Ji Hospital/Visiting Professor1997Shanghai, China
“Collagen antisense oligonucleotide inhibition of type I procollagen synthesis in the transgenic mouse”Gordon Conference on Alcohol1996Ventura, CA
“Targeted inhibition of HCV promoter activity using HCV specific antisense DNA”American Association for the Study of Liver Diseases1995Chicago, IL
“Transfection of DNA into Hepatocytes”American Society for the Study of Liver Diseases/Early Morning Workshop1995Chicago, IL
“Antisense molecular therapy for hepatic fibrosis”Japanese Society for Hepatology/Plenary session1995Fukuoka, Japan
“Hepatic Fibrosis in the Hamster Model of Schistosomiasis”National Research Centre, Department of Biochemistry1994Dokki, Cairo, Egypt
“Liver specific gene delivery”Indiana State University, Dept. of Biochemistry1993Terre Haute, IN
"Molecular techniques for the analysis of liver diseases”American Gastroenterological Association/Meet the Investigator Lunch1992Chicago, IL
“Targeted antisense DNA oligonucleotides specifically inhibit procollagen synthesis in cultured fibroblasts”American Association for the Study of Liver Diseases1992Chicago, IL
“Role of procollagen propetide in regulation of collagen synthesis in the normal liver”University of Maryland, Dept of Medicine1991Baltimore, MD
"Regulation of procollagen synthesis"Sapporo Medical College/Department of Internal Medicine Med. Assoc. Conf.1991Sapporo, Japan
“Feedback regulation of procollagen synthesis”American Association for the Study of Liver Diseases/Connective Tissue & Liver Fibrosis Conf.1989Asilomar, CA
"Regulation of collagen synthesis in hepatic fibrosis"Department of Internal Medicine, Recent Advances in GI1988Jiminy Peak, Hancock, MA
"Impaired inhibitory response to procollagen propetides in fibroblasts from fibrotic liver”Asian Pacific Association for the Study of the Liver/Plenary Session1988New Delhi, India
“Regulation of procollagen synthesis by terminal propeptides”Gordon Conference on Collagen and other Connective Tissue Proteins1988New Hampshire
“Identification of a specific cell surface receptor for Type I procollagen carboxy-terminal propeptides” American Association for the Study of Liver Diseases/Plenary Session1986Chicago, IL
“Transcriptional regulation of Type I collagen synthesis by Type I carboxyterminal propeptide in human fibroblast cultures"American Association for the Study of Liver Diseases/Plenary Session 1985Chicago, IL
“The relationship between Type I collagen alpha chain mRNA levels and collagen synthesis in hepatic fibrogenesis”American Association for the Study of Liver Diseases1984Chicago, IL