Education

Degree	Institution	Major
BA	Macalester College	Biology/Chemistry
MS	University of Wisconsin	Bacteriology
PhD	University of Cincinnati College of Medicine	Molecular Genetics

Post-Graduate Training

Training	Institution	Specialty
Postdoctoral	Ludwig Institute for Cancer Research	Characterization of tumor suppressor genes in human cancer

Awards

Name of Award/Honor	Awarding Organization
Excellence in Mentorship	Glastonbury High School
Elected Member	Connecticut Academy of Science and Engineering
Elected Member	Association for Osteobiology
John G. Haddad Jr. Annual Research Award	Paget Foundation
Outstanding Faculty Award	Univ. Texas/Houston
Predoctoral Fellowship	The Albert J. Ryan Foundation
Predoctoral Traineeship in Molecular Genetics	NIH
Biology Honors	Macalester College
William R. Angell Award for Outstanding Biology Student	Macalester College

Name & Description	Category	Role	Type	Scope	Start Year	End Year
SoM Academic Merit Executive Committee	Advisory Committee	Member	UConn Health	University	2023	2024
NCI ZCA1 RTRB-R (O1) S Transition Career Development Award and Institutional Research Training Grants Review Committee	Study Section	Member	External	National	2023	2023
NCI ZCA1 RTRB-R (J1) S Transition Career Development Award and Institutional Research Training Grants Review Committee	Study Section	Vice Chair	External	National	2023	2023
NCI SEP ZCA1 PCRB-A (A1) S LRP OD-09-108 Clinical Research Loan Repayment Program Review Committee	Study Section	Member	External	National	2023	2023
NCI ZCA1 RTRB-R (O1) Transition Career Development Award (K22) Review Committee	Study Section	Member	External	National	2022	2022
NCI ZCA1 RTRB-R (M1) Transition Career Development Award (K22) Review Committee	Study Section	Member	External	National	2022	2022
SoM Oversight Committee	Advisory Committee	Chair	UConn Health	University	2022	2024
UConn Health Board of Directors Academic Affairs Subcommittee	Advisory Committee	Member	UConn Health	University	2022	2024
CDMRP Rare Cancer Research Program Concept Sarcoma Peer Review Panel	Study Section	Member	External	National	2021	2021
CDMRP RCRP Sarcoma Peer Review Panel	Study Section	Chair	External	National	2021	2021
NCI 2020/05 NCI-F Subcommittee F - Institutional Training and Education	Study Section	Member	External	National	2020	2020
NCI SEP-5: NCI Clinical and Translational R21 and Omnibus R03 Peer Review Committee	Study Section	Member	External	National	2020	2020
NCI 2020/05 NCI-F Subcommittee F - Institutional Training and Education	Study Section	Member	External	National	2020	2020
NCI SEP-5: NCI Clinical and Translational R21 and Omnibus R03 Peer Review Committee	Study Section	Member	External	National	2020	2020
CDMRP Peer Review Cancer Research Review Committee	Study Section	Member	External	National	2019	2019
NICHD ZRG1 SBIB-N (52) Biomarkers: Bridging Pediatric and Adult Therapeutics (R21) Review Committee	Study Section	Member	External	National	2019	2019
Austrian Academy of Sciences Doctoral Fellowship Programme Review Committee	Study Section	Member	External	International	2019	2019
NCATS ZTR1 RD-8 (01) 1 Rare Disease Clinical Research (U54) Review Committee	Study Section	Member	External	National	2019	2019
NCI ZCA1 RPRB-Z (J2) S UH2/UH3 Review Committee	Study Section	Member	External	National	2018	2018
CDMRP BCRP EPI Epidemiology Review Committee	Study Section	Member	External	National	2018	2018
CDMRP BCRP MBG-2 Molecular Biology and Genetics - 2 Review Committee	Study Section	Member	External	National	2018	2018
NCI ZCA1 RPRB-Z (O3) S Multi-Site R01 Review Committee	Study Section	Member	External	National	2018	2018
NCI ZCA1 SRB-X (O1) S - Omnibus SEP-6 (R21/R03) Review Committee	Study Section	Chair	External	National	2018	2018
NCI ZCA1 TCRB-V (M2) S - Omnibus SEP-6 (R21/R03) Review Committee	Study Section	Co-chair	External	National	2018	2018
CDMRP BCRP MBG-2 Molecular Biology and Genetics - 2 Review Committee	Study Section	Member	External	National	2018	2018
CDMRP PRCRP Cancer in Children, Adolescents and Young Adults Review Committee	Study Section	Member	External	National	2017	2017
NCI ZCA1 SRB-X (J1) Innovative Molecular Analysis Technologies and Biospecimen Review Committee	Study Section	Chair	External	National	2017	2017
NCI ZCA1 TCRB-Q (M3) R Innovative Molecular Analysis Technologies (IMAT) R21 Review Committee	Study Section	Chair	External	National	2017	2017
NCI ZCA1 TCRB-Q (M4) R Innovative Molecular Analysis Technologies (IMAT) R33 Review	Study Section	Chair	External	National	2017	2017
NCI ZCA1 SRB-2 (M1) Cancer Target Discovery and Development Network (U01) Review Committee	Study Section	Vice Chair	External	National	2017	2017
NCI ZCA1 RTRB-Z (O1) P NCI Program Project II Review Committee	Study Section	Member	External	National	2016	2016
NCI ZCA1 TCRB-D (O1) R Innovative Molecular Analysis Technologies (IMAT) Review Committee	Study Section	Chair	External	National	2016	2016
NCI Subcommittee A, 2 P30 CA046934-29 University of Colorado Cancer Center Site Visit	Study Section	Member	External	National	2016	2016
NCI ZCA1 TCRB-Q (M3) NCI Omnibus R03 and R21 SEP-13 Review Committee	Study Section	Chair	External	National	2016	2016
NCI ZCA1 TCRB-Y (M1) S - Physical Sciences- Oncology Projects Review Committee	Study Section	Chair	External	National	2016	2016
NCI ZCA1 TCRB-6 (M3) R - Innovative Molecular Analysis Technologies for Cancer Research Review Committee	Study Section	Chair	External	National	2016	2016
NCI ZCA1 TCRB-9 (M1) S - Advanced Development and Validation of Emerging Molecular Analysis Technologies for Cancer Research Review Committee	Study Section	Chair	External	National	2016	2016
NCI Subcommittee A, 2 P30 CA013148-44 University of Alabama, Birmingham Site Visit	Study Section	Member	External	National	2015	2015
NCI ZCA1 TCRB-Q (O2) R – Advanced Development of Technologies for Cancer Research Review Committee	Study Section	Co-chair	External	National	2015	2015
NCI ZCA1 TCRB-6 (A1) B – Cancer Detection, Diagnosis, and Treatment Technologies for Global Health (UH2/UH3) Review Committee	Study Section	Vice Chair	External	National	2015	2015
NCI ZCA1 TCRB-9 (O1) R - Innovative Research in Cancer Nanotechnology (IRCN) (U01) Review Committee	Study Section	Chair	External	National	2015	2015
NCI ZCA1 TCRB-T (O1) – Physical Sciences Oncology Center (U54) Review Committee	Study Section	Member	External	National	2015	2015
NCI ZCA1 SRB-V (O1) S – NCI Exploratory/Development Research Grant Program Omnibus SEP-3 Review Committee	Study Section	Chair	External	National	2015	2015
NCI ZCA1 TCRB-Q (M1) R - Centers of Cancer Nanotechnology Excellence (CCNE) Review Committee	Study Section	Chair	External	National	2015	2015
NCI ZCA1 SRB-V (M1) S - NCI Small Grants Program and Exploratory/Developmental Research Grant Program on Cancer Biology-3 (Omnibus R03/R21) Review Committee	Study Section	Chair	External	National	2015	2015
NCI ZCA1 TCRB-5 (M1) R - Innovative Molecular Analysis Technologies Review Committee	Study Section	Member	External	National	2015	2015
NCI ZCA1 GRB-P (J1) R - NCI Director’s Provocative Questions B Review Committee	Study Section	Chair	External	National	2014	2014
NCI Subcommittee A, 2 P30 CA042014-26 Univ. Utah Huntsman Cancer Center Site Visit	Study Section	Member	External	National	2014	2014
Experiment to Evaluate the Relative Quality of Applications Reviewed in Chartered Study Sections: Oncology 1 – Basic Translational (OBT) Integrated Review Group	Study Section	Member	External	National	2014	2014
KCALSI Patton Trust Review Committee	Study Section	Member	External	National	2014	2014
NCI ZCA1 TCRB-Q (O2) S – Validation and Advanced Development of Emerging Technologies for Cancer Research (R33) Review Committee	Study Section	Chair	External	National	2014	2014
NCI ZCA1 SRB-V (O1) R – NCI Small Grants Program and Exploratory/Developmental Research Grant Program for Cancer Research (Omnibus R03/R21) Review Committee	Study Section	Chair	External	National	2014	2014
NCI ZCA1 SRLB-R (M1) R – Cancer Detection, Diagnosis, and Treatment Technologies for Global Health Review Committee	Study Section	Member	External	National	2014	2014
NCI ZCA1 SRLB-V (M1) R - NCI Small Grants Program and Exploratory/Developmental Research Grant Program on Cancer Biology-3 (Omnibus R03/R21) Review Committee	Study Section	Chair	External	National	2014	2014
CDMRP Peer Reviewed Cancer Research Program Review Committee	Study Section	Member	External	National	2014	2014
NCI ZCA1 GRB-P(A1) R – NCI Director’s Provocative Questions A and C Review Committee	Study Section	Chair	External	National	2014	2014
Syracuse University Doctoral Program in Forensic and Regulatory Science Review Committee	Study Section	Co-chair	External	Regional	2014	2014
Meta Gene	Professional/Scientific Journal	Executive Editor	External	National	2013	2014
NCI ZCA1 SRLB-Q (M1) R – Validation and Advanced Development of Emerging Technologies for Cancer Research	Professional/Scientific Organization	Vice Chair	External	National	2013	2013
NCI SRLB-X (M1) R – Omnibus R03/R21: Developmental Therapeutics	Professional/Scientific Organization	Chairman	External	National	2013	2013
NCI ZCA1 RTRB-Z (M1) R – Omnibus R03/R21: Therapeutics	Professional/Scientific Organization	Member	External	National	2013	2013
NCI ZCA1 SRLB-R (M1) R – Cancer Prevention Research Small Grant Program	Professional/Scientific Organization	Member	External	National	2013	2013
NIH ZRG1 MOSS-B (02) M - Salivary Glands, Oral Microbiology and Oral Pathology	Professional/Scientific Organization	Member	External	National	2013	2013
NCI ZCA1 SRLB-X (Q1) R – Nanotechnology in Cancer	Professional/Scientific Organization	Chairman	External	National	2013	2013
NCI ZCA1 RTRB-E (O1) R - Validation and Advanced Development of Emerging Molecular Analysis Technologies for Cancer Research (R33)	Professional/Scientific Organization	Chairman	External	National	2013	2013
NCI ZCA1 RTRB-Z (O2) M – Special Emphasis Panel for T32 Application Review	Professional/Scientific Organization	Chairman	External	National	2013	2013
NCI ZCA1 SRLB-4 (J1) S - Omnibus Grants on Cancer Genetics and Etiology	Professional/Scientific Organization	Chairman	External	National	2013	2013
NCI ZCA1 SRLB-R (J1) R - NCI Director’s Provocative Questions	Professional/Scientific Organization	Member	External	National	2013	2013
NCI ZCA1 SRLB-X (J1) R – Nanotechnology-Based Theranostics Review Committee	Study Section	Chairman	External	National	2013	2013
NCI ZCA1 SRLB-R (J1) R - NCI Director’s Provocative Questions (R21) Review Committee	Study Section	Vice Chair	External	National	2013	2013
NCI ZCA1 SRLB-Q (J2) R - Advance Development and Validation of Emerging Technologies for Cancer Research (R33) Review Committee	Study Section	Chairman	External	National	2013	2013
NCI ZCA1 SRLB-X (J3) R – NCI Omnibus – Drug and Gene Delivery Review Committee	Study Section	Chairman	External	National	2013	2013
University of Connecticut Health Center: MSI Research Day Organizing Committee	Professional/Scientific Organization	Member	UConn Health	University	2012	2012
University of Connecticut Health Center: Hearing Committee for Misconduct in Research	Professional/Scientific Organization	Member	UConn Health	University	2012	2012
University of Connecticut Health Center:	Professional/Scientific Organization	Member	UConn Health	University	2012
NCI SEP ZCA1 SRLB-9 (M1) R - Provocative Questions R01	Professional/Scientific Organization	Co-Chair	External	National	2012	2012
NCI ZCA1 SRLB-D (M1) R - Provocative Questions R21	Professional/Scientific Organization	Member	External	National	2012	2012
NCI ZCA1 SRLB-4 (O1) R - Validation and Advanced Development of Emerging Technologies for Cancer Research (R33)	Professional/Scientific Organization	Chairman	External	National	2012	2012
NCI ZCA1 SRLB-V (J2) R – Cancer Detection	Professional/Scientific Organization	Chairman	External	National	2012	2012
NCI ZCA1 SRLB-4 (J1) B - Strategic Partnering to Evaluate Cancer Signatures II	Professional/Scientific Organization	Chairman	External	National	2012	2012
Nanomedicine: Nanotechnology, Biology, and Medicine	Professional/Scientific Journal	Associate Editor	External	National	2011	2015
Gene	Professional/Scientific Journal	Board of Editors and Associate Editor	External	National	2011	2019
NCI SEP ZCA1 SRLB-9 (M1) R - In vivo Cellular and Molecular Imaging Centers	Professional/Scientific Organization	Vice Chair	External	National	2011	2011
NCI SEP ZCA1 SRLB-V (M1) R – Emerging Technologies for Cancer Research	Professional/Scientific Organization	Chairman	External	National	2011	2011
NCI SEP ZCA1 SRLB-5 (O1) R - Innovative Emerging Molecular Analysis Technologies	Professional/Scientific Organization	Member	External	National	2011	2011
NCI SEP ZCA1 SRLB-9 (O1) B - Advanced in Vivo Imaging to Understand Cancer Systems	Professional/Scientific Organization	Vice-Chair	External	National	2011	2011
NCI SEP ZCA1 SRLB-X (O1) R - Cancer Diagnostic and Therapeutic Agents Enabled by Nanotechnology	Professional/Scientific Organization	Chairman	External	National	2011
USAMRMC Peer Reviewed Medical Research Program:Paget’s Disease Review Committee	Professional/Scientific Organization	Member	External	National	2011	2011
USAMRMC PRMRP: Osteoporosis and Related Bone Disease Panel 2 Review Committee	Professional/Scientific Organization	Member	External	National	2011	2011
NCI SEP ZCA1 SRLB-4 (J1) S - Strategic Partnering to Evaluate Cancer Signatures	Professional/Scientific Organization	Member	External	National	2011	2011
NCI SEP ZCA1 SRLB-V (j1) R – Cancer Target Discovery and Development	Professional/Scientific Organization	Member	External	National	2011	2011
University of Connecticut Health Center: Search Committee, Chairman of Cell Biology	Professional/Scientific Organization	Member	UConn Health	University	2010	2011
University of Connecticut Health Center: PhD Admissions Review Committee	Professional/Scientific Organization	Member	UConn Health	University	2010
NCI SEP ZCA1 SRLB-9 (M1) R In vivo Cellular and Molecular Imaging Centers (ICMICs)	Professional/Scientific Organization	Chairman	External	National	2010	2010
NCI SEP ZCA1 SRLB-R (M1) R Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA)	Professional/Scientific Organization	Chairman	External	National	2010	2010
NIH SEP ZRG1 MOSS-G (55) R RFA-OD-10-005 Director's Opportunity 5 Themes Oral Musculoskeletal and Imaging	Professional/Scientific Organization	Member	External	National	2010	2010
NCI SEP ZCA1 RTRB-Z (M2) R Special Emphasis Panel	Professional/Scientific Organization	Member	External	National	2010	2010
NCI SEP ZCA1 SRLB-R (O1) – Emerging Technologies for Cancer Research	Professional/Scientific Organization	Chairman	External	National	2010	2010
NCI SEP ZCA1 SRLB-X (J1) R – Emerging Technologies for Cancer Research	Professional/Scientific Organization	Chairman	External	National	2010	2010
NCI SEP ZCA1 SRLB-4 (J1) B ¬– Strategic Partnering to Evaluate Cancer Signatures	Professional/Scientific Organization	Chairman	External	National	2010	2010
Comitato Telethon Fondazione Onlus E Fondazione Telethon Grant Review Panel	Professional/Scientific Organization	Member	External	National	2010	2011
USAMRMC Breast Cancer Research Program TRN CBY-A Peer Review Committee	Professional/Scientific Organization	Member	External	National	2009	2009
NCI SEP ZCA1 PCRB-A (A1) S LRP OD-09-108 Clinical Research Loan Repayment Program	Professional/Scientific Organization	Member	External	National	2009
National Cancer Institute SEP ZCA1 SRLB-V (M1) Application of Emerging Technologies	Professional/Scientific Organization	Chairman	External	National	2009	2009
National Cancer Institute SEP ZCA1 SRLB-9 (O1) Physical Sciences-Oncology Centers	Professional/Scientific Organization	Co-Chairman	External	National	2009	2009
National Institutes of Health SEP ZRG1 MOSS-A (96) S Skeletal Biology II ARRA CR	Professional/Scientific Organization	Member	External	National	2009	2009
National Institutes of Health SEP ZRG1 MOSS-C (58) R RFA OD-09-003: Challenge Grants	Professional/Scientific Organization	Member	External	National	2009	2009
NCI SEP ZCA1 PCRB-G (O9) R NCI-ARRA P30 Biomedical Research Core Centers Review	Professional/Scientific Organization	Member	External	National	2009	2009
National Cancer Institute SEP ZCA1 SRLB-4 (O2) R Bio-specimen Preparation	Professional/Scientific Organization	Chairman	External	National	2009	2009
NCI SEP ZCA1 SRLB-4 (O9) R Grand Opportunities Grants in Human Cancer Proteomics	Professional/Scientific Organization	Chairman	External	National	2009	2009
Howard Hughes Medical Institute Med Into Grad Review Panel	Professional/Scientific Organization	Member	External	State	2009	2009
NCI SEP ZCA1 SRLB-U (O9) R NCI ARRA GO - Transcriptional & Translational	Professional/Scientific Organization	Chairman	External	National	2009	2009
National Institutes of Health SEP ZRG1 CBSS-P (08) F - Tumor Biomarkers	Professional/Scientific Organization	Member	External	National	2009	2009
NCI SEP ZCA1 SRLB-V (J1) R Applied Emerging Technologies in Biospecimen Science	Professional/Scientific Organization	Chairman	External	National	2009	2009
National Cancer Institute SEP ZCA1 GRB-S (M1) P Molecular Oncology	Professional/Scientific Organization	Member	External	National	2008	2008
National Institute of Arthritis, Musculoskeletal and Skin Diseases SEP ZAR1 MLB-G (M2)	Professional/Scientific Organization	Member	External	National	2008	2008
National Cancer Institute SEP ZCA1 SRRB-4 (M1) Application of Emerging Technologies	Professional/Scientific Organization	Chairman	External	National	2008	2008
National Institutes of Health SEP ZRG1 MOSS-L (04) Skeletal Biology/Disease	Professional/Scientific Organization	Member	External	National	2008	2008
National Cancer Institute SEP ZCA1 SRRB-4 (01) Application of Emerging Technologies	Professional/Scientific Organization	Chairman	External	National	2008	2008
National Center for Research Resources SEP ZRR1 RI-4 (01) INBRE Awards	Professional/Scientific Organization	Member	External	National	2008	2008
National Cancer Institute SEP ZCA1 SRRB-4 (J1) Application of Emerging Technologies	Professional/Scientific Organization	Chairman	External	National	2008	2008
University of Connecticut Health Center: Translational Genomic Core Facility Advisory Committee	Professional/Scientific Organization	Member	UConn Health	University	2007
University of Connecticut Health Center: Health Center Appeals Committee	Professional/Scientific Organization	Member	UConn Health	University	2007	2007
National Cancer Institute SEP ZCA1 GRB-S (M1) Molecular Biology PPG SEP	Professional/Scientific Organization	Member	External	National	2007	2007
National Cancer Institute SEP ZCA1 SRRB-4 (M1) Application of Emerging Technologies	Professional/Scientific Organization	Member	External	National	2007	2007
National Institutes of Health SEP ZRG1 MOSS-B (02) Skeletal Biology/Disease	Professional/Scientific Organization	Member	External	National	2007	2007
USAMRMC Prostate Cancer Research Program MBG-2 Peer Review Committee	Professional/Scientific Organization	Member	External	National	2007	2010
University of Connecticut Health Center: Intercampus Interdisciplinary Oncology Program Steering Committee	Professional/Scientific Organization	Member	UConn Health	University	2006	2007
University of Connecticut Health Center: ACS Institutional Research Award Review Committee	Professional/Scientific Organization	Member	UConn Health	University	2006
National Institutes of Health SEP ZRG1 MOSS-B Skeletal Biology/Disease	Professional/Scientific Organization	Member	External	National	2006	2006
National Cancer Institute SEP ZCA1 SRRB-9 (M1) for NCI RFA CA-06-003	Professional/Scientific Organization	Member	External	National	2006	2006
National Cancer Institute SEP ZCA1 RPRB-O (O2) Cellular and Tissue Biology	Professional/Scientific Organization	Member	External	National	2006	2006
National Cancer Institute SEP ZCA1 SRBB-4 (O1) Application of Emerging Technologies	Professional/Scientific Organization	Chairman	External	National	2006	2006
National Cancer Institute SEP ZCA1 SRRB-9 (O1) for NCI RFA CA-07-005	Professional/Scientific Organization	Member	External	National	2006	2006
National Cancer Institute IRG Subcommittee I on Career Development	Professional/Scientific Organization	Member	External	National	2006
National Cancer Institute Ad Hoc Review Committee for K99/R00 Awards	Professional/Scientific Organization	Member	External	National	2006	2006
National Institute of Biomedical Imaging and Bioengineering SEP ZEB1 OSR-A (J1)	Professional/Scientific Organization	Member	External	National	2006	2006
National Cancer Institute SEP ZCA1 RTRB-Z (J1) Transition Career Development Award	Professional/Scientific Organization	Member	External	National	2006	2006
ASBMR State-of-the-Art Lecture: Cancer and Bone Basic/Translational	Professional/Scientific Organization	Co-chair	External	National	2006
Connecticut Academy of Science and Engineering	Professional/Scientific Organization	Member	External	State	2005
University of Connecticut Health Center: Neag Comprehensive Cancer Center Steering Committee	Professional/Scientific Organization	Member	UConn Health	University	2005	2007
University of Connecticut Health Center: Musculoskeletal Oncology Program, Neag Comprehensive Cancer Center	Professional/Scientific Organization	Director	UConn Health	University	2005	2007
University of Connecticut Health Center: Head & Neck Oncology Program, Neag Comprehensive Cancer Center	Professional/Scientific Organization	Deputy Director	UConn Health	University	2005	2007
American Cancer Society Council for Extramural Grants	Professional/Scientific Organization	Member	External	National	2005	2009
James & Esther King Biomedical Research Program Review Committee	Professional/Scientific Organization	Member	External	National	2005
National Institutes of Health Cancer Genetics Study Section	Professional/Scientific Organization	Member	External	National	2004	2009
National Institutes of Health SEP ZRG1 RUS-D(05) Endocrinology/Biology of Bone	Professional/Scientific Organization	Member	External	National	2004	2004
National Institutes of Health SEP ZRG1 GNM(91) ATM Biology	Professional/Scientific Organization	Member	External	National	2004	2004
American Cancer Society Lymphedema Research Committee	Professional/Scientific Organization	Member	External	National	2004	2007
National Cancer Institute Ad Hoc Review Committee for NCI RFA CA-04-015	Professional/Scientific Organization	Member	External	National	2004	2004
Association of Osteobiology	Professional/Scientific Organization	Member	External	National	2003
Florida Biomedical Research Grant Program Study Section	Professional/Scientific Organization	Member	External	State	2003	2003
American Cancer Society Research Opportunity Grants Program Review Committee	Professional/Scientific Organization	Member	External	National	2003	2003
USAMRMC Breast Cancer Research Program Concept Award Review Committee	Professional/Scientific Organization	Member	External	National	2003	2003
National Cancer Institute SRBB-Y (A1), Clinical/Pediatric Loan Repayment program	Professional/Scientific Organization	Member	External	National	2003	2009
National Cancer Institute IRG Subcommittee I on Career Development	Professional/Scientific Organization	Member	External	National	2003	2005
National Institutes of Health SEP ZRG1 ONC (02), Molecular Targets/Cancer Drugs	Professional/Scientific Organization	Member	External	National	2003	2003
National Institutes of Health SEP ZRG1 GRM(03) Musculoskeletal Dental SEP	Professional/Scientific Organization	Member	External	National	2003	2003
USAMRMC Breast Cancer Research Program CBY2 Peer Review Committee	Professional/Scientific Organization	Member	External	National	2003	2003
NIAMS Site Visit Study Section for Program Project AR049363-01A1	Professional/Scientific Organization	Chairman	External	National	2003	2003
National Institutes of Health Skeletal Biology Development/Disease Study Section	Professional/Scientific Organization	Member	External	National	2003	2011
University of Connecticut Health Center: LCME Self-Assessment Committee	Professional/Scientific Organization	Member	UConn Health	University	2002	2003
University of Connecticut Health Center: Health Center Space Advisory Committee	Professional/Scientific Organization	Chair	UConn Health	University	2002	2006
American Cancer Society Molecular Genetics and Oncogenes Committee	Professional/Scientific Organization	Chairman	External	National	2002	2002
NIAMS Site Visit Study Section for Program Project AR049363-01	Professional/Scientific Organization	Chairman	External	National	2002	2002
USAMRMC Breast Cancer Research Program CBY4 Peer Review Committee	Professional/Scientific Organization	Member	External	National	2002	2002
Physiological Medicine Review Panel for Medical Research Council (UK)	Professional/Scientific Organization	Member	External	National	2002	2002
University of Connecticut Health Center: Ad hoc Curriculum Committee on Genetics	Professional/Scientific Organization	Member	UConn Health	University	2001
University of Connecticut Health Center: Health Center Research Advisory Committee	Professional/Scientific Organization	Member	UConn Health	University	2001	2005
University of Connecticut Health Center: GMBB Graduate Program Executive Board	Professional/Scientific Organization	Member	UConn Health	University	2001	2003
American Cancer Society Molecular Genetics and Oncogenes Committee	Professional/Scientific Organization	Member	External	National	2001	2001
National Cancer Institute IRG Subcommittee F on Manpower and Training	Professional/Scientific Organization	Member	External	National	2001	2003
University of Connecticut Health Center: Computer Users Advisory Committee	Professional/Scientific Organization	Member	UConn Health	University	2000	2007
University of Connecticut Health Center: Molecular Core Advisory Committee	Professional/Scientific Organization	Member	UConn Health	University	2000
University of Connecticut Health Center: Microarray Core Advisory Committee	Professional/Scientific Organization	Member	UConn Health	University	2000	2012
University of Connecticut Health Center: Special Review Board for Misconduct in Research	Professional/Scientific Organization	Member	UConn Health	University	2000	2001
American Cancer Society Experts Directory	Professional/Scientific Organization	Member	External	National	2000
American Society for Bone and Mineral Research	Professional/Scientific Organization	Member	External	National	1999
National Institute of Dental and Craniofacial Research Ad Hoc Review Committee	Professional/Scientific Organization	Member	External	National	1999	1999
National Institutes of Health Molecular Biology Study Section Committee	Professional/Scientific Organization	Member	External	National	1999	1999
National Cancer Institute Ad Hoc Review Committee for NCI RFA CA-98-027	Professional/Scientific Organization	Member	External	National	1999	1999
National Cancer Institute IRG Subcommittee C on Basic and Pre-clinical Trials	Professional/Scientific Organization	Member	External	National	1999	2007
National Cancer Institute IRG Subcommittee D on Clinical Studies	Professional/Scientific Organization	Member	External	National	1999	2007
Intergroup Therapeutic Study P-9851: Osteosarcoma Biology Protocol	Professional/Scientific Organization	Member	External	National	1999
Temple Univ. School of Medicine: Molecular Biology Graduate Program	Professional/Scientific Organization	Director	External	University	1998	1999
National Cancer Institute IRG Subcommittee A on Cancer Centers	Professional/Scientific Organization	Member	External	National	1998
National Institutes of Health Mammalian Genetics: Study Section Committee	Professional/Scientific Organization	Member	External	National	1998	1998
National Cancer Institute IRG Subcommittee F on Manpower and Training	Professional/Scientific Organization	Member	External	National	1998	2001
Temple Univ. School of Medicine: Molecular Biology Graduate Program	Professional/Scientific Organization	Co-Director	External	University	1997	1998
Temple Univ. School of Medicine: Molecular Biology Graduate Student Curriculum Committee	Professional/Scientific Organization	Member	External	University	1997	1999
Temple Univ. School of Medicine: Molecular Biology Graduate Student Admissions Committee	Professional/Scientific Organization	Member	External	University	1997	1999
American Cancer Society Molecular Genetics and Oncogenes Committee	Professional/Scientific Organization	Member	External	National	1997	2002
BioTechniques	Professional/Scientific Journal	Board of Editors	External	National	1996	2000
Temple Univ. School of Medicine: Department of Pathology Graduate Program Committee	Professional/Scientific Organization	Member	External	University	1996	1999
USAMRMC Breast Cancer Research Program MGN3 Peer Review Committee	Professional/Scientific Organization	Member	External	National	1996	2001
National Institutes of Health Genome Study Section Committee	Professional/Scientific Organization	Member	External	National	1995
Childrens Cancer Group Bone Tumor Strategy Committee	Professional/Scientific Organization	Member	External	National	1994	1994
Univ. TX MD Anderson Cancer Center: Academic Computing Steering Committee	Professional/Scientific Organization	Member	External	University	1992	1994
Univ. TX MD Anderson Cancer Center: Intellectual Property Committee	Professional/Scientific Organization	Member	External	University	1992	1994
Univ. TX Graduate School of Biomedical Sciences: Genetics Program Curriculum Committee	Professional/Scientific Organization	Member	External	University	1992	1994
American Cancer Society Virology and Molecular Biology Review Board	Professional/Scientific Organization	Member	External	National	1992	1996
National Cancer Institute Cancer Center Review Board Site Visit Committees	Professional/Scientific Organization	Member	External	National	1992	1997
Childrens Cancer Group Study Protocol B-931	Professional/Scientific Organization	Chairman	External	National	1992	1998
Childrens Cancer Group Genetic Epidemiology Steering Committee	Professional/Scientific Organization	Member	External	National	1992	1994
Univ. TX MD Anderson Cancer Center: Executive Vice President's Junior Faculty Forum	Professional/Scientific Organization	Member	External	University	1991	1994
Univ. TX MD Anderson Cancer Center: Genetic Counseling Policy Committee	Professional/Scientific Organization	Member	External	University	1991	1994
Univ. TX Graduate School of Biomedical Sciences: Graduate Student Admissions Committee	Professional/Scientific Organization	Member	External	University	1991	1994
Univ. TX Graduate School of Biomedical Sciences: Genetics Program Steering Committee	Professional/Scientific Organization	Member	External	University	1991	1994
National Institute for Environmental Health Sciences Review Committee	Professional/Scientific Organization	Member	External	National	1990	1990
National Cancer Institute Program Project Review Board Site Visit Committees	Professional/Scientific Organization	Member	External	National	1989	1999
American Society for Microbiology	Professional/Scientific Organization	Member	External	National	1988	1996
American Society of Human Genetics	Professional/Scientific Organization	Member	External	National	1988	2002
American Association for Cancer Research	Professional/Scientific Organization	Member	External	National	1988
Childrens Cancer Group/Childrens Oncology Group	Professional/Scientific Organization	Member	External	National	1988
Canadian Biomedical Research Council Review Panel	Professional/Scientific Organization	Member	External	National	1988	1989
American Journal of Human Genetics	Professional/Scientific Journal	Reviewer	External	National
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NCI ZCA1 RTRB-R (M1) Transition Career Development Award (K22) Review Committee	Study Section	Member	External	National
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CDMRP Peer Review Cancer Research Program Peer Review Panel	Study Section	Member	External	National

Osteosarcoma is the most common primary tumor of bone and represents in important opportunity for interaction between basic and clinical research.

Osteosarcoma is highly variable in its presentation with numerous subtypes based on the histology, age of onset and site of occurrence. We are interested in examining the molecular differences between these subtypes particularly in the context of the osteoprogenitor lineage pathways from which these tumors arose.

The second area of interest in my laboratory is the genetic origins of Paget’s disease of bone. Paget’s disease is a focal disorder of bone remodeling that leads to overgrowth of affected bone, which in rare cases progresses to osteosarcoma. It is the second most common metabolic bone disease after osteoporosis affecting 1-3% of the U.S. population after age 50. Approximately 20% of Paget’s patients have a positive family history for the disease. Although relatively common, the etiology of Paget’s disease has so far eluded researchers. Our data suggests a model in which a subset of cells might be responsible for the pagetic phenotype in the affected bone. My laboratory is interested in learning what genetic events are critical to the initiation and progression of this disease.

We use several approaches to address these problems. Laser capture microdissection combined with allelotype discrimination analysis, high throughput genotype analysis, comparative and arrayed BAC genome hybridization, cDNA microarray and mass spectroscopy analysis allow us to compare genomic and expression profiles. We then validate our analysis using tissue microarrays, quantitative PCR and other high sample throughput methods. Finally, we use in situ hybridization and immunohistochemistry to validate the expression profiles of our candidate genes. We have also begun to develop transgenic mouse models for osteosarcoma to test its relationship with normal bone development.

Not accepting students for Lab Rotations at this time

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