UCONN

HEALTH

Photo of Laura  Haynes, Ph.D.

Laura Haynes, Ph.D.

Professor, Immunology
UConn Center on Aging
Academic Office Location:
Immunology
UConn Health
263 Farmington Avenue
Farmington, CT 06030-5215
Phone: 860-679-8431
Email: lhaynes@uchc.edu
Website(s):

Immunology Graduate Program

immune.uchc.edu

Education
DegreeInstitutionMajor
B.S.University of MiamiBiology
M.S.University of Miami School of MedicineImmunology
Ph.D.University of Rochester School of MedicineImmunology

Post-Graduate Training
TrainingInstitutionSpecialty
FellowshipNIH Predoctoral Immunology Training Grant Fellowship
PostdoctoralUCSDResearch Fellow, Department of Biology
FellowshipNIH Postdoctoral Immunology Training Grant Fellowship
PostdoctoralTrudeau InstituteResearch Scientist
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Longevity and HealthspanEditorial BoardMemberExternalNational2011
NIAIO pal review panel: Towards a universal influenza virus vaccineStudy SectionMemberExternalNational20112012
NIH/NIAID Protection of human health by immunology and vaccinesStudy SectionMemberExternalNational2010
NIAID Study Section for Studies of Immunosenescence and Other Late Effects of Acute Ionizing Radiation Exposure in Atomic Bomb SurvivorsStudy SectionChairExternalNational2009
Aging CellEditorial BoardMemberExternalNational2008
GerontologyEditorial BoardMemberExternalNational2008
Planning Group for Immunization in Older Adults WorkshopWorkshop/ConferenceMemberExternalUniversity20082008
Journal of ImmunologyProfessional/Scientific JournalAssociate EditorExternalNational20062010
AAI Committee on the Status of Women "Managing your lab" workshop at 2006 AAI meeting, Boston, MA. Workshop/ConferenceChairExternalNational20062006
Immunity and Infection session at annual American Aging Association meeting, Boston, MA Workshop/ConferenceChairExternalNational20062006
Organizing Committee for Aging Research in Immunology: the impact of Genomics Symposium, Sept. 2006. Paris, FranceWorkshop/ConferenceMemberExternalInternational20052006
AAI Committee on the Status of WomenProfessional/Scientific OrganizationMemberExternalNational20042007
Trudeau Institute Radiation and Chemical Safety CommitteeProfessional/Scientific OrganizationChairExternalNational2004
Trudeau Institute Flow Cytometry Core CommitteeProfessional/Scientific OrganizationMemberExternalNational2004
Aging Systems and Geriatrics (ASG); Cellular Mechanisms of Aging and Development (CMAO); Vaccines against microbial diseases {VMO}Study SectionAd hoc memberExternalNational2004
2004 Aging and Immunity Workshop, Trudeau InstituteWorkshop/ConferenceOrganizerExternalUniversity20032004
Journal of ImmunologyProfessional/Scientific JournalAd hoc reviewerExternalNational2002
Journal of Experimental MedicineProfessional/Scientific JournalAd hoc reviewerExternalNational2002
Mechanisms of Ageing and DevelopmentProfessional/Scientific JournalAd hoc reviewerExternalNational2002
International ImmunologyProfessional/Scientific JournalAd hoc reviewerExternalNational2002
Experimental GerontologyProfessional/Scientific JournalAd hoc reviewerExternalNational2002
Upstate NY Immunology ConferenceAdvisory CommitteeMemberExternalNational2002
American Foundation for Aging ResearchAdvisory CommitteeMemberExternalNational2002
NIH Geriatric and Rehabllitative Medicine study sectionStudy SectionAd hoc memberExternalNational20022003
American Association of ImmunologistsProfessional/Scientific OrganizationMemberExternalNational1999

Aging has dramatic impacts on all aspects of the immune response. Age-related changes result in significantly reduced immune responses, with lower antibody titers and reduced antibody affinity. My laboratory is interested in determining the specific immune cell types impacted by aging and the mechanisms responsible for these changes. We have focused on CD4 T cells, which are significantly impacted by aging, especially with regards to their ability to differentiate into follicular helper T cells and how this impacts protective antibody production. Using a mouse model of influenza infection, we have shown that these age-related declines in CD4 T cell function have a negative impact on immune responses to both infection and vaccination.


Recent studies have determined that age-related defects in CD4 T cell responses are due to both intrinsic changes in CD4 T cell function as well as disruptions in the microenvironment and chemokine production in secondary lymphoid organs. This results in reduced follicular helper T cell function and poor antibody responses. Current studies are examining the mechanisms involved in this defect. We are also exploring how this defect may be overcome with more potent adjuvants or enhanced T cell priming. Our goal is to determine the most efficient way to enhance the efficacy of influenza vaccines for the elderly.

Accepting Lab Rotation Students: Summer '16, Fall '16, Spring '17

Journal Articles

Book Chapters

  • The Phylogentic Conservation of Cytokines
    Cohen, N., Haynes, L. Phylogenesis of Immune Function 1991 Jan;241

Reviews

Title or AbstractTypeSponsor/EventDate/YearLocation
Protective humoral immunity and Tfh function decline with age.TalkAAI2014AAI meeting, Pittsburgh, PA
Effect of age on immune responses.TalkYale Biology of Aging Interest Group2014
Aging and InfluenzaTalkUConn-Jackson Labs Aging Symposium2014Storrs, CT
Immunity and AgingTalkU Mass Medical School2013Worchester, MA
Vaccination with influenza NP does not protect aged mice.TalkCold Spring Harbor Symposium2013Cold Spring Harbor, NY
Vaccines and Immunotherapy: Infectious Diseases IPanel DiscussionAAI2012Boston, Massachusetts
SpeakerTalkInternational Society of Geriatric Oncology Annual Conference2012Manchester, United Kingdom
How Aging Influnces CD4 T Cell FunctionTalkJohns Hopkins University2011Baltimore, Maryland
How Aging Impacts CD4 T Cells: What This Means for Response to VaccinationTalk2011Cold Spring Harbor, New York
Homeostatis and Aging of LymphocytesTalkAAI2011San Francisco, California
Influence of Aging on CD4 T CellsTalkUniversity of Rochester School of Medicine2011Rochester, New York
Innate Programming of Adaptive Immunity II The Impact of Aging on CD4 T FunctionTalkCold Spring Harbor Symposium2011Cold Spring Harbor, New York
The Influence of Aging on CD4 T Cell Response to VaccinationTalkAaron Diamond AIDS Research Center2010New York, New York
Presentation on Function of Regenerated CD4 T CellsTalkFASEB Summer Conference2010Phoenix, Arizona
SpeakerTalk9th Canadian Immunization Conference2010Quebec City, QC
The Influence of Aging on CD4 T Cell Response to VaccinationTalkGeorge Washington University2009Washington, DC
The Influence of Aging on CD4 T Cell Response to VaccinationTalkUniversity of Pittsburgh Medical School2009Pittsburgh, Pennsylvania
The Influence of Aging on CD4 T Cell Response to VaccinationTalkNIAID/ Department of Defense2008San Francisco, California
The Influence of Aging on CD4 T Cell Response to VaccinationTalkNew York State Department of Health2008Albany, New York
The Effect of Aging on Primary & Memory Responses of CD4 T CellsTalkAging & Memory at Keystone Symposium on Immunologic Memory2007Santa Fe, New Mexico
Networking and Mentoring: How to Make it For YouTalkAAI Committee2007Miami, Florida
T Cell Defects With AgingTalkNIAID/NIA2007Gaithersburg, Maryland
T Cell Defects With AgingTalkYale University School of Medicine, Immunobiology Seminar Series2007New Haven, Connecticut
Cytokine Adjuvants Enhance the Cognate Helper Function of Aged CD4 T CellsPanel DiscussionInternational Congress of Immunology2007Rio de Janeiro, Brazil
The Effect of Aging on CD4 T Cell ResponsesTalkIowa State University2007Ames, Iowa
Newly Generated CD4 T Cells in Aged Animals do not Exhibit Age-Related Defects in Response to AntigenTalkNIA/NIH National Advisory Council on Aging2006Bethesda, Maryland
The Effect of Age on CD4 T Cell FunctionTalkUniversity of Iowa, Cancer and Aging Program2006Iowa City, Iowa
Enhancement of the Cognate Helper Activity of Aged CD4 T cellsTalkNational Institute on Aging: AAI Meeting2006Boston, Massachusetts
The effect of age on the cognate function of CD4 T cellsLectureAmerican Aging Association2006Boston, Massachusetts
How Can Vaccines Work on the Background of the Aging Immune System?LectureAging Research in Immunology2006Paris, France
The Effect of Age on CD4 T Cell MemoryLectureLouisiana State University2005New Orleans, Louisiana
The Effect of Aging on Cognate CD4 Helper FunctionLectureEdward Jenner Institute for Vaccine Research2005Compton, U.K.
The Effect of Age on the Function of CD4 T CellsLectureGerman Cancer Research Center DKFZ2005Heidelberg, Germany
The Effect of Aging on Cognate CD4 Helper FunctionLectureYale University School of Medicine2005New Haven, Connecticut
The Effect of Age on the Function of CD4 T CellsLectureLa Jolla Institute of Molecular Medicine2005La Jolla, California
The Effect of Age on CD4 T Cell MemoryTalkPresident's Symposium, AAI/EB Meeting2005San Diego, California
The Effect of Age on CD4 T Cell FunctionTalkOhio State University2004Ohio
Age-Related Declines in CD4 Cognate Function are Responsible for Reduced Humoral Responses in the AgedTalkLovelace Respiratory Research Institute Symposium2004Santa Fe, New Mexico
The Effect of Age on CD4 T Cell FunctionTalkSidney Kimmel Cancer Center2003La Jolla, California
Impaired CD4 T Cell Cognate Function is Responisble for Age-Related Reductions in Humoral ResponsesTalkUpstate NY Immunology Conference2003Bolton Landing, New York
The Effect of Age on CD4 T Cell FunctionTalkUniversity of Rochester School of Medicine2002Rochester, New York