John Travis Hinson, M.D.Assistant Professor of Cardiology and Genetics
Dr. Travis Hinson is the second joint faculty appointment with The Jackson Laboratory for Genomic Medicine. He brings his expertise in cardiovascular genetics from Brigham and Women’s Hospital. Dr. Hinson’s study of the genetics of heart muscle diseases includes the bioengineering of heart cells derived from pluripotent stem cells. He also treats patients with inherited forms of cardiovascular diseases.
|M.D.||Havard Medical School||Medicine|
|Residency||Massachusetts General Hospital||Internal Medicine|
|Fellowship||Brigham and Women's Hospital||Cardiovascular Medicine|
My laboratory utilizes genomic approaches to interrogate mechanisms of inherited cardiovascular disorders especially those that lead to heart failure. We are particularly interested in developing single cell and cardiac microtissue assays derived from disease-specific, human induced pluripotent stem cells (iPScs) in combination with in vivo mouse models. My lab’s current research focus is directed toward: 1) defining the role of AMPactivated protein kinase in physiologic and pathologic forms of cardiac remodeling; 2) engineering cardiac microtissues to study the most common forms of familial hypertrophic and dilated cardiomyopathies due to sarcomere mutations; and 3) to develop assays for high-throughput functional genomic screens to predict pathogenicity of genetic variation in cardiomyopathy genes. These studies capitalize on the laboratory’s expertise in human genetics, stem cell biology, tissue engineering and computational methods.
Accepting Lab Rotation Students: Summer '18, Fall '18, Spring '19