Photo of Joseph  Lorenzo, M.D.

Joseph Lorenzo, M.D.

Professor of Medicine, Division of Endocrinology and Metabolism, UConn Health
Director of Bone Biology Research, UConn Health
UConn Musculoskeletal Institute
Academic Office Location:
UConn Health
263 Farmington Avenue
Farmington, CT 06030-5456
Phone: 800-535-6232

Dr. Lorenzo is a professor of medicine in the Division of Endocrinology and Metabolism at UConn Health. He is a nationally renowned expert in endocrinology and metabolic bone diseases. Dr. Lorenzo's clinical interests center on the management of patients with osteoporosis and other metabolic bone disorders. He has been named a "Top Doctor in Endocrinology" by U.S. News and World Report since 2011.

Dr. Lorenzo’s research interests center on the regulation of bone remodeling by hormones and cytokines and the interaction of the immune and skeletal systems. He is a founding member of the organizing committee for a series of international conference on "Osteoimmunology: Interactions of the Immune and Skeletal Systems," which have occurred every two years since 2006 and an editor of a textbook on Osteoimmunology (editions 1 and 2). He is also an author of the chapter "Metabolic Bone Disease" in Williams Textbook of Endocrinology (editions 10, 11 and 12). Dr. Lorenzo is a former councilor of the American Society for Bone and Mineral Research, a former deputy editor of the Journal of Bone and Mineral Research and former member of the editorial board of the Journal of Clinical Investigation. He is currently the Scientific Web Page Editor for the American Society for Bone and Mineral Research and a member of the editorial board for the journal Bone.

B.S.Rensselaer Polytechnic InstitutePhysics
M.D.State University of New York, Downstate Medical CenterMedicine

Post-Graduate Training
InternshipUniversity of Illinois Hospital & ClinicMedicine
ResidencyUniversity of Illinois Hospital & ClinicInternal Medicine
FellowshipUniversity of Connecticut School of MedicineEndocrinology/Metabolism

Name of Award/HonorAwarding Organization
Career Development Award, 1983-1988 VA Research Associate
New Investigator Research Award, 1982-1985 NIH

Diabetes and metabolism, endocrinology, osteoporosis, and metabolic bone disease

Lectures in the 2nd year medical and dental school course "Mechanisms of Disease" entitled "Osteoporosis and Metabolic Bone Diseases"

Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Scientific Web Page Editor, American Society for Bone and Mineral ResearchEditorial BoardEditorExternalNational2014
Animal Care CommitteeAdvisory CommitteeChairUConn HealthUniversity2014
Science Education Advisory Committee of the American Society for Bone and Mineral ResearchProfessional/Scientific OrganizationChairExternalNational2013
BoneEditorial BoardEditorial BoardExternalInternational2012
Program Committee Endocrine SocietyEducation CommitteememberExternalInternational20112012
Permanent member, Oral Biology and Medicine 2 NIH Study Section Study SectionMemberExternalNational20002003
Oral Biology and Medicine 2 NIH Study Section Study SectionAd Hoc MemberExternalNational19962000
Deputy Editor Journal of Bone and Mineral Research Editorial BoardEditorExternalNational19911995

Basic Science Research Interests

The influence of hormones and cytokines on both bone resorption, which is mediated by osteoclasts, and bone formation, which is mediated by osteoblasts.

The nature and regulation of osteoclast precursor cells in health and disease.

The influence of the immune system on bone remodeling.

Dr. Lorenzo’s laboratory is actively involved in research that is designed to identify the surface markers of cells that differentiate into osteoclasts in vitro and in vivo. The goal of these studies is to characterize the cells that form osteoclasts and determine if there are different between them in normal and pathologic conditions. It is hoped that this research will lead to the development of targeted therapies that selectively inhibit pathologic osteoclast formation without affecting normal bone turnover.

Clinical Research Interests

The role of hormones in the regulation of serum sclerostin.

The role of hormones in the regulation of osteoclast precursor cells.

Role of Runx1 in osteoclast biology

Not accepting students for Lab Rotations at this time

Journal Articles


  • Effect of exogenous and endogenous prostaglandin E2 on osteoclastogenesis in the RAW 264.7 macrophage cell line.
    Kaneko H, Lee S, Lorenzo JA, Toyama Y, Pilbeam CC, and Raisz LG. J Bone Miner Res 2004 Jan;19(S1)S409
  • Prostaglandin E2 stimulation of osteoclast formation in hematopoietic cell cultures is mediated by a soluble T cell factor.
    Kaneko H, Ono K, Lee SK, Lorenzo JA, Toyama Y, Pilbeam CC, Raisz LG. J Bone Miner Res 2003 Jan;18(S2)S236
  • Effects of aging on the regulation of osteoclast formation in murine bone marrow cultures.
    Lee S, Tomita M, Pilbeam C, Lorenzo J. J Bone Miner Res 2000 Jan;15(S1)S237
  • IL-1 regulation of osteoblastic differentiation in murine bone marrow and primary osteoblastic cultures.
    Tomita M, Okada Y, Alander C, Lorenzo J, Raisz L, Pilbeam C. J Bone Miner Res 2000 Jan;15(S1)S508
  • Effects of prostaglandin G/H synthase-2 knockout on bone.
    Okada Y, Tomita M, Tsurukami H, Nakamura T, Alander C, Sohn J, Raisz L, Lorenzo J, Pilbeam C. J Bone Miner Res 1999 Jan;14(S1)S172
  • Osteoblasts from interleukin 1 receptor type 1 knockout mice have a markedly reduced capacity to support osteoclast function.
    Lorenzo JA, Kalinowski J, Voznesensky O, Pilbeam C. J Bone Miner Res 1999 Jan;14(S1)S164
  • Decreased osteoclastogenic responses in marrow cultures from mice with disruption of the PGHS-2 gene.
    Okada Y, Raisz LG, Lorenzo JA, Alander CB, Freeman A, Voznesensky OS, Hurley MM, Pilbeam CC. J Bone Miner Res 1998 Jan;13(S1)S330
  • Downregulation of mRNA expression for the "decoy" interleukin-1 receptor 2 by ovariectomy in mice.
    Pilbeam C, Rao Y, Alander C, Voznesensky O, Okada Y, Sims J, Raisz L, Lorenzo J. J Bone Min Res 1997 Jan;12(S1)S433
  • Increased production of inflammatory mediators immed-iately after surgery by marrow stromal cell cultures from sham operated and ovariectomized mice.
    Lee SK, Pilbeam CC, Lorenzo JA. J Bone Min Res 1995 Jan;10(S1)S346
  • Ovariectomy or estrogen treatment do not alter interleukin 6 mRNA expression in adult murine bone and bone marrow.
    Vargas SJ, Kawaguchi H, Kalinowski J, Naprta A, Pilbeam C, Raisz L, Lorenzo JA. J Bone Min Res 1994 Jan;9(S1)S389

Conference Papers


  • Osteoimmunology.
    Lorenzo, Joseph; Choi, Yongwon Immunological reviews 2005 Dec;2085-6





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