Liisa T. Kuhn, PhDProfessor, Biomedical Engineering
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- Overview
- Education & Training
- Clinical Interests
- Teaching
- Committees & Organizations
- Research
- Research Opportunities
- Lab Rotations
- Publications
- Presentations
Dr. Kuhn’s laboratory works at the interface of materials science and medicine, and her research spans fundamental studies to translational research and clinical use. She has an expertise in biomaterials and drug delivery and bone regeneration that she gained while working in industry and at UConn Health. She is funded by the National Institutes of Health to develop customized bone grafts for older patients that include controlled release of anti-senescence drugs to rejuvenate bone healing in the elderly. She is Director of the Beekley Lab for Biosymmetrix since Spring 2021, which provides 3D printed personalized breast prostheses for breast cancer survivors. Dr Kuhn is grateful for the funding from the Connecticut Breast Health Initiative and the Beekley Family Foundation for the breast prosthetic project.
The Kuhn Lab's mission is to develop biomaterial technologies to restore or regenerate damaged or diseased tissue.
Degree | Institution | Major |
---|---|---|
BS | Duke University | Mechanical Engineering |
MS | University of California, Santa Barbara | Materials Engineering |
PhD | University of California, Santa Barbara | Materials Engineering |
Post-Graduate Training
Training | Institution | Specialty |
---|---|---|
Postdoctoral | University of California, Santa Barbara | Models for Powder Deformation |
Postdoctoral | Case Western Reserve University | Biomineralization |
Postdoctoral | Children's Hospital - Harvard Medical School | Bone Biology and Bone Mineral |
Awards
Name of Award/Honor | Awarding Organization |
---|---|
Induction to the Connecticut Academy of Science and Engineering | Connecticut Academy of Science and Engineering |
Award for Service from the Society for Biomaterials. Honors significant service to the Society in establishing, developing, maintaining, and promoting its objectives and goals. | Society for Biomaterials |
Elected as Fellow of the International Union of Societies for Biomaterials Science & Engineering (IUSBSE). Recognized for accomplishments as a role model in the field of biomaterials science and engineering. | International Union of Societies for Biomaterials Science & Engineering (IUSBSE) |
Induction as Fellow of the American Institute of Medical & Biological Engineers (AIMBE). Recognized for significant contributions to the medical and biological engineering. Represents top 2% of the medical and engineering community. | American Institute of Medical & Biological Engineers (AIMBE) |
2016-2017 President of the Society for Biomaterials. Elected Board and Council position. | Society for Biomaterials |
Award of Merit and Induction as Fellow of the American Society of Testing & Materials (ASTM). Highest ASTM award for distinguished service and outstanding participation. | American Society of Testing and Materials (ASTM) |
Women of Innovation Award for Academic Innovation and Leadership from the Connecticut Technology Council | Connecticut Technology Council |
Patrick Liang Award for Outstanding and Meritorious Service from the American Society of Testing & Materials (ASTM). Recognition for significant and outstanding contributions in the field of medical and surgical devices. | American Society of Testing and Materials (ASTM) |
Program Chair, Annual Meeting of the Society for Biomaterials. Led the team responsible for coordinating the entire scientific program that was attended by approximately 3000 scientists from the US and abroad; this is the premier biomaterials meeting in the US. | Society for Biomaterials |
Scientific American Award from the American Society of Testing & Materials (ASTM) | American Society of Testing & Materials (ASTM) |
Dr. Kuhn and the clinicians at the Carole and Ray Neag Comprehensive Cancer Center are working together to provide improved prosthetics for women that have undergone mastectomy without reconstruction. The prosthetics are produced in the Beekley Lab for Biosymmetrix at UConn Health and are available free of charge at this time (2024).
Dr. Liisa Kuhn trains the next generation of scientists by advising undergraduate, graduate, and postdoctoral trainees and giving lectures in her own courses and others. She developed and taught the UConn School of Engineering Biomedical Engineering core course called BME 4710/5700 Biomaterials and Tissue Engineering for nearly a decade and then transitioned to teaching Controlling Stem Cells with Biomaterials (BME 4985-003/BME 6086-004). For the last four years, she serves as the course director of Dental Materials, a required core course for all third-year dental students at the UConn Health School of Dental Medicine.
Name & Description | Category | Role | Type | Scope | Start Year | End Year |
---|---|---|---|---|---|---|
Advisory Committee, Connecticut Bioscience Innovation Fund Committee, Connecticut Innovations, 2023 - present | Advisory Committee | Member | External | State | 2023 | |
International Union of Societies for Biomaterials & Engineering (IUSBSE) College of Fellows, 2020 - present | Professional/Scientific Organization | Fellow | External | International | 2020 | |
Dental Senate Member, representing the UConn Health Dept of Biomedical Engineering | Education Committee | Member | UConn Health | University | 2020 | 2022 |
UConn Health Center Research Advisory Council (HCRAC), 2020 - present | Advisory Committee | Member | UConn Health | University | 2020 | |
International Union of Societies for Biomaterials & Engineering (IUSBSE), 2020 - present | Professional/Scientific Organization | Delegate | External | International | 2020 | |
Journal of Biomedical Materials Research Part A, Journal of Biomedical Materials Research Part B – Applied Biomaterials, 2020 - 2024 | Professional/Scientific Journal | Editorial Board Member | External | International | 2020 | |
Search Committee Member, UConn Health Orthodontics Dept Head/Chair | Other | Member | UConn Health | University | 2019 | 2019 |
Awards Committee, Society for Biomaterials (SFB) | Professional/Scientific Organization | Chair | External | International | 2019 | 2020 |
American Society of Testing and Materials (ASTM) F2900 Standard Guide for Characterization of Hydrogels Used in Regenerative Medicine, 2019 - Present | Professional/Scientific Organization | Task Group Chair | External | National | 2019 | |
Board and Council, Society for Biomaterials (SFB) | Professional/Scientific Organization | Second Past-President | External | International | 2018 | 2019 |
American Society of Testing and Materials (ASTM) Work Item WK72274 Standard Test Method for Printability of Bioinks, 2018 - present | Professional/Scientific Organization | Task Group Chair and Primary Author | External | National | 2018 | |
Revision of American Society of Testing and Materials (ASTM) F2450 Standard Guide for Assessing Microstructure of Polymeric Scaffolds for Use in Tissue Engineered Medical Products. Reapproved in 2019. | Professional/Scientific Organization | Task Group Chair | External | International | 2018 | 2019 |
Senior Appointments & Promotions Committee Member, UConn Health School of Dental Medicine | Education Committee | Member | UConn Health | University | 2017 | 2022 |
Search Committee Member - Recruiting 5 Faculty Members, UConn Health Dept of Biomedical Engineering | Other | Original faculty member recruiting others for new dept | UConn Health | International | 2017 | 2019 |
Strategic Planning Committee Member, UConn Health School of Dental Medicine | Education Committee | Member | UConn Health | University | 2017 | 2018 |
Board and Council, Society for Biomaterials (SFB) | Professional/Scientific Organization | Chair and First Past-President | External | International | 2017 | 2018 |
Presidents Advisory Committee | Professional/Scientific Organization | Chair | External | International | 2017 | 2018 |
Annual Meeting Session, BTI Testing Methods for Evaluating Translational Biomaterials, Society for Biomaterials (SFB) | Professional/Scientific Organization | Co-Chair | External | International | 2017 | 2018 |
Dental Senate Member, representing the UConn Health Dept of Reconstructive Sciences | Education Committee | Member | UConn Health | University | 2016 | 2018 |
Group on Women in Medicine and Science (GWIMS) Steering Committee, Local Chapter of the Association of the American Medical Colleges (AAMC) GWIMS, 2016 - present | Professional/Scientific Organization | Member | External | Local | 2016 | |
UConn Research Advisory Council (RAC), representing UConn Health School of Dental Medicine | Advisory Committee | Member | UConn-Storrs | University | 2016 | 2019 |
Society for Biomaterials (SFB) | Professional/Scientific Organization | President | External | International | 2016 | 2017 |
Overall Annual Meeting Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Chair | External | International | 2016 | 2017 |
Permanent Study Section Member, Musculoskeletal Tissue Engineering (MTE) Study Section, National Institutes of Health (NIH), Center for Scientific Review (CSR). | Professional/Scientific Organization | Grant Reviewer | External | National | 2016 | 2020 |
Bordeaux University Consortium for Regenerative Medicine, France | Advisory Committee | Board Member | External | Regional | 2016 | 2019 |
Society for Biomaterials (SFB) | Professional/Scientific Organization | President-Elect | External | International | 2015 | 2016 |
Long Range Planning Committee | Professional/Scientific Organization | Chair | External | International | 2015 | 2016 |
Journal of Regenerative Engineering and Translational Medicine, 2015 - present | Editorial Board | Editorial Board Member | External | International | 2015 | |
"Implantable Drug Delivery Systems for Medical Devices and Cancer Therapy," Society for Biomaterials (SFB) | Professional/Scientific Organization | Annual Meeting Symposium Co-Chair | External | International | 2013 | 2013 |
Biomaterials and Hard Tissue Repair, 9th World Biomaterials Congress in Chengdu, China | Professional/Scientific Organization | Symposium Co-Chair | External | International | 2012 | 2012 |
National Institutes of Health, Center for Scientific Review, Musculoskeletal Tissue Engineering (MTE) Study Section (2014, 2015, 2016), Biomaterials and Biointerfaces (BMBI) Study Section (2013), Nanotechnology Special Emphasis Panel (2012). | Professional/Scientific Organization | Ad Hoc Grant Reviewer | External | National | 2012 | 2016 |
Biomaterials Forum, Society for Biomaterials (SFB) | Editorial Board | Executive Editor | External | National | 2011 | 2016 |
Dental School Admissions Committee, UConn Health School of Dental Medicine | Education Committee | Member | UConn Health | University | 2011 | 2012 |
2011 Annual Program Committee, Society for Biomaterials (SFB) | Professional/Scientific Organization | Invited Member | External | International | 2011 | 2011 |
Drug Delivery Special Interest Group, 2011 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Group Chair | External | International | 2011 | 2011 |
Journal of Biomaterials and Tissue Engineering, 2011 - present | Editorial Board | Member | External | International | 2011 | |
Drug Delivery Special Interest Group, 2010 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Group Chair | External | International | 2010 | 2010 |
Symposium Organizer, 2010 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Symposium Organizer | External | International | 2010 | 2010 |
Session on Multi-Factor Delivery for Musculoskeletal Regeneration | Professional/Scientific Organization | Session Chair | External | International | 2010 | 2010 |
Published Standard for American Society of Testing and Materials (ASTM) F2997 Standard Practice for Quantification of Calcium Deposits in Osteogenic Culture of Progenitor Cells Using Fluorescent Image Analysis | Professional/Scientific Organization | Task Group Chair and Primary Author | External | International | 2010 | 2013 |
Published Standard for American Society of Testing and Materials (ASTM) F3106 Standard Guide for in vitro Osteogenesis | Professional/Scientific Organization | Task Group Chair and Primary Author | External | International | 2010 | 2013 |
Drug Delivery Special Interest Group, 2009 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Group Chair | External | International | 2009 | 2009 |
Workshop Organizer, Regulatory Pathways for Combination Products, 2009 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Workshop Organizer | External | International | 2009 | 2009 |
Elected Member Awards, Ceremonies and Nominations Committee, 2009 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Member | External | International | 2009 | 2009 |
Drug Delivery Special Interest Group, 2008 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Vice-Chair | External | International | 2008 | 2008 |
Drug Delivery Special Interest Group, 2007 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Vice-Chair | External | International | 2007 | 2007 |
Session Moderator, 2007 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Session Moderator | External | International | 2007 | 2007 |
Elected Member Awards, Ceremonies and Nominations Committee, 2007 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Member | External | International | 2007 | 2007 |
Published Standard American Society of Testing and Materials (ASTM) F2739 Standard Guide for Quantitating Cell Viability | Professional/Scientific Organization | Task Group Chair and Primary Author | External | International | 2007 | 2010 |
Advisory Committee, Center for Research & Education in Technology Evaluation (CRETE), UConn Health School of Dental Medicine | Advisory Committee | Member | UConn Health | University | 2006 | |
Drug Delivery Special Interest Group, 2006 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Vice-Chair | External | International | 2006 | 2006 |
Ophthalmic Drug Delivery Symposium Co-organizer, 2006 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Symposium Co-organizer | External | International | 2006 | 2006 |
Drug Delivery Special Interest Group, 2005 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Vice-Chair | External | International | 2005 | 2005 |
Membership Committee, Society for Biomaterials (SFB) | Professional/Scientific Organization | Elected Member | External | International | 2005 | 2005 |
Drug Eluting Surfaces Special Symposium, 2005 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Special Symposium Co-organizer | External | International | 2005 | 2005 |
Biomaterials for Controlled Release Session, 2005 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Session Moderator | External | International | 2005 | 2005 |
Overall Meeting Program, 28th Annual Meeting of the Society for Biomaterials (SFB) | Professional/Scientific Organization | Chair | External | National | 2004 | 2008 |
Main Committee F04 Medical and Surgical Materials and Devices, American Society of Testing and Materials (ASTM) | Professional/Scientific Organization | General Interest Vice-Chair | External | National | 2004 | 2012 |
American Association of Pharmaceutical Scientists (AAPS) | Professional/Scientific Organization | Member | External | National | 2004 | 2008 |
Controlled Release Society (CRS) | Professional/Scientific Organization | Member | External | International | 2004 | 2008 |
American Society of Testing and Materials (ASTM) Main Committee F04. Medical and Surgical Materials and Devices | Professional/Scientific Organization | Elected General Interest Vice-Chair | External | National | 2004 | 2011 |
NIH CSR Study Section Member (NIAMS, SBIR/STTR), 1997 - present. | Study Section | Ad Hoc Member | External | National | 2003 | |
Education and Professional Development Committee, Society for Biomaterials (SFB) | Professional/Scientific Organization | Elected Member | External | International | 2003 | 2003 |
American Society of Testing and Materials (ASTM) F04.42 Biomaterials and Biomolecules Subcommittee, Tissue Engineered Medical Products Division, 2003 - 2023 | Professional/Scientific Organization | Chair | External | National | 2003 | 2023 |
National Institutes of Health, Center for Scientific Review Special Emphasis panel, Orthopedics Small Business Grants (SBIR/STTR) | Professional/Scientific Organization | Grant Reviewer | External | National | 2003 | 2012 |
Book Reviewer, Society for Biomaterials (SFB) | Professional/Scientific Organization | Book Reviewer | External | International | 2002 | 2011 |
Overall Program Chair, 2002 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Overall Program Chair | External | International | 2002 | 2002 |
Assistant Program Chair, 2001 Annual Program, Society for Biomaterials (SFB) | Professional/Scientific Organization | Assistant Program Chair | External | International | 2001 | 2001 |
Orthopedic Special Interest Group, Society for Biomaterials (SFB) | Professional/Scientific Organization | Program Chair | External | International | 2001 | 2001 |
American Society of Testing and Materials (ASTM) F04.42 Biomaterials and Biomolecules Subcommittee, Tissue Engineered Medical Products Division | Professional/Scientific Organization | Vice-Chair | External | National | 2000 | 2003 |
Treasurer, Orthopedic Materials Special Interest Group, Society for Biomaterials (SFB) | Professional/Scientific Organization | Treasurer | External | International | 1999 | 1999 |
Published Standard American Society of Testing and Materials (ASTM) F2027 Standard Guide for Characterization and Testing of Raw or Starting Biomaterials for Tissue Engineered Medical Products | Professional/Scientific Organization | Task Group Chair and Primary Author | External | National | 1999 | 2008 |
Society for Biomaterials (SFB), 1997 - present | Professional/Scientific Organization | Member | External | International | 1997 | |
American Society of Testing & Materials (ASTM), 1994 - present | Professional/Scientific Organization | Member | External | National | 1994 | |
Published Standard American Society of Testing and Materials (ASTM) F1581 Specification for Composition of Anorganic Bone for Surgical Implants | Professional/Scientific Organization | Task Group Chair and Primary Author | External | National | 1994 | 1997 |
Occasional Reviewer for Biomaterials; Tissue Engineering; Biotechnology and Bioengineering; Journal of Cellular Physiology; Stem Cell Research and Therapy; Journal of Biomaterials Applications; PLoS ONE; Stem Cell Reviews and Reports; Advanced Functional Materials; Acta Biomaterialia; Advanced Healthcare Materials; Bone; Advanced Science; Pharmaceutical Research; Journal of Periodontology; Journal of Tissue Engineering; and Regenerative Medicine; prior to 2020 | Professional/Scientific Journal | Reviewer | External | International | 2020 |
Professor Kuhn is a biomaterials scientist and directs a research program with four focus areas:
Project 1: Increasing the rate of bone repair in elderly women through pre-clinical testing of anti-aging drugs delivered by modified bone graft materials. With NIH R01 funding, Professor Kuhn is testing promising therapeutic compounds in aged mouse models of bone injury and repair to identify those that optimize rapid repair of bone defects in craniofacial injuries.
Project 2: Improving the outcomes for adolescents that have broken bones which involve the growth plate and lead to limb shortening and malformation. Professor Kuhn has developed a mouse model for growth plate injuries that uses transgenic mice with fluorescent collagen reporters that allows her to discriminate between promising therapeutics for cartilage repair after growth plate injury. She is collaborating with Professor Yupeng Chen from UConn Storrs on this project.
Project 3: Increasing the self-confidence, comfort, and appearance of breast cancer survivors through 3D-printed breast prosthetics. Customized prosthetics made of a silicone mesh provide unprecedented comfort and customization.
Project 4: Esophageal repair device. Together with Dr. Christine Finck, MD (Connecticut Children’s Medical Center), Professor Kuhn has co-founded Esophadex, Inc and is raising capital to support the development of a 4-in-1 esophageal repair device that will eliminate the multiple surgeries with anesthesia in children under 5 years old with esophageal malformation or injury.
If you are interested in hands-on learning opportunities in biomaterials and medical devices, please contact Dr. Liisa Kuhn for research opportunities.
There are no paid openings available in the Kuhn lab at this time, but volunteer positions are available for the summer or through the Biomedical Science Rotation program.
Not Accepting Lab Rotation Students at this time
Professor Kuhn, Ph.D. conducts preclinical testing of promising dental, orthopedic, and prosthetic technologies that can improve quality of life and promote rapid repair of a variety of medical concerns. Please reach out for more information.
Journal Articles
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Tricolor Transgenic Murine Model for Studying Growth Plate Injury.
Journal of visualized experiments : JoVE 2024 Sep;(211):
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Tri-color transgenic murine model for studying growth plate injury.
Journal of Visualized Experiments (JOVE), under review. 2024 Feb;
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One‐pot synthesis of bioinspired peptide‐decorated apatite nanoparticles for nanomedicine.
Small (Weinheim an der Bergstrasse, Germany) 2024 Feb;20(8):e2306358
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Controlled Self-Assembly of DNA-Mimicking Nanotubes to Form a Layer-by-Layer Scaffold for Homeostatic Tissue Constructs
ACS Applied Materials & Interfaces 2021 Nov;13(43):51321-51332
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Endogenous FGF-2 levels impact FGF-2/BMP-2 growth factor delivery dosing in aged murine calvarial bone defects.
Journal of Biomedical Materials Research. Part A 2021 Jun;
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Self-assembled biomimetic nano-matrix for stem cell anchorage.
Journal of Biomedical Materials Research. Part A 2020 Apr;108(4):984-991
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Cell type influences local delivery of biomolecules from a bioinspired apatite drug delivery system.
Materials. 2018 Sep;11(9):
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Controlled M1-to-M2 transition of aged macrophages by calcium phosphate coatings.
Biomaterials 2018 Jul;
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Calvarial bone regeneration is enhanced by sequential delivery of FGF-2 and BMP-2 from layer-by-layer coatings with a biomimetic calcium phosphate barrier layer.
Tissue Engineering, Part A 2017 Sep;23(23-24):1490-1501
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Enhanced differentiation of dental pulp cells cultured on microtubular polymer scaffolds in vitro.
Regen Eng Transl Med 2017 Jun;3(2):94-105
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Implant-guided supracrestal alveolar bone growth using scaffolds, BMP-2, and novel scaffold-retaining device.
Clinical Oral Implants Research 2017 Mar;281411-1420
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Layer-by-layer nanoparticle platform for cancer active targeting.
International Journal of Pharmaceutics 2017 Jan;517(1-2):58-66
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Comparison of bone morphogenetic protein-2 delivery systems to induce supracrestal bone guided by titanium implants in the rabbit mandible.
Clinical Oral Implants Research 2016 Dec;27(6):676-85
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Design and characterization of calcium phosphate ceramic scaffolds for bone tissue engineering.
Dental materials : official publication of the Academy of Dental Materials 2016 Dec;32(1):43-53
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Biomimetic calcium phosphate/polyelectrolyte multilayer coatings for sequential delivery of multiple biological factors.
Journal of Biomedical Materials Research, Part A 2016 Dec;105(5):1500-1509
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Human biofield therapy does not affect tumor size but modulates immune responses in a mouse model for breast cancer.
Journal of Integrative Medicine 2016 Sep;14(5):389-99
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Age-related changes in FGF-2, fibroblast growth factor receptors and β-catenin expression in human osteoblasts (mesenchyme-derived progenitor cells).
Journal of Cellular Biochemistry 2016 Mar;117(3):721-9
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Carboxymethyl hyaluronan-stabilized nanoparticles for anticancer drug delivery.
Int J Cell Biol 2015 Dec;249573
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Therapeutic touch has significant effects on mouse breast cancer metastasis and immune responses but not primary tumor size.
Evid Based Complement Alternat Med 2015 Dec;926565
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Effects of low dose FGF-2 and BMP-2 on healing of calvarial defects in old mice.
Experimental Gerontology 2015 Apr;6462-69
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Lithium-end-capped polylactide thin films influence osteoblast progenitor cell differentiation and mineralization.
Journal of Biomedical Materials Research, Part A 2015 Feb;103(2):500-10
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Optimizing BMP-2-induced bone repair with FGF-2.
The Journal of the American Academy of Orthopaedic Surgeons 2014 Oct;22(10):677-679
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A site-specific integrated Col2.3GFP reporter identifies osteoblasts within mineralized tissue formed in vivo by human embryonic stem cells.
Stem Cells Translational Medicine 2014 Aug;3(10):1125-37
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Fibroblast growth factor-2 isoform (low molecular weight/18 kDa) overexpression in preosteoblast cells promotes bone regeneration in critical size calvarial defects in male mice.
Endocrinology 2014 Mar;155(3):965-974
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Osteogenetic properties of electrospun nanofibrous PCL scaffolds equipped with chitosan-based nanoreservoirs of growth factors.
Macromolecular Bioscience 2014 Jan;14(1):45-55
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Fibroblast growth factor-2 and bone morphogenetic protein-2 have a synergistic stimulatory effect on bone formation in cell cultures from elderly mouse and human bone.
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2013 Oct;68(10):1170-1180
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Developmental-like bone regeneration using human embryonic stem cell-derived mesenchymal cells.
Tissue Engineering, Part A 2013 Aug;20(1-2):365-377
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Targeting tumor hypoxia with 2-nitroimidazoleindocyanine green dye conjugates.
Journal of Biomedical Optics 2013 Jun;18(6):66009
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Use of a perforated scaffold retaining abutment to achieve vertical bone regeneration around dental implants in the minipig.
Int J Oral Maxillofac Implants 2013 Apr;28(2):432-443
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Lectin concanavalin A coatings for rapid attachment of human embryonic stem cells.
Open Journal of Biomedical Engineering 2013 Jan;1(1):6-14
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Modified hyaluronan hydrogels support the maintenance of mouse embryonic stem cells and human induced pluripotent stem cells.
Macromolecular Bioscience 2012 Aug;12(8):1034-1042
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Implant-guided vertical bone growth in the mini-pig.
Clinical Oral Implants Research. 2012 Jun;23(6):751-757
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One-step derivation of mesenchymal stem cell (MSC)-like cells from human pluripotent stem cells on a fibrillar collagen coating.
PLOS One 2012 Mar;7(3):e33225
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A comparison of roughened and alkaline treated titanium implants used to guide a new layer of bone growth on the rabbit mandible.
Zeitschrift fur Zahnarztliche Implantologie (Journal of Dental Implantology). 2011 Dec;27(2):
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An evaluation of BMP-2 delivery from scaffolds with miniaturized dental implants in a novel rat mandible model.
Journal of Biomedical Materials Research – B Applied Biomaterials 2011 Dec;97(2):315-326
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Synthesis and fluorescent characteristics of imidazole-indocyanine green conjugates.
Dyes and Pigments 2011 Dec;899-15
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Imaging tumor hypoxia by near-infrared fluorescence tomography.
Journal of Biomedical Optics 2011 Jun;16(6):066009
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Fibroblast-growth factor 2 stimulates the proliferation of mesenchyme-derived progenitor cells from aging mouse and human bone.
Journal of Gerontology: A Biol Sci Med Sci 2010 Dec;65(10):1051-1059
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A nondestructive method for evaluating in vitro osteoblast differentiation on biomaterials using osteoblast-specific fluorescence.
Tissue Engineering, Part C Methods 2010 Dec;16(6):1357-1366
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Pro416Arg cherubism mutation in Sh3bp2 knock-in mice affects osteoblasts and alters bone mineral and matrix properties.
Bone 2010 May;46(5):1306-1315
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Fabrication and characterization of hydroxyapatite-coated polystyrene disks for use in osteoprogenitor cell culture.
Journal of biomaterials science - polymer edition 2010 Jan;21(10):1371-1387
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Implant system for guiding a new layer of bone: computed microtomography and histomorphometric analysis in the rabbit mandible.
Clinical Oral Implants Research 2009 Feb;20(2):201-207
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Growth of new bone guided by implants in a murine calvarial model.
Bone 2008 Oct;43(4):781-788
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A comparison of the physical and chemical differences between cancellous and cortical bovine bone mineral at two ages.
Calcified Tissue International 2008 Aug;83(2):146-154
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Chemotherapy drug delivery from calcium phosphate nanoparticles.
International Journal of Nanomedicine 2007 Dec;2(4):667-74
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Effects of the physico-chemical nature of two biomimetic crystals on the innate immune response.
International Immunopharmacology 2007 Dec;7(13):1617-1629
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A novel surgical approach for treatment of class II furcation defects using marginal periosteal membrane.
Journal of the International Academy of Periodontology 2005 Jan;17(1):20-31
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Interactions of cisplatin with calcium phosphate nanoparticles: in vitro controlled adsorption and release.
Journal of Orthopaedic Research 2004 Jul;22(4):703-708
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Size and shape of mineralites in young bovine bone measured by atomic force microscopy.
Calcified Tissue International 2003 Dec;72592-598
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Shape and size of isolated bone mineralites measured using atomic force microscopy.
Journal of Orthopaedic Research 2001 Dec;191027-1034
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Evidence of hydroxyl-ion deficiency in bone apatites: an inelastic neutron scattering study.
Bone 2000 Dec;26(6):599-602
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Structure, composition, and maturation of newly deposited calcium-phosphate crystals in chicken osteoblast cell cultures.
Journal of Bone and Mineral Research 2000 Dec;15(7):1301-1309
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Mechanical properties and the hierarchical structure of bone.
Medical Engineering and Physics 1998 Dec;2092-102
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A biomimetic example of brittle toughening: I. steady state multiple cracking.
J of Computational Materials Science 1996 Dec;5157-166
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Fracture mechanisms of the strombus gigas conch shell: implications for the design of brittle laminates.
Journal of Materials Science 1996 Dec;316583-6594
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Raman spectra of vateritic calcium carbonate.
Spectroscopy Letters 1995 Dec;28(6):983-995
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The effect of organic macromolecules on the vaterite to calcite transformation.
S: Biomolecular Materials by Design, eds. H. Bayley, D. Kaplan, and M. Navia (Mat. Res. Soc. Proc.). 1994 Dec;330127-132
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Yielding of metal powder bonded by isolated contacts.
Journal of Mechanics and Physics of Solids 1992 Dec;40(5):1139-1162
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A diffusional creep law for powder compacts.
Acta Metallurgica et Materialia 1991 Dec;40(5):961-969
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A model for powder consolidation.
Journal of the American Ceramic Society 1991 Dec;74(3):682-685
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Power law creep of metal powder bonded by isolated contacts.
International Journal of Mechanical Sciences 1991 Dec;34563-573
Book Chapters
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Biomaterials
Introduction to Biomedical Engineering, 4th edition 2023 Dec;
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Chapter 3.1.8: Role of Standards for Testing and Performance Requirements of Biomaterials
Biomaterials Science, An Introduction to Materials in Medicine, 4th edition 2020 Dec;
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Chapter 65: Dental implant guided bone tissue engineering.
Stem Cell Biology and Tissue Engineering in Dental Sciences 2015 Dec;
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Chapter 14: Evaluation of bio-inspired materials for mineralized tissue regeneration using type I collagen reporter cells.
Bio-Inspired Materials for Biomedical Engineering 2014 Dec;
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Chapter 5: Biomaterials.
Regenerative Engineering 2013 Dec;
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Chapter 5: Biomaterials.
Introduction to Biomedical Engineering, 3rd Edition 2012 Dec;
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Chapter 6: Biomaterials.
Introduction to Biomedical Engineering 2005 Dec;
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Chapter 8: Bone mineralization.
Encyclopedia of Materials: Science and Technology 2001 Dec;787-794
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Biomimetic Processing of Ceramics.
Encyclopedia of Applied Physics 1999 Dec;27-45
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Biomimetic strategies and materials processing.
Biomimetic Approaches in Materials Science 1995 Dec;41-68
Abstracts
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Calcium phosphate/polyelectrolyte multilayer coatings for sequential delivery of multiple growth factors.
Frontiers Bioeng Biotechnol. Conference Abstract, 10th World Biomaterials Congress 2016 May;
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Visual monitoring of osteoblast progenitor cell differentiation on dewetted PLA thin films.
Materials Research Society 2011 Apr;
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Advanced micro- and nanofabrication technologies for tissue engineering.
Biofabrication 2011 Jan;6(2):020301
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Substantial mouse bone repair by osteo-chondrogenic progenitors derived from hESCs.
Regenerative Medicine:Innovations for Clinical Applications 2011 Jan;
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Substantial mouse calvarial bone defect healing by human embryonic stem cells.
StemCONN 2011 2011 Jan;
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Substantial mouse calvarial bone defect healing by human embryonic stem cells.
Orthopedic Research Society 2011 Jan;
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Varying PLA functionality and texture to influence osteoprogenitors.
Academy of Dental Materials 2010 Oct;
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Non-physiological mineral deposition in vitro by primary human osteoblasts under osteogenic conditions.
Proceedings of the IEEE 36th Annual Northeast Bioengineering Conference 2010 Mar;
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Osteogenesis by hESCs after cell culture on fibrillar Type I collagen coatings.
Proceedings of the IEEE 36th Northeast Bioengineering Conference 2010 Mar;
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Fibrillar collagen thin films promote early osteogenesis.
American Association for Dental Research Annual Meeting 2010 Jan;
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Variance of Extracel hydrogel compositions and the osteogenic effects on GFP-reporter preosteoblasts.
Society for Biomaterials 2010 Jan;
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Biomimetic method for coating tissue culture polystyrene with carbonated hydroxyapaptite.
J Dent Res 2009 Apr;88
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Reduction of chemotherapy side effects and targeted inhibition of lymph node metastasis with a calcium phosphate nanoparticle delivery vehicle. 31st Annual San Antonio Breast Cancer Symposium, San Antonio, TX. Dec 10-14, 2008.
Cancer Research 2009 Jan;69(2 Supplement):2135
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Differential effects of fibrillar and non-fibrillar collagens on osteogenesis of GFP-reporter preosteoblasts.
New England Musculoskeletal Institute Research Day 2009 Jan;
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Fluorescent quantification of osteogenesis of GFP-transgenic mouse calvarial osteoblasts on biomimetic coatings.
Society for Biomaterials 2009 Jan;
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Fluorescent quantification of osteogenesis using GFP-transgenic mouse reporter cell technology.
Regenerative Medicine-Advancing Next Generation Therapies 2009 Jan;
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Quantitative evaluation of supracrestal bone growth around dental implants. International Association for Dental Research Annual Meeting, Toronto, Ontario, Canada. July 2-5, 2008.
J Dent Res 2008 Jul;87(Spec Iss B):
Conference Papers
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Calcium phosphate: carrier for therapeutic agents.
123-190
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Carbonated apatite nanocrystals from bone in synthesis and processing of nanocrystalline powder.
57-68
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Chemoradiotherapy of ME-180 tumors with an intratumoral cisplatin/calcium phosphate drug delivery system.
Proceedings of the IEEE 32nd Northeast Bioengineering Conference 2006189-190
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Constitutive models for the deformation of powder compacts in computational and numerical techniques.
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Eggshell assembly - a model for biomimetic ceramic production in quality of poultry products.
A1-A6
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Evaluation of lymphatic metastasis using calcium phosphate/cisplatin nanoconjugates.
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Improvement of alveolar bone height using novel graft placement.
284-286, 889-892
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Modelling powder consolidation.
331-338
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Osteoinductive composites of calcium phosphate cement and demineralized bone matrix. Poster 1429.
32
Editorials
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Editorial: Enabling biomaterials for new biomedical technologies and clinical therapies.
Frontiers in Bioengineering and Biotechnology. 2020 Jun;8559
Erratums
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Erratum: A comparison of the physical and chemical differences between cancellous and cortical bovine bone mineral at two ages.
Calcified Tissue International 2009 Jan;83(2):146-154
Letters
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Response to the letter "Age and site should be considered when investigating the effect of growth factors on human bone-derived cells."
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 2014 Jul;69(9):1092-3
Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
---|---|---|---|---|
The Anti-SASP Ruxolitinib Modulates Aged Macrophage Phenotype Transitions and Promotes Aged Bone Healing | Lecture | Society For Biomaterials Annual Meeting | 2023 | San Diego, California |
Prevention of Bony Bar Formation in Injured Murine Growth Plate Using a Cytokine Loaded Nano-Matrix | Poster | Musculoskeletal Repair and Regeneration Symposium | 2023 | New York, New York |
A Murine Growth Plate Injury Model Using Tri-lineage Collagen Reporter Technology | Poster | American Society of Bone and Mineral Research | 2023 | Vancouver, British Columbia |
“Biomaterials standards: using them, teaching them, and getting involved” | Panel Discussion | Society For Biomaterials Annual Meeting | 2022 | Baltimore, Maryland |
Teaching Standardization of Bioprinting | Lecture | Society For Biomaterials Annual Meeting | 2021 | Virtual due to COVID-19 |
“Bone Tissue Engineering” | Lecture | Drexel University | 2021 | Philadelphia, Pennsylvania |
“Looking ahead to biomaterials research after 2020” | Lecture | World Biomaterials Congress, IUSBSE Special Fellows Session | 2020 | SEC Glasgow, Scotland, UK |
“Guiding Bone Repair with Biomaterials” | Lecture | University of Washington | 2020 | Seattle, Washington |
“Effects of Mechanical Forces on Cells” | Lecture | University of Maryland | 2020 | Baltimore, Maryland |
“Effects of anti-aging drugs delivered by bioinspired calcium phosphate on bone cells” | Lecture | University of Toulouse, CIRIMAT PPB | 2019 | Toulouse, France |
“Spatiotemporal control of cellular activity within the bone injury microenvironment” | Lecture | Chinese Biomaterials Congress and International Symposium on Advanced Biomaterials | 2019 | Dalian, China |
“Osteogenesis” | Lecture | Spinewave | 2019 | Shelton, Connecticut |
Experimental Models for the Clinical Translation Of Bone Biomaterials: From Small to Large Animals | Lecture | Biomaterials for Medical Devices and Regenerative Medicine Summer School | 2018 | Bordeaux, France |
Delayed Delivery of Simvastatin Increases In Vitro Osteogenesis and Modulates Inflammatory Macrophages | Poster | Society for Biomaterials Annual Meeting | 2018 | Atlanta, Georgia |
“FGF-2 and Tissue Engineering” | Lecture | Gordon Conference | 2018 | Ventura, California |
“Discriminating Bone Formation within Calcium Phosphate-based Medical Implants” | Lecture | University of Rochester | 2018 | Rochester, New York |
“American Society of Testing and Materials Standardization Strategies to Advance the Biofabrication Industry” | Lecture | Advanced Regenerative Medicine Institute (ARMI) BioFABUSA Fall Summit | 2018 | Manchester, New Hampshire |
Tuning Strategies for Sequential Delivery of Multiple Active Biological Factors | Lecture | Society for Biomaterials Annual Meeting | 2017 | Minneapolis, Minnesota |
Tuning Sequential Delivery of Multiple Biological Factors from a Drug Delivery System | Poster | Biomedical Engineering Society (BMES) Annual Meeting | 2017 | Phoenix, Arizona |
Cell Mediated Sequential Delivery of Multiple Biological Factors | Poster | Northeast Regional Discussion Group | 2017 | Farmington, Connecticut |
Cell Type Influences Local Delivery of Biomolecules from a Drug Delivery System | Poster | Annual Northeast Bioengineering Conference | 2017 | Newark, New Jersey |
Cell Type Influences Local Delivery of Biomolecules from a Drug Delivery System | Poster | Annual UConn School of Engineering Poster Competition, University of Connecticut | 2017 | Storrs, Connecticut |
Cell Type Influences Local Delivery of Biomolecules from a Drug Delivery System | Poster | Mid-Atlantic Biomaterials Day, City College of New York | 2017 | New York, New York |
“Reduction of chemotherapy side effects and targeted inhibition of lymph node metastasis” | Lecture | French Technologies for Health (FR TECSAN) | 2017 | Bordeaux, France |
“Modulating bone healing with growth factor combinations” | Lecture | LabEx AMADEus | 2017 | University of Bordeaux, France |
“Localized delivery of growth factors from a polyelectrolyte-calcium phosphate coating” | Lecture | MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University | 2017 | Maastricht, Netherlands |
“Delivery strategies for increasing endogenous progenitor cells for bone defect healing” | Lecture | 6th Annual Musculoskeletal Repair and Regeneration Symposium | 2017 | Albert Einstein College of Medicine, Bronx, New York |
“Biomimetic calcium phosphate coatings for temporally controlled delivery of anti-inflammatory and osteoinductive molecules” | Lecture | Centre Inter-universitaire de Recherche et d’Ingénierie des Matériaux | 2017 | University of Toulouse, France |
Sequential delivery of bioactive factors from nanostructured coatings | Poster | Symposium on Biomaterials Science, New Jersey Center for Biomaterials | 2016 | Iselin, New Jersey |
Calcium Phosphate/Polyelectrolyte Multilayer Coatings for Sequential Delivery of Multiple Growth Factors | Poster | World Biomaterials Congress | 2016 | Montreal, Canada |
“ASTM Standards Development Process for Biomaterials and Biologics” | Lecture | Institutes for Materials Science Industrial Affiliates Program, UConn | 2016 | Storrs, Connecticut |
“Enabling sequential delivery of growth factors from layer-by-layer films with a nanoCaP barrier layer” | Lecture | Penn State Biomedical Engineering Department | 2016 | Penn State, Pennsylvania |
“Pairing biomaterials with vintage bones – age matters” | Lecture | TermStem | 2016 | Guimaraes, Portugal |
“Bone regeneration enabled by growth factors and biomaterial scaffolds-view from the Bench” | Lecture | World Biomaterials Congress | 2016 | Montreal, Canada |
“Practical use of ASTM standards for evaluating biomaterial medical devices” | Lecture | Istituto Nazionale di Ricerca Metrologica (INRIM) | 2016 | Torino, Italy |
“Multi-layer polyelectrolyte/calcium phosphate coatings on scaffolds for temporal control of multiple growth factor delivery” | Lecture | Institut Straumann | 2016 | Basel, Switzerland |
“Cell instructive scaffolds for repair of elderly bone” | Lecture | University of Bordeaux, Pey Berland Place | 2016 | Bordeaux, France |
“Turn to the left, and then turn to the right: Nanostructured drug delivery systems for guiding multiple steps of tissue regeneration” | Lecture | Symposium on Biomaterials Science, New Jersey Center for Biomaterials | 2016 | Iselin, New Jersey |
Enabling Sequential Delivery of Growth Factors with Biomimetic Barrier Cap Within Layer-By-Layer Film Coatings | Lecture | Chinese Society for Biomaterials Annual Meeting | 2015 | Haikou, Hainan, China |
“Nanolayered Temporal control of Growth Factor Delivery” | Lecture | Academy of Dental Materials Meeting: Emerging Materials and Declining Dogmas | 2015 | Lahaina, Maui, Hawaii |
“Practical use of ASTM standards for evaluating biomaterial medical devices” | Lecture | Chinese Biomaterials Congress | 2015 | Haikou, China |
3-D PEM Coatings to Deliver FGF-2 and Promote In vitro and In vivo Osteoprogenitor Cell Proliferation | Poster | Annual Meeting of the Society for Biomaterials | 2014 | Denver, Colorado |
Novel Stabilization of Calcium Phosphate Nanoparticles for Drug Delivery | Poster | Annual Meeting of the Society for Biomaterials | 2014 | Denver, Colorado |
“Standardizing In Vitro Osteoblast Differentiation Assays” | Lecture | TERMIS-Americas 2014 Annual Conference and Exposition | 2014 | Washington, DC |
Sodium Citrate Stabilized Calcium Phosphate Nanoparticles for the Sustained Delivery of Cisplatin E | Poster | Annual Meeting of the Society for Biomaterials | 2013 | Boston, Massachusetts |
“Collagen Type I Reporter Mice: A Tool for Determining Progenitor Cell Differentiation to Functional Osteoblasts” | Lecture | TERMIS-Americas 2013 Annual Conference and Exposition | 2013 | Atlanta, Georgia |
“Identifying Osteoinductive Biomaterials with Progenitor Cells from Collagen/GFP Reporter Transgenic Mice” | Lecture | Worcester Polytechnic Institute Biomedical Engineering Department | 2013 | Worcester, Massachussetts |
“Recapitulation of developmental bone tissue generation by MSCs derived from human embryonic stem cells” | Lecture | MSC 2013, National Center for Regenerative Medicine | 2013 | Case Western Reserve University, Cleveland, Ohio |
“New biological tools for determining progenitor cell differentiation to functional osteoblasts” | Lecture | French National Center for Scientific Research (CNRS) | 2013 | Toulouse, France |
“New biological tools for determining progenitor cell differentiation to functional osteoblasts” | Lecture | Universite de Bordeaux Segalen | 2013 | Bordeaux, France |