Photo of Gordon G. Carmichael, Ph.D.

Gordon G. Carmichael, Ph.D.

Professor, Genetics and Genome Sciences
Academic Office Location:
Genetics and Genome Sciences
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3301
Phone: 860-679-2259
Fax: 860-679-8345
Email: carmichael@uchc.edu
Website(s):

Cell Biology Graduate Program

Genetics and Developmental Biology Graduate Program

Molecular Biology and Biochemistry Graduate Program

Education
DegreeInstitutionMajor
B.S.Duke UniversityPhysics
Ph.D.Harvard UniversityBiophysics

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralSwiss Institute for Experimental Cancer ResearchPostdoctoral Fellow in the Department of Virology, Laboratory of Dr. Bernhard Hirt
FellowshipHarvard Medical SchoolResearch Fellow in Pathology
PostdoctoralEstablished Investigator of the American Heart AssociationPostdoctoral Fellow of The Jane Coffin Childs Memorial Fund for Medical Research

Awards
Name of Award/HonorAwarding Organization
Faculty of 1000University of Connecticut Health Center
Osborn Biomedical Science Graduate Teaching Award Recipient Graduate Student Organization
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
MGB Study SectionStudy SectionReviewerExternalNational20132013
WIRES RNA This is a scientific journalEditorial BoardAssociate EditorExternalInternational2010
Review Panel, NSFStudy SectionReviewerExternalNational20102013
RNA SocietyProfessional/Scientific OrganizationmemberExternalInternational
UCHC Medical Selectives committeeEducation CommitteememberUConn HealthUniversity

The primary interests of my group are the molecular signals which control the expression and function of RNA molecules, both in the nucleus and in the cytoplasm. In recent years we have been especially interested in noncoding RNA molecules, particularly ones that play important roles in development, cellular physiology and disease. We have discovered a new class of long noncoding RNAs that may underlie human Prader-Willi Syndrome and have recently developed a new deep sequencing methodology to identify and study RNA 2’-O methylation, which is important in ribosome maturation and function, and which may also have unexpected roles in mRNA translation and fate. Our work involves molecular biology and genomics approaches, including CRISPR and the study of embryonic and induced pluripotent stem cells. 

Accepting students for Lab Rotations: Fall '17 and Spring '18


We study many aspects of RNA synthesis, processing and function. Of particular recent interest is the posttranscriptional modification of RNAs by either adenosine-to-inosine editing or 2’-O ribose methylation. We have developed novel biochemical and genomics tools to study these modifications and rotation projects will participate in this work and the discovery of RNA modifications that may play a role in development and disease. 

Journal Articles

Books

  • Methods in Molecular Biology: RNA Silencing
    G.G. Carmichael Methods in Molecular Biology: RNA Silencing 2005 Jan;

Book Chapters

  • Nucleocytoplasmic mRNA transport
    Y. Huang and G.G. Carmichael Results and Problems in Cell Differentiation 2001 Jan;140-155

Book Sections

  • A role for RNA editing in gene silencing
    J. Zhou, L. Chen and G.G. Carmichael Frontiers of RNA and DNA editing 2008 Jan;190-202
  • Mechanism of action of antisense RNA in eukaryotic cells
    Z. Zhang and G.G. Carmichael Cancer Drug Discovery and development: Nucleic Acid Therapeutics in Cancer 2003 Jan;89-104
  • Polyoma virus hr-t gene products
    T.L. Benjamin, B.S. Schaffhausen and G.G. Carmichael Animal Virus Genetics, ICN-UCLA Symposium on Molecular and Cellular Biology, vol. XVIII 1980 Jan;295-308
  • Assay and partial purification of Epstein-Barr virus nuclear antigen
    D. Baron, W.C. Benz, G. Carmichael, R.R. Yocum and J.L. Strominger Epstein-Barr Virus, Production, Concentration, and Purification, IARC Internal Technical Report 1975 Jan;257-262

Notes

Other

  • Bacterial RNA-binding proteins involved in Qβ RNA replication
    G.G. Carmichael Ph.D. Thesis, Harvard University 1975 Jan;

Reviews

Short Surveys

Title or AbstractTypeSponsor/EventDate/YearLocation
Recent RNA StoriesTalkHarvard University2013Boston, MA
Innate Immunity in Stem CellsTalkBedford Stem Cell Research Foundation2013Waltham, MA
Innate Immunity in Pluripotent CellsPosterCold Spring Harbor, Asia2013Suzhou, China
New Insights into Gene Expression from Deep SequencingTalkTufts University Medical School2012Tufts Medical School
New Insights into Gene Expression from Deep SequencingTalkAlbert Einstein College of Medicine2012Albert Einstein Medical School
New Insights into Gene Expression from Deep SequencingTalkOhio State University2012Ohio State University
A New Class of Intron-derived Long Noncoding RNAsTalkExperimental Biology Meeting2012San Diego
New Intron-derived Long Noncoding RNAsTalkGordon Research Conference2012GRC, Newport, RI
A New Class of Intron-derived Long Noncoding RNAsTalkRiboclub (Sherbrooke, Quebec, Canada)2012Riboclub, Sherbrooke, Canada
Long Noncoding RNAs with snoRNA EndsTalkCold Spring Harbor, Asia2012Suzhou, China
New Insights into Gene Expression from Deep SequencingTalkMedical School, Xian, China2012Xian, China