UCONN

HEALTH

Photo of Bruce T. Liang, M.D., F.A.C.C.

Bruce T. Liang, M.D., F.A.C.C.

Dean, UConn School of Medicine
Director, Pat and Jim Calhoun Cardiology Center
Chief, Division of Cardiology
Ray Neag Distinguished Professor of Vascular Biology
Academic Office Location:
Medicine
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3946
Phone: 860-679-3343
Website(s):

UConn School of Medicine

Calhoun Cardiology Center

Cell Biology Graduate Program

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Dr. Liang is a fellow of the American College of Cardiology, the American Heart Association and the Council on Clinical Cardiology and Basic Cardiovascular Sciences. He is also a member of the American Society for Clinical Investigation.

Education
DegreeInstitutionMajor
B.A.Harvard CollegeBiochemistry and Molecular Biology
M.D.Harvard Medical SchoolMedicine

Post-Graduate Training
TrainingInstitutionSpecialty
InternshipHospital of the University of PennsylvaniaMedicine
ResidencyHospital of the University of PennsylvaniaInternal Medicine
FellowshipBrigham and Women's HospitalMedicine (Research/Clinical)
FellowshipHarvard Medical SchoolMedicine (Research)

Awards
Name of Award/HonorAwarding Organization
Blue Precision Designation in CardiologyAnthem Blue Cross and Blue Shield
Elected as a Member of the Connecticut Academy of Science and EngineeringConnecticut Academy of Science and Engineering
National Steering Committee of LEADERS in Clinical Weight Management
Development of a New Method to Detect Heart Failure via a Simple Blood Test
Lifetime Member of Global Who's Who
Named an America’s Top Doctor by Castle Connolly in Cardiovascular Disease Since 2006Castle Connolly Medical Ltd.
Elected and Inducted into the Association of University CardiologistsAssociation of University Cardiologists
Elected and Inducted into the American Society for Clinical InvestigationAmerican Society for Clinical Investigation
Established Investigatorship, 1993-1998 American Heart Association
First Place, Mead Johnson Excellence of Research Award National Student Research Forum
First Place, Roche Laboratories Award in Basic Sciences, National Student Research ForumRoche Laboratories
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Election as a new member of the Connecticut Academy of Science and EngineeringProfessional/Scientific OrganizationMemberExternalState2009
National Institute of Biomedical Imaging and Bioengineering REVIEW PANEL: Enabling Technologies for Tissue Engineering and Regenerative MedicineAdvisory CommitteePanel memberExternalNational20082009
Peer Review Committee, Integrated Cardiac Biology, Northeast Affiliate of American Heart AssocationProfessional/Scientific OrganizationCommittee MemberExternalNational2007
Association of University CardiologistsProfessional/Scientific OrganizationMemberExternalNational2005
NHLBI/NIH SCCOR Review PanelAdvisory CommitteePanel memberExternalNational2004
Center for Scientific Review, Cardiovascular System and Pharmacology ZRG1 HP Panel Professional/Scientific OrganizationPanel memberExternalNational2003
Peer Review Committee, Cardiovascular Pathophysiology III, National American Heart AssociationProfessional/Scientific OrganizationCommittee MemberExternalNational20022004
American Journal of PhysiologyEditorial BoardEditorial BoardExternalNational1999
Peer Review Committee, Molecular Signaling, National American Heart AssociationProfessional/Scientific OrganizationCommittee MemberExternalNational19972001
Dr. Liang’s research program has focused on the fundamental signaling mechanisms that regulate cardiovascular functions. Using the concepts and tools of biochemistry and molecular biology, integrated with a cellular and pharmacological approach, the program has addressed and elucidated novel functions and signaling mechanisms for the various purinergic receptors in the heart. Two tracks of development have evolved new directions and models relevant to advances in cardiovascular research. The first direction is exemplified by the development of a novel cardiac cell model for cardioprotection and ischemic preconditioning. The development of efficient cardiac myocyte transfection enables the use of an approach to delineate mechanism and to develop new receptor ligands important in protecting the myocyte against ischemia. This model is now widely recognized and is currently used by different laboratories. Certain basic observations, for example, those related to his studies on the cardiac adenosine A3 receptor, have been repeated and investigated further by others. His research has yielded new insights on the fundamental mechanisms of cardiac myocyte protection. In a second example, a new transgenic mouse line overexpressing a novel P2X purinergic ligand-gated receptor channel shows enhanced basal cardiac contractility and relaxation. This transgenic line provides the proof of principle that this ligand-gated channel is a potential novel therapeutic target for the treatment of heart failure.

It is anticipated that the program will continue to develop new translational/clinical research projects. Some examples of such research include the ongoing studies on novel purine receptors and their ligands in protecting the ischemic myocardium and in treating heart failure. Study on identifying novel mutations of the adenosine transporter represents another example. Overall, He has had continuous NIH support for the last 16 years. His work advances novel concepts on signaling mechanisms and receptor function. He is an internationally recognized expert on adenosine receptor biology and myocyte function.

Not accepting students for Lab Rotations at this time

Journal Articles

Conference Papers