I-Ping Chen, D.D.S., Ph.D.Assistant Professor, Oral Health and Diagnostic Sciences
In the Chen laboratory, we mainly focus on the investigation of pathogenic mechanisms of craniometaphyseal dysplasia (CMD) using multiple genetic and molecular biology approaches including a knock-in mouse model for CMD and induced pluripotent stem cells (iPSCs) from CMD patients. We have characterized the CMD mouse model replicating many features of human CMD and identified abnormal properties of osteoclasts and osteoblasts in CMD. Subsequently, I have generated integration-free induced pluripotent stem (iPS) cells from peripheral blood of CMD patients and control subjects. These hiPSCs will be differentiated into osteoclasts to study osteoclast defects in CMD. My long-term goal is to develop therapeutic strategies that can benefit patients with CMD and similar rare bone disorders.
As an endodontist, I am also interested in dental research. My laboratory has been funded by the American Association of Endodontists to establish a 3D culture modeling system that can be easily analyzed and improve or complement the current assays for testing new dental materials.
Accepting students for Lab Rotations: Summer '17, Fall '17, Spring '18