Faculty Directory › UConn Health

Jeremy R. Egbert, Ph.D.

Assistant Professor, Department of Cell Biology


Academic Office Location: Cell Biology, E-6029 UConn Health 263 Farmington Avenue Farmington, CT 06030-3636
Phone:	860-679-2677
Email:	EGBERT@uchc.edu
Website(s):	Lab website

Overview
Education & Training
Publications
Presentations

Dr. Egbert joined the UConn Health faculty in 2016 after postdoctoral training in the lab of Prof. Laurinda Jaffe at UConn Health. As a postdoc, Dr. Egbert studied the mechanisms by which luteinizing hormone (LH) signaling rapidly reduces cGMP levels in the granulosa cells of ovarian follicles. The decrease in cGMP levels causes the oocyte to resume meiosis, which is required for the oocyte to be fertilized. Dr. Egbert is currently using novel mice that express different calcium sensors and confocal microscopy to study the mechanisms and functions of calcium increases within granulosa cells in response to the gonadotropins follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Dr. Egbert received his PhD in 2011 from Washington State University, working in the lab of Prof. Hubert Schwabl to study the sources of variation in the levels of avian yolk steroids, which impact offspring health and behavior.

Education

Degree	Institution	Major
B.S.	Boise State University	Biology
M.S.	Washington State University	Zoology
Ph.D.	Washington State University	Zoology

Degree

Institution

Major

B.S.

Boise State University

Biology

M.S.

Washington State University

Zoology

Ph.D.

Washington State University

Zoology

Post-Graduate Training

Training	Institution	Specialty
Scientific Training	Marine Biological Laboratory	Attended Frontiers in Reproduction, a 6-week scientific training course May — June 2011.

Training

Institution

Specialty

Scientific Training

Marine Biological Laboratory

Attended Frontiers in Reproduction, a 6-week scientific training course May — June 2011.

Awards

Name of Award/Honor	Awarding Organization
Trainee Travel Fund Award, SSR annual meeting.	Larry Ewing Memorial
Brislawn Graduate Fellowship	WSU
Abelson Science Scholarship (3 years)	WSU
2003 Best Poster Award	Cooper Ornithological Society meeting, Flagstaff, AZ
Associate Member, Sigma Xi	The Scientific Research Society, BSU Chapter
Top Ten Scholars Award, 2002 — 2003 academic year.	Boise State University
Scholarship, BSU (4 years)	Laura Moore Cunningham Foundation

Name of Award/Honor

Awarding Organization

Trainee Travel Fund Award, SSR annual meeting.

Larry Ewing Memorial

Brislawn Graduate Fellowship

WSU

Abelson Science Scholarship (3 years)

WSU

2003 Best Poster Award

Cooper Ornithological Society meeting, Flagstaff, AZ

Associate Member, Sigma Xi

The Scientific Research Society, BSU Chapter

Top Ten Scholars Award, 2002 — 2003 academic year.

Boise State University

Scholarship, BSU (4 years)

Laura Moore Cunningham Foundation

Journal Articles

Phosphatases modified by LH signaling in ovarian follicles: testing their role in regulating the NPR2 guanylyl cyclase.
Egbert, Jeremy R*; Silbern, Ivan; Uliasz, Tracy F; Lowther, Katie M; Yee, Siu-Pok; Urlaub, Henning*; Jaffe, Laurinda A* Biology of reproduction 2023 Sep;
Epitope-tagged and phosphomimetic mouse models for investigating natriuretic peptide-stimulated receptor guanylyl cyclases.
Egbert, Jeremy R*; Uliasz, Tracy F; Lowther, Katie M; Kaback, Deborah; Wagner, Brandon M; Healy, Chastity L; O'Connell, Timothy D; Potter, Lincoln R; Jaffe, Laurinda A*; Yee, Siu-Pok* Frontiers in molecular neuroscience 2022 Oct;151007026
A CRISPR toolbox for generating intersectional genetic mouse models for functional, molecular, and anatomical circuit mapping.
Lusk, Savannah J; McKinney, Andrew; Hunt, Patrick J; Fahey, Paul G; Patel, Jay; Chang, Andersen; Sun, Jenny J; Martinez, Vena K; Zhu, Ping Jun; Egbert, Jeremy R; Allen, Genevera; Jiang, Xiaolong; Arenkiel, Benjamin R; Tolias, Andreas S; Costa-Mattioli, Mauro; Ray, Russell S BMC biology 2022 Jan;20(1):28
Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth.
Shuhaibar, Leia C; Kaci, Nabil; Egbert, Jeremy R; Horville, Thibault; Loisay, Léa; Vigone, Giulia; Uliasz, Tracy F; Dambroise, Emilie; Swingle, Mark R; Honkanen, Richard E; Biosse Duplan, Martin; Jaffe, Laurinda A; Legeai-Mallet, Laurence JCI insight 2021 May;6(9):e141426
Cyclic AMP links luteinizing hormone signaling to dephosphorylation and inactivation of the NPR2 guanylyl cyclase in ovarian follicles.
Egbert, Jeremy R; Robinson, Jerid W; Uliasz, Tracy F; Potter, Lincoln R; Jaffe, Laurinda A Biology of reproduction 2021 Feb;104(5):939-941
Cellular heterogeneity of the LH receptor and its significance for cyclic GMP signaling in mouse preovulatory follicles.
Baena, Valentina; Owen, Corie M; Uliasz, Tracy F; Lowther, Katie M; Yee, Siu-Pok; Terasaki, Mark; Egbert, Jeremy R; Jaffe, Laurinda A Endocrinology 2020 May;161(7)bgaa074
Follicle-stimulating hormone and luteinizing hormone increase Ca2+ in the granulosa cells of mouse ovarian follicles.
Egbert, Jeremy R; Fahey, Paul G; Reimer, Jacob; Owen, Corie M; Evsikov, Alexei V; Nikolaev, Viacheslav O; Griesbeck, Oliver; Ray, Russell S; Tolias, Andreas S; Jaffe, Laurinda A Biology of Reproduction 2019 Aug;101(2)433-444
Multiple cAMP phosphodiesterases act together to prevent premature oocyte meiosis and ovulation.
Vigone, Giulia; Shuhaibar, Leia C; Egbert, Jeremy R; Uliasz, Tracy F; Movsesian, Matthew A; Jaffe, Laurinda A Endocrinology 2018 Mar;1592142-2152
Luteinizing hormone signaling phosphorylates and activates the cyclic GMP phosphodiesterase PDE5 in mouse ovarian follicles, contributing an additional component to the hormonally induced decrease in cyclic GMP that reinitiates meiosis.
Egbert, Jeremy R; Yee, Siu-Pok; Jaffe, Laurinda A Developmental biology 2018 Mar;435(1):6-14
Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor.
Shuhaibar, Leia C; Robinson, Jerid W; Vigone, Giulia; Shuhaibar, Ninna P; Egbert, Jeremy R; Baena, Valentina; Uliasz, Tracy F; Kaback, Deborah; Yee, Siu-Pok; Feil, Robert; Fisher, Melanie C; Dealy, Caroline N; Potter, Lincoln R; Jaffe, Laurinda A eLife 2017 Dec;6
Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B.
Robinson, Jerid W; Egbert, Jeremy R; Davydova, Julia; Schmidt, Hannes; Jaffe, Laurinda A; Potter, Lincoln R Cellular signalling 2017 Sep;40222-229
Regulation of Mammalian Oocyte Meiosis by Intercellular Communication Within the Ovarian Follicle.
Jaffe, Laurinda; Egbert, Jeremy R Annual review of physiology 2017 Jan;79237-260
Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis.
Egbert, Jeremy R; Uliasz, Tracy F; Shuhaibar, Leia C; Geerts, Andreas; Wunder, Frank; Kleiman, Robin J; Humphrey, John M; Lampe, Paul D; Artemyev, Nikolai O; Rybalkin, Sergei D; Beavo, Joseph A; Movsesian, Matthew A; Jaffe, Laurinda A Biology of reproduction 2016 May;94(5):110
Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.
Shuhaibar, Leia C; Egbert, Jeremy R; Edmund, Aaron B; Uliasz, Tracy F; Dickey, Deborah M; Yee, Siu-Pok; Potter, Lincoln R; Jaffe, Laurinda A Developmental biology 2015 Oct;409194-201
Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.
Shuhaibar, Leia C; Egbert, Jeremy R; Norris, Rachael P; Lampe, Paul D; Nikolaev, Viacheslav O; Thunemann, Martin; Wen, Lai; Feil, Robert; Jaffe, Laurinda A Proceedings of the National Academy of Sciences of the United States of America 2015 Mar;112(17):5527-32
Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.
Egbert, Jeremy R; Shuhaibar, Leia C; Edmund, Aaron B; Van Helden, Dusty A; Robinson, Jerid W; Uliasz, Tracy F; Baena, Valentina; Geerts, Andreas; Wunder, Frank; Potter, Lincoln R; Jaffe, Laurinda A Development (Cambridge, England) 2014 Sep;141(18):3594-604

Title or Abstract	Type	Sponsor/Event	Date/Year	Location
Effect of tamoxifen on yolk steroid levels in house sparrows: toward a mechanism of yolk steroid accumulation	Talk	American Ornithologist’s Union meeting	2009	Philadelphia, PA
A novel experimental test of the relationship between plasma and yolk testosterone levels in the house sparrow (Passer domesticus)	Talk	Society for Integrative and Comparative Biology meeting	2007	Phoenix, AZ
Behavioral and endocrine responses of female house sparrows to a social challenge: the relationship between plasma and yolk testosterone	Poster	North American Ornithological Congress	2006	Veracruz, Mexico
Wing shape in house finches differs relative to migratory habit in eastern and western North America	Poster	Cooper Ornithological Society meeting	2003	Flagstaff, AZ

Title or Abstract

Type

Sponsor/Event

Date/Year

Location

Effect of tamoxifen on yolk steroid levels in house sparrows: toward a mechanism of yolk steroid accumulation

Talk

American Ornithologist’s Union meeting

2009

Philadelphia, PA

A novel experimental test of the relationship between plasma and yolk testosterone levels in the house sparrow (Passer domesticus)

Talk

Society for Integrative and Comparative Biology meeting

2007

Phoenix, AZ

Behavioral and endocrine responses of female house sparrows to a social challenge: the relationship between plasma and yolk testosterone

Poster

North American Ornithological Congress

2006

Veracruz, Mexico

Wing shape in house finches differs relative to migratory habit in eastern and western North America

Poster

Cooper Ornithological Society meeting

2003

Flagstaff, AZ