Our research program focuses on the molecular and cellular processes that regulate the development of the cerebellum. The cerebellum is best known for its crucial rule in motor coordination. However, emerging evidence indicates that the cerebellum contributes to cognition and emotion as well. Accordingly, abnormalities in cerebellar development and function are linked to a wide variety of developmental brain diseases, such as autism spectrum disorder, schizophrenia, and language impairment. Despite the uniform appearance in its cytoarchitecture, the cerebellar cortex is subdivided into different functional areas resembling the cortical maps of the cerebrum. We are interested in the mechanisms that control the cellular heterogeneity and connectivity, which culminate in the parcellation of the cerebellar cortex. We use single-cell genomics and computational analysis to systematically study the gene regulatory networks that govern cell fate specification and cell differentiation in the developing cerebellum. Concurrently, we use mouse genetics to investigate how alterations of the regulatory network affect cerebellar development and function. Through these studies, our long-term goal is to gain insight into the causes of cerebellar-related diseases and develop therapeutic strategies to improve the quality of life of affected individuals.

Accepting Lab Rotation Students: Fall Block 2024, Spring 1 and 2 Block 2025

We also have openings for postdoctoral research associates!

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