Faculty Directory > Moss, Isaac
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Isaac L. Moss, MD, CM, MASc, FRCSCChair, Department of Orthopaedic SurgeryProfessor of Orthopaedic Surgery Co-Director, Comprehensive Spine Center Program Director, UConn Spine Surgery Fellowship
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Dr. Moss is a fellowship trained spine surgeon and assistant professor in the Department of Orthopedic Surgery and the Comprehensive Spine Center at the UConn Musculoskeletal Institute. Dr. Moss completed residency training in the renowned University of Toronto orthopedic program, where he was awarded the Lawson Family Post Graduate Fellowship as the department’s top graduate.After completion of his residency, Dr. Moss received specialized training in advanced spinal and scoliosis surgery at Rush University Medical Center in Chicago, where he developed expertise in treating a variety of complex spinal disorders under the guidance of internationally recognized surgeons.
Dr. Moss’ clinical focus is on the treatment of all disorders of the neck and back. He has specific interest in conditions related to both spinal degeneration and deformity. He has extensive experience in minimally invasive surgery (MIS) solutions to many spinal ailments.
Dr. Moss has a master’s degree in biomedical engineering. He has been recognized with several awards and scholarships for his involvement in cutting edge research to develop novel biologic therapies for intervertebral disc degeneration. He is a member of the North American Spine Society and the Orthopedic Research Society.
Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| Other | Dawson College | Health Science (First Choice Program) |
| Other | McGill University | Medicine |
| Other | University of Toronto | Applied Science |
| Other | Royal College of Physicians and Surgeons of Canada | Clinician Investigator Program |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Residency | University of Toronto | Orthopaedic Surgery |
| Fellowship | Rush University Medical Center | Spine Surgery |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Lawson Family Post Graduate Fellowships | University of Toronto |
| R.I. Harris Award | University of Toronto |
| Top Scoring Posters | Canadian Orthopedic Association Annual Meeting |
| T.R. Sullivan Award | University of Toronto |
| Gallie Bateman Award | Department of Surgery University of Toronto |
| Canada Graduate Scholarship Masters Award | Canadian Institute of Health Research |
| J.A. Nutter Award | Canadian Orthopaedic Resident Association |
| Research Scholarship | Advanced Regenerative Tissue Engineering Centre |
| Surgeon Scientist Fellowship Research 2006-2008 | Draxis Health |
| Ontario Graduate Scholarship | Government of Ontario |
| J.W. McConnell Award | McGill University |
| Dean's Honours List | McGill Faculty of Medicineip Research |
| Glaxo Wellcome Award | McGill Faculty of Medicineip Researchps |
| Dean's Honour's List 1996-1998 | Dawson College |
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| American Orthopaedic Association: Emerging Leaders Program | Professional/Scientific Organization | Member | External | National | 2016 | |
| International Society for the Advancement of Spine Surgery | Professional/Scientific Organization | Member | External | International | 2013 | |
| North American Spine Society SECTION ON SPINE BIOLOGICS AND RESEARCH | Professional/Scientific Organization | Member | External | International | 2012 | |
| North American Spine Society | Professional/Scientific Organization | Member | External | International | 2010 | |
| American Medical Association | Professional/Scientific Organization | Member | External | National | 2010 | |
| Orthopedic Research Society | Professional/Scientific Organization | Member | External | National | 2007 | |
| Canadian Orthopaedic Association | Professional/Scientific Organization | Member | External | National | 2006 | |
| University of Toronto Division Orthopaedic Surgery | Research Committee | Member | External | University | 2005 | 2009 |
| American Academy of Orthopedic Surgeons | Professional/Scientific Organization | Member | External | National | 2003 | |
| Canadian Medical Association | Professional/Scientific Organization | Member | External | National | 2003 | |
| Ontario Medical Association | Professional/Scientific Organization | Member | External | National | 2003 |
Clinical Research: Evaluating the efficacy and clinical outcomes of spinal surgical techniques including both well-established and novel decompression and fusion strategies.
Basic Science Research: Tissue engineering of the intervertebral disc with an eventual goal to develop a biologic regenerative treatment for degenerative disc disease.
Journal Articles
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Dorsal arachnoid web of the thoracic spine associated with an arachnoid cyst and a presyrinx state as an unexplained cause of thoracic myelopathy: illustrative case.
Halloran, Patrick J; Leclair, Nathan K; Bulsara, Ketan R; Chozick, Bruce S; Moss, Isaac L; Becker, Kevin P; Gershon, Abner S; Onyiuke, Hilary C Journal of neurosurgery. Case lessons 2024 Aug;8(8):
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Clinical Outcomes of Prone Transpsoas Lumbar Interbody Fusion: A 1-Year Follow-Up.
Singh, Hardeep; Wellington, Ian; Zeng, Francine; Antonacci, Christopher; Mancini, Michael; Mohamed, Mirghani; Broska, Joellen; Mallozzi, Scott; Moss, Isaac International journal of spine surgery 2024 Jul;
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Hydrogel-Based Strategies for Intervertebral Disc Regeneration: Advances, Challenges and Clinical Prospects.
Desai, Shivam U; Srinivasan, Sai Sadhananth; Kumbar, Sangamesh Gurappa; Moss, Isaac L Gels (Basel, Switzerland) 2024 Jan;10(1):
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The Effects of Interbody Device Design and Placement on Lumbar Lordosis and Disc Height in Transforaminal Lumbar Interbody Fusion.
Wellington IJ, Kaufman CR, Antonacci CL, Coskun E, Cote MP, Singh H, Mallozzi SS, Moss IL Prosthesis 2023 Oct;5(3):752-762
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Allergic reactions from tissue adhesives in spine surgery: a sticky situation.
Wellington, Ian J; Antonacci, Christopher L; Mancini, Michael R; Moss, Isaac L Journal of spine surgery (Hong Kong) 2023 Sep;9(3):233-235
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Comparison of PEEK vs 3D printed titanium cage for ACDF- Is there any difference in subsidence?
Patel HA, Zeng F, Singh H, Mallozzi SS, Cote M, Moss IL Journal of Spine Research and Surgery 2023 Jul;5(3):69-75
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Complications of the Prone Transpsoas Lateral Lumbar Interbody Fusion for Degenerative Lumbar Spine Disease: A Multicenter Study.
Soliman, Mohamed A R; Diaz-Aguilar, Luis; Kuo, Cathleen C; Aguirre, Alexander O; Khan, Asham; San Miguel-Ruiz, Jose E; Amaral, Rodrigo; Abd-El-Barr, Muhammad M; Moss, Isaac L; Smith, Tyler; Deol, Gurvinder S; Ehresman, Jeff; Battista, Madison; Lee, Bryan S; McMains, M Craig; Joseph, Samuel A; Schwartz, David; Nguyen, Andrew D; Taylor, William R; Pimenta, Luiz; Pollina, John Neurosurgery 2023 Jun;
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Current Trends in Recombinant Human Bone Morphogenetic Protein 2 (rhBMP2) Usage for Spinal Fusion Surgery.
Patel, Harshadkumar A; Wellington, Ian J; Lubonja, Klair; Stelzer, John W; Antonacci, Christopher L; Coskun, Ergin; Cote, Mark P; Singh, Hardeep; Mallozzi, Scott S; Moss, Isaac L Medicina (Kaunas, Lithuania) 2023 May;59(5):
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The Prone Lateral Approach for Lumbar Fusion-A Review of the Literature and Case Series.
Barkay, Gal; Wellington, Ian; Mallozzi, Scott; Singh, Hardeep; Moss, Isaac L Medicina (Kaunas, Lithuania) 2023 Jan;59(2):
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Early Clinical Outcomes of the Prone Transpsoas Lumbar Interbody Fusion Technique.
Wellington, Ian J; Antonacci, Christopher L; Chaudhary, Chirag; Coskun, Ergin; Cote, Mark P; Singh, Hardeep; Mallozzi, Scott S; Moss, Isaac L International journal of spine surgery 2023 Jan;
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Novel Injectable Fluorescent Polymeric Nanocarriers for Intervertebral Disc Application.
Arul, Michael R; Zhang, Changli; Alahmadi, Ibtihal; Moss, Isaac L; Banasavadi-Siddegowda, Yeshavanth Kumar; Abdulmalik, Sama; Illien-Junger, Svenja; Kumbar, Sangamesh G Journal of functional biomaterials 2023 Jan;14(2):
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Radiographic alignment outcomes after the single-position prone transpsoas approach: a multi-institutional retrospective review of 363 cases.
Diaz-Aguilar, Luis; Stone, Lauren E; Soliman, Mohamed A R; Padovano, Alexander; Ehresman, Jeff; Brown, Nolan J; Produturi, Gautam; Battista, Madison; Khan, Asham; Pollina, John; Amaral, Rodrigo; Abd-El-Barr, Muhammad M; Moss, Isaac; Smith, Tyler; Deol, Gurvinder S; Lee, Bryan S; McMains, M Craig; Joseph, Samuel A; Schwartz, David; Pimenta, Luiz; Nguyen, Andrew D; Taylor, William R Neurosurgical focus 2023 Jan;54(1):E3
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Modifiable Patient Factors Demonstrate No Increased Risk for 30-Day Complication Rate for Elective 1-2 Level Posterior Lumbar Fusion Surgery: A Comparison Between a National Database and Local Registry.
Kia, Cameron; Yannopoulos, Aris; Gulati, Sagar; Cremins, Michael; Cote, Mark; Moss, Isaac International journal of spine surgery 2022 Jul;
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Determination of a Neurologic Safe Zone for Bicortical S1 Pedicle Screw Placement.
Coskun, Ergin; Wellington, Ian J; Bellas, Nicholas; Singh, Hardeep; Mallozzi, Scott S; Cote, Mark P; Moss, Isaac L The spine journal : official journal of the North American Spine Society 2022 Apr;
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Editors' Introduction: Advances in the Evolution of the Lateral Approach to the Thoracolumbar Spine.
Moss, Isaac L; Eastlack, Robert K International journal of spine surgery 2022 Apr;16(S1):S7-S8
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Notch signaling enhances bone regeneration in the zebrafish mandible.
Kraus, Jessica M; Giovannone, Dion; Rydzik, Renata; Balsbaugh, Jeremy L; Moss, Isaac L; Schwedler, Jennifer L; Bertrand, Julien Y; Traver, David; Hankenson, Kurt D; Crump, J Gage; Youngstrom, Daniel W Development (Cambridge, England) 2022 Mar;149(5):
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Role of simultaneous bilateral transforaminal epidural steroid injections in patients with prior lumbar fusions or laminectomies: A retrospective case series.
Zeng F, Mallozzi S, Moss IL, Cote M, Sakalkale D. Interventional Pain Medicine 2021 Dec;1(1):100066
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Onyiuke Grading Scale: A clinical classification system for the diagnosis and management of Bertolotti syndrome.
Knopf, J; Lee, S; Bulsara, K; Moss, I; Choi, D; Onyiuke, H Neuro-Chirurgie 2021 May;
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Atomic force microscopy imaging for nanoscale and microscale assessments of extracellular matrix in intervertebral disc and degeneration.
Cauble, Meagan A; Mancini, Nickolas S; Kalinowski, Judith; Lykotrafitis, George; Moss, Isaac L JOR spine 2020 Sep;3(3):e1125
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Lumbar Laminectomy in the Outpatient Setting Is Associated With Lower 30-Day Complication Rates.
Karukonda, Teja R; Mancini, Nickolas; Katz, Austen; Cote, Mark P; Moss, Isaac L Global spine journal 2020 Jun;10(4):384-392
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Growing a backbone - functional biomaterials and structures for intervertebral disc (IVD) repair and regeneration: challenges, innovations, and future directions.
Harmon, Matthew D; Ramos, Daisy M; Nithyadevi, D; Bordett, Rosalie; Rudraiah, Swetha; Nukavarapu, Syam P; Moss, Isaac L; Kumbar, Sangamesh G Biomaterials science 2020 Jan;
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Growing a Backbone- Functional Biomaterials and Structures for Intervertebral Disc (IVD) Repair and Regeneration: Challenges, Innovations, and Future Directions
Harmon MD, Ramo DM, Duraisamy N, Bordett R, Rudraiah S, Nukavarapu S, Moss IL, Kumbar S Biomaterials Science 2020 Jan;
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Transcriptional Profiling of Non-injured Nociceptors After Spinal Cord Injury Reveals Diverse Molecular Changes.
Yasko JR, Moss IL, Mains RE Frontier in Molecular Neuroscience 2019 Nov;12284
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Comparative and Predictor Analysis of 30-Day Readmission, Reoperation, and Morbidity in Patients Undergoing Multilevel ACDF vs Single and Multilevel ACCF Using the ACS-NSQIP Dataset.
Katz, Austen David; Mancini, Nickolas; Karukonda, Teja; Cote, Mark; Moss, Isaac Spine 2019 Jul;
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Clinical and Radiographic Evaluation of Multilevel Lateral Lumbar Interbody Fusion in Adult Degenerative Scoliosis.
Katz, Austen D; Singh, Hardeep; Greenwood, Matthew; Cote, Mark; Moss, Isaac L Clinical spine surgery 2019 Mar;
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Approach-Based Comparative and Predictor Analysis of 30-Day Readmission, Reoperation, and Morbidity in Patients Undergoing Lumbar Interbody Fusion Using the ACS-NSQIP Dataset.
Katz, Austen David; Mancini, Nickolas; Karukonda, Teja; Greenwood, Matthew; Cote, Mark; Moss, Isaac Spine 2018 Aug;
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Team Approach: Upper-Extremity Numbness.
Merrill, Christian A; Ferreira, Joel; Parrino, Anthony; Moss, Isaac L JBJS reviews 2018 Jun;6(6):e3
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PDGF-BB Delays Degeneration of the Intervertebral Discs in a Rabbit Preclinical Model.
Paglia, David N; Singh, Hardeep; Karukonda, Teja; Drissi, Hicham; Moss, Isaac L Spine 2016 Apr;41(8):E449-58
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Intradural calcifying pseudoneoplasm.
Singh, Hardeep; Zengou, Ryan; Moss, Isaac L The spine journal : official journal of the North American Spine Society 2015 Sep;16e45-6
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Allogeneic Articular Chondrocyte Transplantation Downregulates Interleukin 8 Gene Expression in the Degenerating Rabbit Intervertebral Disk In Vivo.
Zhang, Yejia; Chee, Ana; Shi, Peng; Wang, Rui; Moss, Isaac; Chen, Er-Yun; He, Tong-Chuan; An, Howard S American journal of physical medicine & rehabilitation / Association of Academic Physiatrists 2014 Aug;94(7):530-8
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PDGF-BB inhibits intervertebral disc cell apoptosis in vitro.
Presciutti, Steven M; Paglia, David N; Karukonda, Teja; Soung, Do Yu; Guzzo, Rosa; Drissi, Hicham; Moss, Isaac L Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2014 May;32(9):1181-8
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Effects of Wnt5a Haploinsufficiency on Bone Repair.
Clifton, Kari B; Paglia, David N; Soung, Do Y; Wolf, Jennifer M; Moss, Isaac L; Drissi, Hicham Journal of orthopaedic trauma 2013 Dec;28(8):e191-7
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Retroperitoneal approach to the intervertebral disc for the annular puncture model of intervertebral disc degeneration in the rabbit.
Moss, Isaac L; Zhang, Yejia; Shi, Peng; Chee, Ana; Piel, Marge J; An, Howard S The spine journal : official journal of the North American Spine Society 2013 Mar;13(3):229-34
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A novel thiol-modified hyaluronan and elastin-like polypetide composite material for tissue engineering of the nucleus pulposus of the intervertebral disc.
Moss, Isaac L; Gordon, Lyle; Woodhouse, Kimberly A; Whyne, Cari M; Yee, Albert J M Spine 2011 Jun;36(13):1022-9
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Assessment of biocompatibility and initial evaluation of genipin cross-linked elastin-like polypeptides in the treatment of an osteochondral knee defect in rabbits.
Hrabchak, Christopher; Rouleau, Jessica; Moss, Isaac; Woodhouse, Kimberly; Akens, Margarete; Bellingham, Catherine; Keeley, Fred; Dennis, Madison; Yee, Albert Acta biomaterialia 2010 Jun;6(6):2108-15
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Molecular basis of species-specific expression of repolarizing K+ currents in the heart.
Zicha, Stephen; Moss, Isaac; Allen, Bruce; Varro, Andras; Papp, Julius; Dumaine, Robert; Antzelevich, Charles; Nattel, Stanley American journal of physiology. Heart and circulatory physiology 2003 Oct;285(4):H1641-9
Book Chapters
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Anatomy and Physiology of the Spine
Moss IL Orthopaedic Knowledge Update: Spine 2018 Sep;
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Musculoskeletal Anatomy and
Physiology
Isaac L Moss Scott S Mallozzi AAOS: Orthopaedic Knowledge Update: Spine 6
Abstracts
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Potential Molecular Basis of Different Repolarizing K+ Current Profiles Between Rabbit and Guinea Pig
Zicha S, Moss I, Wang Z, Nattel S Biophysical Journal 2002 Jan;82(1):245
Case Reports
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Chronic Atlantoaxial Rotatory Subluxation in an Adult Following a Traumatic Event: A Case Report
Kia C, Mallozzi SS, Moss IL International Journal of Spine Surgery
Erratums
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Correction: Growing a backbone - functional biomaterials and structures for intervertebral disc (IVD) repair and regeneration: challenges, innovations, and future directions.
Harmon, Matthew D; Ramos, Daisy M; Nithyadevi, D; Bordett, Rosalie; Rudraiah, Swetha; Nukavarapu, Syam P; Moss, Isaac L; Kumbar, Sangamesh G Biomaterials science 2021 Mar;9(6):2322-2323
Other
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Superposition of Standing Waves on Guitar Strings
Moss I Dawson College Journal of Experimental Science 1999 Jan;14-6
Reviews
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Clinical and radiologic outcomes of posterior column extension, pedicle subtraction, and vertebral column resection osteotomies in adult chin on chest deformity: A systematic review.
Coskun, Ergin; Wellington, Ian J; Chaudhary, Chirag; Crea, Kathleen; Cote, Mark P; Rhee, John M; Mallozzi, Scott; Moss, Isaac L; Singh, Hardeep North American Spine Society journal 2024 Jun;18100324
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The Relationship between Preoperative Expectations and the Short-Term Postoperative Satisfaction and Functional Outcome in Lumbar Spine Surgery: A Systematic Review.
Ellis, Daniel J; Mallozzi, Scott S; Mathews, Jacob E; Moss, Isaac L; Ouellet, Jean A; Jarzem, Peter; Weber, Michael H Global spine journal 2015 Oct;5(5):436-52
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
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| Allogeneic Articular Chondrocyte Survived in the Degenerating Rabbit Intervertebral Disc In Vivo: Implications for Cell Therapy with Allogeneic Cells | Talk | Orthopaedic Research Society Annual Meeting | 2012 | San Francisco, CA |
| Why Don't Annular Defects Heal? Does Interposed Nucleus Pulposus Prevent Healing? An In Vivo Histological Study | Talk | North American Spine Society Meeting | 2011 | Chicago, IL |
| Repair of Osteochondral Defects Using Genepin-cross-linked Elastin-like Polypeptide Hydrogels | Poster | Canadian Orthopaedic Association Annual Meeting | 2009 | Whistler, British Columbia, Canada |
| In Vivo Feasibility of Thiol-modified Hyaluronan and Elastin-like Polypeptide Hydrogels for the Treatment of Early Degenerative Disc Disease | Poster | Canadian Orthopaedic Association Annual Meeting | 2009 | Whistler, British Columbia, Canada |
| Biomechanical and Biochemical Evaluation Composite Scaffolds for Nucleus Pulposus Tissue Engineering | Talk | Gallie Day, Department of Surgery, University of Toronto | 2008 | Toronto, Canada |
| Mechanical and Biological Investigation of A Novel Hyaluronan and Elastin-like Polypeptide Nucleus Pulposus Scaffold | Talk | Canadian Spine Society Annual Meeting | 2008 | Sun Peaks, British Columbia |
| Nucleus Pulposus Tissue Repair in Intervertebral Disc Degeneration: Biochemical and Mechanical Evaluation of a Novel Human Disc Cell - Hyaluronan/Elastin Polypeptide Scaffold Composite | Poster | Orthopedic Research Society Annual Meeting | 2008 | San Francisco, CA |
| Novel Hyaluronan and Elastin Biomaterial for Tissue Engineering of the Nucleus Pulposus | Talk | Canadian Orthopedic Residents Association | 2007 | Halifax, Nova Scotia |
| A Novel Composite Scaffold for Tissue Engineering of the Intervertebral Disc | Poster | Canadian Connective Tissue Conference | 2007 | Toronto, Ont. Canada |
| A Tissue Engineering Approach to Degenerative Disc Disease | Poster | TERMIS NA annual meeting | 2007 | Toronto, Ont. Canada |
| Does Repair of Distal Radius Fractures Require Orthopedic Expertise? | Talk | Orthopedic Trauma Association Annual Meeting | 2004 | Hollywood, FL |