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Photo of Syam P. Nukavarapu, Ph.D.

Syam P. Nukavarapu, Ph.D.

Assistant Professor, Orthopaedic Surgery, Biomedical Engineering, Materials Science & Engineering
Academic Office Location:
Orthopaedic Surgery
UConn Health
263 Farmington Avenue
Farmington, CT 06030
Phone: 860-679-4183
Fax: 860-679-1553
Email: syam@uchc.edu
Website(s):

Skeletal Biology and Regeneration Graduate Program

Biomedical Engineering

Materials Science & Engineering

Education
DegreeInstitutionMajor
B.Sc.Nagarjuna UniversityPhysical Sciences
M.Sc.University of HyderabadChemistry
Ph.D.Materials Research Centre, IIScMaterials Science and Engineering

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralLehigh UniversityPost Doctoral Fellow, Materials Science and Engineering

Awards
Name of Award/HonorAwarding Organization
Junior Investigator AwardMusculoskeletal Transplant Foundation (MTF)
Mentorship AwardConnecticut Institute for Clinical and Translational Science (CICATS)
Young Investigator AwardAO Foundation
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Journal of Regenerative Medicine and Tissue EngineeringEditorial BoardMemberExternalNational2012
Encyclopedia of Biomedical Polymers and Polymeric BiomaterialsEditorial BoardMemberExternalNational2012
Hierarchical Three-dimensional Structures for Tissue Regeneration, The 9th Biomaterials Congress, Chengdu, China, 2012Advisory CommitteeSession OrganizerExternalInternational20122012
Journal of Biomaterials and Tissue EngineeringEditorial BoardMemberExternalNational2011
Journal of Nanomedicine and NanotechnologyEditorial BoardMemberExternalNational2011
Journal of Tissue Science and EngineeringEditorial BoardMemberExternalNational2011
Controlled Release Society (CRS)Professional/Scientific OrganizationMemberExternalNational2011
Biomedical Engineering Society (BMES)Professional/Scientific OrganizationMemberExternalNational2011
Vascular Tissue Engineering, IEEE Engineering in Medicine and Biology (EMBC) annual meeting, Boston, 2011Advisory CommitteeSession Co-ChairpersonExternalInternational20112011
Tissue Regeneration and Repair, New England Musculoskeletal Institute 5th Annual Meeting, Farmington, CT, 2011.Advisory CommitteeSession Co-ChairpersonUConn HealthRegional20112011
Scaffold Assisted Bone Defect Repair/Regeneration, Society for Biomaterials (SFB) Annual Meeting, Orlando, FL, 2011.Advisory CommitteeSession Organizer and ChairpersonExternalNational20112011
Biomaterial technologies for Treating Nonunion bone defects: Research developments and Clinical applications, Society for Biomaterials Annual Meeting, Washington, WA, 2010Advisory CommitteeSession Organizer and ChairpersonExternalNational20102010
Orthopaedic Biomaterials, Society for Biomaterials (SFB) Annual Meeting, Washington, WA, 2010.Advisory CommitteeSession Organizer and Chair PersonExternalNational20102010
Artificial OrgansEditorial BoardMemberExternalNational2009
U.S. Army Medical Research and Materiel CommandAdvisory CommitteeMail Grant ReviewerExternalNational20092009
NIH Challenge GrantspAdvisory CommitteeMail Grant ReviewerExternalNational20092009
Orthopaedic Biomaterials Special Interest Group, Society for BiomaterialsAdvisory CommitteeGeneral SecretaryExternalNational20092011
Arnold and Mabel Beckman Institute for Macular Research Annual Meeting. Participated in the task group of Nanoscience and Nanotechnology. Irvine, CA, 2009.OtherMemberExternalNational20092009
Tissue Engineering International & Regenerative Medicine Society (TERMIS)Professional/Scientific OrganizationMemberExternalInternational2008
Materials Research Society (MRS)Professional/Scientific OrganizationMemberExternalNational2008
Orthopaedic Research Society (ORS)Professional/Scientific OrganizationMemberExternalNational2007
Sigma Xi, The Scientific Research SocietyProfessional/Scientific OrganizationMemberExternalNational2007
Society for Biomaterials (SFB)Professional/Scientific OrganizationMemberExternalNational2005
PNASProfessional/Scientific JournalReviewerExternalNational
Tissue EngineeringProfessional/Scientific JournalReviewerExternalNational
Artificial OrgansProfessional/Scientific JournalReviewerExternalNational
Acta BiomateriliaProfessional/Scientific OrganizationReviewerExternalNational
Polymer InternationalProfessional/Scientific JournalReviewerExternalNational
Biomedical MaterialsProfessional/Scientific JournalReviewerExternalNational
Journal of Biomaterials ApplicationsProfessional/Scientific JournalReviewerExternalNational
NanotechnologyProfessional/Scientific JournalReviewerExternalNational
Journal of Tissue Engineering and Regenerative MedicineProfessional/Scientific JournalReviewerExternalNational
Journal of Biomaterials Science, Polymer EditionProfessional/Scientific OrganizationReviewerExternalNational
Journal of Biomedical Materials Research Part B: Applied BiomaterialsProfessional/Scientific JournalReviewerExternalNational
Journal of the American Ceramic SocietyProfessional/Scientific JournalReviewerExternalNational
Journal of Applied Polymer ScienceProfessional/Scientific JournalReviewerExternalNational

I built a unique research program comprising of basic science, engineering and translational elements of Biomaterials Science and Engineering. My basic research programs focus on creating composite biomaterials for load-bearing bone healing applications, stem cell synergy for vascularized bone regeneration, and inverse gradient structures for bone-cartilage interfacial tissue engineering. My laboratory engineered oxygen tension controlled matrices for large-area bone regeneration and study the matrix potential in vitro and in vivo conditions. Our work in endochondral bone regeneration mimics the natural bone formation through a synthetic graft system. My translational research focuses on applying synthetic matrices in combination with the intra-operatively derived stem cells to develop clinically relevant tissue engineering strategies for bone and bone-cartilage interface defect repair and regeneration. Major research interests of my laboratory are outlined below.



  • Oxygen-tension controlled matrices for large-area bone regeneration

  • Stem cell synergy for vascularized bone formation

  • Advanced composite biomaterials

  • Engineered bone via endochondral ossification

  • Bone-cartilage interfacial tissue engineering

  • Clinically translatable tissue engineering strategies


 

Accepting Lab Rotation Students: Summer '16, Fall '16, Spring '17


Lab Rotation Projects



  • Oxygen-tension controlled matrices for large-area bone regeneration

  • Stem cell synergy for vascularized bone formation

  • Advanced composite biomaterials

  • Engineered bone via endochondral ossification

  • Bone-cartilage interfacial tissue engineering

  • Clinically translatable tissue engineering strategies

Journal Articles

Book Chapters

  • Bone and Biomaterials
    Nukavarapu SP, Wallace J, Elgendy H, Lieberman J, Laurencin C An Introduction to Biomaterials 2011 Jan;571-593
  • Nanostructured Scaffolds for Bone Tissue Engineering
    Igwe J, Amini A, Mikael P, Laurencin CT, Nukavarapu SP Active Implants and Scaffolds for Tissue Regeneration 2011 Jan;169-192
  • Biodegradable polyphosphazene scaffolds for tissue engineering
    Nukavarapu SP, Kumbar SG, Laurencin CT Polyphosphazenes for Biomedical Applications 2009 Jan;119-138
  • Electrospun polymeric nanofiber scaffolds for tissue regeneration
    Nukavarapu SP, Kumbar SG, Merrell JG, Laurencin CT Nanotechnology and Tissue Engineering: The Scaffold 2008 Jan;199-219
  • Nanostructures for Tissue Engineering/Regenerative Medicine
    Nukavarapu SP, Kumbar SG, Nair LS, Laurencin CT Biomedical Nanostructures 2007 Jan;371-401

Book Sections

  • Nanostructures for regenerative medicine
    Nukuvarapu SP, Kumbar SG, Nair LS, Laurencin CT Biomedical Nanostructures 2007 Jan;261-287

Conference Papers

  • Fabrication and in vitro evaluation of novel polyphosphazene-nano hydroxyapatite microsphere scaffolds for bone tissue engineering
    Nukavarapu SP, Kumbar SG, Krogman N, Nair LS, Allcock HR, Laurencin CT 2008 Jan;

Erratums

Reviews

Title or AbstractTypeSponsor/EventDate/YearLocation
Tissue Engineered Matrices for Large Area Bone RegenerationPosterGordon Research Conference on Musculoskeletal Biology & Bioengineering2012Andover, NH
Microtomy of Reinforced Polymer ScaffoldsPosterMicroscopy Society of America Meeting2012
Development and Evaluation of Optimized Scaffolds Pre-seeded with Effective Progenitor Combination for Vascularized Bone RegenerationTalkOrthopaedic Research Society Annual Meeting2012
Fabrication and Evaluation of a Novel Scaffold System with High-Density Cell Seeding for Bone Regeneration: An Investigation of Cell Density Enhanced Osteogenic ExpressionPosterOrthopaedic Research Society Annual Meetings2012
Comparative Analysis of Endothelial Progenitor Cells Isolated from Peripheral Blood and Bone Marrow for Enhanced Vascularization in Bone Tissue Engineering ApplicationsPosterTissue Engineering and Regenerative Medicine International Society2011
Fully Osteoconductive and Mechanically Compatible Scaffolds for Effective Bone RegenerationPosterOrthopaedic Research Society Annual Meeting2011
Polymer-Hydrogel Hybrid Scaffolds: An Effective Graft System for Bone Tissue EngineeringTalkIEEE EMBC 2011 Annual Meeting2011Boston, MA
Carbon Nanotubes composite scaffolds for Bone Tissue Engineering: Mechanical and In Vivo InvestigationPosterBiomedical Engineering Society Annual Meeting2011Hartford, CT
Two Pronged Approach for Engineering Vascularized BonePosterGordon Research Conference on Biomaterials & Tissue Engineering2011Holderness, NH
Design and Characterization of Fully Osteoconductive Scaffolds for Homogeneous and Enhanced Bone RegenerationTalkSociety for Biomaterials Annual Meeting2011
Osteogenic and Mechanically Compatible Hybrid Grafts for in situ Bone RegenerationPosterTissue Engineering and Regenerative Medicine International Society2010
Biodegradable Polymer-Magnesium Composite scaffolds for Bone Tissue Engineering: Effect of Magnesium on Osteoblast Proliferation, Maturation and MineralizationTalkSociety for Biomaterials Meeting2010
Characterization of Carbon Nanotube Reinforced Polymer Scaffold for Bone Tissue EngineeringPosterMicroscopy Society of America Meeting2010
In Vivo Bone Formation Using Chitosan/PLAGA Based Scaffolds in A Rabbit Ulnar Non-Union Defect ModelTalkOrthopaedic Research Society Meeting 2010
Scaffold Based Bone Tissue Engineering: Advances and Challenges, Biomedical EngineeringTalkSUNY Downstate2010Brooklyn, NY
Novel Nanostructured Scaffolds as Therapeutic Replacement Options for Rotator Cuff DiseaseTalkAmerican Academy of Orthopaedic Surgeons Annual Meeting2009
Novel water dispersible carbon nanotube composite scaffolds for bone tissue engineeringPosterTissue Engineering and Regenerative Medicine International Society2008
Infection resistant polyphosphazene-PLGA blend electrospun nanofiber matrices for wound healing applicationsPosterAmerican Academy of Orthopaedic Surgeons Annual Meeting2008
Fabrication and In-Vitro Evaluation of Novel Bone Regeneration Scaffolds Based on Polyphosphazene-Nano Hydroxyapatite CompositesPosterOrthopedic Research Society Meeting2008
Biodegradable Materials for Tissue Engineering ApplicationsTalkMaterials Research Center, Indian Institute of Science2008Bangalore, Karnataka, India
Novel Biodegradable Polyphosphazene-Nanohydroxyapatite Microsphere Scaffolds for Bone Tissue EngineeringPosterSociety for Biomaterials Meeting2007
Nanobased Fiber Matrices for Wound Repair: Optimization for Human Skin Fibroblast GrowthTalkSociety for Biomaterials Meeting2007
Biodegradable Poly[(ethyl alanato)(phenylphenoxy)phosphazene] - Poly(lactide-co-glycolide) Blends : Miscibility and Osteocompatibility EvaluationsTalkSociety for Biomaterials Meeting2007