Faculty Directory › University of Connecticut Health Center

Stefan Brocke, M.D., Ph.D.

Assistant Professor of Immunology

Academic Office Location: Immunology University of Connecticut Health Center 263 Farmington Avenue Farmington, CT 06030
Phone:	860-679-8860
Website(s):	Cell Biology Graduate Program

Research
Lab Rotations
Publications

My laboratory studies the cellular and molecular mechanisms of brain injury in inflammatory and inflammation-associated disorders of the central nervous system. For this purpose, we focus on:

vascular triggers leading to the invasion of pathogenic lymphocytes into the normal and inflamed brain,

regulation of inflammatory and anti-inflammatory processes at the level of cell surface molecules, and

cellular mechanisms regulating injury or survival/regeneration of neurons in areas affected by inflammation.

Accepting Lab Rotation Students: Summer '13, Fall '13, Spring '14

Lab Rotation Projects
Expression and function of lymphocyte recruitment signals at the blood-CNS barrier.

Journal Articles

Antigen-specific splenic CD4 and CD8 regulatory T cells generated via the eye suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase
Bhowmick S, Clark RB, Brocke S, Cone RE. (2011) Int Immunol. 2 (23) 119-28
Antigen-specific splenic CD4+ and CD8+ regulatory T cells generated via the eye, suppress experimental autoimmune encephalomyelitis either at the priming or at the effector phase
Bhowmick S., Clark R.B., Brocke S., Cone R.E. (2011) Int Immunol 2 (23) 119-128
Peroxisome Proliferator-Activated Receptor {gamma} Is Required for CD4+ T Cell-Mediated Lymphopenia-Associated Autoimmunity
Housley W.J., Adams C.O., Vang A.G., Brocke S., Nichols F.C., Lacombe M., Rajan TV, Clark RB. (2011) J Immunol 8 (187) 4161-4169
PDE8 regulates rapid Teff cell adhesion and proliferation independent of ICER
Vang AG, Ben-Sasson SZ, Dong H, Kream B, DeNinno MP, Claffey MM, Housley W, Clark RB, Epstein PM, Brocke S. (2010) PLoS One 5(8) (9) e12011
Role of dipeptidyl peptidase IV (DP IV)-like enzymes in T lymphocyte activation: Investigations in DP IV/CD26-knockout mice
Reinhold D., Goihl A., Wrenger S., Reinhold A., Kuhlmann U.C., Faust J., Neubert K., Thielitz A., Brocke S., Tager M., Ansorge S., Bank U. (2009) Clinical Chemistry and Laboratory Medicine 3 (47) 268-274
Prophylactic and therapeutic suppression of experimental autoimmune encephalomyelitis by a novel bifunctional peptide inhibitor
Kobayashi N., Kiptoo P., Kobayashi H., Ridwan R., Brocke S., Siahaan T.J. (2008) Clinical Immunology 1 (129) 69-79
Geranylgeranylation but not GTP loading determines rho migratory function in T cells
Waiczies S., Bendix I., Prozorovski T., Ratner M., Nazarenko I., Pfueller C.F., Brandt A.U., Herz J., Brocke S., Ullrich O., Zipp F. (2007) Journal of Immunology 9 (179) 6024-6032
TGF-β1-mediated control of central nervous system inflammation and autoimmunity through the inhibitory receptor CD26
Preller V., Gerber A., Wrenger S., Togni M., Marguet D., Tadje J., Lendeckel U., Rocken C., Faust J., Neubert K., Schraven B., Martin R., Ansorge S., Brocke S., Reinhold D. (2007) Journal of Immunology 7 (178) 4632-4640
Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation
Reinhold D., Biton A., Pieper S., Lendeckel U., Faust J., Neubert K., Bank U., Tager M., Ansorge S., Brocke S. (2006) International Immunopharmacology 13-14 (6) 1935-1942
Phosphodiesterase 8 (PDE8) regulates chemotaxis of activated lymphocytes
Dong H., Osmanova V., Epstein P.M., Brocke S. (2006) Biochemical and Biophysical Research Communications 2 (345) 713-719

Conference Papers

Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses
Reinhold D., Biton A., Goihl A., Pieper S., Lendeckel U., Faust J., Neubert K., Bank U., Tager M., Ansorge S., Brocke S. (2007) Annals of the New York Academy of Sciences (1110) 402-409

Reviews

DP IV/CD26, APN/CD13 and related enzymes as regulators of T cell immunity: Implications for experimental encephalomyelitis and multiple sclerosis
Reinhold D., Bank U., Tager M., Ansorge S., Wrenger S., Thielitz A., Lendeckel U., Faust J., Neubert K., Brocke S. (2008) Frontiers in Bioscience 6 (13) 2356-2363