Photo of Laurinda A. Jaffe, Ph.D.

Laurinda A. Jaffe, Ph.D.

Professor and Chair, Department of Cell Biology
Academic Office Location:
Cell Biology, E-6029
UConn Health
263 Farmington Avenue
Farmington, CT 06030
Phone: 860-679-2661
Fax: 860-679-1269

Jaffe Lab Page

Cell Biology Graduate Program

Genetics & Developmental Biology Graduate Program

B.S.Purdue UniversityBiology
Ph.D.University of California, Los AngelesBiology

Post-Graduate Training
PostdoctoralMarine Biological Laboratory, Woods HoleCell Biology
PostdoctoralUniversity of California, San DiegoCell Biology

Name of Award/HonorAwarding Organization
MERIT Award, 2014National Institute of Health
Human Frontier Science Program Award 2000-2004Human Frontier Science Program
Faculty Award for Women 1991-1997National Science Foundation
Loeser Award for Outstanding TeachingUniversity of Connecticut Health Center
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
2012 Cold Spring Harbor meeting on Germ Cells Workshop/ConferenceOrganizerExternalNational20122012
Department of Cell BiologyEducation CommitteeChairUConn HealthUniversity2011
2011 American Society for Cell Biology minisymposiumWorkshop/ConferenceOrganizerExternalNational20112011
NICHD Board of scientific counselorsAdvisory CommitteeMemberExternalNational20112016
Developmental BiologyEditorial BoardMemberExternalNational2007
Department of Cell BiologyEducation CommitteeInterim ChairUConn HealthUniversity20062011
Cellular, Molecular, and Integrative Reproduction, NIH study section Study SectionMemberExternalNational20062012
Department of Cell BiologyEducation CommitteeVice ChairUConn HealthUniversity20032006
Education Council, Marine Biological Lab (Woods Hole)Education CommitteeMemberExternalUniversity2000
Cell Development and Function, NIH study sectionStudy SectionMemberExternalNational19982002
Developmental Biology Professional/Scientific JournalEditorExternalNational19952007
Developmental Biology Professional/Scientific JournalAssociate EditorExternalNational19861995

My lab's research concerns the physiological mechanisms that regulate the oocyte cell cycle and fertilization. Currently, our studies are focused on meiotic regulation in the ovarian follicle. We are investigating how the ovarian follicle functions as a coordinated system in which events in the somatic cells surrounding the oocyte regulate its meiotic progression.


Accepting Lab Rotation Students: Summer '18, Fall '18, Spring '19

Journal Articles

Book Chapters

  • Initiation of the meiotic prophase-to-metaphase transition in mammalian oocytes
    Jaffe LA, Norris RP Oogenesis -- The Universal Process 2010 Jan;181-197
  • Egg membranes during fertilization
    Jaffe LA Molecular Biology of Membrane Transport Disorders 1996 Jan;367-378
  • Egg activation at fertilization: structural changes in the endoplasmic reticulum
    Jaffe LA, Terasaki M Meiosis II: Contemporary Approaches to the Study of Meiosis 1993 Jan;167-174
  • Receptors, G-proteins, and activation of the amphibian egg
    Kline D, Kado RT, Kopf GS, Jaffe LA Mechanisms of Fertilization, NATO ASI Series, volume H45 1990 Jan;529-541
  • G proteins and the regulation of oocyte maturation and fertilization
    Turner PR, Jaffe LA The Cell Biology of Fertilization 1989 Jan;297-318
  • Receptors, G-proteins, and egg activation
    Jaffe LA Mechanisms of Egg Activation 1989 Jan;151-155
  • Polyspermy prevention mechanisms
    Jaffe LA, Gould M Biology of Fertilization vol 3 1985 Jan;223 250
  • Control of cell fusion at fertilization by membrane potential
    Gould-Somero M, Jaffe LA Cell Fusion: Gene Transfer and Transformation 1984 Jan;27-38
  • Fertilization potentials from eggs of the marine worms Chaetopterus and Saccoglossus
    Jaffe LA The Physiology of Excitable Cells 1983 Jan;211-218