Photo of Linda S. Cauley, Ph.D.

Linda S. Cauley, Ph.D.

Associate Professor of Immunology
Associate Director, Graduate Program in Immunology
Academic Office Location:
Immunology
UConn Health
263 Farmington Avenue
Farmington, CT 06030
Phone: 860-679-3866
Website(s):

Immunology Graduate Program

Education
DegreeInstitutionMajor
B.S.University of KeeleBiology and Geography
Ph.D.University of OxfordMolecular Medicine

Post-Graduate Training
TrainingInstitutionSpecialty
Ph.D. StudentshipUniversity of Oxford
PostdoctoralThe Scripps Research Institute, Department of ImmunologyAssembly of Class I MHC Molecules

Awards
Name of Award/HonorAwarding Organization
Junior Faculty Travel AwardFASEB
Junior Faculty Travel AwardFASEB
Junior Faculty Travel Award FASEB
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
NIH study section: ZGM1 TWD-A (CB) COBRE multiple project grantsStudy SectionMemberExternalNational2012
NIH Special Emphasis Panel: ZAI1-QV-I-M1. Immunobiology of Host Defense PO1 grantsAdvisory CommitteeMemberExternalNational2012
NIH Special emphasis panel: ZAI1-RRS-I-J1- Integrated Immune Control of Virus Infection Advisory CommitteeMemberExternalNational2010
NIH study section: ZAI1 EB-A (M1) - Basic HIV Vaccine Discovery ProgramStudy SectionMemberExternalNational2010
Student Affairs Committee Advisory CommitteeMemberUConn HealthUniversity20102012
NIH Study section: ZAI1 BDP-I (J3) - Immune Mechanisms of Virus ControlStudy SectionMemberExternalNational2009
NIH Study section: - ZAI1 EL-M (J1) Integrated Immune Control of Virus InfectionStudy SectionMemberExternalNational2009
NIH Study section: HIV Vaccine Discovery ResearchStudy SectionMemberExternalNational2009
ZRG1 IDM-C- Challenge grants. OtherreviewerExternalNational2009
American Heart Association Study Section, Immunology and Virology Study SectionMemberExternalNational2008
Federation of American Societies for Experimental BiologyProfessional/Scientific OrganizationSymposium chairExternalNational2008
NIH Study section: (U19) ZAI1 KS-I (J3) - “Cooperative Centers for Translational Research on Human Immunology and Biodefense. Study SectionMemberExternalNational2008
Graduate Student Admissions Committee Education CommitteeMemberUConn HealthUniversity20082012
University of Connecticut Graduate Program Admissions Committee Editorial BoardMemberUConn HealthUniversity20072010
American Heart Association Study Section, Immunology and Microbiology II. Study SectionMemberExternalNational20072010
NIH New Investigator Workshop Professional/Scientific OrganizationMemberExternalNational2007
Consultant for VaxInnated Corp.OtherConsultantExternalLocal20052007
British Medical Research Council Grant. Professional/Scientific OrganizationMail reviewer ExternalInternational
UCONN Immunology Graduate Program Education CommitteeMemberUConn HealthUniversity
Doctoral thesis, Alex Chen - University of Massachusetts Education CommitteeExternal ExaminerExternalUniversity
Doctoral thesis Ching Tsai, The Geisel School of Medicine at DartmouthEducation CommitteeExternal ExaminerExternalUniversity
The Journal of Experimental Medicine; The Journal of Immunology; The European Journal of Immunology; Immunology Letters; PLoS One; PLoS Pathogens; Cell Host and Microbe; Immunity. J. Leuk. Biol.; J. Immunol. MethodsProfessional/Scientific JournalAd Hoc reviewerExternalNational
American Association of Immunology Professional/Scientific OrganizationMemberExternalNational
Society of Mucosal Immunology Professional/Scientific OrganizationMemberExternalNational
American Society for MicrobiologyProfessional/Scientific OrganizationMemberExternalNational
Thesis committees: Crystal Morales, Nandini AcharyaEducation CommitteeMemberUConn HealthUniversity

The major focus of my lab is to investigate the mechanisms that control protective immunity to influenza and other respiratory virus infections. These pathogens are a major cause of human mortality every year. Cytotoxic T cells (CTL) play an important role in viral clearance and can provide short-term heterosubtypic immunity, indicating that they could be an effective target for vaccination. Unfortunately, cellular immunity to viral infections lasts only a few months even when large self-renewing populations of virus-specific memory CD8 T cells have been established. An important goal of my lab is to determine why protective cellular immunity declines so rapidly and why circulating memory T cells become ineffective at accelerating viral clearance during secondary challenge. Better understanding of the mechanisms that regulate T cell responses in vivo are likely to lead to more effective methods of vaccination against viruses and other pathogens that invade the respiratory tract. Transgenic mice, recombinant strains of influenza virus and MHC class I tetramer technology will be used to track CD4 and CD8 T cell response in vivo by flow cytometry and confocal microscopy. Influenza virus infection is largely limited to the respiratory tract, enabling us to analyze the local effects of a tissue-specific infection.


In a recent study, we showed that processed T cell antigens persist near the site of virus amplification in the lungs and draining lymph node for at least two months after influenza virus infection (Zammit et al.). Our data show that these processed T cell antigens have a profound influence on local T cell migration and activation in the lungs. Ongoing studies will investigate the effects of residual antigen presentation on memory T cells responses in vivo after influenza and other viral infections. These studies will include analysis of the antigen presentation pathways that are used during the different stages of the response. The effects of residual antigen presentation on adhesion molecules and other inflammatory mediators that influence local T cell migration will also be analyzed. Evidence suggests that T cell activation and location at the time of secondary viral challenge are likely to be important factors in protection. We will therefore investigate whether residual antigen presentation is an essential component of protective immunity.


Another long-term goal of my lab is to investigate how antibody responses influence, and potentially interfere with, T cell responses in immune animals. Preliminary data show that repeated pulmonary challenge with the same respiratory virus leads to extensive proliferation by virus-specific CD8 T cells in the draining lymph nodes, but little or no T cell response or local inflammation in the lungs. This study will investigate whether neutralizing antibodies redirect antigen presentation in the lungs to a pathway that is suppressive for T cell activation.

Accepting students for Lab Rotations: Summer '17, Fall '17

Journal Articles

Reviews