Wendy Mok, Ph.D.Assistant Professor, Department of Molecular Biology and Biophysics
|H.BSc.||McMaster University||Biochemistry, Molecular Biology Specialization|
|Postdoctoral||Princeton University||Postdoctoral Research Associate, Chemical and Biological Engineering|
|Name of Award/Honor||Awarding Organization|
|Boehringer Ingelheim Foundation Travel Fellowship||University of Basel|
|Charles H. Revson Senior Fellowship in Biomedical Science||Charles H. Revson Foundation|
|Alexander Graham Bell Canada Graduate Scholarship, Doctoral Level||Natural Sciences and Engineering Research Council of Canada|
|Alexander Graham Bell Canada Graduate Scholarship, Master’s Level||Natural Sciences and Engineering Research Council of Canada|
|Undergraduate Student Research Award (USRA), 2004, 2006, 2007||Natural Sciences and Engineering Research Council of Canada|
Medical Microbiology MEDS 444-40
Our research focuses on how bacteria respond to and survive antibiotic treatment. We are especially interested in bacterial persisters, which are rare cell types in a population that can tolerate lethal doses of antibiotics that kill their genetically identical kin. Unlike antibiotic resistant mutants, persisters have not acquired heritable genetic changes that allow them to grow in the presence of antibiotics. Rather, the persister phenotype is transient. Once the antibiotic is removed and cells resume growth, the phenotype is lost. As persisters are recalcitrant to antibiotic treatment, they can potentially fuel the development of relapsing chronic infections and antibiotic resistance.
Our major goal is to understand the triggers and survival strategies of bacterial persisters. We use genetic, biochemical, and systems biology approaches to investigate how fluctuations in the host environment impact persistence and how bacteria respond to and recover from treatment with antibiotics that target different cellular components. Contact us to find out more.
Accepting students for lab rotations.
|Title or Abstract||Type||Sponsor/Event||Date/Year||Location|
|DNA Damage Repair in Fluoroquinolone Persisters Can Fuel Antibiotic Failure||Talk||Bridging Theory and Experiment in Microbial Communities||2018||Princeton Center for Theoretical Science, Princeton, New Jersey|
|Tick-tock: Timing of DNA damage responses impacts fluoroquinolone persistence||Talk||EMBO Workshop on Bacterial Persistence and Antimicrobial Therapy||2018||Congressi Stefano Franscini, Ascona, Switzerland|
|Timing of replication and repair impacts persistence to ofloxacin||Talk||EMBO|EMBL Symposium: New Approaches and Concepts in Microbiology||2017||EMBL, Heidelberg, Germany|
|A macromolecular futile cycle in model Escherichia coli persisters||Talk||Molecular Genetics of Bacteria and Phages Meeting||2015||University of Wisconsin, Madison, WI|
|Decoding toxicity: Characterization of a type I toxin in Escherichia coli||Talk||93rd Canadian Chemistry Conference and Exhibition||2010||Toronto, Ontario, Canada|