Photo of Mayu  Inaba, M.D., Ph.D.

Mayu Inaba, M.D., Ph.D.

Assistant Professor, Department of Cell Biology
Academic Office Location:
Cell Biology
UConn Health
263 Farmington Avenue
Farmington, CT 06030
Phone: 860-679-8739
Email: inaba@uchc.edu
Website(s):

Inaba Lab Page

Cell Biology Graduate Program

Genetics and Developmental Biology Graduate Program

Education
DegreeInstitutionMajor
M.D.Ehime University School of MedicineMedicine
Ph.D.Graduate School of Kyushu UniversityPathological Medicine

Awards
Name of Award/HonorAwarding Organization
DeLill Nasser Travel Award for Professional Development in GeneticsGenetics Society of America
Travel Award for 52nd Annual Meeting of the American Society for Cell BiologyAmerican Society for Cell Biology
Research Fellowship 2003 - 2006Japan Society for the Promotion of Science for Young Scientists

Adult tissue stem cells produce highly differentiated but short-lived cells throughout life, contributing to the tissue maintenance and repair. To balance between stem cell self-renewal and differentiation, stem cell often divide asymmetrically to produce two distinct daughters. We investigate the molecular and cellular mechanisms that regulate asymmetric stem cell division using male and female Drosophila germline stem cell systems. We are currently focusing on several specific questions, 1) How the niche signal is the spatially restricted with the emphasis on the novel stem cell specific structure, MT (microtubule based)-nanotubes? 2) How are the physical obstacles (e.g., protein diffusion b?arrier) of dividing stem cells localized, and how does it contribute to precise fate asymmetry? 3) How does the niche monitors stem cell behavior to globally regulate stem cell activities? 4) Mechanism of stem cell clonal expansion. Taking the advantage of small size and simple anatomy of Drosophila gonads, we can conduct whole tissue live imaging to monitor in vivo stem cell behavior. We generate tools to investigate various protein dynamics in asymmetrically dividing stem cells. Our effort will contribute to comprehensively understand how the extrinsic and intrinsic regulations are integrated to ensure the precise cell fate determination.

Accepting Lab Rotation Students: Summer '17, Fall '17 and Spring '18


Rotation projects

1) Live imaging of germline stem cell division and MT-nanotube formation. Investigate several gene functions comparing mutant vs. wild type stem cells.
2) Mechanism of stem cell clonal expansion. Score the clone domination using heat shock mediated genetic marking of stem cell clone. Compare mutant vs. wild type stem cell clones.
3) Global regulation of total stem cell division. Clonal knockdown of candidate genes in small population of stem cells. Look for the gene which affect division rate of neighboring stem cells.

Journal Articles

Reviews