Photo of Gloria  Gronowicz, Ph.D.

Gloria Gronowicz, Ph.D.

Professor, Department of Surgery
Academic Office Location:
Surgery
Orthopaedics
University of Connecticut Health Center
263 Farmington Avenue MC3105
Farmington, CT 06030-3105
Phone: 860-679-3842
Fax: 860-679-2103
Email: gronowicz@nso1.uchc.edu
Website(s): Skeletal, Craniofacial & Oral Biology Graduate Program
Education
DegreeInstitutionMajor
Ph.D.Columbia UniversityCell Biology
B.B.A.Barnard CollegeBiology

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralUniversity of Chicago
PostdoctoralUConn Health CenterPostdoc with Dr. Gideon Rodan

Awards
Name of Award/HonorAwarding Organization
Elected Director of the Skeletal Craniofacial and Oral Biology (SCOB) Graduate programSCOB faculty
Merit Award Connecticut Microscopy Society
“Outstanding Service as Chair of Connective Tissue Subject Committee” award UConn Schools of Medicine and Dental Medicine
The major interest of my laboratory is the study of bone cell responses to implants in aging. Both dental and orthopaedic implant materials are being investigated. Presently with Drs. Kuhn and Hurley, we are developing new implant materials that are able to sequentially release different growth factor to stimulate bone formation. These novel scaffolds are being applied to a critical-size, bone defect model in aging mice and in human osteoblast cultures that are derived from bone discarded after orthopaedic procedures in elderly patients. We are also studying the effect of an integrative medicine therapy, Therapeutic Touch, on the growth and differentiation of bone cells and osteosarcoma-derived cell lines. Therapeutic Touch involves the application of human biofields from practitioners’ hand. Plates of cells are treated twice a week for 10 minutes without any touching. We have found highly significant effects on cell proliferation and differentiation compared to untreated cells and placebo-treated cells. Presently we are also working with a breast cancer model in mice, treating these mice with Therapeutic Touch and studying tumor growth, metastasis and immune responses. Our third project is to study the etiology of otosclerosis. Otosclerosis is a focal disease of the human temporal bone and is among the most common causes of acquired hearing loss in the U.S., as it affects 0.1-1% of the general population. There are several stage of otosclerosis but the last stage involves hypermineralization of the stapes bone. We acquire stapes bone discarded from patients with otosclerosis and compare their phenotypic properties with osteoblast cultures from peripheral bone of age and sex-matched patients and from normal stapes of patients with other medical issues that require removal of the normal stapes. We have also found that bisphosphonates can normalize the properties of the otosclerotic cultures and we are presently studying the effects of bisphosphonates on these bone cells. We use molecular biology, histology, histomorphometry and biochemistry to address these research projects.

Not accepting students for Lab Rotations at this time


Lab Rotation Projects
Please contact Dr. Gronowicz, if interested in any of these projects.

Journal Articles

Book Chapters

  • Chapter 2 Cell Biology
    Gronowicz, G. and K. Sagomonyants Regenerative Engineering 2013 Jun;Chapt 2
  • Integrin activated responses to metallic implant surfaces.
    Sagomonyants, K and G. Gronowicz Comprehensive Biomaterials 2011 Oct;Vol 4, Chapt 9101-113

Abstracts

  • Collagen Type I reporter mice: a tool for determining progenitor cell differentiation to functional osteoblasts
    Kuhn, LT, L Zhu, E Jacobs, DW Rowe, J. Goldberg, M. Hurley, G. Gronowicz. 2013 Jan;
  • Osteoblast cultures from the stapes of patients with otosclerosis demonstrate hypermineralization, which is corrected by alendronate
    Gronowicz, G, Y. Richardson, J. Flynn, G. Leonard and K. Parham Transactions of the Annual Meeting of the Orthopaedic Research Society 2012 Jan;
  • Non-physiological mineral deposition in vitro by primary human osteoblasts under osteogenic conditions.
    L.F. Charles, J.L. Woodman, A.J. Goldberg, G.A. Gronowicz and L.T. Kuhn Northeast Bioengineering Conference 2010 Jan;
  • Biomimetic method for coating tissue culture polystyrene with carbonated hydroxyapaptite.
    Kuhn, L.T.; Advincula, M.C.; Liu, Y.; Gronowicz, G.; Habibovic, P. and Goldberg, A.J. J. Dent. Res 2009 Jan; 88
  • Release of multiple growth factors for stimulating endogenous progenitor cells in aging bone.
    Kuhn,LT, G Ou, M Hurley, G Gronowicz 9th World Biomaterials Conference, China.

Conference Papers

Letters

Reviews

Title or AbstractTypeSponsor/EventDate/YearLocation
Effects of Therapeutic Touch on mice with breast cancer tumorsPlenary LectureTT Advanced International2013Craryville, NY
Effects of Therapeutic Touch on Cell Culture and Cancer in MiceOtherTheosophical Society2012 at Pumpkin Hollow in Craryville, NY.