Photo of Asis K. Das, Ph.D.

Asis K. Das, Ph.D.

Professor, Department of Molecular Biology and Biophysics
Academic Office Location:
Molecular Biology and Biophysics
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3205
Phone: 860-679-3405
Fax: 860-679-1239
Email: adas@nso2.uchc.edu
Website(s):

Genetics & Developmental Biology Graduate Program

Molecular Biology & Biochemistry Graduate Program

Education
DegreeInstitutionMajor
B.Sc.University of CalcuttaChemistry
M.Sc.University of CalcuttaBiochemistry
Ph.D.Bose Institute, University of CalcuttaBiochemistry

Post-Graduate Training
TrainingInstitutionSpecialty
CourseCold Spring Harbor LaboratoryMolecular Biology and Genetics of Yeast Summer Workshop
PostdoctoralNational Cancer InstitutePostdoctoral work on Bacterial Genetics

Awards
Name of Award/HonorAwarding Organization
Osborn Biomedical Science Graduate Teaching Award Recipient Graduate Student Organization
Fulbright Senior Specialist AwardUS Department of State
Established Investigator AwardAmerican Heart Association
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
NIH Study Section on Genes, GEnetics, GenomesStudy SectionExternalNational20092011
UCHC Microbial Pathogenesis Research SeminarsOtherConvenerUConn HealthLocal20052006
UCHC RNA ClubProfessional/Scientific OrganizationConvenerUConn HealthLocal20042006
NIH Microbial Genetics and Physiology Study SectionmemberExternalNational19951998
Nucleic Acids ResearchEditorial BoardmemberUConn HealthLocal19891994
NIH Biomedial Sciences Study SectionOthermemberExternalNational19861989
Institutional Biosafety CommitteeAdvisory CommitteeChairUConn HealthLocal
School of Medicine CouncilAdvisory CommitteeChairUConn HealthLocal
SOM Council Research CommitteeStudy SectionChairUConn HealthLocal
Dental CouncilAdvisory CommitteeChairUConn HealthLocal
Biomedical Sciences Graduate Programs Admissions CommitteeEducation CommitteeChairUConn HealthLocal
MBB Graduate Program Admissions CommitteeEducation CommitteeChairUConn HealthLocal
MBB Graduate Program Curriculum CommitteeEducation CommitteeChairExternalLocal
Department of Microbiology RetreatsAdvisory CommitteeOrganizerUConn HealthLocal
Department of Microbiology Seminar SeriesOtherOrganizerUConn HealthLocal
Microbiology Faculty Search CommitteeResearch CommitteeChairUConn HealthLocal
Department of Molecular, Microbial & Structural Biology RetreatOtherCo-ChairUConn HealthLocal

Gene Regulation in Bacteria. We study basic gene regulatory mechanisms in prokaryotes by a combination of biochemistry and classic and molecular genetics. Current research efforts are devoted in three areas: Genetics, genomics and mechanisms of bacterial adaptive response. Genetic control of bacteriophage lysogeny and lysis. Non-coding RNAs in prokaryotic development.

Not accepting students for Lab Rotations at this time


Lab Rotation Projects
We are interested in the regulation of gene expression in bacteria with an emphasis on genetics and genomics. Rotation students are welcome in one of the following areas under investigation:
1. To elucidate the regulation of stress response in E. coli and Salmonella by the Gre factors, two conserved RNA polymerase binding proteins that are induced by several forms of stress.
2. To test the function of Gre factors and various two-component systems in the pathogenesis of model gram-negative organisms using C. elegans as a surrogate host.
The basic approach for these studies is to create knock-out mutants through chromosomal “recombineering”, investigate the patterns of gene expression using reporter gene fusions and molecular techniques, and deduce the phenotypic consequences of the mutants by a combination of physiological experiments and infections of worms as well as human cells in culture.

Journal Articles

Book Sections

  • Actinomyces oris fimbriae: An adhesive principle in bacterial biofilms and tissue tropism
    Ton-That H, Das A, Mishra A Oral Biofilm Communities: Genomic Inquiry and Interspecies Communication 2011 Jan;63-77
  • Positive regulation of galactokinase synthesis by phage lambda nut site in plasmid pBR322
    Das A, Shoemaker K Microbiology 1983 Jan;49-52
  • Role of E. coli NusAB genes in lambda N protein mediated transcription antitermination in Plasmid pBR322 leading to galactokinase synthesis
    Das A, Shoemaker K, Wardwell J, Wolska K Microbiology 1983 Jan;43-48
  • Pleiotropy of rho mutation in E. coli
    Das A, Court D, Adhya S Molecular Basis of Host Virus Interactions 1979 Jan;459-468
  • Action of Indole Acetic Acid: a plant growth hormone on transcription
    Biswas BB, Das A, Ganguly A, Roy P Regulation of Growth and Differentiated Function in Eukaryotic Cells 1975 Jan;461-477
  • Eukaryotic RNA polymerases and the Controlling Systems
    Biswas BB, Ganguly A, Das A Progress in Nucleic Acids Research and Molecular Biology 1974 Jan;145-185
  • RNA polymerases and controlling factors from plant cell nuclei.
    Biswas, B B; Mondal, H; Ganguly, A; Das, A; Mandal, R K Basic life sciences 1974 Jan;3279-93

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