UCONN

HEALTH

Photo of Patrick A. Murphy, Ph.D.

Patrick A. Murphy, Ph.D.

Assistant Professor
Academic Office Location:
Center for Vascular Biology
UConn Health
263 Farmington Avenue
Farmington, CT 06030
Website(s):

Murphy Lab

Center for Vascular Biology

Education
DegreeInstitutionMajor
Ph.D.University of California, San FranciscoBiomedical Sciences
B.S., B.A.Hamilton CollegeBiology and English

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralMassachusetts Institute of TechnologyRichard Hynes Lab

Awards
Name of Award/HonorAwarding Organization
National Institutes of Health Pathway to Independence Award (R00)National Institutes of Health - NHLBI
National Institutes of Health Pathway to Independence Award (K99)National Institutes of Health - NHLBI
Postdoctoral FellowshipAmerican Heart Association
Ruth L. Kirschstein National Research Service Award (NRSA) Individual Postdoctoral Fellowship (F32)National Institutes of Health - NHLBI
Predoctoral FellowshipAmerican Heart Association

Disturbed blood flow patterns can lead to chronic inflammatory conditions in the arterial wall, a precipitating event in cardiovascular components of heart attack and stroke.  The Murphy lab is dissecting the interactions between recruited immune cells and the arterial wall using inducible genetic models combined with intravital imaging, and in vitro co-culture models under varying flow regimes. We are endothelial-centric and focused on changes in alternative splicing and the sub-endothelial extracellular matrix induced by innate immune cell recruitment, which our data suggests play an important role in the progression of arterial inflammation. A deeper understanding of how the endothelium interacts with recruited immune cells will reveal ways to intervene with the processes underlying the growth and rupture of aneurysms and atherosclerotic plaques.


Accepting students for Lab Rotations: Summer '17, Fall '17, Spring '18


Journal Articles

Title or AbstractTypeSponsor/EventDate/YearLocation
A Splice in Time: Alternative Splicing Regulation and Functions in Flow-induced Arterial InflammationTalkCenter for Excellence in Vascular Biology at Brigham and Women's Hospital2015Boston, MA
A Splice Odyssey :  Alternative RNA Splicing Regulates Arterial Response to Innate Immune Cell Recruitment under Altered FlowTalkBoston Angiogenesis Meeting2015Boston, MA
Endothelial Regulation of the Arterial Subendothelial Matrix by Disturbed Flow: A Quantitative Transcriptomic and Proteomic CharacterizationTalkNorth American Vascular Biology Organization : Matrix Biology2015Hyannis, MA
A Splice Odyssey: an epic drama of alternative splicing in vascular inflammationTalkMassachusetts Institute of Technology2015Cambridge, MA
Macrophages induce an alternative splicing program in arterial endothelium exposed to disturbed flowTalkNorth American Vascular Biology Organization : Vascular Inflammation2014Monterey, CA
Alternative splicing of fibronectin protects against dissecting aneurysmTalkNorth American Vascular Biology Organization : Matrix Biology2013Hyannis, MA
Alternative splicing in the vascular response to pathological shear stressPosterNAVBO : International Vascular Biology Meeting2012Wiesbaden, GER
Notch reversibly converts veins to arteries and regulates arteriovenous hierarchy in miceTalkCold Spring Harbor : Blood Brain Barrier2010Cold Spring Harbor, NY
Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the diseaseTalkNorth American Vascular Biology Organization : Genetics and Genomics2009Hyannis, MA
Endothelial expression of constitutively activated Notch4 promotes Brain Arterio-Venous Malformations (BAVM) and characteristics of stroke in miceTalkGordon Research Conference : Angiogenesis and Microcirculation2007Newport, RI