Photo of Alan  Fein, Ph.D.

Alan Fein, Ph.D.

Professor, Department of Cell Biology
Academic Office Location:
Cell Biology
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3505
Phone: 860-679-2263
Fax: 860-679-1269
Website(s):

Fein Lab Page

Cell Biology Graduate Program

Education
DegreeInstitutionMajor
B.S.E.E.City College of New YorkElectrical Engineering
M.S.Columbia UniversityElectical Engineering
Ph.D.Johns Hopkins Medical School Biomedical Engineering

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralJohns Hopkins UniversityBiophysics

Awards
Name of Award/HonorAwarding Organization
Zyma Foundation Fellow-1987
Zyma Foundation Fellow-1986
Fogarty Senior International Fellowship-1980
Fogarty Senior International Fellowship-1979
M.B.L. Award-1978
Alfred P. Sloan Fellow-1977
Alfred P. Sloan Fellow-1976
Alfred P. Sloan Fellow-1975
Grass Fellow-1972
N.I.H. Special Research Fellow-1971
N.I.H. Special Research Fellow-1970
N.I.H. Special Research Fellow-1969
N.I.H. Special Research Fellow-1968

My research has two primary goals. The first is to elucidate the molecular basis of visual excitation and adaptation. The basic approach is to use electrophysiological and pharmacological techniques to study phototransduction of individual photoreceptor cells. The second, done in collaboration with Dr. Terasaki, is to study membrane disruption and repair using combined electrophysiological and optical techniques.

Not accepting students for Lab Rotations at this time

Lab Rotation Projects Fein/Terasaki Lab Cell Wounding Project We have developed an electrophysiological method for studying plasma membrane wound repair in single cells. Large plasma membrane disruptions in starfish oocytes, made by femtosecond pulses from a Ti-Sapphire laser, are repaired within a few seconds as shown by stabilization of membrane electrical properties and restoration of dye exclusion. The membrane potential after wounding is sensitive to the extracellular Cl- concentration but not to that of Na+, K+ or H+ indicating that Cl- permeable intracellular membranes have fused with the plasma membrane. We believe that cell wounding provides a novel means for the electrophysiological analysis of chloride permeable intracellular membranes that have been translocated to the plasma membrane.

Journal Articles

Book Chapters

  • Phototransduction in Limulus Ventral Photoreceptors: Roles of Calcium and Inositol Trisphosphate
    Fein, A. and R. Payne Facets of Vision
  • The Release of Calcium by Light in the Photoreceptors of Invertebrates
    Payne, R. and A. Fein G Proteins and Calcium Signaling

Letters

Title or AbstractTypeSponsor/EventDate/YearLocation
Sensory Transduction and Cell Physiology of Photo- and Chemoreceptors in Invertebrates Talk1993Regensburg, Germany
The Biology and Chemistry of VisionTalkFederation of American Societies for Experimental Biology1991
The Biology and Chemistry of VisionTalkFederation of American Societies for Experimental Biology1989
Molecular Physiology of Retinal ProteinsTalkXXI Yamada Conference 1988Kyoto, Japan
The Biology and Chemistry of VisionTalkFederation of American Societies for Experimental Biology1987
Inositol LipidsTalkRoyal Society Discussion Meeting 1987London, England
Facets of Vision, Compound Eyes, from Exner to Autrum and BeyondTalkInternational symposium on Compound Eyes1987Regensburg, West Germany
The Biology and Chemistry of VisionTalkFederation of American Societies for Experimental Biology1985
Calcium and the CellTalkCiba Foundation Symposium 1985London, England