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Photo of Michael J. Murphy, M.B., B.Ch., B.A.O., M.Med.Sc., (N.U.I.)

Michael J. Murphy, M.B., B.Ch., B.A.O., M.Med.Sc., (N.U.I.)

Professor of Dermatology and Dermatopathology
Director of Immunopathology
Academic Office Location:
Division of Dermatopathology
Department of Dermatology
University of Connecticut Health Center
21 South Road
Farmington, CT 06030--6230
Website(s):

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Dr. Murphy is a professor of dermatology and dermatopathology, attending dermatopathologist, and director of the Immunopathology Laboratory within the Department of Dermatology at the UConn Health Center. He graduated from the medical school at University College Dublin, Ireland. Dr. Murphy completed his residency and chief residency in anatomic pathology at the Beth Israel Deaconess Medical Center, Harvard Medical School in Boston, MA, and his fellowship in dermatopathology at Albany Medical College, Albany, NY.

His research focuses on the proteomic characterization of skin cancers. Dr. Murphy has a particular interest in the role of molecular technologies in the diagnosis and management of skin disorders, and the education of residents and fellows on this subject.

Molecular Diagnostics in Dermatology and Dermatopathology written by Dr. Murphy, is the first textbook of its kind. It presents the basics of molecular biology and molecular diagnostic methods most commonly used in the clinical laboratory, with an emphasis on the concepts and testing most relevant to skin diseases.

Education
DegreeInstitutionMajor
M.D.University College Dublin, IrelandMedicine
M.S.University College Dublin, IrelandPhysiology
DiplomaRoyal College of Surgeons in IrelandSports Medicine

Post-Graduate Training
TrainingInstitutionSpecialty
InternshipMater Misericordiae Hospital General Medicine/Surgery
ResidencyBeth Israel Deaconess Medical CenterResident in Anatomic Pathology
ResidencyBeth Israel Deaconess Medical Center Harvard Medical SchoolChief Resident in Anatomic Pathology
FellowshipAlbany Medical Center Dermatopathology
OtherUniversity of DundeeEnrolled: Postgraduate Certificate in Medical Education (PG CertMedEd), College of Medicine, Dentistry and Nursing

Awards
Name of Award/HonorAwarding Organization
Research GrantDermatology Foundation and American Society of Dermatopathology
Munksgaard and Journal of Cutaneous Pathology Prize Awarded for the Paper: Murphy M. et al. Detection of Clonal T-Cell Receptor Gamma Gene Rearrangements in Early Mycosis Fungoides by Polymerase Chain Reaction and Non-radioactive Single Strand Conformational Polymorphism (PCR-SSCP). J Cutan Pathol 2000;27:228-234Journal of Cutaneous Pathology
Best Resident/Fellow Poster Presentation: “A Novel Paraffin-reactive CD7 Antibody: Experiences with Benign and Malignant Cutaneous Lymphocytic Infiltrates.” 37th Annual Meeting of the American Society of Dermatopathology, Baltimore, MDAmerican Society of Dermatopathology
Finalist in Patrick N. Meehan Prize CompetitionUCD Medical Postgraduates Association Meeting
New England Cancer Society Daland Award for Best Oral Presentation: “Detection of T-cell Clonality by Novel Non-radioactive PCR-SSCP: Diagnostic Uses.” Annual Meeting of the New England Cancer Society, Worcester, MANew England Cancer Society
Undergraduate Award in AnesthesiaNUI
Immunohistochemistry, molecular diagnostics, and curriculum development
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
International Society of DermatologyProfessional/Scientific OrganizationMemberExternalInternational2012
Pediatric Dermatology, International Journal of Tropical Disease & Health Professional/Scientific JournalAd Hoc ReviewerExternalInternational2012
Archives of Pathology and Laboratory Medicine Professional/Scientific JournalAd Hoc ReviewerExternalNational2009
American Journal of Clinical Dermatology Professional/Scientific JournalAd Hoc ReviewerExternalNational2007
British Society for DermatopathologyProfessional/Scientific OrganizationMemberExternalInternational2005
Journal of the American Academy of Dermatology Professional/Scientific JournalAd Hoc ReviewerExternalNational2004
American Society of DermatopathologyProfessional/Scientific OrganizationMemberExternalNational2003
International Society of DermatopathologyProfessional/Scientific OrganizationMemberExternalInternational2003
Journal of Cutaneous Pathology Professional/Scientific JournalAd Hoc ReviewerExternalNational2000
Association for Molecular PathologyProfessional/Scientific OrganizationMemberExternalNational1999
Tumorigenesis and proteomics

Journal Articles

Books

  • Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma.(Current Clinical Pathology and Oncology series) 2011 Dec;
  • Molecular Diagnostics in Dermatology and Dermatopathology. (Current Clinical Pathology and Oncology series 2011 Jun;

Book Chapters

  • Melanocytic Nevi
    Grant-Kels J, Murphy M. Connecticut's Current Therapy 2013 Jan;
  • Melanocytic Nevi
    Grant-Kels J, Murphy M. Connecticut's Current Therapy 2012 Jan;236-239
  • Clinical and Histopathological Parameters in Melanoma
    Bilinski C, LaChance A, Murphy M. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma 2011 Jan;49-67
  • Evidence of Skin Field Cancerization
    Carlson JA, Murphy M, Slominski A, Wilson VL. Field Cancerization: Basic Science and Clinical Applications 2011 Jan;317-369
  • Infectious Diseases of the Skin II: Non-Dermatophytic Infections
    Murphy M, LaChance A. Molecular Diagnostics in Dermatology and Dermatopathology 2011 Jan;339-357
  • Inflammatory disorders of the skin
    Murphy M, Phelps A, Braun-Falco M. Molecular Diagnostics in Dermatology and Dermatopathology,(Current Clinical Pathology and Oncology series) 2011 Jan;283-310
  • Inflammatory Disorders of the Skin
    Murphy M, Phelps A, Braun-Falco M. Molecular Diagnostics in Dermatology and Dermatopathology 2011 Jan;283-310
  • Introduction to Dianostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma
    Murphy M Diagnostic and Prognostic Biomakers and Therapeutic Targets in Melanoma 2011 Jan;1-7
  • Introduction to Molecular Diagnostic Testing in Dermatology and Dermatopathology
    Murphy M. Molecular Dianostics in Dermatology and Dermatopathology 2011 Jan;1-12
  • Leukemia Cutis
    Murphy M. Molecular Diagnostics in Dermatology and Dermatopathology 2011 Jan;263-281
  • Melanocytic Neoplasms I: Molecular Diagnosis
    Gerami P, Gammon B, Murphy M. Molecular Diagnostics in Dermatology and Dermatopathology 2011 Jan;73-103
  • Melanocytic Neoplasms II: Molecular Staging
    Murphy M, Carlson JA. Molecular Dianostics in Dermatology and Dermatopatholgy 2011 Jan;105-130
  • Melanocytic Nevi
    Grant-Kels J, Murphy M. Connecticut's Current Therapy 2011 Jan;845-848
  • Molecular Aspects of Skin Aging
    Murphy M. Molecular Diagnostics in Dermatology and Dermatopathology 2011 Jan;411-418
  • Molecular Determination of Tissue Margins, Clonal Origin and Histogenesis of Skin Cancers
    Murphy M. Molecular Diagnostics in Dermatology and Dermatopathology 2011 Jan;191-202
  • Molecular Pathogenesis of Melanoma: Established and Novel Pathways
    Ascierto PA, Ascierto ML, Capone M, Elaba Z, Murphy M, Palmieri G. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma 2011 Jan;19-37
  • Mycosis Fungoides and Related Lesions
    Murphy M. Molecular Diagnostics in Dermatology and Dermatopathology 2011 Jan;203-231
  • Pharmacogenetics and Pharmacogenomics I: Linking Diagnostic Classification to Therapeutic Decisions
    Murphy M, Pincelli C, Hoss D, Borroni R. Molecular Diagnostics in Dermatology and Dermatopathology 2011 Jan;419-441
  • Staging of Melanoma
    Elaba Z, Murphy M, Kerr P, Grant-Kels J. Diagnostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma 2011 Jan;39-48
  • Surgical Management of Melanoma, Concept of Field Cancerization and Molecular Evaluation of Tissue Margins
    Phelps A, Murphy M. Dianostic and Prognostic Biomarkers and Therapeutic Targets in Melanoma 2011 Jan;243-246
  • Technologies in the Molecular Diagnostics Laboratory
    Elaba Z, Murphy M, Mnayer L. Molecular Diagnostics in Dermatology and Dermatopathology 2011 Jan;27-55
  • Tissue-Based Protein Biomarkers in Melanoma: Mass Spectrometry-Based Strategies
    Murphy M, Rezaul K, Han DK Diagnostic and Prognostic Biomarkers and Therapeutics Targets in Melanoma 2011 Jan;189-194
  • Wound Healing Disorders: Chronic Ulcers and Keloids
    Murphy M. Molecular Diagnostics in Dermatology and Dermatopathology 2011 Jan;359-368

Abstracts

  • Mass spectrometry-based identification of proteins in archival malignant melanoma tissue samples
    Elaba Z, Rezaul K, Murphy M, Han D. Mod Pathol 2010 Jan;23113A
  • Acid-fast (ziehl-nielson) staining facilitates follicular counting in horizontally-sectioned scalp biopsies
    Hoss D, Berke A, Murphy M, Kerr P, Grant-Kels J. J Cutan Pathol 2005 Jan;(31):93
  • Prominent Papillary Dermal Edema in Dermatophytosis. (41st Annual Meeting of The American Society of Dermatopathology (ASDP).)
    Hoss DM, Berke A, Kerr P, Murphy M, Grant-Kels JM. J Cutan Pathol 2004 Jan;3293
  • Pseudo-zellballen features: Dermal response to metastatic renal cell carcinoma. A diagnostic pitfall
    Murphy M, Berke A, Chartier M, Grant-Kels J, Hoss D. J Cutan Pathol 2004 Jan;31118
  • The sensitivity and specificity of "caterpillar bodies" in the differential diagnosis of subepidermal blistering disorders.
    Fung, Maxwell A; Murphy, Michael J; Hoss, Diane M; Berke, Adrienne; Grant-Kels, Jane M The American Journal of dermatopathology 2003 Aug;25(4):287-90
  • Caterpillar bodies in porphyria: How specific are they?
    Fung M, Hoss D, Berke A, Murphy M, Grant-Kels J. J Invest Dermatol 2002 Jan;119322
  • A novel paraffin-reactive CD7 antibody: experiences with benign and malignant cutaneous lymphocytic infiltrates
    Murphy M, Fullen D, Carlson JA. J Cutan Pathol 2000 Jan;27566A
  • Hypoxia upregulates p27 in solid tumors
    Murphy M, Signoretti S, Thomas GV, Carlson JA, Loda M. Lab Invest 2000 Jan;80200A
  • p27 protein expression in malignant melanoma: inverse correlation with depth of invasion
    Murphy M, Signoretti S, Carlson JA, Loda M. J Cutan Pathol 2000 Jan;27324
  • cdc25A and p27 expression in human non-Hodgkin's lymphomas
    Murphy M, Moreira G Jr, Signoretti S, Soung P, Sherburne B, Loda M. Lab Invest 1999 Jan;79143A
  • Detection of clonal T-cell receptor gamma gene rearrangements in early CTCL by polymerase chain reaction and non-radioactive single strand conformational polymorphism (PCR-SSCP).
    Murphy M, Signoretti S, Kadin ME, Loda M. Lab Invest 1999 Jan;7961A
  • Detection of clonal T-cell receptor gamma gene rearrangements by PCR and non-radioactive single strand conformational polymorphism (SSCP) in paraffin embedded tissue
    Signoretti S, Murphy M, Cangi MG, Puddu P, Sherburne B, Kadin M, Loda M. Lab Invest 1998 Jan;78188A
  • Detection of recurrent non-Hodgkins lymphoma in serous effusions by PCR
    Murphy M, Signoretti S, Nasser I, Loda M Lab Invest 1998 Jan;7841A

Case Reports

  • aCGH as a diagnostic aid in a childhood spitzoid melanoma
    Danialan R, Gopinath A, Murphy M, Rader C, Ricci A, Earle J, Elaba Z CAP Today 2013 Jan;946
  • Yellow nodule on the distal finger. Xanthomatous giant cell tumor of tendon sheath
    Murphy M, Kristjansson A, Luis J, Makkar HP Arch Dermatol 2009 Jan;145931-936
  • Bacterial infection within a rheumatoid nodule: A rarely reported finding
    Murphy M, Murphy L, Berke A, Kerr P, Grant-Kels J, Greenberg R, Hoss D. Internet Journal of Dermatology 2007 Jan;51

Letters

Reviews

  • Molecular diagnostic strategies: a role in the practice of dermatology.
    Elaba, Zendee; Phelps, Amanda; Murphy, Michael J International journal of dermatology 2012 Nov;51(11):1292-302
  • Accurate identification of melanoma tumor margins: A review of the literature
    Danialan R, Gopinath A, Phelps A, Murphy M, Grant-Kels J. Exp Rev Dermatol 2012 Jan;7343-358
  • Ethical conundrums in research.
    LaChance, Avery; Murphy, Michael J Clinics in dermatology 2012 Jan;30(2):220-5
  • Molecular diagnostics in dermatology.
    Murphy M Irish Medical Times 2012 Jan;
  • MDx: Coming of age in dermatology, dermatopathology
    Murphy M Advance for Administrators of the Laboratory 2011 Jan;2024-28
  • Molecular diagnostic testing in dermatology and dermatopathology
    Elaba Z, Murphy M J Phil Dermatol Soc 2011 Jan;2016-24
  • Molecular diagnostics.
    Murphy M Dermatology Times 2011 Jan;16
  • Nutrition and bullous skin diseases.
    Fedeles, Flavia; Murphy, Michael; Rothe, Marti J; Grant-Kels, Jane M Clinics in dermatology 2010 Jan;28(6):627-43
  • Childhood melanoma.
    Jen, Melinda; Murphy, Michael; Grant-Kels, Jane M Clinics in dermatology 2009 Jan;27(6):529-36
  • Melanoma on the move: the progression of melanoma: novel concepts with histologic correlates.
    Kluk, Michael J; Grant-Kels, Jane M; Kerr, Philip; Hoss, Diane; Berke, Adrienne; Claffey, Kevin P; Murphy, Michael The American Journal of dermatopathology 2004 Dec;26(6):504-10
  • Proliferation, apoptosis and cell cycle regulation in prostatic carcinogenesis.
    Magi-Galluzzi, C; Murphy, M; Cangi, M G; Loda, M Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 1998 Oct;20(5):343-50
Title or AbstractTypeSponsor/EventDate/YearLocation
Spindle cell melanoma with a component of combined tumor showing features of melanoma and basal cell carcinoma.PosterXXXIV Symposium of the International Society of Dermatopathology.2013Florence, Italy
Childhood-type spitzoid melanoma with diffuse p16 immunoreactivityTalk16th Joint Meeting of the International Society of Dermatopathology2013Miami, FL
Metastatic high grade urothelial carcinoma to the scalp: a case reportPoster49th Annual Meeting of the American Society of Dermatopathology2012Chicago, IL
Grand Rounds: “Molecular Diagnostics in Dermatology and Dermatopathology”LectureUniversity of Connecticut Health Center Department of Dermatology2012Farmington, CT
Mass spectrometry-based identification of proteins in archival cutaneous lymphomaPosterUniversity of Connecticut Medical/Dental Student Scientific Research Day2011Farmington, CT
Mass spectrometry-based identification of proteins in archival malignant melanoma tissue samples. Talk99th Annual Meeting of the U.S. and Canadian Div. of the Internat. Academy 2010Washington, DC
Acid-fast (ziehl-nielson) staining facilitates follicular counting in horizontally-sectioned scalp biopsies.Talk41st Annual Meeting of the Amer. Soc. of Dermatopathology2004Boston, MA
Prominent papillary edema in dermatophytosisPoster41st Annual Meeting of the American Society of Dermatopathology2004Boston, MA
Pseudo-zellballen features: Dermal response to metastatic renal cell carcinoma. A diagnostic pitfallPoster40th Annual Meeting of the American Society of Dermatopathology2003Chicago, IL
Caterpillar bodies in porphyria: How specific are they?Poster63rd Annual Meeting of the Society for Investigative Dermatology2002Los Angeles, CA
A novel paraffin-reactive CD7 antibody: experiences with benign and malignant cutaneous lymphocytic infiltratesPoster37th Annual Meeting of the American Society of Dermatopathology2000Baltimore, MD
Primary cutaneous CD30- large T-cell lymphoma versus mycosis fungoides with transformationTalkAnnual Dermatology Teaching Day2000Albany Medical College, Albany, NY
Cutaneous polyarteritis nodosaTalkAnnual Dermatology Teaching Day2000Albany Medical College, Albany, NY
Hypoxia upregulates p27 in solid tumorsPoster89th Annual Meeting of the U.S./Canadian Division of Internat. Academy of P2000New Orleans, LA
Grand Rounds: “Angiogenesis and Malignant Melanoma”LectureDepartment of Dermatology, Albany Medical Center 2000Albany, NY
cdc25A and p27 expression in human non-Hodgkin's lymphomasPoster88th Annual Meeting of the U.S./Canadian Division of the Intern. Academy of1999San Francisco, CA
Grand Rounds: “Metastatic Carcinoma of Unknown Primary: Utility of CK7/20 Expression”LectureDepartment of Pathology, Beth Israel Deaconess Medical Center1999Boston, MA
p27 protein expression in malignant melanoma: inverse correlation with depth of invasion.Talk36th Annual Meeting of the American Society of Dermatopathology1999San Diego, CA
Detection of clonal T-cell receptor gamma gene rearrangements in early CTCL by polymerase chain reaction and non-radioactive single strand conformational polymorphism (PCR-SSCP).Talk88th Annual Meeting of the United States and Canadian Division of the Inter1999San Francisco, CA
Grand Rounds: “Pathology of Pancreatic Transplantation”,LectureDepartment of Pathology, Beth Israel Deaconess Medical Center1998Boston, MA
Detection of T-cell clonality by novel non-radioactive PCR-SSCP: diagnostic uses. TalkAnnual Meeting of the New England Cancer Society1998Worcester, MA
Detection of T-cell clonality by novel non-radioactive PCR-SSCP: diagnostic usesTalkUCD Medical Postgraduates Association Meeting1998Dublin, Ireland
IgH gene rearrangement analysis by PCR on microdissected B-cell subpopulations in cutaneous B-cell infiltratesTalk22nd International Congress of the International Academy of Pathology1998Nice, France
Detection of clonal T-cell receptor gamma gene rearrangements by PCR and non-radioactive single strand conformational polymorphism (SSCP) in paraffin embedded tissueTalk87th Annual Meeting of the United States and Canadian Division of the Inter1998Boston, MA
Detection of recurrent non-Hodgkins lymphoma in serous effusions by PCRPoster87th Annual Meeting of the United States and Canadian Division of the Inter1998Boston, MA
Grand Rounds: “Rhabdomyosarcomas"LectureDepartment of Pathology, Beth Israel Deaconess Medical Center1996Boston, MA
CGH analysis of low and high grade invasive breast carcinomas. Increased copy number of 8q12-qter associated with aggressive phenotypePosterIrish Cancer Society Annual Meeting1996Limerick, Ireland