UCONN

HEALTH

Photo of Sidney M. Hopfer, Ph.D.

Sidney M. Hopfer, Ph.D.

Professor, Department of Pathology and Laboratory Medicine
Academic Office Location:
Pathology and Laboratory Medicine
UConn Health
263 Farmington Avenue
Farmington, CT 06030-2235
Phone: 860-679-2665
Fax: 860-679-2154
Education
DegreeInstitutionMajor
B.S.Colorado State UniversityBiology
M.S.University of ConnecticutPathobiology
Ph.D.University of ConnecticutPathobiology

Awards
Name of Award/HonorAwarding Organization
Clinical Scientist of the Year Association of Clinical Scientists
Diploma of HonorAssociation of Clinical Scientists
Young Investigator AwardAssociation of Clinical Scientists
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Cystic Fibrosis Foundation Newborn Screening Quality Improvement ConsortiumProfessional/Scientific OrganizationMemberExternalNational2012
Medical Laboratory Sciences ProgramProfessional/Scientific OrganizationMemberUConn HealthUniversity2011
Quality Resource Manangement Committee: John Dempsey HosptialProfessional/Scientific OrganizationMemberExternalLocal20092013
Association of Clinical Scientists: Awards CommitteeProfessional/Scientific OrganizationMemberExternalNational2006
State of Connecticut, Expert Genomics Advisory PanelAdvisory CommitteeMemberExternalState2006
State of Connecticut, Dept of Public Health: Chemical Terrorism Disaster Advisory BoardAdvisory CommitteeMemberExternalState2004
Medical Advisory Committee Connecticut Poison Control CenterProfessional/Scientific OrganizationMemberExternalState2004
Annals of Clinical and Laboratory Science: Editorial BoardEditorial BoardMemberExternalNational2004
Association of Clinical Scientists: Executive CommitteeProfessional/Scientific OrganizationMemberExternalNational19961999
Association of Clinical Scientists: Nominating CommitteeProfessional/Scientific OrganizationMemberExternalNational19951997
Associaton of Clinical ScientistsProfessional/Scientific OrganizationPresidentExternalNational19941995
Association of Clinical Scientists: Awards CommitteeProfessional/Scientific OrganizationMemberExternalNational19931997
Association of Clinical ScientistsProfessional/Scientific OrganizationVice-PresidentExternalNational19931994
Association of Clinical Scientists: Credentials CommitteeProfessional/Scientific OrganizationMemberExternalNational19891992
Environmental Health Criteria Document for NickelProfessional/Scientific OrganizationTemporary AdvisorExternalInternational1989
Association of Clinical Scientists: Scientific CouncilProfessional/Scientific OrganizationMemberExternalNational1987
Association of Clinical Scientists: Membership CommitteeProfessional/Scientific OrganizationChairmanExternalNational19841994
Association of Clinical Scientists: Membership CommitteeProfessional/Scientific OrganizationMemberExternalNational1983
American Association for Clinical ChemistryProfessional/Scientific OrganizationMemberExternalNational
Specialty Areas: Clinical Chemistry, Cystic Fibrosis Newborn Screening

Journal Articles

Books

  • Hopfer, S.M. Tietz Clinical Guide to Laboratory Tests

Book Chapters

  • Detection of oligoclonal bands in patients with neurologic diseases: comparison between agarose gel-, immunofixation- and isoelectric-focusing electrophoresis.
    Shan, D E; Yeh, S I Zhonghua yi xue za zhi = Chinese medical journal; Free China ed 1998 Jul;61(7):375-81
  • Search for molecular mechanisms in the genotoxicity of nickel.
    Sunderman, F W Scandinavian journal of work, environment & health 1993 Jan;19 Suppl 175-80
  • Acute Depletion of Pulmonary Lavage Cells and Enhanced Lipid Peroxidation in Alveolar Macrophages Following Parenteral Administration of Nickel Chloride to Rats
    Sunderman, F.W., An, L.L., Zaharia, O., Wong, S.H-Y. and Hopfer, S.M. Pharmacology 817-820
  • Bioassay of Serum Erythropoietin Activity
    Hopfer, S.M Manual on the Laboratory Diagnosis and Monitoring of Cancer 223-234
  • Bioassay of Serum Erythropoietin Activity
    Hopfer, S.M. Manual on Seminar on Diagnostic Hematology
  • Bioassay of Serum Erythropoietin Activity
    Hopfer, S.M., Sunderman, F.W., Fredrickson, T.N. and Morse, E.E. Manual on Clinical Pathology of Cancer of the Endocrine Glands and Target Organs 115-124
  • Comparison of Immunoassays for Human Chorionic Gonadotrophin Using Polyclonal and Monoclonal Antisera
    Horak, E. and Hopfer, S.M. Manual on Clinical Pathology of Reproductive Systems 97-110
  • Compositional Changes in Sexually Differentiated Forms of Hepatic Cytochrome P-450 in the Diabetic Rat
    Thummel, K.E., Hopfer, S.M. and Schenkman, J.B. Highlights of Modern Biochemistry 247-256
  • Correlation Between the Carcinogenic Activities of Nickel Compounds and Their Potencies for Stimulating Erythropoiesis in Rats
    Sunderman, F.W., Jr. and Hopfer, S.M. Biological Aspects of Metals and Metal-Related Diseases 171-181
  • Identification of Three Nickel-Binding Proteins that may be Molecular Targets for Teratogenesis and Embryotoxicity in Xenopus Laevis
    Sunderman, F.W. Jr., Antonijczuk, A., Antonijczuk, K., Grbac-Ivankovic, S., Hopfer, S., Plowman, M.C., Slaisova, O. and Varghese, A.H. Proceedings of the Eight International Symposium on Trace Elements in Man and Animals (TEMA-8) 798-806
  • Measurement of 5'-Nucleotidase
    Stojanovic, T., Horak,E. and Hopfer, S.M. Manual on Diseases of the Liver 49-60
  • Measurement of Lipoperoxides in Plasma
    Hopfer, S.M., Wong, S.W-Y. and Knight, J.A. Manual on Toxicology 81-93
  • Measurement of Phagocytic Actibity of Mononuclear Cells by Fluorescent Microscopy of Ingested Polystyrene Microspheres
    Hopfer, S.M. Ziebka, L. and Sunderman, F.W.Jr Manual on Seminar on Diagnostic Hematology 129-136
  • Measurement of Trace Metals in Serum by Electrothermal Atomic Absorption Spectrophotometry
    Hopfer, S.M. and Sunderman, F.W., Jr. Manual on Laboratory Diagnosis of Cardiovascular Disorders 169-181
  • Neonatal Cystic Fibrosis Screening: Implications of Apparent Seasonal Variations in Immunoreactive Trypsinogen Concentration
    Nadeau, F.L., Makowski, G.S., and Hopfer, S.M. Proceedings of the Eleventh National Neonatal Screening Symposium 200-201
  • Nickel-Induced Derangements of Thermoregulation
    Hopfer, S.M. and Sunderman, F.W.,Jr. Nickel and Human Health: Current Perspectives 561-571
  • Premature Infants Treated with Furosemide have Increased Urinary Calcium and Unchanged Urinary Citrate Excretion Compared to Controls
    Adams, N.D., Rowe, J.C., Sawhney, R., Lazar, A.M., Horak, E., Hopfer, S.M. and Condren, TB Proceedings of the Sixth International Symposium on Urolithiasis 379-382
  • Quantitative Determination of Amino Acids in Plasma and Urine by High Pressure Ion Exchange Chromatography
    Horak, E. and Hopfer, S.M. Manual on Laboratory Diagnosis of Disorders of the Fetus, Newborn, and Infant 19-36
  • Radioimmumoassays of Erythropoietin Concentrations in Serum and Kidney Extracts of Rats with Nickel Subsulfide-Induced Erythrocytosis
    Hopfer, S.M., Sunderman, F.W., Jr. and Goldwasser, E. Progress in Nickel Toxicology 133-136
  • Selective Removal of PCR Inhibitors from Guthrie card Bloodspots: Rapid Detection of Cystic Fibrosis Mutations in Exon 10 and 11
    Hopfer, S.M., Makowski, G.S., and Davis, E.L. Proceedings of the Eleventh National Neonatal Screening Symposium 104-106
  • Spectrophotometric Assay of N-Acetyl-Beta-D-Glucosaminidase Activity in Urine
    Horak, E., Hopfer, S.M. and Sunderman, F.W., Jr. Manual on Laboratory Diagnosis and Monitoring of Disorders of the Kidney 157-170
  • Teratogenicity of Cadmium Chloride in the South African Frog, Xenopus laevis
    Sunderman, F.W., Jr., Plowman, M.C. and Hopfer, S.M. Cadmium in the Human Environment: Toxicity and Carcinogenicity 249-255
  • Teratogenicity of Ni2+ in Xenopus laevis
    Hopfer, S.M., Plowman, M.C. Bantle, J.A,. and Sunderman, F.W., Jr International Symposium on Trace Elements in Health and Disease 169-175
  • The FETAX Test for Teratogenicity of Chemicals and Environmental Samples
    Hopfer, S.M., Plowman, M.C. and Sunderman, F.W. Jr. Manual on Laboratory Diagnosis of Disorders of the Fetus, Newborn, and Early Childhood 79-86
  • The Measurement of Estradiol by Direct Radioimmunoassay
    Horak, E. and Hopfer S.M. Manual on Clinical Pathology of Reproductive Systems 229-236

Abstracts

  • Joint counts to assess rheumatoid arthritis for clinical research and usual clinical care: advantages and limitations.
    Sokka, Tuulikki; Pincus, Theodore Rheumatic diseases clinics of North America 2009 Nov;35(4):713-22, v-vi
  • Trace element status in alcoholism before and during disulfiram treatment.
    Grandjean, P; Kristensen, K; Jørgensen, P J; Nielsen, G D; Andersen, O Annals of clinical and laboratory science 1990 Jan;20(1):28-35
  • 63Ni2+-Binding Proteins in Xenopus Oocytes and Embryos
    Sunderman, F.W., Jr., Henjum, D.C., Beck, B.L., Makowski, G.M., Nomoto, S., Korza, G., Ozols, J., Hopfer, S.M., and Barber, A.: Ann. Clin. Lab. Sci. 21363
  • Changes in LDH Isoenzymes in Bronchoalveolar Lavage Fluid and in Lung Tissue at Various Stages During the Development of Bleomycin-Induced Pulmonary Fibrosis in the Rat
    Thrall, R.S., Parkinson, D. and Hopfer, S.M. Am. Rev. Resp. Dis. 12764
  • Comparisons of the Efficacies of Nickel Compounds for Induction of Erythrocytosis Following Injection in Rats
    Hopfer, S.M., Sunderman, F.W., Jr., Fredrickson, T.N. and Morse, E.E. Ann. Clin. Lab. Sci 7369-370
  • Comparisons of the Efficacies of Nickel Compounds for Induction of Erythrocytosis Following Intrarenal Injection in Rats
    Hopfer, S.M., Sunderman, F.W., Jr., Fredrickson, T.N., and Morse, E.E. Proc. Amer. Soc. Hematol 109
  • Cystic Fibrosis or CFTR-Related Metabolic Syndrome (CRMS) A Diagnosis Obtained from Newborn Screening?
    Hopfer, S.M. AnClin Lab Sci 43341
  • Detection of Hybridization Products of the F508 Mutation in Neonates with Cystic Fibrosis Using a Monoclonal Antibody Against Double-Stranded DNA
    Hopfer, S.M., Makowski, G.S. and Aslandadeh, J. Ann Clin Lab Sci 24469
  • Detection of Plasma Factor XIII (transglutaminase) with a Fluorescent Polyamine Following Electrophoresis
    Makowski, G.S. and Hopfer, S.M. Clin Chem 401124
  • Differences in Blood and Urine in Furosemide (F) Treated VlBW Infants With and Without Nephrocalcinosis (NC)
    Adams, N.D., Rowe, J.C., Lazar, A.M., Horak, E., Hopfer, S.M., Condren, T.B. Proc. Amer. Ped. Soc
  • Effects of Unilateral Intrarenal Administration of Nickel Subsulfide to Rats on Erythropoietin Concentrations in Serum and Kidney Extracts and on Plasma Renin and Renin-Substrate Concentrations
    Hopfer, S.M., Sunderman, F.W., Jr., Goldwasser, E. and Fyrquist, F. Ann. Clin. Lab. Sci. 15344-345
  • Embryotoxicity and teratogenecity of Co2+ in Xenopus Laevis
    Hopfer, S.M., Plowman, M.C., Peracha, H. and Sunderman, F.W., Jr. Ann. Clin. Lab. Sci. 21364
  • Environmental Impurity: Singing Canaries vs Freaky Frogs
    Hopfer, S.M. Comparitive Pathology Seminar Series
  • Erythropoietin-Mediated Erythrocytosis in Rodents Following Intrarenal Injection of Nickel Subsulfide
    Sunderman, F.W., Jr., Hopfer, S.M., Reid, M.C., Shen, S.K and Delaney, L. Exper. Hemat 8191
  • Evaluation of Ionized Calcium in Arterial and Venous Specimens: Comparison of Whole Blood (iSTAT) and Plasma-Serum (Corning 634) Analyzer
    Makowski, G.S., Schuler, C.K., Whitfield, D., McNally, D.P. and Hopfer, S.M. Clin Chem 41S176-S177
  • Evaluation of the Incstar 25-Hydroxyvitamin D (25-OH-D) 125I RIA Kit
    King, E.H., Hopfer, S.M., and Stone, J.A. Clin Chem 401035
  • Extraction and Preliminary Characterization of Polymerase Chain Reaction (PCR) Inhibitors from Guthrie Card Bloodspots: Detection of Genetic Mutations in Neonates
    Hopfer. S.M., Makowski, G.S. and Aslanzadeh, J. Ann Clin Lab Sci 25343
  • Extraction of Genomic DNA from Guthrie Card Filter Paper: Avidity of Nucleic Acids for Filter Matrices
    Makowski, G.S., Davis, E.L., and Hopfer, S.M. Clin Chem 44A41
  • Factors which Influence the Induction of Erythrocytosis by Intrarenal Injection of Nickel Subsulfide
    Sunderman, F.W., Jr., Reid, M.C., Delaney, L., Shen, S.K. and Hopfer, S.M. Ann. Clin. Lab. Sci. 10453
  • Folate and Neural Tube Defects: Analytical Considerations
    Hopfer, S.M. and Makowski, G.S. Ann Clin Lab Sci 2777
  • Hypernickelemia in Patients Receiving Disulfiram
    Hopfer, S.M., Linden, J.V., Crisostomo, C., O'Brien, J.E. and Sunderman, F.W., Jr. Ann. Clin. Lab. Sci. 14319
  • Identification of Neonates with Cystic Fibrosis Following Multiplex PCR Amplification of Eight Common Mutations in a Neonatal Screening Program
    Makowski, G.S., Aslanzadeh, J., and Hopfer, S.M. Ann Clin Lab Sci 24469-470
  • Induction of Renal Carcinomas by Intrarenal Injection of Nickel Subsulfide in Rats
    Sunderman, F.W., Jr., Maenza, R.M., Hopfer, S.M., Mitchell, J.M., Allpass, P.R. and Damjanov, I. Proc. Amer. Assoc. Cancer Res. 19127
  • Isoelectric Focusing of Spinal Fluid Proteins
    Hopfer, S.M. Ann. Clin. Lab. Sci. 2260-61
  • Measurement of 25-Hydroxycholecalciferol in Human Serum Using Sephadex LH-20 and High-Performance Liquid Chromatography
    Hopfer, S.M., Horak, E., Person, N., and Wong, S.H-Y. Ann. Clin. Lab. Sci. 13350
  • Neonatal Screening for Cystic Fibrosis: Comparison of Two DNA-Based Algorithms
    Hopfer, S.M., Makowski, G.S. Ann Clin Lab Sci 35(2):206
  • Newborn Screening for Cystic Fibrosis: Benefits of Molecular Detection Methods for F508 and Non-F508 Mutations
    Hopfer, S.M., Nadeau, F.L. and Makowski, G.S. Ann Clin Lab Sci 28180-181
  • Nickel Concentrations in Body Fluids of Healthy Adults and Hemodialysis Patients in Sudbury, Ontario, Canada
    Hopfer, S.M., Sunderman, F.W., Jr. and Fay, W.P. Ann. Clin. Lab. Sci. 17274-275
  • Novel Approaches for Collection of DNA for Genetic and Epidemiological Studies
    Hopfer, S.M., Kolakoski, C.J., Avery, L.A., Senh, M.C., Ryan, R.W. Ann Clin Lab Sci 36228
  • Pathologic and Hematologic Sequellae of Intrarenal Injection of Nickel Subsulfide Induced Erythrocytosis in Rats
    Hopfer, S.M., Fredrickson, T.N., Morse, E.E. and Sunderman. F.W., Jr. Ann. Clin. Lab. Sci. 9435
  • Radioimmunoassays of Erythropoietin Concentrations in Serum and Kidney Extracts of Rats with Nickel Subsulfide-Induced Erythrocytosis
    Ann. Clin. Lab. Sci. Hopfer, S.M., Sunderman, F.W., Jr. and Goldwasser, E. 14407
  • Renal Carcinoma Cell Line Derived from Nickel Subsulfide-Induced Rat Tumor
    Yamase, H., Marzouk, A., Liber, C., Hopfer, S.M., Helmut., M., Donskoy, M., Gillies, C., and Sunderman, F.W., Jr.: Ann. Clin. Lab. Sci. 15347
  • Silk Purses from Sow’s Ears - An Outcome Analysis of a Laboratory Medicine Residency Program
    Morse, E.E., Pisciotto, P.T., Hopfer, S.M., Makowski, G.S., Ryan, R.R., Aslanzadeh, J. and Sunderman, F.W. Jr. Ann Clin Lab Sci 27316
  • Strain Differences in Susceptibility of Rats to Induction of Erythrocytosis After Intrarenal Injection of Nickel Subsulfide
    Hopfer, S.M., Sunderman, F.W., Jr., Fredrickson, T.N., and Morse, E.E. Ann. Clin. Lab. Sci 354-355
  • Test Consolidation with Pre-Analytical Automation in a Small University Hospital Laboratory
    Hopfer, S.M., Makowski, G.S. Ann Clin Lab Sci 34(3):359
  • Whole Blood and Serum Storage on Filter Paper (Guthrie Cards) for Immunoassay Analysis
    Hopfer, S.M. and Makowski, G.S. Ann Clin Lab Sci 31307

Conference Papers

Letters

Newsletters

  • Deformed Frogs Remain a Mystery
    Hopfer, S.M. and Mokowski, G.S. The Center for Environmental Health Newsletter 710-11

Other

Reviews

Title or AbstractTypeSponsor/EventDate/YearLocation
Consolidation and Automation: A Safer EnvironmentLectureBeckman Coulter Symposia2004White Plains, New York
Laboratory Redesign with Automation: An Ongoing ProcessLectureBeckman Coulter Symposia2003White Plains, New York
Laboratory Redesign with Automation: An Ongoing ProcessLectureBeckman Coulter Symposia2003Boston, Massachusetts
Consolidation and Automation in a Small Hospital LaboratoryLectureBeckman Coulter Symposia2002White Plains, New York
Consolidation and Automation in a Small Hospital LaboratoryLectureBeckman Coulter Symposia2002Philadelphia, Pennsylvania
Consolidation and Automation in a Small Hospital LaboratoryLectureBeckman Coulter Symposia2002Waltham, Massachusetts
Decisions for Laboratory Redesign with AutomationLectureAmerican Society for Clinical Laboratory Science2002Hartford, Connecticut
Newborn Screening for Cystic FibrosisLectureAssciation of Public Health Laboratories2001Washington, DC
Detection of Cystic Fibrosis in a 24 Week-Old Infant: Application of Neonatal Screening in Premature PopulationsTalkNeonatal Screening Symposium1998San Diego, California
Newborn Screening for Cystic Fibrosis: Early Detection of Infants with Non-?F508 MutationsTalkNational Neonatal Screening Symposium1998San Diego, California
Detection of Cystic Fibrosis in a 24 Week Old Infant: Application of Neonatal Screening in Premature PopulationsLectureNational Neonatal Screening Symposium1998San Diego, California
Newborn Screening for Cystic Fibrosis: Early Detection of Infants with Non-?F508 MutationsLectureNational Neonatal Screening Symposium1998San Diego, California
Amplification of Guthrie Card DNA: Differential Binding of Natural PCR Inhibitors to Guanidine Thiocyanate-Impregnated Filter PaperTalkNeonatal Screening Symposium1996Boston, Massachusetts
Triad Approach for Detection of Cystic Fibrosis in a Neonatal Screening Program: Identification of an Infant Homozygous for the 2789+G?A MutationTalkNeonatal Screening Symposium1996Boston, Massachusetts
Amplification of Guthrie Card DNA: Differential Binding of Natural PCR Inhibitors to Guanidine Thiocyanate-Impregnated Filter PaperLecture3rd International Neonatal Screening Symposium1996Boston, Massachusetts
Triad Approach for Detection of Cystic Fibrosis in a Neonatal Screening Program: Identification of an Infant Homozygous for the 2789+G?A MutationLectureInternational Neonatal Screening Symposium1996Boston, Massachusetts
Selective Removal of PCR Inhibitors from Guthrie Card Bloodspots: Rapid Detection of Cystic Fibrosis Mutations in Exon 10 and 11LectureNorth American Regional Neonatal Screening Symposium1995Corpus Christi, Texas
Neonatal Cystic Fibrosis Screening: Implications of Apparent Seasonal Variations in Immunoreactive Trypsinogen ConcentrationLectureNorth American Regional Neonatal Screening Symposium1995Corpus Christi, Texas
Post-Metamorphosis Sequellae of Ni 2+, Co 2+, and Cd 2+ in Xenopus Laevis Assayed by a Modification of the Frog Embryo Teratogenesis Assay Xenopus (FETAX)LectureInternational Conference on Nickel Metabolism and Toxicology1992Sudbury, Ontario, Canada
Excretion of Nickel into Rat Milk and the Effect of Nickel Chloride on Lactating Rats and Their Suckling PupsLectureSociety of Toxicology Annual Meeting1989
Thermoregulatory Impairment in Nickel-Treated RatsTalkInternational Conference on Nickel Metabolism and Toxicology1988Espoo, Finland
Biological Reactivity of Nickel Oxides and Related CompoundsLectureInternational Conference on Nickel Metabolism and Toxicology1988Espoo, Finland
Nickel Absorption and Elimination in Human VolunteersTalkSecond Nordic Symposium, World Health Organization1987Copenhagen, Denmark
Nickel Concentrations in Body Fluids of Healthy Adults and Hemodialysis Patients in Sudbury, Ontario, CanadaTalkSecond Nordic Symposium, World Health Organization1987Copenhagen, Denmark
Cobalt, Chromium, and Nickel Concentrations in Body Fluids of Patients with Porous-Coated Co/Cr ProsthesesTalk1987Odense, Denmark
Serum Nickel Concentrations in Patients with Iatrogenic Exposures to NickelTalkAmerican Chemical Society1985Miami, Florida