Faculty Directory

Education

Degree	Institution	Major
Ph.D.	Stanford University	Biophysics
B.S.	University of Connecticut	Biophysics
M.S.	University of Connecticut	Chemistry

Post-Graduate Training

Training	Institution	Specialty
Post Doctoral	European Molecular Biology Laboratory	Postdoctoral Research Assistant in the Laboratory of Dr. Hartmut Oschkinat.
Post Doctoral	University of Connecticut Health Center	Postdoctoral Research Assistant in the Laboratory of Dr. Gregory P. Mullen

Awards

Name of Award/Honor	Awarding Organization
DAAD post-doctoral fellowship (declined)	Deutscher Akademischer Austausch Dienst
Training Grant 1990-1994	NIH
Member	Golden Key National Honor Society
Biophysics Award for Distinguished Undergraduate Research Honors Scholar	Phi Beta Kappa Honor Society
Who's Who Among Students in American Universities	Who's Who Among Students in American Universities
University Scholar	UCONN Phi Kappa Phi Honor Society
Member	Alpha Lambda Delta Honor Society
Bruce Mahon Scholarship 1986-1990

The focus of our laboratory is structural bioinformatics. We are currently involved in several projects on this topic, mainly the use of NMR spectroscopy as a tool for macromolecular characterization and molecular structure as an aid to bioinformatics.

Particular projects include the development of CONNJUR (connjur.uchc.edu) – an open source integration platform for biomolecular NMR data processing; utilizing non-uniform sampling techniques and the use of maximum entropy methods for spectral reconstruction; and the development of a database of short linear motifs which confer specific functions to proteins (mnm.engr.uconn.edu). NMR studies involve DNA repair proteins of relatively large molecular weight for NMR spectroscopy (20-70 kDa). Current methods to overcome the difficulties inherent in studying these large systems include extensive labeling using stable isotopes and the use of TROSY-based pulse sequences. A critical mission of the lab is the facility approach to NMR, such that as advancements are made, they are tailored for ease-of-use both internally and externally when possible.

--CONNJUR NMR Software Integration
--MiniMotif Miner
--Structural Biology Facility
--Structural Biology Tools

Accepting Lab Rotation Students for FAll '13, Spring '14

Journal Articles

Conference Papers

Letters

Notes

Reviews