UCONN

HEALTH

Photo of Andrew  Arnold, M.D.

Andrew Arnold, M.D.

Murray-Heilig Chair in Molecular Medicine
Professor of Medicine and Genetics & Genome Sciences
Director, Center for Molecular Medicine
Chief, Division of Endocrinology & Metabolism
Director, Office of Physician-Scientist Career Development
Academic Office Location:
Center for Molecular Medicine
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3101
Phone: 860-679-7640
Website(s):

Center for Molecular Medicine

Curriculum Vitae:
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Pathogenesis of parathyroid and other endocrine tumors, and role of the cyclin D1 oncogene in neoplasia, including breast cancer.

Education
No data available

Post-Graduate Training
TrainingInstitutionSpecialty
ResidencyUniversity of ChicagoInternal Medicine
FellowshipNational Cancer Institute/NIHMolecular Oncology
FellowshipMassachusetts General HospitalMedicine, Endocrinology

Awards
Name of Award/HonorAwarding Organization
Refer to Abbreviated CV Link

Parathyroid disorders; genetic/inherited endocrine tumor syndromes

The most longstanding interest of our laboratory has been in the molecular genetic underpinnings of tumors of the endocrine glands. It was in the context of a search for a parathyroid tumor oncogene lying adjacent to a clonal chromosomal breakpoint that we discovered cyclin D1 (PRAD1). Cyclin D1 has proven to play a key role in cell cycle regulation, and has emerged as a major human oncogene, important in multiple types of tumors including breast cancer and B-cell lymphoma. We are currently pursuing a number of approaches, including the use of transgenic mouse models, to learn more about the precise mechanisms by which cyclin D1 exerts its oncogenic effects. In addition to the cyclin D1 work, we are continuing a major initiative seeking additional genes that contribute to endocrine neoplasia. In this context, we identified the HRPT2 gene as a major factor in the development of malignant parathyroid tumors, a finding that carries important clinical implications.

Accepting students for Lab Rotations: Summer '17, Fall '17, Spring '18