Ivo Kalajzic, M.D., Ph.D.Professor of Reconstructive Sciences
Center for Regenerative Medicine and Skeletal Development
Professor, Department of Genetics and Genome Sciences
|M.D.||Zagreb University School of Medicine||Medicine|
|Ph.D.||Split University School of Medicine||Basic Medical Sciences - Genetics|
|Name of Award/Honor||Awarding Organization|
|Career Enhancement Award||American Society of Bone and Mineral Research|
|Harold Frost Young Investigator Award||American Society of Bone and Mineral Research|
|Young Investigator Award, Annual Meeting||American Society of Bone and Mineral Research|
|Fellowship Award||Children Brittle Bone Foundation|
|John Haddad Young Investigator Award||American Society of Bone and Mineral Research|
|Outstanding Presentation Award, Washington, DC||East Coast Connective Tissue Society Meeting|
|Michael Geisman Fellowship Award||Osteogenesis Imperfecta Foundation|
|Name & Description||Category||Role||Type||Scope||Start Year||End Year|
|Orthopedic Research Society||Professional/Scientific Organization||Member||External||National||2012|
|American Society of Bone and Mineral Research||Professional/Scientific Organization||Member||External||National||2006|
|International Chinese Hard Tissue Society||Professional/Scientific Organization||Member||External||International||2006|
“Growth factor based enhancement of bone repair”
Our project will define the signaling mechanisms by which PDGF regulate BMP induced osteogenesis using in vitro and in vivo models. Understanding how these two critical factors for interact can pave the way for more targeted therapies in future. In addition, we will evaluate the efficacy of combining these two clinically approved growth factors, BMP2 and PDGF, with the aim of improving healing, and reducing BMP2 dosage to prevent complications and reduce cost.
“Notch signaling and bone fracture healing”
The effects of Notch signaling modulation will be evaluated In vivo using stage specific Notch gain- and loss-of-function models during fracture healing. We postulate that inhibition of Notch will provide evidence for potential future application to accelerate or improve fracture healing. Our results will provide a better understanding of the role of Notch signaling during fracture healing and will evaluate the potential for therapeutic modulation of the healing process.
“Transplantation of Mesenchymal Stem Cells as therapy for Osteogenesis Imperfecta”,
This purpose of this project is to test the efficacy of direct intrabone transplantation of mesenchymal stem cells as a therapeutic approach for osteogenesis imperfecta.
Not accepting lab rotation students at this time