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Syam P. Nukavarapu, Ph.D.Interim Department Head, Biomedical Engineering
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Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| B.Sc. | Nagarjuna University | Physical Sciences |
| M.Sc. | University of Hyderabad | Chemistry |
| Ph.D. | Materials Research Centre, IISc | Materials Science and Engineering |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Postdoctoral | Lehigh University | Postdoctoral Fellow, Materials Science and Engineering |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Junior Investigator Award | Musculoskeletal Transplant Foundation (MTF) |
| Mentorship Award | Connecticut Institute for Clinical and Translational Science (CICATS) |
| Young Investigator Award | AO Foundation |
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| Journal of Regenerative Medicine and Tissue Engineering | Editorial Board | Member | External | National | 2012 | |
| Encyclopedia of Biomedical Polymers and Polymeric Biomaterials | Editorial Board | Member | External | National | 2012 | |
| Hierarchical Three-dimensional Structures for Tissue Regeneration, The 9th Biomaterials Congress, Chengdu, China, 2012 | Advisory Committee | Session Organizer | External | International | 2012 | 2012 |
| Journal of Biomaterials and Tissue Engineering | Editorial Board | Member | External | National | 2011 | |
| Journal of Nanomedicine and Nanotechnology | Editorial Board | Member | External | National | 2011 | |
| Journal of Tissue Science and Engineering | Editorial Board | Member | External | National | 2011 | |
| Controlled Release Society (CRS) | Professional/Scientific Organization | Member | External | National | 2011 | |
| Biomedical Engineering Society (BMES) | Professional/Scientific Organization | Member | External | National | 2011 | |
| Vascular Tissue Engineering, IEEE Engineering in Medicine and Biology (EMBC) annual meeting, Boston, 2011 | Advisory Committee | Session Co-Chairperson | External | International | 2011 | 2011 |
| Tissue Regeneration and Repair, New England Musculoskeletal Institute 5th Annual Meeting, Farmington, CT, 2011. | Advisory Committee | Session Co-Chairperson | UConn Health | Regional | 2011 | 2011 |
| Scaffold Assisted Bone Defect Repair/Regeneration, Society for Biomaterials (SFB) Annual Meeting, Orlando, FL, 2011. | Advisory Committee | Session Organizer and Chairperson | External | National | 2011 | 2011 |
| Biomaterial technologies for Treating Nonunion bone defects: Research developments and Clinical applications, Society for Biomaterials Annual Meeting, Washington, WA, 2010 | Advisory Committee | Session Organizer and Chairperson | External | National | 2010 | 2010 |
| Orthopaedic Biomaterials, Society for Biomaterials (SFB) Annual Meeting, Washington, WA, 2010. | Advisory Committee | Session Organizer and Chair Person | External | National | 2010 | 2010 |
| Artificial Organs | Editorial Board | Member | External | National | 2009 | |
| U.S. Army Medical Research and Materiel Command | Advisory Committee | Mail Grant Reviewer | External | National | 2009 | 2009 |
| NIH Challenge Grantsp | Advisory Committee | Mail Grant Reviewer | External | National | 2009 | 2009 |
| Orthopaedic Biomaterials Special Interest Group, Society for Biomaterials | Advisory Committee | General Secretary | External | National | 2009 | 2011 |
| Arnold and Mabel Beckman Institute for Macular Research Annual Meeting. Participated in the task group of Nanoscience and Nanotechnology. Irvine, CA, 2009. | Other | Member | External | National | 2009 | 2009 |
| Tissue Engineering International & Regenerative Medicine Society (TERMIS) | Professional/Scientific Organization | Member | External | International | 2008 | |
| Materials Research Society (MRS) | Professional/Scientific Organization | Member | External | National | 2008 | |
| Orthopaedic Research Society (ORS) | Professional/Scientific Organization | Member | External | National | 2007 | |
| Sigma Xi, The Scientific Research Society | Professional/Scientific Organization | Member | External | National | 2007 | |
| Society for Biomaterials (SFB) | Professional/Scientific Organization | Member | External | National | 2005 | |
| PNAS | Professional/Scientific Journal | Reviewer | External | National | ||
| Tissue Engineering | Professional/Scientific Journal | Reviewer | External | National | ||
| Artificial Organs | Professional/Scientific Journal | Reviewer | External | National | ||
| Acta Biomaterilia | Professional/Scientific Organization | Reviewer | External | National | ||
| Polymer International | Professional/Scientific Journal | Reviewer | External | National | ||
| Biomedical Materials | Professional/Scientific Journal | Reviewer | External | National | ||
| Journal of Biomaterials Applications | Professional/Scientific Journal | Reviewer | External | National | ||
| Nanotechnology | Professional/Scientific Journal | Reviewer | External | National | ||
| Journal of Tissue Engineering and Regenerative Medicine | Professional/Scientific Journal | Reviewer | External | National | ||
| Journal of Biomaterials Science, Polymer Edition | Professional/Scientific Organization | Reviewer | External | National | ||
| Journal of Biomedical Materials Research Part B: Applied Biomaterials | Professional/Scientific Journal | Reviewer | External | National | ||
| Journal of the American Ceramic Society | Professional/Scientific Journal | Reviewer | External | National | ||
| Journal of Applied Polymer Science | Professional/Scientific Journal | Reviewer | External | National |
I built a unique research program comprising of basic science, engineering and translational elements of Biomaterials Science and Engineering. My basic research programs focus on creating composite biomaterials for load-bearing bone healing applications, stem cell synergy for vascularized bone regeneration, and inverse gradient structures for bone-cartilage interfacial tissue engineering. My laboratory engineered oxygen tension controlled matrices for large-area bone regeneration and study the matrix potential in vitro and in vivo conditions. Our work in endochondral bone regeneration mimics the natural bone formation through a synthetic graft system. My translational research focuses on applying synthetic matrices in combination with the intra-operatively derived stem cells to develop clinically relevant tissue engineering strategies for bone and bone-cartilage interface defect repair and regeneration. Major research interests of my laboratory are outlined below.
- Oxygen-tension controlled matrices for large-area bone regeneration
- Stem cell synergy for vascularized bone formation
- Advanced composite biomaterials
- Engineered bone via endochondral ossification
- Bone-cartilage interfacial tissue engineering
- Clinically translatable tissue engineering strategies
Not accepting students for Lab Rotations at this time
Lab Rotation Projects
- Oxygen-tension controlled matrices for large-area bone regeneration
- Stem cell synergy for vascularized bone formation
- Advanced composite biomaterials
- Engineered bone via endochondral ossification
- Bone-cartilage interfacial tissue engineering
- Clinically translatable tissue engineering strategies
Journal Articles
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Nanofiber matrix formulations for the delivery of Exendin-4 for tendon regeneration: In vitro and in vivo assessment.
Bioactive materials 2023 Jul;2542-60
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Decellularized Tissue-Induced Cellular Recruitment for Tissue Engineering and Regenerative Medicine.
Annals of biomedical engineering 2023 Mar;
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Smart Orthopedic Biomaterials and Implants.
Current opinion in biomedical engineering 2023 Mar;25
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Amorphous silica fiber matrix biomaterials: An analysis of material synthesis and characterization for tissue engineering
Bioactive materials 2023 Jan;19155-166
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Biomaterial-directed cell behavior for tissue engineering.
Current opinion in biomedical engineering 2021 Mar;17
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Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration.
Bioactive materials 2020 Sep;5(3):468-485
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Evaluation of Autologously Derived Biomaterials and Stem Cells for Bone Tissue Engineering.
Tissue engineering. Part A 2020 May;
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Growing a backbone - functional biomaterials and structures for intervertebral disc (IVD) repair and regeneration: challenges, innovations, and future directions.
Biomaterials science 2020 Jan;
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Evaluation of an Engineered Hybrid Matrix for Bone Regeneration via Endochondral Ossification.
Annals of biomedical engineering 2019 Apr;
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Histological Criteria that Distinguish Human and Mouse Bone Formed Within a Mouse Skeletal Repair Defect.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2019 Mar;22155419836436
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Self-neutralizing PLGA/magnesium composites as novel biomaterials for tissue engineering.
Biomedical materials (Bristol, England) 2018 Jan;13035013
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Noninvasive Absolute EPR Oxygen Imaging for the Assessment of Tissue Graft Oxygenation.
Tissue engineering. Part C, Methods 2017 Aug;2414-19
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Harnessing External Cues: Development and Evaluation of an In Vitro Culture System for Osteochondral Tissue Engineering.
Tissue engineering. Part A 2017 Mar;23719-737
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Hybrid extracellular matrix design for cartilage-mediated bone regeneration.
Journal of biomedical materials research. Part B, Applied biomaterials 2017 Jan;106300-309
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High Field Sodium MRI Assessment of Stem Cell Chondrogenesis in a Tissue-Engineered Matrix.
Annals of biomedical engineering 2016 Apr;44(4):1120-7
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Oxygen Tension Controlled Matrices with Osteogenic and Vasculogenic Cells for Vascularized Bone Regeneration In Vivo.
Tissue engineering. Part A 2016 Feb;22610-20
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Functionalized carbon nanotube reinforced scaffolds for bone regenerative engineering: fabrication, in vitro and in vivo evaluation.
Biomedical materials (Bristol, England) 2014 Mar;9(3):035001
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Oxygen-tension controlled matrices for enhanced osteogenic cell survival and performance.
Annals of biomedical engineering 2014 Feb;42(6):1261-70
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Differential analysis of peripheral blood- and bone marrow-derived endothelial progenitor cells for enhanced vascularization in bone tissue engineering.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2012 Sep;30(9):1507-15
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Optimally porous and biomechanically compatible scaffolds for large-area bone regeneration.
Tissue engineering. Part A 2012 Jul;18(13-14):1376-88
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Design, fabrication and in vitro evaluation of a novel polymer-hydrogel hybrid scaffold for bone tissue engineering.
Journal of tissue engineering and regenerative medicine 2012 Jun;8(2):131-42
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Functionalized Carbon Nanotube Composite Scaffolds for Bone Tissue Engineering: Prospects and Progress
Journal of Biomaterials and Tissue Engineering 2011 Jan;1(1):76-85
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Optimal scaffold design and effective progenitor cell identification for the regeneration of vascularized bone.
Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference 2011 Jan;20112464-7
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Short-term and long-term effects of orthopedic biodegradable implants.
Journal of long-term effects of medical implants 2011 Jan;21(2):93-122
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Novel nanostructured scaffolds as therapeutic replacement options for rotator cuff disease.
The Journal of bone and joint surgery. American volume 2010 Dec;92 Suppl 2170-9
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In Situ Porous Structures: A Unique Polymer Erosion Mechanism in Biodegradable Dipeptide-based Polyphosphazene and Polyester Blends Producing Matrices for Regenerative Engineering.
Advanced functional materials 2010 Sep;20(17):2743-2957
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Chitosan-poly(lactide-co-glycolide) microsphere-based scaffolds for bone tissue engineering: in vitro degradation and in vivo bone regeneration studies.
Acta biomaterialia 2010 Sep;6(9):3457-70
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Dipeptide-based polyphosphazene and polyester blends for bone tissue engineering.
Biomaterials 2010 Jun;31(18):4898-908
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Biomimetic, bioactive etheric polyphosphazene-poly(lactide-co-glycolide) blends for bone tissue engineering.
Journal of biomedical materials research. Part A 2010 Jan;92(1):114-25
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Hydrogen bonding in blends of polyesters with dipeptide-containing polyphosphazenes
Journal of Applied Polymer Science 2010 Jan;115(1):431-437
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The influence of side group modification in polyphosphazenes on hydrolysis and cell adhesion of blends with PLGA.
Biomaterials 2009 Jun;30(17):3035-41
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Nanotechnology and orthopedics: a personal perspective.
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology 2009 Jan;1(1):6-10
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Electrospun poly(lactic acid-co-glycolic acid) scaffolds for skin tissue engineering.
Biomaterials 2008 Oct;29(30):4100-7
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Electrospun nanofiber scaffolds: engineering soft tissues.
Biomedical materials (Bristol, England) 2008 Sep;3(3):034002
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Polyphosphazene/nano-hydroxyapatite composite microsphere scaffolds for bone tissue engineering.
Biomacromolecules 2008 Jul;9(7):1818-25
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Miscibility and in vitro osteocompatibility of biodegradable blends of poly[(ethyl alanato) (p-phenyl phenoxy) phosphazene] and poly(lactic acid-glycolic acid).
Biomaterials 2008 Jan;29(3):337-49
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Synthesis and characterization of novel biodegradable phenyl phenoxy polyphosphazene blends: in vitro osteocompatibility evaluation
Biomaterials 2008 Jan;29337-349
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In Vitro and In Vivo Characterization of Biodegradable Poly(organophosphazenes) for Biomedical Applications
Journal of Inorganic and Organometallic Polymers and Materials 2006 Jan;16(4):365-385
Book Chapters
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Bone and Biomaterials
An Introduction to Biomaterials 2011 Jan;571-593
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Nanostructured Scaffolds for Bone Tissue Engineering
Active Implants and Scaffolds for Tissue Regeneration 2011 Jan;169-192
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Biodegradable polyphosphazene scaffolds for tissue engineering
Polyphosphazenes for Biomedical Applications 2009 Jan;119-138
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Electrospun polymeric nanofiber scaffolds for tissue regeneration
Nanotechnology and Tissue Engineering: The Scaffold 2008 Jan;199-219
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Nanostructures for Tissue Engineering/Regenerative Medicine
Biomedical Nanostructures 2007 Jan;371-401
Book Sections
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Nanostructures for regenerative medicine
Biomedical Nanostructures 2007 Jan;261-287
Conference Papers
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Fabrication and in vitro evaluation of novel polyphosphazene-nano hydroxyapatite microsphere scaffolds for bone tissue engineering
2008 Jan;
Erratums
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Correction: Growing a backbone - functional biomaterials and structures for intervertebral disc (IVD) repair and regeneration: challenges, innovations, and future directions.
Biomaterials science 2021 Mar;9(6):2322-2323
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Erratum to: High Field Sodium MRI Assessment of Stem Cell Chondrogenesis in a Tissue-Engineered Matrix.
Annals of biomedical engineering 2016 Jan;44833
Reviews
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Decellularized extracellular matrix biomaterials for regenerative therapies: Advances, challenges and clinical prospects.
Bioactive materials 2024 Feb;3298-123
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Recent Patents on Electrospun Biomedical Nanostructures: An Overview
Recent Patents on Biomedical Engineering 2008 Jan;1(1):68-78
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| Tissue Engineered Matrices for Large Area Bone Regeneration | Poster | Gordon Research Conference on Musculoskeletal Biology & Bioengineering | 2012 | Andover, NH |
| Microtomy of Reinforced Polymer Scaffolds | Poster | Microscopy Society of America Meeting | 2012 | |
| Development and Evaluation of Optimized Scaffolds Pre-seeded with Effective Progenitor Combination for Vascularized Bone Regeneration | Talk | Orthopaedic Research Society Annual Meeting | 2012 | |
| Fabrication and Evaluation of a Novel Scaffold System with High-Density Cell Seeding for Bone Regeneration: An Investigation of Cell Density Enhanced Osteogenic Expression | Poster | Orthopaedic Research Society Annual Meetings | 2012 | |
| Comparative Analysis of Endothelial Progenitor Cells Isolated from Peripheral Blood and Bone Marrow for Enhanced Vascularization in Bone Tissue Engineering Applications | Poster | Tissue Engineering and Regenerative Medicine International Society | 2011 | |
| Fully Osteoconductive and Mechanically Compatible Scaffolds for Effective Bone Regeneration | Poster | Orthopaedic Research Society Annual Meeting | 2011 | |
| Polymer-Hydrogel Hybrid Scaffolds: An Effective Graft System for Bone Tissue Engineering | Talk | IEEE EMBC 2011 Annual Meeting | 2011 | Boston, MA |
| Carbon Nanotubes composite scaffolds for Bone Tissue Engineering: Mechanical and In Vivo Investigation | Poster | Biomedical Engineering Society Annual Meeting | 2011 | Hartford, CT |
| Two Pronged Approach for Engineering Vascularized Bone | Poster | Gordon Research Conference on Biomaterials & Tissue Engineering | 2011 | Holderness, NH |
| Design and Characterization of Fully Osteoconductive Scaffolds for Homogeneous and Enhanced Bone Regeneration | Talk | Society for Biomaterials Annual Meeting | 2011 | |
| Osteogenic and Mechanically Compatible Hybrid Grafts for in situ Bone Regeneration | Poster | Tissue Engineering and Regenerative Medicine International Society | 2010 | |
| Biodegradable Polymer-Magnesium Composite scaffolds for Bone Tissue Engineering: Effect of Magnesium on Osteoblast Proliferation, Maturation and Mineralization | Talk | Society for Biomaterials Meeting | 2010 | |
| Characterization of Carbon Nanotube Reinforced Polymer Scaffold for Bone Tissue Engineering | Poster | Microscopy Society of America Meeting | 2010 | |
| In Vivo Bone Formation Using Chitosan/PLAGA Based Scaffolds in A Rabbit Ulnar Non-Union Defect Model | Talk | Orthopaedic Research Society Meeting | 2010 | |
| Scaffold Based Bone Tissue Engineering: Advances and Challenges, Biomedical Engineering | Talk | SUNY Downstate | 2010 | Brooklyn, NY |
| Novel Nanostructured Scaffolds as Therapeutic Replacement Options for Rotator Cuff Disease | Talk | American Academy of Orthopaedic Surgeons Annual Meeting | 2009 | |
| Novel water dispersible carbon nanotube composite scaffolds for bone tissue engineering | Poster | Tissue Engineering and Regenerative Medicine International Society | 2008 | |
| Infection resistant polyphosphazene-PLGA blend electrospun nanofiber matrices for wound healing applications | Poster | American Academy of Orthopaedic Surgeons Annual Meeting | 2008 | |
| Fabrication and In-Vitro Evaluation of Novel Bone Regeneration Scaffolds Based on Polyphosphazene-Nano Hydroxyapatite Composites | Poster | Orthopedic Research Society Meeting | 2008 | |
| Biodegradable Materials for Tissue Engineering Applications | Talk | Materials Research Center, Indian Institute of Science | 2008 | Bangalore, Karnataka, India |
| Novel Biodegradable Polyphosphazene-Nanohydroxyapatite Microsphere Scaffolds for Bone Tissue Engineering | Poster | Society for Biomaterials Meeting | 2007 | |
| Nanobased Fiber Matrices for Wound Repair: Optimization for Human Skin Fibroblast Growth | Talk | Society for Biomaterials Meeting | 2007 | |
| Biodegradable Poly[(ethyl alanato)(phenylphenoxy)phosphazene] - Poly(lactide-co-glycolide) Blends : Miscibility and Osteocompatibility Evaluations | Talk | Society for Biomaterials Meeting | 2007 |