Carol C. Pilbeam, M.D., Ph.D.

Professor of Medicine and Orthopaedics
Director, M.D./Ph.D. Combined Degree Program
Academic Office Location:
Medical Arts Research Building
University of Connecticut Health Center
263 Farmington Avenue
Farmington, CT 06030-5456
Phone: 860-679-3846
Fax: 860-679-1932
Website(s): Cell Biology Graduate Program
Skeletal, Craniofacial & Oral Biology Graduate Program
Biomedical Engineering Program

Education
DegreeInstitutionMajor
M.D.Yale University School of MedicineMedicine
Ph.D.Yale University Geophysics
B.S.SMUGeology

Post-Graduate Training
TrainingInstitutionSpecialty
FellowshipNSFGeology/Geophysics Graduate Program at Yale
InternshipWaterbury HospitalIntern in Medicine
ResidencyWaterbury HospitalInternal Medicine
FellowshipHARVARD MEDICAL SCHOOLGeriatrics
FellowshipBrookdale Foundation Brookdale National Fellowship in Geriatrics at UCHC

Awards
Name of Award/HonorAwarding Organization
Bridging award (national competition, 1 of 2 selected) American Society of Bone and Mineral Research
JBMR paper (Chikatzu et al, 2002) selected as 20th Anniversary ClassicJBMR
Paper chosen as one of 12 best papers published in Journal of Bone and Mineral Research over 20 year period and republished in journal as 20th Anniversary Classic Journal of Bone and Mineral Research
Donaghue Foundation Investigator in Health Related Research Award (2002-7)
Fred F. Schudy Memorial Research AwardAAOF
Honorary member, Chinese Hard Tissue Society
CT Community Care Award for Research in Geriatrics
Travel award XIIInternational Conference on Calcium Regulating Hormones
Shannon Award (new investigator award), 1993-1995NIH
Abstract awardAm. Geriatrics Soc.
Brookdale Foundation National Fellowship in Geriatrics 1987-1990 Brookdale Foundation
National Science Foundation Fellowship (graduate work at Yale)1964- 1967 National Science Foundation
Phi Beta Kappa
I lead first and second year conferences on bone biology and calcium metabolism and teach skeletal biology in the SCOB program for graduate students.
1. Regulation and function of cyclooxygenase-2 (COX-2) in bone. COX-2 is responsible for most prostaglandin regulation in bone. Ongoing research projects include examination of transcriptional regulation of COX-2 in osteoblastic cells and examination of the effects of COX-2 gene disruption on bone resorption and formation. We are particularly interested in the inhibition by COX-2 of the anabolic effects of PTH on bone, an effect that appears to be mediated by cells of the osteoclast lineage.

2. Role of COX-2 in the osteoblastic response to mechanical loading. COX-2 may mediate effects of mechanical loading on bone. We are studying fluid shear stress induction of COX-2 expression--signaling pathways and transactivating factors involved.

Accepting students for Lab Rotations: Summer '13, Fall '13, Spring '14

Journal Articles

Book Chapters

  • Current Therapy in Orthodontics
    Wadhwa S, Nanda R, Pilbeam C. (2009) Mechanotransduction of Orthodontic Forces 341-352
  • Principles of Bone Biology
    Pilbeam CC, Choudhary S, Blackwell K, Raisz LG (2008) Prostaglandins and Bone Metabolism 1235-1271
  • The Eicosanoids
    Pilbeam CC, LG Raisz (2004) Prostaglandins, Leukotrienes, and Bone Metabolism
  • Principles of Bone Biology, second edition
    Pilbeam CC, Harrison J, Raisz LG. (2002) Prostaglandins and Leukotrienes 874-994
  • Therapeutic Roles of Selective COX-2 Inhibitors
    Pilbeam C and Okada Y. (2001) Cyclooxygenase-2 and bone turnover 307-328
  • Oxford Textbook of Geriatric Medicine
    Pilbeam CC. and Raisz LG (2000) Osteomalacia
  • Clinical Significance and Potential of Selective COX-2 Inhibitors
    Pilbeam CC. (1998) Cyclooxgenase-2 and bone resorption. 49-56
  • Principles of Bone Biology
    Pilbeam CC, Harrison J, Raisz LG. (1996) Prostaglandins and Leukotrienes. 715-728
  • Oxford Textbook of Geriatric Medicine
    Raisz LG, Pilbeam CC. (1992) Osteomalacia.
  • Osteoporosis 1990
    Raisz LG, Pilbeam CC, Klein Nulend J, Harrison JR. (1990) Prostaglandins and bone metabolism: Possible role in osteoporosis. 253-258
  • Geriatric Medicine
    Pilbeam CC, Resnick NM. (1988) Osteoporosis. 431-439

Abstracts

  • Role of osteoclasts in the COX-2 mediated inhibition of PTH-stimulated osteoblastic differentiation in vitro. Choudhary won President’s Poster Award
    Choudhary S, Voznesensky O, Xu M, Alander C, Raisz L, Pilbeam C (2010) J Bone Miner Res (Suppl 1) (25)
  • Effects of MKP-1 deletion on osteoblast growth and differentiation. Available at http://www.asbmr.org/Meetings/AnnualMeeting/AbstractDetail.aspx?aid=b9f49eaa-e06d-423b-9ec4-629d067dc93e.
    Ma L, Choudhary S, Voznesensky O, Raisz L, Pilbeam C. (2009) J Bone Miner Res (Suppl 1) (24)
  • Targeted overexpression of Cox-2 in osteoblasts.
    Choudhary S, Diaz-Doran V, Voznesensky O, Xu M, Adams D, Herschman H, Kamei K, Ishikawa K, Kream B, Raisz L, and Pilbeam C. (2009) J Bone Miner Res (Suppl 1) (24 )
  • Mechanism of BMP-2 enhancement of PGE2 stimulated osteoclastogenesis.
    Blackwell KA, Hortschansky P, Sanovic S, Alander C, Raisz L, Pilbeam C. (2008) J Bone Miner Res (23) S263
  • PTH induces COX-2 in MC3T3-E1 osteoblasts via cAMP-PKA and caclcium-calcineurin pathways.
    Huang H, Chikazu D, Voznesensky O, Doge-Kafka K, Drissi H, Pilbeam C. (2008) J Bone Miner Res (23) S140
  • BMP-2 induces sustained expression of COX-2 in MC3T3-E1 osteoblasts.
    Blackwell K, Hortschansky P, Raisz L, and Pilbeam C. (2007) J Bone Miner Res (22) S165
  • Continuous treatment with PTH is anabolic in cultured osteoblasts from COX-2 knockout mice.
    Huang H, Choudhary S, Raisz L, and Pilbeam C. (2007) J Bone Miner Res (22) S371
  • Demonstration of an anabolic effect of prostaglandin E 2 on bone in CD-1 mice.
    Gao Q, Xu M, Zhan P, Alander CB, Pilbeam CC, and Raisz LG. (2007) J Bone Miner Res (22) S167
  • Role of prostaglandins in strontium ranelate effects on osteoblastic differentiation and growth factor production.
    Choudhary S, Halbout P, Alander C, Pilbeam C, and Raisz L. (2007) J Bone Miner Res (22) S445
  • Effect of deletion of the prostaglandin EP2 receptor on the anabolic response to a selective EP2 agonist.
    Choudhary S, Alander C, Zhan P, Pilbeam C, and Raisz L. (2006) J Bone Miner Res (21(S1)) S253
  • Null mutation for macrophage migration inhibitory factor (MIF) is associated with less aggressive bladder cancer in mice.
    Taylor JA, Voznesensky O, Kuchel GA, Hegde P, Claffey K, Tsimikas J, Leng L, Bucala R, Pilbeam C. (2006) J Urol (175) 204
  • Regulation of MAPK phosphatase-1 by fluid flow in MC3T3-E1 osteoblastic cells.
    Mehrotra M, Voznesensky O, Saegusa M, and Pilbeam C. (2006) J Bone Miner Res (21(S1)) S372
  • Role of n-3 fatty acids in osteoclastogenesis.
    Blackwell K, Raisz L, and Pilbeam C. (2006) J Bone Miner Res (21(S1)) S393
  • Strontium ranelate effects on osteoblastic differentiation: involvement of prostaglandins.
    Choudhary S, Halbout P, Alander P, Raisz L, and Pilbeam C. (2006) J Bone Miner Res (21(S1)) S301
  • Macrophage migration inhibitory factor mediates smooth muscle death in bladder outlet obstruction.
    Taylor JA, Zhu Q, Sasso D, Leng L, Bucala R, Pilbeam C, Kuchel GA. (2005) J Urol (173) 38
  • Fluid flow regulation of the 3’- untranslated region of cyclooxygnase-2 in MC3T3-E1 cells.
    Mehrotra M, Voznesensky O, Saegusa M, Pilbeam C. (2005) J Bone Miner Res (20(S1)) S169
  • Null mutation in macrophage migration inhibitory factor (MIF) inhibits compensatory smooth muscle growth in bladder outlet obstruction.
    Taylor JA, Zhu Q, Sasso D, Leng L, Bucala R, Pilbeam C, Kuchel GA. (2005) J Am Geriatr Soc. (53) 8
  • Fluid shear stress induces MMP-13 in murine osteoblastic cells.
    Saegusa M, Mehrotra M, Nakamura K, Kawaguchi H, and Pilbeam C. (2004) J Miner Res (19(S1)) S137
  • Effect of exogenous and endogenous prostaglandin E2 on osteoclastogenesis in the RAW 264.7 macrophage cell line.
    Kaneko H, Lee S, Lorenzo JA, Toyama Y, Pilbeam CC, and Raisz LG. (2004) J Bone Miner Res (19(S1)) S409
  • Effects of global or targeted deletion of the EP4 receptor on the response of cultured osteoblasts to prostaglandin E2.
    Raisz LG, Alander CA, Zhan P, Breyer MD, Kream BE, and Pilbeam CC. (2004) J Bone Miner Res (19(S1)) S5
  • Endogenous COX-2 gene expression does not alter apoptosis in murine osteoblastic cells.
    Choudhary S, Xu Z, Raisz LG, and Pilbeam CC. (2004) J Bone Miner Res (19(S1)) S140
  • Five minutes of fluid shear stress is sufficient to induce cyclooxygenase-2 in MC3T3-E1 cells.
    Saegusa M, Mehrotra M, Raisz LG, and Pilbeam C. (2004) J Miner Res S137 (19(S1))
  • Fluid shear stress induces cyclooxygenase-2 via activation of protein kinase D in murine primary osteoblasts.
    Mehrotra M, Alander CB, Voznesensky O, Raisz LG, and Pilbeam CC. (2004) J Miner Res (19(S1)) S390
  • Fluid shear stress induces RANKL expression in primary osteoblastic cells.
    Mehrotra M, Lee S-K, Saegusa M, Alander CB, Raisz LG, and Pilbeam CC. (2004) J Miner Res (19(S1)) S391
  • Overexpression of COX-2 in Saos- 2 human osteosarcoma cells increases apoptosis via oxidative stress.
    Choudhary S, Xu Z, Vozensensky O, and Pilbeam CC. (2004) J Bone Miner Res (19(S1)) S140
  • Parathyroid hormone injection induces cyclooxygenase-2 in bone, kidney, and muscle in vivo.
    Xu M, Vozensenky O, Raisz L, and Pilbeam C. (2004) J Miner Res (19(S1)) S335
  • Transcription factors involved in the regulation of IL-6 in mouse calvarial osteoblasts by vasoactive intestinal peptide.
    Persson E, Voznesensky O, Pilbeam CC, and Lerner UH. (2004) J Bone Miner Res (19(S1)) S265
  • Early induction of cyclooxygenase-2 in osteoblasts by fluid flow depends on the protein kinase C signaling pathway.
    Wadhwa S, Mehrotra M, Alander C, Voznesensky O, Pilbeam CC. (2003) J Bone Miner Res ( 18(S2)) S218
  • Overexpression of cyclooxygenase-2 decreases proliferation of osteoblastic cells.
    Xu Z, Voznesensky O, Choudhary S, Raisz LG, Pilbeam CC. (2003) J Bone Miner Res (18(S2)) S340
  • Platelet-derived growth factor stimulates osteoblastic migration and proliferation via independent signaling pathways.
    Mehrotra M, Mehrotra S, Pilbeam CC. (2003) J Bone Miner Res (18(S2)) S194
  • Prostaglandin E2 stimulation of osteoclast formation in hematopoietic cell cultures is mediated by a soluble T cell factor.
    Kaneko H, Ono K, Lee SK, Lorenzo JA, Toyama Y, Pilbeam CC, Raisz LG. (2003) J Bone Miner Res (18(S2)) S236
  • Biphasis effect of prostaglandin E2 on osteoclast formation from spleen cells.
    Ono K, Akatsu T, Kugai N, Pilbeam CC, Raisz LG. (2002) J Bone Miner Res (17(S1)) S345
  • Effects of cyclooxygenase-2 gene disruption on osteoblastic cell growth.
    Xu Z, Choudhary S, Alander CB, Raisz LG, Pilbeam CC. (2002) J Bone Miner Res (17(S1)) S340
  • Effects of Prostaglandin E2 (PGE2) and selective prostaglandin E receptor (EP) agonists on 3’5’ cyclic adenosine monophosphate (cAMP) production in osteoblastic cells from wild type and EP2 or EP4 knockout mice.
    Sakuma Y, Pilbeam CC, Pan L C, Raisz LG. (2002) J Bone Miner Res (17(S1)) S441
  • Extracellular calcium transriptionally induces cyclooxygenase-2 in osteoblasts via an ERK signaling pathway.
    Choudhary S, Godwin S, Mellas S, Wadhwa S, Jacobs B, Alander C, Raisz L, Pilbeam C. (2001) J Bone Miner Res (16(S1)) S427
  • Signaling pathways for the fluid shear stress induction of cyclooxygenase-2 in murine osteoblasts.
    Wadhwa S, Godwin S, Raisz L, Pilbeam C. (2001) J Bone Miner Res (16(S1)) S255
  • Effects of aging on the regulation of osteoclast formation in murine bone marrow cultures.
    Lee S, Tomita M, Pilbeam C, Lorenzo J. (2000) J Bone Miner Res (15(S1)) S237
  • Fluid shear stress transcriptionally induces cyclooxygenase-2 expression in murine osteoblasts.
    Wadhwa S, Godwin S, Peterson D, Freeman A, Epstein M, Pilbeam C. (2000) J Bone Miner Res (15(S1)) S499
  • IL-1 regulation of osteoblastic differentiation in murine bone marrow and primary osteoblastic cultures.
    Tomita M, Okada Y, Alander C, Lorenzo J, Raisz L, Pilbeam C. (2000) J Bone Miner Res (15(S1)) S508
  • Involvement of AP-1 and CRE sites in the parathyroid hormone induction of COX-2 promoter activity in osteoblastic MC3T3-E1 cells.
    Chikazu D, Voznesensky O, Tetradis S, Tomita M, Kream B, Pilbeam C. (2000) J Bone Miner Res (15(S1)) S497
  • Effects of a selective EP4 antagonist on osteoclast formation and bone resorption in vitro.
    Tomita M, Woodiel FN, Okada Y, Pilbeam CC, Raisz LG. (1999) J Bone Miner Res (14(S1)) S245
  • Effects of prostaglandin G/H synthase-2 knockout on bone.
    Okada Y, Tomita M, Tsurukami H, Nakamura T, Alander C, Sohn J, Raisz L, Lorenzo J, Pilbeam C. (1999) J Bone Miner Res (14(S1)) S172
  • Osteoblasts from interleukin 1 receptor type 1 knockout mice have a markedly reduced capacity to support osteoclast function.
    Lorenzo JA, Kalinowski J, Voznesensky O, Pilbeam C. (1999) J Bone Miner Res (14(S1)) S164
  • Prostaglandins induce ICER expression in osteoblastic cells and mouse calvariae.
    Ammari Z, Nervina JM, Tetradis S, Pilbeam CC, Kream BE. (1999) J Bone Miner Res (14(S1)) S350
  • Transcriptional regulation of prostaglandin G/H synthase-2 in transgenic mice.
    Freeman A, Mallico E, Voznesensky O, Bhatt A, Clark S, Pilbeam C. (1999) J Bone Miner Res S472 (14(S1))
  • AP-1 and CRE sites jointly mediate the induction of prostaglandin G/H synthase-2 promoter activity basic fibroblast growth factor in osteoblastic MC3T3-E1 cells.
    Okada Y, Tetradis S, Voznesensky O S, Kream BE, Herschman HR, Hurley MM, Pilbeam CC. (1998) J Bone Miner Res (13(S1)) S245
  • Decreased osteoclastogenic responses in marrow cultures from mice with disruption of the PGHS-2 gene.
    Okada Y, Raisz LG, Lorenzo JA, Alander CB, Freeman A, Voznesensky OS, Hurley MM, Pilbeam CC. (1998) J Bone Miner Res (13(S1)) S330
  • Expression and regulation of fibroblast growth factor-2 by cytokines and growth factors in human osteoblasts.
    Hurley MM, Montero A, Abreu C, Min YK, Pilbeam C, Raisz, Hand A, Florkiewicz R. (1998) J Bone Miner Res (13(S1)) S440
  • Identification of promoter sites mediating induction of transcription of PGHS-2 by phobol ester in MC3T3-E1 cells.
    Okada Y, Voznesensky O, Herschman H, Harrison J, Raisz L, Pilbeam C. (1998) Bone (22) 16S
  • Turnor necrosis factor-? stimulation of prostaglandin G/H synthase-2 promoter activity in osteoblastic MC3T3-E1 cells requires and intact AP-1 site.
    Tomita M, Harrison JR, Okada Y, Voznesensky OS, Raisz LG, Pilbeam CC. (1998) J Bone Miner Res (13(S1)) S354
  • Basic fibroblast growth factor stimulates bone resorption through mitogenic effects on immature osteoblastic cells as well as cyclooxygenase-2 induction.
    Kawaguchi H, Kurokawa T, Tanaka S, Pilbeam CC, Raisz LG, Hurley MM. (1997) J Bone Min Res (12(S1)) S209
  • Downregulation of mRNA expression for the "decoy" interleukin-1 receptor 2 by ovariectomy in mice.
    Pilbeam C, Rao Y, Alander C, Voznesensky O, Okada Y, Sims J, Raisz L, Lorenzo J. (1997) J Bone Min Res (12(S1)) S433
  • Expression and regulation of prostaglandin F receptor mRNA in rodent osteoblastic cells.
    Tamura K, Nemoto K, Pilbeam CC, Raisz LG. (1997) J Bone Min Res (12 (S1)) S189
  • Induction of the prostaglandin G/H synthase-2 gene by Interleukin-1 in MC3T3-E1 cells is mediated by C/EBP transcription factors.
    Harrison JR, Kelly PL, Pilbeam CC. (1997) J Bone Min Res (12(S1)) S433
  • Overexpression and suppression of prostaglandin EP2 and FP receptors in rat osteoblastic cells.
    Nemoto K, Tamura K, Pilbeam CC, Itabashi A, Raisz LG. (1997) J Bone Min Res (12(S1)) 190
  • The expression and regulation of IL-1? mRNA in human osteosarcoma MG-63 cells.
    Min YK, Voznesensky O, Raisz LG, Pilbeam CC. (1997) J Bone Min Res (12(S1)) S433
  • Estrogen and calcium have an additive effect on bone turnover in older women.
    Prestwood KM, Fall PM, Pilbeam CC, Kenny AM, Robbins B, Shepherd T, Raisz LG. (1996) J Bone Min Res S450 (1(S1))
  • Molecular cloning and expression of a rat prostaglandin E2 receptor of the EP2 subtype.
    Nemoto K, Pilbeam CC, Raisz Lg. (1996) J Bone Min Res (11(S1)) S174
  • The effect of estrogen on serum cross-linked N-telopeptides of type I collagen.
    Prestwood KM, Clemens JD, Fall PM, Pilbeam CC, Raisz LG. (1996) J Bone Min Res (11(S1)) S449
  • Transcriptional induction of prostaglandin G/H synthase-2 by transforming growth factor-beta1 in osteoblastic MC3T3-E1 cells requires an intact C/EBP (N-IL6) site.
    Rao Y, Voznesensky O, Harrison J, Alander C, Raisz L, Pilbeam C. (1996) J Bone Min Res (11(S1)) S378
  • Differential effects of nonsteroidal anti-inflammatory drugs on constitutive and inducible prostaglandin G/H synthase in cultured bone cells.
    Fall PM, Alander CB, Pilbeam CC, Raisz LG. (1995) J Bone Min Res (10(S1)) S418
  • Identification of prostaglandin receptor mRNA in bone cells by reverse transcriptase polymerase chain reaction methodology.
    Nemoto K, Bernecker PM, Pilbeam CC, Raisz LG. (1995) J Bone Min Res (10(S1)) S420
  • Increased production of inflammatory mediators immed-iately after surgery by marrow stromal cell cultures from sham operated and ovariectomized mice.
    Lee SK, Pilbeam CC, Lorenzo JA. (1995) J Bone Min Res (10(S1)) S346
  • Low dose conjugated estrogen reduces biochemical markers of bone turnover in older women.
    Prestwood KM, Pilbeam CC, Fall PM, Raisz LG. (1995) J Bone Min Res (10(S1)) S256
  • Parathyroid hormone induces prostaglandin synthase-2 gene expression in MC3T3-E1 cells.
    Tetradis S, Liu Y, Herschman HR, Pilbeam CC, Kream BE. (1995) J Bone Min Res (10(S1)) S280
  • Pulsating fluid flow stimulates prostaglandin E2 release and inducible prostaglandin G/H synthase mRNA expression in primary mouse bone cells.
    Klein Nulend J, Burger EH, Semeins CM, Raisz LG, Pilbeam CC. (1995) J Bone Min Res (10(S1)) 1S405
  • Retinoic acid inhibits induction of prostaglandin G/H synthase-2 mRNA and promoter activity in MC3T3 E 1 osteoblastic cells.
    Pilbeam CC, Bernecker P, Harrison J, Alander C, Voznesensky O, Herschman H, Raisz L. (1995) J Bone Min Res (10(S1)) S496
  • Transcriptional regulation prostaglandin G/H synthase 2 by transforming growth factor ß in MC3T3 E1 cells.
    Pilbeam C, Kawaguchi H, Voznesensky O, Alander C, Fletcher B, Herschman H, Raisz L. (1995) Bone (16(S1)) 39
  • Nuclear factor binding to an NF-IL-6 site in the prostaglandin G/H synthase 2 promoter induced by IL 1 in MC3T3 E1 cells.
    Harrison JR, Kawaguchi H, Raisz LG, Pilbeam CC. (1994) J Bone Min Res (9(S1)) S122
  • Ovariectomy enhances and estrogen replacement inhibits the activity of marrow factors which stimulate prostaglandin production in cultured mouse calvariae.
    Kawaguchi H, Pilbeam C, Vargas S, Morse E, Lorenzo J, Raisz LG. (1994) J Bone Min Res (9(S1)) S263
  • Ovariectomy or estrogen treatment do not alter interleukin 6 mRNA expression in adult murine bone and bone marrow.
    Vargas SJ, Kawaguchi H, Kalinowski J, Naprta A, Pilbeam C, Raisz L, Lorenzo JA. (1994) J Bone Min Res (9(S1)) S389
  • Regulation of inducible prostaglandin G/H synthase mRNA levels and promoter activity by basic fibroblast growth factor in osteoblastic cells.
    Kawaguchi H, Pilbeam C, Abreu C, Raisz L, Hurley M. (1994) J Bone Min Res (9(S1)) S124
  • Regulation of prostaglandin production and bone resorption by interleukin 4 (IL 4) in cultured mouse calvariae.
    Kawaguchi H, Raisz LG, Alander C, Voznesensky O, Pilbeam C. (1994) J Bone Min Res (9(S1)) S236
  • The effect of calcium and vitamin D supplementation on bone turnover in healthy older women.
    Prestwood KM, Kenny AM, Pannullo AM, Pilbeam CC, Fall PM, Raisz LG. (1994) J Bone Min Res (9(S1)) S391
  • Transcriptional regulation of inducible prostaglandin G/H synthase (PGHS 2) in osteoblastic cells.
    Pilbeam C, Kawaguchi H, Voznesensky O, Alander C, Harrison J, Herschman H, Raisz LG. (1994) J Bone Min Res (9(S1)) S357
  • Auto amplification of inducible prostaglandin G/H synthase (cyclooxygenase)in osteoblastic MC3T3 E1 and Pyla cells.
    Raisz LG, Voznesensky OS, Alander CB, Kawaguchi H, Pilbeam CC. (1993) J Bone Miner Res (8(S1)) S161
  • Effects of a short course of conjugated estrogen on bone turnover in older women
    Prestwood KM, Pilbeam CC, Woodiel FN, Raisz LG. (1993) J Bone Miner Res ( 8(S1):) S253
  • Insulin like growth factor binding protein 5 accumulates in bone matrix and is released by parathyroid hormone and prostaglandin E2.
    Hakeda Y, Kawaguchi H, Hand A, Pilbeam C, Hurley M, Abreu C, Kumegawa M, Raisz LG. (1993) J Bone Miner Res (8(S1)) S237
  • Quantitation of constitutive prostaglandin G/H synthase (cyclooxygenase) mRNA levels in mouse osteo-blastic MC3T3 E1 cells using competitive polymerase chain reaction.
    Kawaguchi H, Yavari R, Stover ML, Rowe DW, Raisz LG, Pilbeam CC. (1993) J Bone and Miner Res S299 (8(S1))
  • Regulation of inducible prostaglandin G/H synthase (cyclooxygenase) by interleukin 1 and transform¬ing growth factors ? and ß in osteoblastic cells.
    Pilbeam CC, Alander CB, Voznesensky OS, Kawaguchi H, Harrison JR, Raisz LG. (1993) J Bone Miner Res (8(S1)) S299
  • Role of inducible prostaglandin G/H synthase (cyclooxygenase) in the regulation of prostaglandin produc¬tion in cultured mouse calvariae.
    Kawaguchi H, Pilbeam CC, Voznesensky OS, Alander CB, Hakeda Y, Raisz LG. (1993) J Bone Miner Res (8(S1)) S159
  • Separate regulation of the mRNA transcripts for the two prostaglandin endoperoxide synthases in MC3T3 E1 osteoblastic cells by serum and glucocorticoid.
    Pilbeam CC, Kawaguchi H, Voznesensky O, Alander CB, Raisz LG. (1993) Calcif Tissue Int (52(S1)) S99
  • Short term effects of tamoxifen on bone turnover in older postmenopausal women.
    Kenny A, Prestwood KM, Pilbeam CC, Woodiel FN, Raisz LG. (1993) J Bone Miner Res ( 8(S):) S252
  • Comparison of the effects of 3,5,3' triiodothyro¬acetic acid and triiodothyronine on bone resorption in cultured fetal rat long bones.
    Kawaguchi H, Pilbeam CC, Woodiel FN, Raisz LG. (1992) J Bone Miner Res (7(S1)) S145
  • Short term effects of estrogen on bone turnover in older women.
    Prestwood KM, Pilbeam CC, Winsemius DK, Raisz LG. (1992) Bone and Mineral (17(S1)) 357
  • Estradiol inhibition of 1,25 dihydroxyvitamin D3 stimulated release in cultured fetal rat long bones.
    Alander CB, Pilbeam CC, Raisz LG. (1991) J Bone Miner Res (6(S1)) S99
  • Inhibition of prostaglandin E2 production by 17ß estradiol in osteoblast like cells.
    Pilbeam CC, Alander CB, Jones S, Raisz LG. (1991) Calcif Tissue Int (48(S1)) A31
  • Comparison of the effects of various forms of synthetic human parathyroid hormone related peptide of malignancy on bone resorption and formation in organ culture.
    Alander CB, Pilbeam CC, Simmons HA, Raisz LG. (1990) J Bone Miner Res (5(S2)) S475
  • In vitro inhibition of interleukin 1 stimulated prostaglandin E2 production by 17ß estradiol.
    Pilbeam CC, Alander CB, Raisz LG. (1990) Calcif Tissue Int (46(S2)) A44
  • Stimulation of prostaglandin E2 production in an immortalized osteoblastic cell line (Py1a) by arachidonic acid, transforming growth factor 6, and interleukin 1.
    Pilbeam CC, Raisz LG. (1990) J Bone Miner Res (5(S2)) S310
  • Effects of testosterone on IL 1 and PTH stimulated prostaglandin production and resorption in neonatal mouse calvariae.
    Pilbeam CC, Raisz LG. (1989) J Bone Miner Res (4(S1):) S283
  • In vitro inhibition of PTH stimulated prostaglandin (PGE2) production by 17 beta estradiol (ßE2).
    Pilbeam CC, Raisz LG. (1988) J Bone Miner Res (3(S1)) S219
  • Vitamin D status in nursing home elders.
    Pilbeam CC, Webb AR, Holick MF. (1988) The Gerontologist (28) 23A

Conference Papers

Editorials

  • Hip fractures and vitamin D. Guest editorial
    Pilbeam CC, Raisz LG. (1991) Complications in Orthopedics

Erratums

Notes

  • Commentary: Take two aspirin for osteoporosis? Does aspirin have potential as an anti-osteoporosis drug? A new study by Yamaza and colleagues, published in PLoS One suggests that it just might.
    Blackwell KA, Pilbeam C, Raisz L. (2008) IBMS BoneKEy Newsletter (Dec. 15)

Reviews

Title or AbstractSponsor/EventDate/YearLocation
Anabolic effects of intermittent PTH are impaired in MAP kinase phosphatase-1 knockout mice. Xu M, Ma L, Choudhary S, Vosnesensky O, Adams G, Raisz L, Pilbeam C. American Society of Bone and Mineral Research2010Toronto, Canada
Intermittent PTH has increased anabolic effects in cyclooxygenase-2 knockout mice. Xu won travel award. Xu M, Gao Q, Voznesensky O, Choudhary S, Diaz-Doran V, Raisz L, and Pilbeam C. American Society of Bone and Mineral Research2007Honolulu, Hawaii
COX-2 and PTHMusculoskeletal Institute Research Day2006
Discussant; presentation of my research Orthopedics Resident’s Graduation 2006
Effects of global or targeted deletion of the EP4 receptor on the response of cultured osteoblasts to prostaglandin E2. Raisz LG, Alander CA, Zhan P, Breyer MD, Kream BE, and Pibeam CC.American Society of Bone and Mineral Research2004
COX-2 and osteosarcomaResearch Retreats or Research Days: UCONN Comprehensive Cancer Center Retreat2004UCONN
update on researchCenter on Aging Retreat 2004
BMP-2 induces COX-2 in osteoblasts via a Cbfa1 binding site: Role in osteoblast and osteoclast differentiation and ectopic bone formation. Bones and Teeth Gordon Conference2001Kimball Academy, NH.
Prostaglandins and Bone.Geriatrics Division, University of Wisconsin2000Madison, WI
topics included mechanical loading of bone, role of COX-2 in boneGeriatrics grand rounds2000UCHC
Function of COX-2 in bone. The Potential of Specific Cox-2 Inhibition William Harvey Research Conference1999Lisbon, Portugal
Role of COX-2 in bone turnover. Merck management meeting1999Skamandia Lodge, Steveson, WA
Bone metabolism in prostaglandin G/H synthase deficient mice.Bones and Teeth Gordon Conference1999Kimball Academy, NH
Osteoclast function is inhibited in marrow cultures from COX-2 knockout mice. Okada Y, Freeman A, Tomita M, Morham S, and Pilbeam C. Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases1999Boston, MA
Endotoxin induction of luciferase activity in mice transgenic for a COX-2 promoter-luciferase reporter construct. Freeman A, Herschman H, Voznesensky O, Bhatt A, Clark S, Pilbeam C.Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases1999Boston, MA
Effects of prostaglandin G/H synthase-2 knockout on bone. Okada won Young Investigator Award for his presentation. Okada Y, Tomita M, Tsurukami H, Nakamura T, Alander C, Sohn J, Raisz L, Lorenzo J, Pilbeam C. Annual Meeting of the American Society for Bone and Mineral Research1999St. Louis, MO
The role of IL-1 in the bone loss of estrogen withdrawal. Gerontological Society of America workshop1998Philadelphia, PA.
COX-2 and bone resorption.Clinical Roundtable: Preferential Cyclooxygenase Inhibitors-Their Impact in the Prevention and Manag1998Frankfurt, Germany.
Role of COX-2 in the inflammatory process of bone resorption. Clinical Benefits of Selective COX-2 InhibitorsWilliam Harvey Research Conference1998Boston,MA
Role of COX-2 in bone formation and resorption. Workshop: Is COX-2 a Physiologic Necessity?1998NYC
COX-2 and bone resorption. The Promise of Specific Cox-2 Inhibition by Novel AgentsWilliam Harvey Research Conference1998Cannes, France
Regulation of inducible prostaglandin G/H synthase in bone.International Conference on Biological Mechanisms of Tooth Eruption, Resorption, and Replacement by 1997Toledo, Spain
Expression and regulation of Cox-2 in bone.First International Workshop on Cox-21997New Orleans
Retinoic acid transcriptionally inhibits prostaglandin G/H synthase expression in osteoblastic cells. Pilbeam C, Herschman H, Alander C, Voznesensky O, Raisz L.Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and Related Diseases1997La Jolla, CA
Decreased parathyroid-stimulated resorption in cultured calvaria from neonatal mice with resistance to collagenase. Pilbeam C, Zhao W, Krane SM. Gordon Research Conference, Matrix Metalloproteinases1997Andover, NH
Regulation of prostaglandin synthesis in bone.10th International Conference on Prostaglandins and Related Compounds1996Vienna, Austria
Osteoblastic differentiation reduces serum induced transcription of prostaglandin G/H synthase-2 in MC3T3-E1 cells. Pilbeam CC, Voznesensky OS, Alander CB, Raisz LG. Bone, Abstracts from the Sixth Workshop on Cells and Cytokines in Bone and Cartilage1996
The role of prostaglandins as local regulators of bone metabolism.Research Trends in Osteoporosis, IBC UK Conference1995London, England
Regulation of inducible prostaglandin G/H synthase promoter activity by transforming growth factor ß in osteoblastic MC3T3 E1 cells. Pilbeam C, Kawaguchi H, Voznesensky O, Alander C, Fletcher B, Herschman H, Raisz LG.Xllth International Conference on Calcium Regulating Hormones1995Melbourne, Australia
The regulation of prostaglandin synthesis in bone tissue.Workshop on Prostaglandin and Bone: From Basic Research to Clinical Medicine1994Brussels, Belgium
Regulation of inducible prostaglandin G/H synthase by interleukin 1, transforming growth factors alpha and ß, and prostaglandins in bone cells. Pilbeam CC, Kawaguchi H, Voznesensky O, Alander CB, Raisz LG.3rd International Conference on Eicosanoids and Other Bioactive Lipids in Cancer, Inflammation and 1993Washington DC
Separate regulation of the mRNA transcripts for the two prostaglandin endoperoxide synthases In MC3T3 E1 osteoblastic cells by serum and glucocorticoid. Pilbeam CC, Kawaguchi H, Voznesensky O, Alander CB, Raisz LG. XXIIIrd European Symposium on Calcified Tissues1993Heidelberg, Germany
Effects of calcium supple mentation on bone turnover in healthy older women Pannullo AM, Prestwood KM, Pilbeam CC, Raisz LG. Annual meeting of the Gerontological Society of America1993
aging boneYale New Haven Hospital Grand Rounds1993Yale New Haven Hospital
Anabolic effect of progesterone on cultured fetal rat calvarial bone. Manzi DL, Pilbeam CC, Raisz LG. Society for Gynecologic Investigations1993
The effects of tamoxifen on bone turnover, lipids, and health perception in older women. Kenny AM, Prestwood KM, Pilbeam CC, Raisz L. American Geriatrics Society1993
osteoporosis and agingHartford Hospital Grand Rounds1992Hartford Hospital
Quantitative reverse transcrip¬tase PCR: A new method to assess the expression of prostaglandin endoperoxide synthase in bone. Yavari R, Stover ML, Pilbeam C, Kawaguchi H, Raisz LG, Rowe D. East Coast Connective Tissue Conference1992
osteomalaciaJohn Dempsey Hospital Grand Rounds1991John Dempsey Hospital
Inhibition of prostaglandin E2 production by 17ß estradiol in osteoblast like cells. Pilbeam C, Gustafson S, Alander C, Raisz LG. The American Geriatrics Society meeting1991Chicago, IL
In vitro inhibition of interleukin 1 stimulated prostaglandin E2 production by 17ß-estradiol. PiIbeam CC, Alander CB, Raisz LG. Third International Workshop on Cells and Cytokines in Bone and Cartilage1990Davos, Switzerland
osteoporosisWinsted Memorial Hospital Grand Rounds1990Winsted Memorial Hospital
vitamin D and agingMt. Sinai Hospital Grand Rounds1990Mt. Sinai Hospital
osteoporosisSt. Francis Hospital Grand Rounds1990St. Francis Hospital
Interaction of estrogen and PTH in osteoporosis. NIH-sponsored Brookdale Foundation Summer Institute on Aging Research1989Bethesda, MD
osteoporosisWilliam Beaumont Hospital Grand Rounds1989Detroit, MI
In vitro inhibition of PTH stimulated resorption and prostaglandin production by 17ß estradiol. Steenbock Symposium on Osteoporosis1989Madison, WI
In vitro inhibition of PTH stimulated prostaglandin E2 production by 17ß estradiol. Pilbeam CC, Raisz LG. Annual Meeting of the American Society for Bone and Mineral Research1988New Orleans, LA
Vitamin D status in nursing home elders. Pilbeam CC, Webb AR, Holick MF. Annual Meeting of the Gerontological Society of America1988San Francisco, CA
(geriatrics, osteoporosis) Waterbury Hospital Grand Rounds1988Waterbury Hospital
Pilbeam CC, Webb AR, Hanifin N, Holick MF. Vitamin D status of residents in Boston nursing home. The American Geriatrics Society meeting1988Boston, MA
(osteoporosis)St. Vincent's Medical Center Grand Rounds1987St. Vincent's Medical Center, Bridgeport