UCONN

HEALTH

Photo of Marc F. Hansen, Ph.D.

Marc F. Hansen, Ph.D.

Professor of Medicine, Genetics and Developmental Biology
Academic Office Location:
Center for Molecular Oncology
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3101
Phone: 860-679-2261
Fax: 860-679-7639
Website(s):

Center for Molecular Oncology

Cell Biology Graduate Program

Genetics and Developmental Biology Graduate Program

Skeletal Biology and Regeneration Graduate Program

Education
DegreeInstitutionMajor
B.A.Macalester CollegeBiology/Chemistry
M.S.University of WisconsinBacteriology
Ph.D.University of Cincinnati College of MedicineMolecular Genetics

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralLudwig Institute for Cancer ResearchCharacterization of tumor suppressor genes in human cancer

Awards
Name of Award/HonorAwarding Organization
John G. Haddad Jr. Annual Research AwardPaget Foundation
Outstanding Faculty AwardUniv. Texas/Houston
Biology HonorsMacalester College
William R. Angell Award for Outstanding Biology StudentMacalester College
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Meta GeneProfessional/Scientific JournalExecutive EditorExternalNational2013
NCI ZCA1 SRLB-Q (M1) R – Validation and Advanced Development of Emerging Technologies for Cancer ResearchProfessional/Scientific OrganizationVice ChairExternalNational20132013
NCI SRLB-X (M1) R – Omnibus R03/R21: Developmental TherapeuticsProfessional/Scientific OrganizationChairmanExternalNational20132013
NCI ZCA1 RTRB-Z (M1) R – Omnibus R03/R21: TherapeuticsProfessional/Scientific OrganizationMemberExternalNational20132013
NCI ZCA1 SRLB-R (M1) R – Cancer Prevention Research Small Grant ProgramProfessional/Scientific OrganizationMemberExternalNational20132013
NIH ZRG1 MOSS-B (02) M - Salivary Glands, Oral Microbiology and Oral PathologyProfessional/Scientific OrganizationMemberExternalNational20132013
NCI ZCA1 SRLB-X (Q1) R – Nanotechnology in CancerProfessional/Scientific OrganizationChairmanExternalNational20132013
NCI ZCA1 RTRB-E (O1) R - Validation and Advanced Development of Emerging Molecular Analysis Technologies for Cancer Research (R33)Professional/Scientific OrganizationChairmanExternalNational20132013
NCI ZCA1 RTRB-Z (O2) M – Special Emphasis Panel for T32 Application ReviewProfessional/Scientific OrganizationChairmanExternalNational20132013
NCI ZCA1 SRLB-4 (J1) S - Omnibus Grants on Cancer Genetics and EtiologyProfessional/Scientific OrganizationChairmanExternalNational20132013
NCI ZCA1 SRLB-R (J1) R - NCI Director’s Provocative QuestionsProfessional/Scientific OrganizationMemberExternalNational20132013
University of Connecticut Health Center: MSI Research Day Organizing CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity20122012
University of Connecticut Health Center: Hearing Committee for Misconduct in ResearchProfessional/Scientific OrganizationMemberUConn HealthUniversity20122012
University of Connecticut Health Center:Professional/Scientific OrganizationMemberUConn HealthUniversity2012
NCI SEP ZCA1 SRLB-9 (M1) R - Provocative Questions R01Professional/Scientific OrganizationCo-ChairExternalNational20122012
NCI ZCA1 SRLB-D (M1) R - Provocative Questions R21Professional/Scientific OrganizationMemberExternalNational20122012
NCI ZCA1 SRLB-4 (O1) R - Validation and Advanced Development of Emerging Technologies for Cancer Research (R33)Professional/Scientific OrganizationChairmanExternalNational20122012
NCI ZCA1 SRLB-V (J2) R – Cancer DetectionProfessional/Scientific OrganizationChairmanExternalNational20122012
NCI ZCA1 SRLB-4 (J1) B - Strategic Partnering to Evaluate Cancer Signatures IIProfessional/Scientific OrganizationChairmanExternalNational20122012
Nanomedicine: Nanotechnology, Biology, and MedicineProfessional/Scientific JournalAssociate EditorExternalNational2011
GeneProfessional/Scientific JournalBoard of Editors and Associate EditorExternalNational2011
NCI SEP ZCA1 SRLB-9 (M1) R - In vivo Cellular and Molecular Imaging CentersProfessional/Scientific OrganizationVice ChairExternalNational20112011
NCI SEP ZCA1 SRLB-V (M1) R – Emerging Technologies for Cancer ResearchProfessional/Scientific OrganizationChairmanExternalNational20112011
NCI SEP ZCA1 SRLB-5 (O1) R - Innovative Emerging Molecular Analysis TechnologiesProfessional/Scientific OrganizationMemberExternalNational20112011
NCI SEP ZCA1 SRLB-9 (O1) B - Advanced in Vivo Imaging to Understand Cancer SystemsProfessional/Scientific OrganizationVice-ChairExternalNational20112011
NCI SEP ZCA1 SRLB-X (O1) R - Cancer Diagnostic and Therapeutic Agents Enabled by NanotechnologyProfessional/Scientific OrganizationChairmanExternalNational2011
USAMRMC Peer Reviewed Medical Research Program:Paget’s Disease Review CommitteeProfessional/Scientific OrganizationMemberExternalNational20112011
USAMRMC PRMRP: Osteoporosis and Related Bone Disease Panel 2 Review CommitteeProfessional/Scientific OrganizationMemberExternalNational20112011
NCI SEP ZCA1 SRLB-4 (J1) S - Strategic Partnering to Evaluate Cancer SignaturesProfessional/Scientific OrganizationMemberExternalNational20112011
NCI SEP ZCA1 SRLB-V (j1) R – Cancer Target Discovery and DevelopmentProfessional/Scientific OrganizationMemberExternalNational20112011
University of Connecticut Health Center: Search Committee, Chairman of Cell BiologyProfessional/Scientific OrganizationMemberUConn HealthUniversity20102011
University of Connecticut Health Center: PhD Admissions Review CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity2010
NCI SEP ZCA1 SRLB-9 (M1) R In vivo Cellular and Molecular Imaging Centers (ICMICs)Professional/Scientific OrganizationChairmanExternalNational20102010
NCI SEP ZCA1 SRLB-R (M1) R Exceptional, Unconventional Research Enabling Knowledge Acceleration (EUREKA)Professional/Scientific OrganizationChairmanExternalNational20102010
NIH SEP ZRG1 MOSS-G (55) R RFA-OD-10-005 Director's Opportunity 5 Themes Oral Musculoskeletal and ImagingProfessional/Scientific OrganizationMemberExternalNational20102010
NCI SEP ZCA1 RTRB-Z (M2) R Special Emphasis PanelProfessional/Scientific OrganizationMemberExternalNational20102010
NCI SEP ZCA1 SRLB-R (O1) – Emerging Technologies for Cancer ResearchProfessional/Scientific OrganizationChairmanExternalNational20102010
NCI SEP ZCA1 SRLB-X (J1) R – Emerging Technologies for Cancer ResearchProfessional/Scientific OrganizationChairmanExternalNational20102010
NCI SEP ZCA1 SRLB-4 (J1) B ¬– Strategic Partnering to Evaluate Cancer SignaturesProfessional/Scientific OrganizationChairmanExternalNational20102010
Comitato Telethon Fondazione Onlus E Fondazione Telethon Grant Review PanelProfessional/Scientific OrganizationMemberExternalNational20102011
USAMRMC Breast Cancer Research Program TRN CBY-A Peer Review CommitteeProfessional/Scientific OrganizationMemberExternalNational20092009
NCI SEP ZCA1 PCRB-A (A1) S LRP OD-09-108 Clinical Research Loan Repayment ProgramProfessional/Scientific OrganizationMemberExternalNational2009
National Cancer Institute SEP ZCA1 SRLB-V (M1) Application of Emerging TechnologiesProfessional/Scientific OrganizationChairmanExternalNational20092009
National Cancer Institute SEP ZCA1 SRLB-9 (O1) Physical Sciences-Oncology CentersProfessional/Scientific OrganizationCo-ChairmanExternalNational20092009
National Institutes of Health SEP ZRG1 MOSS-A (96) S Skeletal Biology II ARRA CRProfessional/Scientific OrganizationMemberExternalNational20092009
National Institutes of Health SEP ZRG1 MOSS-C (58) R RFA OD-09-003: Challenge GrantsProfessional/Scientific OrganizationMemberExternalNational20092009
NCI SEP ZCA1 PCRB-G (O9) R NCI-ARRA P30 Biomedical Research Core Centers ReviewProfessional/Scientific OrganizationMemberExternalNational20092009
National Cancer Institute SEP ZCA1 SRLB-4 (O2) R Bio-specimen PreparationProfessional/Scientific OrganizationChairmanExternalNational20092009
NCI SEP ZCA1 SRLB-4 (O9) R Grand Opportunities Grants in Human Cancer ProteomicsProfessional/Scientific OrganizationChairmanExternalNational20092009
Howard Hughes Medical Institute Med Into Grad Review PanelProfessional/Scientific OrganizationMemberExternalState20092009
NCI SEP ZCA1 SRLB-U (O9) R NCI ARRA GO - Transcriptional & TranslationalProfessional/Scientific OrganizationChairmanExternalNational20092009
National Institutes of Health SEP ZRG1 CBSS-P (08) F - Tumor BiomarkersProfessional/Scientific OrganizationMemberExternalNational20092009
NCI SEP ZCA1 SRLB-V (J1) R Applied Emerging Technologies in Biospecimen ScienceProfessional/Scientific OrganizationChairmanExternalNational20092009
National Cancer Institute SEP ZCA1 GRB-S (M1) P Molecular OncologyProfessional/Scientific OrganizationMemberExternalNational20082008
National Institute of Arthritis, Musculoskeletal and Skin Diseases SEP ZAR1 MLB-G (M2)Professional/Scientific OrganizationMemberExternalNational20082008
National Cancer Institute SEP ZCA1 SRRB-4 (M1) Application of Emerging TechnologiesProfessional/Scientific OrganizationChairmanExternalNational20082008
National Institutes of Health SEP ZRG1 MOSS-L (04) Skeletal Biology/DiseaseProfessional/Scientific OrganizationMemberExternalNational20082008
National Cancer Institute SEP ZCA1 SRRB-4 (01) Application of Emerging TechnologiesProfessional/Scientific OrganizationChairmanExternalNational20082008
National Center for Research Resources SEP ZRR1 RI-4 (01) INBRE AwardsProfessional/Scientific OrganizationMemberExternalNational20082008
National Cancer Institute SEP ZCA1 SRRB-4 (J1) Application of Emerging TechnologiesProfessional/Scientific OrganizationChairmanExternalNational20082008
University of Connecticut Health Center: Translational Genomic Core Facility Advisory CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity2007
University of Connecticut Health Center: Health Center Appeals CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity20072007
National Cancer Institute SEP ZCA1 GRB-S (M1) Molecular Biology PPG SEPProfessional/Scientific OrganizationMemberExternalNational20072007
National Cancer Institute SEP ZCA1 SRRB-4 (M1) Application of Emerging TechnologiesProfessional/Scientific OrganizationMemberExternalNational20072007
National Institutes of Health SEP ZRG1 MOSS-B (02) Skeletal Biology/DiseaseProfessional/Scientific OrganizationMemberExternalNational20072007
USAMRMC Prostate Cancer Research Program MBG-2 Peer Review CommitteeProfessional/Scientific OrganizationMemberExternalNational20072010
University of Connecticut Health Center: Intercampus Interdisciplinary Oncology Program Steering CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity20062007
University of Connecticut Health Center: ACS Institutional Research Award Review CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity2006
National Institutes of Health SEP ZRG1 MOSS-B Skeletal Biology/DiseaseProfessional/Scientific OrganizationMemberExternalNational20062006
National Cancer Institute SEP ZCA1 SRRB-9 (M1) for NCI RFA CA-06-003Professional/Scientific OrganizationMemberExternalNational20062006
National Cancer Institute SEP ZCA1 RPRB-O (O2) Cellular and Tissue BiologyProfessional/Scientific OrganizationMemberExternalNational20062006
National Cancer Institute SEP ZCA1 SRBB-4 (O1) Application of Emerging TechnologiesProfessional/Scientific OrganizationChairmanExternalNational20062006
National Cancer Institute SEP ZCA1 SRRB-9 (O1) for NCI RFA CA-07-005Professional/Scientific OrganizationMemberExternalNational20062006
National Cancer Institute IRG Subcommittee I on Career DevelopmentProfessional/Scientific OrganizationMemberExternalNational2006
National Cancer Institute Ad Hoc Review Committee for K99/R00 AwardsProfessional/Scientific OrganizationMemberExternalNational20062006
National Institute of Biomedical Imaging and Bioengineering SEP ZEB1 OSR-A (J1)Professional/Scientific OrganizationMemberExternalNational20062006
National Cancer Institute SEP ZCA1 RTRB-Z (J1) Transition Career Development AwardProfessional/Scientific OrganizationMemberExternalNational20062006
ASBMR State-of-the-Art Lecture: Cancer and Bone Basic/TranslationalProfessional/Scientific OrganizationCo-chairExternalNational2006
Connecticut Academy of Science and EngineeringProfessional/Scientific OrganizationMemberExternalState2005
University of Connecticut Health Center: Neag Comprehensive Cancer Center Steering CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity20052007
University of Connecticut Health Center: Musculoskeletal Oncology Program, Neag Comprehensive Cancer CenterProfessional/Scientific OrganizationDirectorUConn HealthUniversity20052007
University of Connecticut Health Center: Head & Neck Oncology Program, Neag Comprehensive Cancer CenterProfessional/Scientific OrganizationDeputy DirectorUConn HealthUniversity20052007
American Cancer Society Council for Extramural GrantsProfessional/Scientific OrganizationMemberExternalNational20052009
James & Esther King Biomedical Research Program Review CommitteeProfessional/Scientific OrganizationMemberExternalNational2005
National Institutes of Health Cancer Genetics Study SectionProfessional/Scientific OrganizationMemberExternalNational20042009
National Institutes of Health SEP ZRG1 RUS-D(05) Endocrinology/Biology of BoneProfessional/Scientific OrganizationMemberExternalNational20042004
National Institutes of Health SEP ZRG1 GNM(91) ATM BiologyProfessional/Scientific OrganizationMemberExternalNational20042004
American Cancer Society Lymphedema Research CommitteeProfessional/Scientific OrganizationMemberExternalNational20042007
National Cancer Institute Ad Hoc Review Committee for NCI RFA CA-04-015Professional/Scientific OrganizationMemberExternalNational20042004
Association of OsteobiologyProfessional/Scientific OrganizationMemberExternalNational2003
Florida Biomedical Research Grant Program Study SectionProfessional/Scientific OrganizationMemberExternalState20032003
American Cancer Society Research Opportunity Grants Program Review CommitteeProfessional/Scientific OrganizationMemberExternalNational20032003
USAMRMC Breast Cancer Research Program Concept Award Review CommitteeProfessional/Scientific OrganizationMemberExternalNational20032003
National Cancer Institute SRBB-Y (A1), Clinical/Pediatric Loan Repayment programProfessional/Scientific OrganizationMemberExternalNational20032009
National Cancer Institute IRG Subcommittee I on Career DevelopmentProfessional/Scientific OrganizationMemberExternalNational20032005
National Institutes of Health SEP ZRG1 ONC (02), Molecular Targets/Cancer DrugsProfessional/Scientific OrganizationMemberExternalNational20032003
National Institutes of Health SEP ZRG1 GRM(03) Musculoskeletal Dental SEPProfessional/Scientific OrganizationMemberExternalNational20032003
USAMRMC Breast Cancer Research Program CBY2 Peer Review CommitteeProfessional/Scientific OrganizationMemberExternalNational20032003
NIAMS Site Visit Study Section for Program Project AR049363-01A1Professional/Scientific OrganizationChairmanExternalNational20032003
National Institutes of Health Skeletal Biology Development/Disease Study SectionProfessional/Scientific OrganizationMemberExternalNational20032011
University of Connecticut Health Center: LCME Self-Assessment CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity20022003
University of Connecticut Health Center: Health Center Space Advisory CommitteeProfessional/Scientific OrganizationChairUConn HealthUniversity20022006
American Cancer Society Molecular Genetics and Oncogenes CommitteeProfessional/Scientific OrganizationChairmanExternalNational20022002
NIAMS Site Visit Study Section for Program Project AR049363-01Professional/Scientific OrganizationChairmanExternalNational20022002
USAMRMC Breast Cancer Research Program CBY4 Peer Review CommitteeProfessional/Scientific OrganizationMemberExternalNational20022002
Physiological Medicine Review Panel for Medical Research Council (UK)Professional/Scientific OrganizationMemberExternalNational20022002
University of Connecticut Health Center: Ad hoc Curriculum Committee on GeneticsProfessional/Scientific OrganizationMemberUConn HealthUniversity2001
University of Connecticut Health Center: Health Center Research Advisory CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity20012005
University of Connecticut Health Center: GMBB Graduate Program Executive BoardProfessional/Scientific OrganizationMemberUConn HealthUniversity20012003
American Cancer Society Molecular Genetics and Oncogenes CommitteeProfessional/Scientific OrganizationMemberExternalNational20012001
National Cancer Institute IRG Subcommittee F on Manpower and TrainingProfessional/Scientific OrganizationMemberExternalNational20012003
University of Connecticut Health Center: Computer Users Advisory CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity20002007
University of Connecticut Health Center: Molecular Core Advisory CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity2000
University of Connecticut Health Center: Microarray Core Advisory CommitteeProfessional/Scientific OrganizationMemberUConn HealthUniversity20002012
University of Connecticut Health Center: Special Review Board for Misconduct in ResearchProfessional/Scientific OrganizationMemberUConn HealthUniversity20002001
American Cancer Society Experts DirectoryProfessional/Scientific OrganizationMemberExternalNational2000
American Society for Bone and Mineral ResearchProfessional/Scientific OrganizationMemberExternalNational1999
National Institute of Dental and Craniofacial Research Ad Hoc Review CommitteeProfessional/Scientific OrganizationMemberExternalNational19991999
National Institutes of Health Molecular Biology Study Section CommitteeProfessional/Scientific OrganizationMemberExternalNational19991999
National Cancer Institute Ad Hoc Review Committee for NCI RFA CA-98-027Professional/Scientific OrganizationMemberExternalNational19991999
National Cancer Institute IRG Subcommittee C on Basic and Pre-clinical TrialsProfessional/Scientific OrganizationMemberExternalNational19992007
National Cancer Institute IRG Subcommittee D on Clinical StudiesProfessional/Scientific OrganizationMemberExternalNational19992007
Intergroup Therapeutic Study P-9851: Osteosarcoma Biology ProtocolProfessional/Scientific OrganizationMemberExternalNational1999
Temple Univ. School of Medicine: Molecular Biology Graduate ProgramProfessional/Scientific OrganizationDirectorExternalUniversity19981999
National Cancer Institute IRG Subcommittee A on Cancer CentersProfessional/Scientific OrganizationMemberExternalNational1998
National Institutes of Health Mammalian Genetics: Study Section CommitteeProfessional/Scientific OrganizationMemberExternalNational19981998
National Cancer Institute IRG Subcommittee F on Manpower and TrainingProfessional/Scientific OrganizationMemberExternalNational19982001
Temple Univ. School of Medicine: Molecular Biology Graduate ProgramProfessional/Scientific OrganizationCo-DirectorExternalUniversity19971998
Temple Univ. School of Medicine: Molecular Biology Graduate Student Curriculum CommitteeProfessional/Scientific OrganizationMemberExternalUniversity19971999
Temple Univ. School of Medicine: Molecular Biology Graduate Student Admissions CommitteeProfessional/Scientific OrganizationMemberExternalUniversity19971999
American Cancer Society Molecular Genetics and Oncogenes CommitteeProfessional/Scientific OrganizationMemberExternalNational19972002
BioTechniquesProfessional/Scientific JournalBoard of EditorsExternalNational19962000
Temple Univ. School of Medicine: Department of Pathology Graduate Program CommitteeProfessional/Scientific OrganizationMemberExternalUniversity19961999
USAMRMC Breast Cancer Research Program MGN3 Peer Review CommitteeProfessional/Scientific OrganizationMemberExternalNational19962001
National Institutes of Health Genome Study Section CommitteeProfessional/Scientific OrganizationMemberExternalNational1995
Childrens Cancer Group Bone Tumor Strategy CommitteeProfessional/Scientific OrganizationMemberExternalNational19941994
Univ. TX MD Anderson Cancer Center: Academic Computing Steering CommitteeProfessional/Scientific OrganizationMemberExternalUniversity19921994
Univ. TX MD Anderson Cancer Center: Intellectual Property CommitteeProfessional/Scientific OrganizationMemberExternalUniversity19921994
Univ. TX Graduate School of Biomedical Sciences: Genetics Program Curriculum CommitteeProfessional/Scientific OrganizationMemberExternalUniversity19921994
American Cancer Society Virology and Molecular Biology Review BoardProfessional/Scientific OrganizationMemberExternalNational19921996
National Cancer Institute Cancer Center Review Board Site Visit CommitteesProfessional/Scientific OrganizationMemberExternalNational19921997
Childrens Cancer Group Study Protocol B-931Professional/Scientific OrganizationChairmanExternalNational19921998
Childrens Cancer Group Genetic Epidemiology Steering CommitteeProfessional/Scientific OrganizationMemberExternalNational19921994
Univ. TX MD Anderson Cancer Center: Executive Vice President's Junior Faculty ForumProfessional/Scientific OrganizationMemberExternalUniversity19911994
Univ. TX MD Anderson Cancer Center: Genetic Counseling Policy CommitteeProfessional/Scientific OrganizationMemberExternalUniversity19911994
Univ. TX Graduate School of Biomedical Sciences: Graduate Student Admissions CommitteeProfessional/Scientific OrganizationMemberExternalUniversity19911994
Univ. TX Graduate School of Biomedical Sciences: Genetics Program Steering CommitteeProfessional/Scientific OrganizationMemberExternalUniversity19911994
National Institute for Environmental Health Sciences Review CommitteeProfessional/Scientific OrganizationMemberExternalNational19901990
National Cancer Institute Program Project Review Board Site Visit CommitteesProfessional/Scientific OrganizationMemberExternalNational19891999
American Society for MicrobiologyProfessional/Scientific OrganizationMemberExternalNational19881996
American Society of Human GeneticsProfessional/Scientific OrganizationMemberExternalNational19882002
American Association for Cancer ResearchProfessional/Scientific OrganizationMemberExternalNational1988
Childrens Cancer Group/Childrens Oncology GroupProfessional/Scientific OrganizationMemberExternalNational1988
Canadian Biomedical Research Council Review PanelProfessional/Scientific OrganizationMemberExternalNational19881989
American Journal of Human GeneticsProfessional/Scientific JournalReviewerExternalNational
American Journal of Medical GeneticsProfessional/Scientific OrganizationReviewerExternalNational
American Journal of PathologyProfessional/Scientific OrganizationReviewerExternalNational
BioTechniquesProfessional/Scientific OrganizationReviewerExternalNational
BoneProfessional/Scientific JournalReviewerExternalNational
Calcified Tissue InternationalProfessional/Scientific JournalReviewerExternalNational
CancerProfessional/Scientific JournalReviewerExternalNational
Cancer Epidemiology & BiomarkersProfessional/Scientific JournalReviewerExternalNational
Cancer LettersProfessional/Scientific JournalReviewerExternalNational
Cancer ResearchProfessional/Scientific OrganizationReviewerExternalNational
Clinical Cancer ResearchProfessional/Scientific JournalReviewerExternalNational
CellProfessional/Scientific JournalReviewerExternalNational
Developmental BiologyProfessional/Scientific JournalReviewerExternalNational
GeneProfessional/Scientific JournalReviewerExternalNational
Genes and DevelopmentProfessional/Scientific JournalReviewerExternalNational
GenesProfessional/Scientific JournalReviewerExternalNational
Chromosomes & CancerProfessional/Scientific JournalReviewerExternalNational
Genome ResearchProfessional/Scientific JournalReviewerExternalNational
GenomicsProfessional/Scientific JournalReviewerExternalNational
Human GeneticsProfessional/Scientific JournalReviewerExternalNational
Human Molecular GeneticsProfessional/Scientific JournalReviewerExternalNational
International Journal of CancerProfessional/Scientific JournalReviewerExternalInternational
Journal of Cellular BiochemistryProfessional/Scientific JournalReviewerExternalNational
Journal of Cellular PhysiologyProfessional/Scientific JournalReviewerExternalNational
Journal of Experimental MedicineProfessional/Scientific JournalReviewerExternalNational
Journal of Bone and Mineral ResearchProfessional/Scientific JournalReviewerExternalNational
Journal of Molecular DiagnosisProfessional/Scientific JournalReviewerExternalNational
MetaGeneProfessional/Scientific JournalReviewerExternalNational
Molecular and Cellular BiologyProfessional/Scientific JournalReviewerExternalNational
Molecular Biology ReportsProfessional/Scientific JournalReviewerExternalNational
Molecular CarcinogenesisProfessional/Scientific JournalReviewerExternalNational
Mutation ResearchProfessional/Scientific JournalReviewerExternalNational
NatureProfessional/Scientific JournalReviewerExternalNational
Nature GeneticsProfessional/Scientific JournalReviewerExternalNational
New England Journal of MedicineProfessional/Scientific OrganizationReviewerExternalNational
OncogeneProfessional/Scientific JournalReviewerExternalNational
PLoS MedicineProfessional/Scientific JournalReviewerExternalNational
Proceedings of the National Academy of Sciences (USA)Professional/Scientific JournalReviewerExternalNational
ScienceProfessional/Scientific JournalReviewerExternalNational

Osteosarcoma is the most common primary tumor of bone and represents in important opportunity for interaction between basic and clinical research.


Osteosarcoma is highly variable in its presentation with numerous subtypes based on the histology, age of onset and site of occurrence. We are interested in examining the molecular differences between these subtypes particularly in the context of the osteoprogenitor lineage pathways from which these tumors arose.


The second area of interest in my laboratory is the genetic origins of Paget’s disease of bone. Paget’s disease is a focal disorder of bone remodeling that leads to overgrowth of affected bone, which in rare cases progresses to osteosarcoma. It is the second most common metabolic bone disease after osteoporosis affecting 1-3% of the U.S. population after age 50. Approximately 20% of Paget’s patients have a positive family history for the disease. Although relatively common, the etiology of Paget’s disease has so far eluded researchers. Our data suggests a model in which a subset of cells might be responsible for the pagetic phenotype in the affected bone. My laboratory is interested in learning what genetic events are critical to the initiation and progression of this disease.


We use several approaches to address these problems. Laser capture microdissection combined with allelotype discrimination analysis, high throughput genotype analysis, comparative and arrayed BAC genome hybridization, cDNA microarray and mass spectroscopy analysis allow us to compare genomic and expression profiles. We then validate our analysis using tissue microarrays, quantitative PCR and other high sample throughput methods. Finally, we use in situ hybridization and immunohistochemistry to validate the expression profiles of our candidate genes. We have also begun to develop transgenic mouse models for osteosarcoma to test its relationship with normal bone development.

Not accepting lab rotation students at this time.

Journal Articles

Book Chapters

  • Expression Patterns of the Retinoblastoma Susceptibility Gene in Conventional and Variant Histology Osteosarcoma
    Hansen, M.F., Xu, H.J., Zhao, J., Hu, S.X., Raymond, A.K., and Benedict, W.F. Frontiers of Osteosarcoma Research 347-357
  • Genetics of Cancer Predisposition
    Hansen, M.F. Developmental Biology and Cancer 277-312
  • Genetics of Osteosarcoma
    Hansen M Topics in Bone Biology: Bone and Cancer 19-42
  • Loss of the Retinoblastoma Susceptibility Gene is Heterologous in Osteosarcoma
    Hansen, M.F. Current Communications in Molecular Biology: Recessive Oncogenes and Tumor Suppression 125-131
  • Osteosarcoma in Paget’s Disease of Bone
    Seton, M., and Hansen, M.F. Paget’s Disease of Bone
  • Retinoblastoma Susceptibility, p53, and Other Tumor Suppressors
    Ruteshouser, E.C., and Hansen, M.F. The Molecular Basis of Clinical Medicine 100-129

Conference Papers

  • Biology of childhood osteogenic sarcoma and potential targets for therapeutic development: meeting summary.
    Gorlick, Richard; Anderson, Peter; Andrulis, Irene; Arndt, Carola; Beardsley, G Peter; Bernstein, Mark; Bridge, Julia; Cheung, Nai-Kong; Dome, Jeffrey S; Ebb, David; Gardner, Thomas; Gebhardt, Mark; Grier, Holcombe; Hansen, Marc; Healey, John; Helman, Lee; Hock, Janet; Houghton, Janet; Houghton, Peter; Huvos, Andrew; Khanna, Chand; Kieran, Mark; Kleinerman, Eugenie; Ladanyi, Marc; Lau, Ching; Malkin, David; Marina, Neyssa; Meltzer, Paul; Meyers, Paul; Schofield, Deborah; Schwartz, Cindy; Smith, Malcolm A; Toretsky, Jeffrey; Tsokos, Maria; Wexler, Leonard; Wigginton, Jon; Withrow, Stephen; Schoenfeldt, Mason; Anderson, Barry Clinical cancer research : an official journal of the American Association for Cancer Research 2003 Nov;9(15):5442-53
  • Common mechanisms of osteosarcoma and Paget's disease.
    Hansen, M F; Nellissery, M J; Bhatia, P Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1999 Oct;14 Suppl 2(SUPPL. 2):39-44

Monographs

Newsletters

  • Functional Characterization of Inherited p53 Mutations
    Lozano, G., Hansen, M.F., and Strong, L.C. Cancer Bulletin 46247-253
  • Genetics of Familial Breast Cancer
    Bischoff, F.Z., and Hansen, M.F. Cancer Bulletin 45476-482
  • Molecular Genetics of Familial Colon Cancer
    Lynch, P.M., Howard, L.D., Pleasants, L.M., and Hansen, M.F. Cancer Bulletin 46315-321
  • Recessive Oncogenes in tTumorigenesis
    Couture, J., and Hansen, M.F. Cancer Bulletin 4341-49

Reviews