Carolyn M. Drazinic, M.D., Ph.D.

Assistant Professor, Psychiatry
Academic Office Location:
Psychiatry
University of Connecticut Health Center
263 Farmington Avenue
Farmington, CT 06030
Phone: 860-679-3316

Dr. Drazinic is a tenure-track assistant professor in the Department of Psychiatry and the Department of Genetics and Developmental Biology. She completed her adult psychiatry residency and post-doctoral fellowships at Yale University, where she was one of the founders of the Yale Behavioral Genetics Project, providing consultations on patients with VeloCardioFacial (DiGeorge or 22q11.2 Deletion) Syndrome, Williams Syndrome, Klinefelter Syndrome, and other chromosomal disorders with behavioral manifestations.

With the support of the General Clinical Research Center at UConn, Dr. Drazinic is actively recruiting patients and families with bipolar spectrum disorders, (bipolar disorder, schizoaffective disorder, or schizophrenia), and those with bipolar spectrum disorders with history of alcohol abuse, for her research on the genetic basis of these disorders. Subjects and family members are asked to donate a few tubes of blood for the UConn Behavioral Gene Bank (BGB) collection. Her laboratory is conducting pioneering molecular research with the donated BGB samples in order to identify new candidate genes for bipolar disorder, bipolar disorder with alcohol use disorders, and schizophrenia. Her laboratory utilizes the latest technologies, including microarrays, fluorescence in situ hybridization (FISH), and induction of pluripotent neuroprogenitor cells.

Dr. Drazinic also has a special interest in patients with white matter abnormalities on MRI scanning and the mental illnesses above, as well as patients with 18p monosomy (18p deletion syndrome, De Grouchy), a chromosomal abnormality in which some individuals have behaviors consistent with bipolar spectrum disorders or schizophrenia.

Education
DegreeInstitutionMajor
Ph.D.University of FloridaMolecular Genetics and Microbiology
M.D.College of Medicine, University of FloridaMedicine
OtherJunior Honors Accelerated Medical Program, University of FloridaAcademic
B.S.University of FloridaInterdisciplinary Major
DiplomaEustis High SchoolAcademic

Post-Graduate Training
TrainingInstitutionSpecialty
InternshipYale-New Haven HospitalPsychiatry
ResidencyYale-New Haven HospitalPsychiatry
FellowshipYale UniversityForensic Psychiatry Fellowship, Division of Law and Psychiatry
FellowshipYale University School of Medicine/West Haven Veterans Administration HospiNeuropsychiatry Fellowship, postdoctoral research with Dr. Joseph Cubells, Department of Psychiatry
FellowshipChild Study Center, Yale University School of MedicineChild Neurodevelopmental Fellowship, postdoctoral research with Dr. Matthew State Research topic: Molecular characterization of chromosomal abnormalities in patients with 18p monosomy and schizoaffective disorder

Awards
Name of Award/HonorAwarding Organization
Future Leaders in Psychiatry Award SymposiumEmory University
Junior Research Colloquium Award Recipient-2004
Career Development Institute Award RecipientUniversity of Pittsburgh and Stanford University
Laughlin Fellowship Award Recipient American College of Psychiatrists
Career Development Institute Award RecipientUniversity of Pittsburgh and Stanford University
Junior Research Colloquium Award Recipient-2003
Janssen Resident of the Year Award Recipient
Laughlin Merit Award for Excellence during ResidencyYale School of Medicine
NARSAD Young Investigator Award
Head of Call/CIU Task ForcePsychiatric Residents Association
Head of Call/CIU Task ForceYale University
ValedictorianEustis High School
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
American Psychiatric AssociationProfessional/Scientific OrganizationFellowExternalNational2012
Society of Biological Psychiatry: Education Committee Professional/Scientific OrganizationMemberExternalNational2012
Society of Biological PsychiatryProfessional/Scientific OrganizationJudge for best poster competitionExternalNational2011
Society of Biological Psychiatry: Education Task ForceProfessional/Scientific OrganizationMemberExternalNational2011
Society of Biological Psychiatry: Program Committee Professional/Scientific OrganizationMemberExternalNational2011
American College of Physician ExecutivesProfessional/Scientific OrganizationMemberExternalNational2010
American Society of Addiction MedicineProfessional/Scientific OrganizationMemberExternalNational2010
European Huntington’s Disease NetworkProfessional/Scientific OrganizationAssociate MemberExternalInternational2010
National Institute of Mental Health K99 Study SectionProfessional/Scientific OrganizationReviewerExternalNational20102010
Huntington’s Study GroupProfessional/Scientific OrganizationMemberExternalLocal2009
International Society of Psychiatric GeneticsProfessional/Scientific OrganizationMemberExternalInternational20062008
Behavioral Genetics AssociationProfessional/Scientific OrganizationMemberExternalNational2005
American Academy for the Advancement of ScienceProfessional/Scientific OrganizationMemberExternalNational20042005
Society of Biological PsychiatryProfessional/Scientific OrganizationAssociate MemberExternalNational2003
American Academy of Psychiatry and the LawProfessional/Scientific OrganizationMemberExternalNational2002
American Society for Human GeneticsProfessional/Scientific OrganizationMemberExternalNational20022007
Connecticut State Medical Society Professional/Scientific OrganizationMemberExternalState2000
American Psychiatry Association, Connecticut Psychiatric Society Professional/Scientific OrganizationMemberExternalNational1998
American Medical Association, Connecticut State Medical SocietyProfessional/Scientific OrganizationMemberExternalNational1996
Her laboratory is conducting pioneering molecular research with the donated BGB samples in order to identify new candidate genes for bipolar disorder, bipolar disorder with alcohol use disorders, and schizophrenia. Her laboratory utilizes the latest technologies, including microarrays, fluorescence in situ hybridization (FISH), and induction of pluripotent neuroprogenitor cells. Dr. Drazinic also has a special interest in patients with white matter abnormalities on MRI scanning and the mental illnesses above, as well as patients with 18p monosomy (18p deletion syndrome, De Grouchy), a chromosomal abnormality in which some individuals have behaviors consistent with bipolar spectrum disorders or schizophrenia.

Journal Articles

  • Characterization of a large group of individuals with huntington disease and their relatives enrolled in the COHORT study.
    Shoulson, Ira; Gusella, James; Foroud, Tatiana; Van Kammen, Daniel P; Foroud, Tatiana; Dorsey, E Ray; Warner, John; Giuliano, Joseph; Vetter, Louise; Suchowersky, Oksana; Beck, Christopher; Oakes, David; Marshall, Frederick; Marder, Karen; Frucht, Steven; Moskowitz, Carol; Clouse, Ronda; Wasserman, Paula; Shannon, Kathleen; Jaglin, Jeana; Jankovic, Josepth; Palao, Alicia; Harrison, Madaline; Singer, Carlos; Quesada, Monica; Hersch, Steven; Rosas, Diana; Tanev, Kaloyan; Malarick, Keith; Colcher, Amy; Sanchez-Ramos, Juan; Kostyk, Sandra; Paulsen, Jane; Perlmutter, Joel; Tabbal, Samer; Ross, Christopher; Dorsey, E Ray; Nucifora, Frederick; Dubinsky, Richard; Dubinsky, Hilary; Suchowersky, Oksana; Klimek, Mary Lou; Jones, Randi; Testa, Claudia; Factor, Stewart; Jennings, Dana; Morgan, John; Higgins, Donald; Molho, Eric; Adams, John; Frank, Samuel; Saint-Hilaire, Marie; Diggin, Melissa; Furtado, Sarah; Walker, Francis; O'Neill, Christines; Hunt, Vicki; Quaid, Kimberly; LeDoux, Mark; Raymond, Lynn; Leavitt, Blair; Decolongon, Joji; Perlman, Susan; Corey-Bloom, Jody; Peavy, Guerry; Goldstein, Jodi; Kumar, Rajeev; McCusker, Elizabeth; Griffith, Jane; Loy, Clement; Wheelock, Vicki; Tempkin, Terry; Martin, Amanda; Nance, Martha; Kang, Un; Mallonee, William; Suter, Greg; Revilla, Fred; Gartner, Maureen; Drazinic, Carolyn; Fitzpatrick, Mary Jane; Panisset, Michel; Duff, Kevin; Scott, Burton; Weiner, William; Robottom, Bradley; Chiu, Edmond; Yastrubetskaya, Olga; Churchyard, Andrew; Greenamyre, Timothy John; Agarwal, Pinky; Oakes, David; Beck, Christopher; Robertson, Suzanne; Holt, Dustina; Eaton, Ken; Lindsay, Patricia; Deuel, Lisa; MacDonald, Marcy; Antonijevic, Irina; Hickey, Charlyne; Muratori, Lisa; Louis, Elan; Doucette, Nick; Uc, Ergun; Rodnitzky, Robert; Leserman, Anne; Vik, Stacie; Davis, Robert; Dietrich, Susan; Segro, Vicki; Erickson, Diane; Hunt, Vicki; Lucarelli, Nancy; Broyles, Janice; DeLaRosa, Jeanen; Louis, Elan; Panegyres, Peter; Schmidt, Amy; Barton, Stacey; Sperin, Elaine; Testa, Claudia; Zauber, S Elizabeth; Wesson, Melissa; McInnis, Robert; Welsh, Claire; Wesson, Melissa; Coleman, Allison; Dorsey, E Ray (2012) PloS one 2 (7) e29522
  • Rapid array-based genomic characterization of a subtle structural abnormality: a patient with psychosis and der(18)t(5;18)(p14.1;p11.23).
    Drazinic, Carolyn M; Ercan-Sencicek, Adife G; Gault, Laura M; Hisama, Fuki M; Qumsiyeh, Mazin B; Nowak, Norma J; Cubells, Joseph F; State, Matthew W (2005) American journal of medical genetics. Part A 3 (134) 282-9
  • Activation mechanism of the multifunctional transcription factor repressor-activator protein 1 (Rap1p).
    Drazinic, C M; Smerage, J B; López, M C; Baker, H V (1996) Molecular and cellular biology 6 (16) 3187-96
  • Characterization of the DNA-binding activity of GCR1: in vivo evidence for two GCR1-binding sites in the upstream activating sequence of TPI of Saccharomyces cerevisiae.
    Huie, M A; Scott, E W; Drazinic, C M; Lopez, M C; Hornstra, I K; Yang, T P; Baker, H V (1992) Molecular and cellular biology 6 (12) 2690-700
  • Drawing the Line Between Mania with Capacity and Diminished Mental Capacity; The Jury Decides the Ultimate Question of Diminished Mental Capacity
    Drazinic, C.M. Journal of the American Academy of Psychiatry and the Law 1 (30) 174-178
  • Overturning Summary Judgment: Genuine Issues Preclude Summary Judgment in the Case of a Patient who Died of Hyperthermia at a State Hospital
    Drazinic, C.M. Journal of the American Academy of Psychiatry and the Law 1 (31) 131-136
Title or AbstractTypeSponsor/EventDate/YearLocation
Tizanidine to Treat Severe Jaw Dystonia in Young Huntington’s Disease PatientTalkSociety of Biological Psychiatry2013San Francisco, California
Mitochondrial Abnormalities in hESCs with Huntington’s Disease MutationTalkStem Conn Conference2013New Haven, Connecticut
Ultrastructural Abnormalities in hESCs with Huntington’s Disease MutationTalkStem Conn Conference2013New Haven, Connecticut
Brain Power: Explore the Mysteries of the MindTalkHigh School Career Day/ University of Connecticut 2013Farmington, Connecticut
Psychiatry: A Career in Discovering how the Brain Works. Rowe Mini-Medical/Dental School Insights into Dental Science and Clinical MedicineLectureUniversity of Connecticut 2013Storrs, Connecticut
Huntington’s Disease Second Annual Program SymposiumTalkThe University of Connecticut Health Center2013Farmington, Connecticut
Testimony to American Psychiatric Assembly about CPS Mental Health Response to Newtown TragedyOtherAmerican Psychiatric Assembly 2013
The New DSM-V Bible: The Devil is in the Details. Grand Rounds, Department of PsychiatryLectureThe University of Connecticut Health Center2013Farmington, Connecticut
“Can we Read the Brain the Way we Read a Book?”LectureCREC Medical Professions and Teacher Preparation Academy2013
Discovery Series: “Hidden Eating Disorders” LectureThe University of Connecticut Health Center2013Farmington, Connecticut
ECT Treatment Required for One of Two Depressed Sisters with Huntington’s DiseaseTalkSociety of Biological Psychiatry2012Philadelphia, Pennsylvania
Huntington’s Disease: A Dominant Neurological Illness with Substantial Psychiatric Comorbidity TalkManchester Memorial Hospital 2012Manchester, Connecticut
Huntington’s Disease: A Dominant Neurological Illness with Substantial Psychiatric Comorbidity TalkRockville Memorial Hospital2012Rockville, Connecticut
Huntington’s Disease Program TalkThe University of Connecticut Health Center2012Farmington, Connecticut
ECT Treatment for Medication-Refractory Depression, Persistent Suicidal Ideation, and Obsessions with Contamination in Advanced Huntington's DiseaseTalkWorld Congress on Huntington’s Disease2011Melbourne, Australia
The Neurobiology of Psychosis. PGY3 Advanced Neuropsychopharmacology SeminarTalkUniversity of Connecticut Health Center2011Farmington, Connecticut
First-Person Experiences of an MD/PhD Building a Career in Translational ResearchTalkTrinity College2011Hartford, Connecticut
Psychiatry: a Fascinating Career Discovering How Your Brain WorksTalkUniversity of Connecticut 2011Storrs, Connecticut
Persisting Challenges in Finding a Treatment, Even Though the Gene for Huntington's Disease is KnownTalkUniversity of Connecticut Health Center2011Farmington, Connecticut
Behavioral Genetics: the New Frontier in Translational ResearchTalkUniversity of Connecticut 2011Storrs, Connecticut
Justifying ECT Against Will in a Case of Advanced Huntington's Disease with Refractory Depression and ObsessionsTalkUniversity of Connecticut Health Center2011Farmington, Connecticut
Psychiatric Association with Medical DiseasesTalkU. Conn./Hartford Hospital2011Hartford, Connecticut
Open Review of Cases with Residents. Psychiatry Crash Course, Department of PsychiatryTalkThe University of Connecticut Health Center2011Farmington, Connecticut
When the Treatment Makes You Sick. Schwartz RoundsPanel DiscussionThe University of Connecticut Health Center2011Farmington, Connecticut
Schwartz Rounds, Physician panelistTalkUniversity of Connecticut Health Center2010Farmington, Connecticut
Behavioral Genetics Disorders. Advances in Psychiatry SeminarTalkDepartment of Psychiatry, University of Connecticut Health Center2010Farmington, Connecticut
Brain Power: The Latest About Psychiatry and Psychiatric Genetics ResearchTalkHigh School Career Day/ University of Connecticut Health Center2010Farmington, Connecticut
Persisting Challenges in Finding a Treatment, Even Though the Gene for Huntington's Disease is Known. Grand RoundsTalkUniversity of Connecticut Health Center2010Farmington, Connecticut
Huntington's Disease, Huntington's Disease ProgramOtherUniversity of Connecticut Health Center2010Farmington, Connecticut
Gene Disorders Cause Mental Disorders: The Promise of Translational ResearchTalkUniversity of Connecticut Health Center2010Farmington, Connecticut
Schwartz Rounds, Physician PanelistTalkUniversity of Connecticut Health Center2010Farmington, Connecticut
Ethics of Involuntary Hospitalization and Emergency Care in PsychiatryTalkUniversity of Connecticut Health Center2010Farmington, Connecticut
GRM7: A Novel Candidate Gene Implicated in Alcohol Dependence and Bipolar DisorderTalkUniversity of Connecticut2009
GRM7 Candidate Gene SNP Association and Novel Mutation Screening by High-Resolution DNA Melting Analysis Using LightScanner TechnologyTalkSociety of Biological Psychiatry2009Vancouver, Canada
Brain Power: The Latest About Psychiatry and Psychiatric Genetics ResearchTalkHigh School Career Day/ University of Connecticut Health Center2009Farmington, Connecticut
GRM7: A Novel Candidate Gene Implicated in Alcohol Dependence and Bipolar DisorderTalkDepartment of Psychiatry Research Bonanza/UConn Health Center2009Farmington, Connecticut
Childhood Behavioral Genetic Disorder. Child Psychiatry Fellowship Seminar SeriesTalkUniversity of Connecticut Health Center2009Farmington, Connecticut
High-throughput Screening for SNPs and Novel Mutations in the Bipolar Disorder Candidate Gene GRM7 by High Resolution DNA Melting Analysis Using Lightscanner TechnologyTalkAmerican College of Neuropsychopharmacology 2008Scottsdale, Arizona
Possibilities, Implications, and Limitations of Genetic MedicineTalkAmerican Medical Student Association2008Washington, D.C.
The New World: Discovering Genes that Cause Schizophrenia and Bipolar Disorder...Promise and PerilsTalkPsychiatry Interest Group2008Farmington, Connecticut
Breakpoints Lead to Breakthroughs in Bipolar Disorder with Comorbid AlcoholismTalkUniversity of Connecticut Health Center2008Farmington, Connecticut
Behavioral Gene Bank. National Alliance for the Mentally Ill (NAMI)TalkPrime Time House2008Torrington, Connecticut
Microarrays and FISH to Explore Genetic Abnormalities in Schizophrenia and Bipolar DisordersTalkHigh School Career Day University of Connecticut Health Center2008Farmington, Connecticut
Introduction to the Behavioral Gene Bank, Morning MeetingTalkInstitute of Living2008Hartford, Connecticut
Translational Genetics Research in Patients with Schizophrenia and Bipolar Disorders. MD/PhD Second Look Seminar SeriesTalkUniversity of Connecticut Health Center2008Farmington, Connecticut
No Child is Safe From Drugs, Celebrate Women SeriesTalkUniversity of Connecticut Health Center2008Farmington, Connecticut
Psychosis and Leukodystrophy in 18p Monosomy PatientsTalkUniversity of Connecticut Health Center2008Farmington, Connecticut
A Case and Point of Why New Treatments Must be Developed for Bipolar DisorderTalkUniversity of Connecticut Health Center2008Farmington, Connecticut
Leukodystrophy and Behavioral Abnormalities in a 4-Year Old Dysmorphic Male with 18p MonosomyTalkWorld Congress on Psychiatric Genetics2007New York, New York
Dysmorphology, Mental Illness, and Learning Disabilities: Genetic Syndromes with Behavioral PhenotypesTalkAmerican Psychiatric Association2007San Diego, California
Behavioral Phenotypes of Genetic SyndromesTalkUniversity of Connecticut Health Center2007Farmington, Connecticut
Behavioral Gene Bank. Depression and Bipolar Support Alliance TalkCharlotte Hungerford Hospital2007Torrington, Connecticut
Breakpoints Lead to Breakthroughs in Understanding Mental IllnessTalkUniversity of Connecticut Health Center2007Farmington, Connecticut
Anxiety Disorders in Williams SyndromeTalkWilliams Syndrome Annual Conference2006Richmond, Virginia
Is There a Biological Basis for Gender Identity Disorder? Grand RoundsTalkUniversity of Connecticut Health Center2006Farmington, Connecticut
Microarray Analysis in a Second Reported Case of 18p11.2 Monosomy in a Psychotic PatientTalkAmerican Society of Human Genetics 2005Salt Lake City, Utah
Rapid Genomic Array Analysis of Copy Number Abnormalities in a Patient with PsychosisPosterAmerican College of Neuropsychopharmacology 2004San Juan, Puerto Rico
Genomic Array Analyses of an Unbalanced Chromosome 18 Translocation in a Patient with PsychosisPosterAmerican Society of Human Genetics2004Toronto, Canada
Large-Scale Molecular Screening of Clozapine-Treated Psychotic Patients for the 22q11.2 DeletionPosterInternational Conference for 22q11.2 Deletions2004Atlanta, Georgia
Feasibility of Large-Scale FISH Screening of Refractory Schizophrenic Patients for the 22q11.2 Chromosomal DisorderTalkSociety of Biological Psychiatry2004
Molecular Survey for VCFS Deletions in Clozapine-Treated Psychotic PatientsTalkThird International Deletion 22q11.2 Meeting2002Rome, Italy
The Changing Relationship Between the Pharmaceutical Industry and Psychiatric TrainingTalkDepartment of Psychiatry Alumni Day, Yale University2002New Haven, Connecticut
Genetics of Aggression and Its Legal ImplicationsLectureAmerican Academy of Psychiatry and the Law2002Newport Beach, California
Use of Synthetic UAS Elements to Study the Importance of Spatial Relationships Between Rap1p- and Gcr1p-Binding SitesTalkInternational Conference on Yeast Genetics and Molecular Biology1995Lisbon, Portugal
Combinatorial Interactions Between Transcription Factors at Glycolytic Enzyme Gene UAS ElementsTalkInternational Conference on Yeast Genetics and Molecular Biology1995Lisbon, Portugal
Native Gcr1p Requires a Functional CT-Box to Mediate GCR1-Dependent Gene ExpressionTalkYeast Genetics and Molecular Biology Meeting1994Seattle, Washington
A Model for the Concerted Action of REB1, RAP1, and GCR1 in High-Level Expression of the Glycolytic Gene TPITalkInternational Conference on Yeast Genetics and Molecular Biology1992Vienna, Austria