Education

Degree	Institution	Major
BA	Wesleyan University	Biology
PhD	Rockefeller University	Viral Oncology

Post-Graduate Training

Training	Institution	Specialty
Fellowship	National Science Foundation	Graduate Fellowship
Postdoctoral	Rockefeller University	Postdoctoral Fellow under Dr. Hidesaburo Hanafusa
Postdoctoral	Whitehead Institute for Biomedical Research and the Rockefeller University	Postdoctoral Fellow under Dr. David Baltimore
Postdoctoral	National Institutes of Health (NIH)	Postdoctoral Fellowship, Functional Significance of Nuclear c-Abl Gene Product

Awards

Name of Award/Honor	Awarding Organization
Raymond and Beverly Sackler Endowment Award	UConn Health Center
Phi Beta Kappa	The Phi Beta Kappa Society

Name & Description	Category	Role	Type	Scope	Start Year	End Year
Faculty Opinions Landmarks Cell Biology Advisory Board	Editorial Board	Board member to evaluate recent publications for Landmark status	External	International	2022	2023
UCHC School of Medicine Oversight Committee	Other	member	UConn Health	University	2021	2024
Institutional Animal Care and Use Committee (IACUC)	Advisory Committee	member	UConn Health	University	2021	2024
ZCA1 SRB-X (J1) NCI Review of Informatics Technology in Cancer Research (10/15-10/16/21)	Study Section	member	External	National	2021	2021
ZCA1 SRB-1 (J2) Research Projects in Cancer Systems Biology (U01) (11/04/21)	Study Section	Chair	External	National	2021	2021
Special Emphasis Panel/Scientific Review Group 2020/10 ZRG1 BCMB-F (50) R (SEP to review NIGMS RM1 applications)	Study Section	member	External	National	2020	2020
Special Emphasis Panel/Scientific Review Group 2020/10 ZEB1 OSR-E (O1) S (NIBIB SEP to review K award applications)	Study Section	member	External	National	2020	2020
Special Emphasis Panel/Scientific Review Group 2021/01 ZCA1 TCRB-T (J1) R (NCI SEP to review Informatics Technology for Cancer Research (ITCR) applications)	Study Section	member	External	National	2020	2020
NIH F31/F32 Fellowship study section (November 2019)	Study Section	member	External	National	2019	2019
Graduate Programs Committee Curriculum Committee	Education Committee	member	UConn Health	University	2019	2024
President's Research Advisory Committee (PRAC)	Advisory Committee	member	UConn-Storrs	University	2019
NIH F31/F32 Fellowship study section (November 2018)	Study Section	member	External	National	2018	2018
DoD Ovarian Cancer Research Program peer review panel (October 2018)	Study Section	member	External	National	2018	2018
UCH Space Appeals Committee	Research Committee	member	UConn Health	Local	2018	2024
NIH F31/F32 Fellowship study section (November 2017)	Study Section	ad hoc member	External	National	2017	2017
NIH MIRA proposal review for NIGMS (March 2017)	Study Section	ad hoc member	External	National	2017	2017
LCME self-study committee on faculty standards	Advisory Committee	chair	UConn Health	Local	2017	2017
LCME Task Force	Advisory Committee	member	UConn Health	Local	2017	2017
Research IT Advisory Group (RITAG)	Advisory Committee	member	UConn Health	University	2017
National Institutes of Health, MIST study section (ad hoc)	Study Section	reviewer	External	National	2016	2016
National Institutes of Health, NIGMS MIRA grant proposal review	Study Section	reviewer	External	National	2016	2016
Journal of Biological Chemistry Editorial Board	Editorial Board	Editorial Board member	External	International	2016	2026
NIH SEP to assess U01 proposals for Centers for Cancer Systems Biology (CCSB) February 2015	Study Section	chair		National	2015	2015
CSR’s NIH Application Comparison Pilot (February 2015)	Study Section	reviewer	External	National	2015	2015
NIH F31/F32 Fellowship study section (July 2015)	Study Section	reviewer	External	National	2015	2015
NIH MIRA proposal review for NIGMS (November 2015)	Study Section	reviewer	External	National	2015	2015
Graduate Programs Committee Admissions Committee	Education Committee	member	UConn Health	Local	2014	2017
MIST study section (NIH), June meeting	Study Section	ad hoc member	External	National	2013	2013
NCI Provocative Questions R01 and R21 proposals	Study Section	mail reviewer	External	National	2012	2012
NIH Director's Early Independence Award Review	Study Section	mail reviewer	External	National	2012	2012
National Institutes of Health, College of CSR Reviewers	Advisory Committee	Member	External	National	2010	2012
Senior Appointments and Promotions Committee	Advisory Committee	member	UConn Health	Local	2010	2025
Member, Susan Komen for the Cure Career Catalyst Research grant review panel	Study Section	grant reviewer	External	National	2010	2011
BMC Biology (previously Journal of Biology)	Editorial Board	Editorial Board member	External	International	2008	2024
National Institutes of Health, CSRS study section	Study Section	Chair	External	National	2007	2009
Health Center Research Advisory Council (HCRAC)	Advisory Committee	member	UConn Health	University	2007	2024
National Institutes of Health, member, CSD study section	Study Section	Member	External	National	2006	2007
UCHC School of Medicine Education Council	Education Committee	Member	UConn Health	Local	2006	2012
Department of Defense, US Army Ovarian Cancer Research Program, member OC-1 study section	Study Section	Member	UConn Health	National	2004	2006
National Institutes of Health, CSD study section (ad hoc)	Study Section	Ad Hoc Member	External	National	2003	2006
Graduate Programs Committee, UCHC	Education Committee	Chair	UConn Health	Local	2003	2005
Department of Defense, US Army Breast Cancer Research Program, member MBG-2 study section	Study Section	Member	External	National	2001	2005
Graduate Programs Committee, UCHC	Education Committee	Vice-chair	UConn Health	Local	2001	2003
American Association for the Advancement of Science	Professional/Scientific Organization	Member	External	National

Our group is interested in mechanisms of signal transduction. The ability of a cell to receive signals from the surrounding environment and respond to those signals appropriately is literally a matter of life and death. Whether a cell will proliferate, differentiate, or die, where it will adhere or migrate, virtually all aspects of its behavior depend on the ability to accurately interpret signals. Not only is signaling critical for normal development and the day-to-day function of an organism, but disregulated signaling underlies many human diseases such as cancer and autoimmune disorders. It is now appreciated that one of the central elements of the signaling machinery is the highly regulated and specific formation of protein-protein complexes. The fact that signaling relies on the binding of proteins to each other presents extraordinary opportunities: binding can be used as a means of identifying critical components of signaling pathways, and also provides the basis for strategies to inhibit those pathways in the laboratory or the clinic. We use a combination of biochemical and cell biological techniques to understand signaling pathways such as those that control cell proliferation and the organization of the cytoskeleton. We are also actively pursuing novel proteomic approaches to identify functionally important protein interactions and to characterize interactions on a global scale.

Not accepting lab rotation students at this time

Lab Rotation Projects Various projects aimed at profiling tyrosine phosphorylation in cells and tumor samples; signal transduction via tyrosine kinases and their substrates; regulation of actin cytoskeleton by extracellular signals.

Journal Articles

Books

Book Chapters

Conference Papers

Editorials

Other

Reviews

Title or Abstract	Type	Sponsor/Event	Date/Year	Location
Using phosphotyrosine binding domains to interrogate the state of cell signaling (2/18/21)	Lecture	combined BBB and CCBIO seminar series	2021	University of Bergen, Norway (virtual)
Using phosphotyrosine binding domains to interrogate the state of cell signaling (University of Bergen, Norway). Visit coincided with beginning of pandemic shutdowns in March 2020, so provided informal seminar to host's research group instead of formal seminar	Talk	University of Bergen	2020	Norway
Using SH2 domains to profile cell signaling and cancer	Lecture	Department of Pathology, Kyoto University	2019	Kyoto, Japan
Integrating tyrosine phosphoproteomics and computational modeling in cancer	Lecture	38th Sapporo International Cancer Symposium	2019	Sapporo, Japan
EMBO Workshop Organizer, "The modularity of signalling proteins and networks" (September 16-21, 2018)	Other	EMBO	2018	Seefeld, Austria
Center for Biological Systems Engineering, Washington University	Talk		2016	St. Louis
EMBO Workshop Organizer, "The modularity of signalling proteins and networks" (September 20-25, 2016)	Other	EMBO	2016	Seefeld, Austria
Keystone Symposium “The Biological Code of Cell Signaling: A Tribute to Tony Pawson” (session chair)	Plenary Lecture	Keystone Symposia	2015	Steamboat Springs, CO
ICBP Steering Committee Meeting	Talk	NIH	2014	Rockville, MD
Research seminar, University of Colorado School of Medicine	Lecture	University of Colorado School of Medicine	2013	Aurora, CO
Symposium in honor of David Foster.	Talk	Hunter College, NY	2012	New York, NY
Duke University School of Medicine	Talk		2012	Durham, NC
Roswell Park Cancer Institute	Talk		2012	Buffalo, NY
Center for Molecular Medicine	Talk		2012	UCHC
ICBP Investigator's Meeting	Talk	NCI ICPB program	2012	San Francisco, CA
Keystone Symposium on the Evolution of Protein Phosphorylation.	Talk		2011	Keystone CO
5th FEBS workshop on modular protein domains.	Talk		2011	Seefeld Austria
University of Nevada/Las Vegas	Talk		2011	Las Vegas, NV
Connecticut College			2011	New London, CT
Scientific symposium in memory of Hidesaburo Hanafusa.	Talk	Rockefeller University	2009	New York, NY
4th FEBS workshop on modular protein domains.	Talk		2009	Seefeld Austria
Boehringer Ingelheim Pharmaceuticals	Talk		2009	Ridgefield CT
West Virginia University	Talk	Mary Babb Randolph Cancer Center	2009	Morgantown, WV
Case Western Reserve University	Talk		2009	Cleveland, OH
University of Connecticut Stem Cell Institute Symposium.	Talk	University of Connecticut	2008	CT
3rd FEBS workshop on modular protein domains.	Talk		2007	Seefeld Austria
Gordon Research Conference on Growth Factor Receptor Signaling.	Talk		2006	New London CT
4th Biennial International Conference on Molecular Oncogenesis.	Talk		2006	Osaka Japan
2nd FEBS workshop on modular protein domains.	Talk		2005	Seefeld Austria
The Oncogene Revolution	Talk	Osaka Bioscience Institute Symposium	2004	Osaka Japan
IBC Proteomics Symposium	Talk		2002	Philadelphia PA
14th Methods in Protein Structure Analysis Meeting	Talk		2002	Valencia Spain
COE International Symposium on Molecular Pathogenesis and Therapeutic Strategies for Neurodegenerative Disease and Malignant Tumor.	Talk		2002	Nagoya Japan
Euresco Conference on Functional Protein Modules in Cytoskeleton and Signaling Proteins	Talk		2001	Seefeld, Austria
Tyrosine phosphorylation and cell signaling: The third decade	Talk	Salk Institute	2000
Roles of protein tyrosine phosphorylation in signal transduction: the 25th anniversary of the discovery of c-Src,	Talk	Osaka Bioscience Institute	2000	Osaka Japan
Northeast Branch of the American Society for Microbiology meeting, “Drug Discovery for the 21st Century.”	Talk		1999	Worcester, MA
Memorial Symposium for Teruko Hanafusa; FASEB Summer Research Conference, GI Tract VII; Twelfth Rinshoken International Conference	Talk		1997	Tokyo, Japan
Biochemistry of Signal Transduction course.	Talk	Graduate School of the City University of New York	1996	New York
FASEB Summer Research Conference, Protein Kinases and Phosphorylation	Talk		1995
Symposium on Molecular Biology of Cancer	Talk		1994	Seoul, Korea
SH2/SH3 Domains and Tyrosine Kinase Signaling Symposium	Talk		1993	Boston MA
Chronic Myelogenous Leukemia Meeting	Talk		1992	Martha's Vinyard, MA
AACR Normal and Neoplastic Growth and Development Meeting	Talk		1992	Chatham, MA
SH2/SH3 Domains and Tyrosine Kinase Signaling Symposium	Talk		1992	Boston MA
Cold Spring Harbor Symposium on Quantitative Biology	Talk		1988	Cold Spring Harbor, NY