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John R. Harrison, PhD

Associate Professor, Orthodontics


Academic Office Location: Orthodontics UConn Health 263 Farmington Avenue Farmington, CT 06030-1850
Phone:	860-679-3847
Fax:	860-679-1258

Lab Rotations
Publications

Not accepting students for lab rotations at this time

Journal Articles

Evaluation of a Required Vertical Point-of-Care Ultrasound Curriculum for Undergraduate Medical Students.
Boivin, Zachary; Carpenter, Sandra; Lee, Grace; Chimileski, Brock; Harrison, John; Choudhary, Dharamainder; Herbst, Meghan Cureus 2022 Oct;14(10):e30002
Col3.6-HSD2 transgenic mice: a glucocorticoid loss-of-function model spanning early and late osteoblast differentiation.
Yang, Maobin; Trettel, Lorin B; Adams, Douglas J; Harrison, John R; Canalis, Ernesto; Kream, Barbara E Bone 2010 Sep;47(3):573-82
The role of proximal camp responsive element (cre) in parathyroid hormone and camp induction of human interleukin-6 promoter activity
Huang Y.-F., Harrison J.R., Kream B.E. Journal of Hard Tissue Biology 2010 Jan;19(1):65-74
Osteopenia in transgenic mice with osteoblast-targeted expression of the inducible cAMP early repressor.
Chandhoke, Taranpreet K; Huang, Yu-Feng; Liu, Fei; Gronowicz, Gloria A; Adams, Douglas J; Harrison, John R; Kream, Barbara E Bone 2008 Jul;43(1):101-9
Mandibular phenotype of p20C/EBPbeta transgenic mice: Reduced alveolar bone mass and site-specific dentin dysplasia.
Savage, T; Bennett, T; Huang, Y-F; Kelly, P L; Durant, N E; Adams, D J; Mina, M; Harrison, J R Bone 2006 Sep;39(3):552-64
Impaired cortical bone acquisition and osteoblast differentiation in mice with osteoblast-targeted disruption of glucocorticoid signaling.
Sher, L B; Harrison, J R; Adams, D J; Kream, B E Calcified tissue international 2006 Aug;79(2):118-25
Col1a1 promoter-targeted expression of p20 CCAAT enhancer-binding protein beta (C/EBPbeta), a truncated C/EBPbeta isoform, causes osteopenia in transgenic mice.
Harrison, John R; Huang, Yu-Feng; Wilson, K Amanda; Kelly, Penny L; Adams, Douglas J; Gronowicz, Gloria A; Clark, Stephen H The Journal of biological chemistry 2005 Mar;280(9):8117-24
Transgenic expression of 11beta-hydroxysteroid dehydrogenase type 2 in osteoblasts reveals an anabolic role for endogenous glucocorticoids in bone.
Sher, Lorin B; Woitge, Henning W; Adams, Douglas J; Gronowicz, Gloria A; Krozowski, Zygmunt; Harrison, John R; Kream, Barbara E Endocrinology 2004 Feb;145(2):922-9
Genetic approaches to determine the role of glucocorticoid signaling in osteoblasts.
Harrison, John R; Woitge, Henning W; Kream, Barbara E Endocrine 2002 Feb;17(1):37-42
Cloning and in vitro characterization of alpha 1(I)-collagen 11 beta-hydroxysteroid dehydrogenase type 2 transgenes as models for osteoblast-selective inactivation of natural glucocorticoids.
Woitge, H; Harrison, J; Ivkosic, A; Krozowski, Z; Kream, B Endocrinology 2001 Mar;142(3):1341-8
Involvement of CCAAT enhancer binding protein transcription factors in the regulation of prostaglandin G/H synthase 2 expression by interleukin-1 in osteoblastic MC3T3-E1 cells.
Harrison, J R; Kelly, P L; Pilbeam, C C Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2000 Jun;15(6):1138-46
Identification of multiple cis-acting elements mediating the induction of prostaglandin G/H synthase-2 by phorbol ester in murine osteoblastic cells.
Okada, Y; Voznesensky, O; Herschman, H; Harrison, J; Pilbeam, C Journal of cellular biochemistry 2000 May;78(2):197-209
Parathyroid hormone induces interleukin-6 heterogeneous nuclear and messenger RNA expression in murine calvarial organ cultures.
Huang, Y F; Harrison, J R; Lorenzo, J A; Kream, B E Bone 1998 Oct;23(4):327-32
Interleukin-1 represses COLIA1 promoter activity in calvarial bones of transgenic ColCAT mice in vitro and in vivo.
Harrison, J R; Kleinert, L M; Kelly, P L; Krebsbach, P H; Woody, C; Clark, S; Rowe, D W; Lichtler, A C; Kream, B E Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1998 Jul;13(7):1076-83
Interleukin-4 inhibits prostaglandin G/H synthase-2 and cytosolic phospholipase A2 induction in neonatal mouse parietal bone cultures.
Kawaguchi, H; Nemoto, K; Raisz, L G; Harrison, J R; Voznesensky, O S; Alander, C B; Pilbeam, C C Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1996 Mar;11(3):358-66
Regulation of type I collagen gene expression in bone.
Kream, B E; Harrison, J R; Krebsbach, P H; Bogdanovic, Z; Bedalov, A; Pavlin, D; Woody, C O; Clark, S H; Rowe, D; Lichtler, A C Connective tissue research 1995 Jan;31(4):261-4
Stimulation of prostaglandin E2 production by interleukin-1 alpha and transforming growth factor alpha in osteoblastic MC3T3-E1 cells.
Harrison, J R; Lorenzo, J A; Kawaguchi, H; Raisz, L G; Pilbeam, C Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994 Jun;9(6):817-23
Transgenic expression of COL1A1-chloramphenicol acetyltransferase fusion genes in bone: differential utilization of promoter elements in vivo and in cultured cells.
Krebsbach, P H; Harrison, J R; Lichtler, A C; Woody, C O; Rowe, D W; Kream, B E Molecular and cellular biology 1993 Sep;13(9):5168-74
Basic fibroblast growth factor inhibits type I collagen gene expression in osteoblastic MC3T3-E1 cells.
Hurley, M M; Abreu, C; Harrison, J R; Lichtler, A C; Raisz, L G; Kream, B E The Journal of biological chemistry 1993 Mar;268(8):5588-93
Differential utilization of regulatory domains within the alpha 1(I) collagen promoter in osseous and fibroblastic cells.
Pavlin, D; Lichtler, A C; Bedalov, A; Kream, B E; Harrison, J R; Thomas, H F; Gronowicz, G A; Clark, S H; Woody, C O; Rowe, D W The Journal of cell biology 1992 Jan;116(1):227-36
Mechanism of regulation of prostaglandin production by parathyroid hormone, interleukin-1, and cortisol in cultured mouse parietal bones.
Klein-Nulend, J; Pilbeam, C C; Harrison, J R; Fall, P M; Raisz, L G Endocrinology 1991 May;128(5):2503-10
Effects and regulation of prostaglandins in bone: Possible implications for the pathogenesis of osteoporosis
Raisz L.G., Pilbeam C.C., Klein-Nulend J., Harrison J.R. Journal of Bone and Mineral Metabolism 1991 Jan;9(2):39-44
Interleukin-1 alpha and phorbol ester inhibit collagen synthesis in osteoblastic MC3T3-E1 cells by a transcriptional mechanism.
Harrison, J R; Vargas, S J; Petersen, D N; Lorenzo, J A; Kream, B E Molecular endocrinology (Baltimore, Md.) 1990 Feb;4(2):184-90
Effects of transforming growth factor alpha and interleukin-1 on DNA synthesis, collagen synthesis, procollagen mRNA levels, and prostaglandin E2 production in cultured fetal rat calvaria.
Hurley, M M; Fall, P; Harrison, J R; Petersen, D N; Kream, B E; Raisz, L G Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1989 Oct;4(5):731-6
1,25-Dihydroxyvitamin D3 inhibits transcription of type I collagen genes in the rat osteosarcoma cell line ROS 17/2.8.
Harrison, J R; Petersen, D N; Lichtler, A C; Mador, A T; Rowe, D W; Kream, B E Endocrinology 1989 Jul;125(1):327-33

Abstracts

Identification of promoter sites mediating induction of transcription of PGHS-2 by phobol ester in MC3T3-E1 cells.
Okada Y, Voznesensky O, Herschman H, Harrison J, Raisz L, Pilbeam C. Bone 1998 Jan;2216S
Turnor necrosis factor-? stimulation of prostaglandin G/H synthase-2 promoter activity in osteoblastic MC3T3-E1 cells requires and intact AP-1 site.
Tomita M, Harrison JR, Okada Y, Voznesensky OS, Raisz LG, Pilbeam CC. J Bone Miner Res 1998 Jan;13(S1)S354
Induction of the prostaglandin G/H synthase-2 gene by Interleukin-1 in MC3T3-E1 cells is mediated by C/EBP transcription factors.
Harrison JR, Kelly PL, Pilbeam CC. J Bone Min Res 1997 Jan;12(S1)S433
Transcriptional induction of prostaglandin G/H synthase-2 by transforming growth factor-beta1 in osteoblastic MC3T3-E1 cells requires an intact C/EBP (N-IL6) site.
Rao Y, Voznesensky O, Harrison J, Alander C, Raisz L, Pilbeam C. J Bone Min Res 1996 Jan;11(S1)S378
Retinoic acid inhibits induction of prostaglandin G/H synthase-2 mRNA and promoter activity in MC3T3 E 1 osteoblastic cells.
Pilbeam CC, Bernecker P, Harrison J, Alander C, Voznesensky O, Herschman H, Raisz L. J Bone Min Res 1995 Jan;10(S1)S496
Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins.
Pilbeam, C C; Raisz, L G; Voznesensky, O; Alander, C B; Delman, B N; Kawaguchi, H Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 1994 Jan;10(3):406-14
Nuclear factor binding to an NF-IL-6 site in the prostaglandin G/H synthase 2 promoter induced by IL 1 in MC3T3 E1 cells.
Harrison JR, Kawaguchi H, Raisz LG, Pilbeam CC. J Bone Min Res 1994 Jan;9(S1)S122
Regulation of inducible prostaglandin G/H synthase (cyclooxygenase) by interleukin 1 and transform¬ing growth factors ? and ß in osteoblastic cells.
Pilbeam CC, Alander CB, Voznesensky OS, Kawaguchi H, Harrison JR, Raisz LG. J Bone Miner Res 1993 Jan;8(S1)S299

Conference Papers

The role of prostaglandins in the regulation of bone metabolism.
Kawaguchi, H; Pilbeam, C C; Harrison, J R; Raisz, L G Clinical orthopaedics and related research 1995 Apr;(313):36-46
Transcriptional regulation of type I collagen synthesis by 1,25-dihydroxyvitamin D<sub>3</sub> in bone cells
Pavlin D., Harrison J., Lichtler A., Kream B.E., Rowe D.W. Calcium regulation and bone metabolism. Basic and clinical aspects: proceedings of the 10th International Conference on calcium regulating hormones and bone metabolism. ICS886 1990 Jan;163-167

Reviews

Effects and regulation of prostaglandins in bone: Possible implications for the pathogenesis of osteoporosis. ,.
Raisz LG, Pilbeam CC, Klein Nulend J, Harrison JR. J Bone Miner Metab (Japan), 1992 Jan;9(39 ):44
Hormonal regulation of collagen gene expression in osteoblastic cell-overview and new findings.
Kream, B; Harrison, J; Bailey, R; Petersen, D; Rowe, D; Lichtler, A Connective tissue research 1989 Jan;20(1-4):187-92