UCONN

HEALTH

Photo of John J. Peluso, Ph.D.

John J. Peluso, Ph.D.

Professor, Department of Cell Biology
Academic Office Location:
Cell Biology
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3505
Phone: 860-679-2860
Fax: 860-679-1269
Email: peluso@nso2.uchc.edu
Website(s):

Peluso Lab Page

Cell Biology Graduate Program

Education
DegreeInstitutionMajor
B.S.Slippery Rock CollegeBiology
M.S.Slippery Rock CollegeBiology
Ph.D.West Virginia UniversityReproductive Physiology

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralWayne State UniversityReproductive Physiology
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
U54 Review PanelStudy SectionChairExternalNational20112012
Heritage Committee; Society for the Study of Reproduction Advisory CommitteeMemberExternalNational2011
Search Committee for Cell Biology Advisory CommitteeChairman UConn HealthUniversity20102010
Women’s Reproductive Health Panel (ZHD1 DSR-L) Study SectionChairmanExternalNational20092009
U54 Grant review PanelStudy SectionMemberExternalNational20092011
Challenge Grant Review Panel (ZRG1-EMNR-C58)Study SectionMemberOtherNational20092009
Reproduction, Andrology and Gynecology SSStudy SectionChairExternalNational20082010
Faculty Review Board Advisory CommitteeMemberUConn HealthUniversity2008
Conflict of Interest in Research Management Committee Research CommitteeMemberUConn HealthUniversity2008
Ethics Stem Cell Research Committee Advisory CommitteeMemberUConn HealthUniversity20062007
Institution Review BoardAdvisory CommitteeVice-Chair Panel 3 UConn HealthUniversity20062010
Human Subjects Protection Office Executive Council Advisory CommitteeMemberUConn HealthUniversity20062010
Institution Review BoardAdvisory CommitteeChair Panel 4 (Stem Cell Panel) UConn HealthUniversity20062008
Nuclear Receptor SignalingEditorial BoardReviewerExternalNational2005
Reproduction, Andrology and Gynecology SSStudy SectionGrant ReviewerExternalNational20052010
Special NIH Review PanelStudy SectionMemberExternalNational20032003
Dental School CouncilEducation CommitteeMemberUConn HealthUniversity20022007
Endocrinology Editorial BoardMemberExternalNational20012005
Reproductive Endocrinology and Biology Editorial BoardMemberExternalNational2001
REB Study Section Study SectionAd Hoc Grant ReviewerExternalNational20012001
Special NIH Review PanelStudy SectionChairmanExternalNational20012001
U54 Review PanelStudy SectionDiscussion LeaderExternalNational20012001
Biology of ReproductionEditorial BoardMemberExternalNational20002004
Ob/Gyn Research Committee - University of Connecticut Health CenterResearch CommitteeMemberUConn HealthUniversity19992001
MRC-CanadaProfessional/Scientific OrganizationGrant ReviewerExternalInternational19981998
Scientific Program Committee: Society for Study of Reproduction Annual MeetingsAdvisory CommitteeMemberExternalNational19981999
NIH-Site Visit Team: Biol Pgm ProjectsStudy SectionGrant ReviewerExternalNational19971999
Lab Services Work Redesign Team Advisory CommitteeMemberUConn HealthUniversity19971997
Senior Appointments and Promotion CommitteeAdvisory CommitteeMemberUConn HealthUniversity19962007
Developmental Biology Graduate ProgramAdvisory CommitteeDirector UConn HealthUniversity19951997
Endocrine Society's Animal WelfareAdvisory CommitteeState Chair ExternalState19951995
Scientific Program Committee: Society for Gynecologic Investigation Annual MeetingsProfessional/Scientific OrganizationMemberExternalNational19941999
Mini-Course Committee - Devel Biol Grad Pgm Education CommitteeMemberUConn HealthUniversity19941995
Senior Appointments and Promotion CommitteeAdvisory CommitteeMemberUConn HealthUniversity19931994
Design Committee for the "New" Research BldAdvisory CommitteeMemberUConn HealthUniversity19921993
Combined Admissions Committee for the Graduate Program - Developmental Biology Rep. Advisory CommitteeMemberUConn HealthUniversity19911994
Animal Care Committee - University of Connecticut Health CenterAdvisory CommitteeMemberUConn HealthUniversity19901994
Institutional Review Board - University of Connecticut Health CenterAdvisory CommitteeMemberUConn HealthUniversity19871994
Reproduction Professional/Scientific JournalAd Hoc ReviewerExternalNational
Fertility and SterilityProfessional/Scientific JournalAd Hoc ReviewerExternalNational
Am J.Physiol: Endocrology and MetabolismProfessional/Scientific JournalAd Hoc ReviewerExternalNational
EndocrineProfessional/Scientific JournalAd Hoc ReviewerExternalNational
ProstaglandinProfessional/Scientific JournalAd Hoc ReviewerExternalNational
Developmental BiologyProfessional/Scientific JournalAd Hoc ReviewerExternalNational
BioTechiquesProfessional/Scientific JournalAd Hoc ReviewerExternalNational
Molecular and Cellular EndocrinologyProfessional/Scientific JournalAd Hoc ReviewerExternalNational
National Science FoundationProfessional/Scientific OrganizationGrant ReviewerExternalNational
March of DimesProfessional/Scientific OrganizationGrant ReviewerExternalNational
USDAProfessional/Scientific OrganizationGrant ReviewerExternalNational
Lalor FoundationProfessional/Scientific OrganizationGrant ReviewerExternalNational
The Endocrine SocietyProfessional/Scientific OrganizationMemberExternalNational
Society for the Study of ReproductionProfessional/Scientific OrganizationMemberExternalNational
Grade Inflation Committee - Loyola University of ChicagoAdvisory CommitteeMemberExternalUniversity
University Research Committee - Loyola UniversityAdvisory CommitteeMemberExternalUniversity
Graduate Program Committee-Chairman-Loyola UniversityAdvisory CommitteeMemberExternalUniversity
Radiation Safety Committee-Loyola UniversityAdvisory CommitteeMemberExternalUniversity
Animal Care Committee-Loyola UniversityAdvisory CommitteeMemberExternalUniversity
Hormonal control of ovarian follicular growth and atresia; cellular and molecular mechanisms involved in apoptosis; Characterization of a novel membrane receptor for progesterone (PGRMC1) including the elucidation of its signal transduction pathway. Studies included identification of proteins that bind PGRMC1 using proteomics, protein-protein interaction assays and genetic approaches to deplete or enhance expression. Additional studies are being conducted on PGRMC1's role in modulating the sensitivity of ovarian cancer cells to chemotherapy both in vitro and in vivo.

Expression and structural features of a novel membrane receptor for progesterone (PGRMC1). The panel at the left shows the different domains of PGRMC1. However, the proteins that bind PGRMC1 and are presumably involved in ligand activated signal transduction have not been identified. The panel at the right shows the expression of PGRMC1 within the immature rat ovary.

Not accepting students for Lab Rotations at this time


Journal Articles

Book Chapters

  • Cell-to-cell contact and the role of cadherins in cell survival
    Peluso JJ Cell Death and Reproductive Physiology 1996 Jan;
  • Structure and function of the mammalian ovary
    Peluso JJ Handbook of Endocrinology Vol II 1996 Jan;101-119
  • Steroids as negative regulators of granulosa cell proliferation and differentiation
    Peluso JJ Cell Culture in pharmaceutical research Vol 11 Schering Foundation Workshop 1994 Jan;215-238
  • An ovarian perifusion culture system: a tool to assess ovarian toxicity
    Peluso JJ, Pappalardo A Methods in reproductive toxicology 1993 Jan;180-194
  • Morphological and physiological changes within the ovary from conception through adulthood
    Peluso JJ The pathology of the aging rat 1992 Jan;
  • Nonneoplastic and neoplastic changes in the ovary
    Peluso JJ, Gordon L The pathology of the aging rat 1992 Jan;
  • Regulation of ovarian steroid production
    Nulsen JC, Peluso JJ Infertility and Reproductive Medicine Clinics of North America 1992 Jan;43-58
  • Expression of JUN/AP-1 superfamily genes and cell cycle related genes in mitotically-active rat granulosa cells
    Delidow B, Lynch J, White BA, Peluso JJ Signaling mechanisms and gene expression in the ovary 1991 Jan;329
  • PMSG induction of c-fos and c-myc proteins within granulosa cells of immature rat ovaries
    Peluso JJ, Pappalardo A Paracrine Communication in the Ovary- Oncogenesis and Growth Factors 1989 Jan;251-255
  • Endocrine factors in ovarian function
    Peluso JJ Handbook of Endocrinology Vol II 1987 Jan;
  • Follicular development and function in vitro
    Peluso JJ Development and function of the reproductive organs 1986 Jan;
  • A new technique to study the effect of dynamic administration of biochemical agents in vitro and in vivo
    Gruenberg ML, Peluso JJ Biological rhythms and medications (Ann Rev Chronopharm Vol 1) 1985 Jan;
  • A process to regulate tissue function in vitro: an alternative to in vivo tests
    Gruenberg ML, Peluso JJ Product safety evaluation alternative methods in toxicology Vol. 1 1983 Jan;271-284
  • Anterior Pituitary
    Steger RW, Peluso JJ Handbook of Endocrinology 1982 Jan;27-33
  • The gonadotropes
    Handbook of Endocrinology Steger RW, Peluso JJ 1982 Jan;87-110
  • Aged-related alterations in preovulatory oocytes
    Peluso JJ, Hutz R, England-Charlesworth C Dynamics of ovarian function 1981 Jan;303-308
  • Atresia of ovarian follicles and ova
    Peluso JJ, Breitencker G, Hafez E Human ovulation 1979 Jan;177-218
  • In vitro maturation of oocytes collected from atretic follicles
    Peluso JJ Ovarian follicular development and function 1979 Jan;85-90
  • Control of ovarian development
    Peluso JJ Sexual Maturity 1976 Jan;71-84
  • Aging of mammalian ova
    Peluso JJ Aging and Reproduction 1975 Jan;35-50

Book Sections

  • Surface ultrastructure of the granulosa cells of human and rat ovarian follicles
    Steger RW, Peluso JJ, Ismail M, Hafez E, Hallen LJ S.E.M. 1977 Jan;349-354

Conference Papers

Reviews

Short Surveys

Title or AbstractTypeSponsor/EventDate/YearLocation
Sumoylation and Nuclear Action of Progesterone Receptor Membrane Component-1Talk7th International Meeting on Rapid Responses to Steroid Hormones2011Crete, Greece
Progesterone signaling in ovarian cancerTalkFASEB Summer Research Conference, The Physiology of Integrated Nuclear and Extranuclear Steroid Sign2010Snowmass, CO
Progesterone receptor membrane component-1 in regulating normal and cancerous ovarian cellsTalk28th Annual Ottawa Reproductive Biology Workshop2010Toronto, Ontario, Canada
Progesterone Membrane Receptor Component 1 as a Mediator of Progesterone’s Actions in Normal and Neoplastic Ovarian CellsTalk5th Annual Gilbert S. Greenwald Symposium on Reproduction2008Kansas City, KS
Identification of a Membrane Receptor Complex That Mediates Progesterone’s Anti-apoptotic ActionTalk26th Annual Symposium in Reproductive Sciences and Women’s Health2007Lexington, KY
Identification of a Novel Membrane Receptor Complex that Mediates Progesterone’s Anti-Apoptotic Action in Granulosa and Luteal Cells Talk23rd Annual Ottawa Reproductive Biology Workshop2005Toronto, Ontario, Canada
Identification of a Putative Progesterone Receptor Complex and Signal Transduction pathway that Mediate Progesterone’s Non-genomic Action in Granulosa CellsTalk38th Meeting of the Society for the Study of Reproduction2005Quebec City, Quebec, Canada
Basic FGF and Ovarian ApoptosisTalkInternational Symposium on Apoptosis2003Luxembourg
Rapid Actions of Progesterone on Granulosa CellsTalkIII International Meeting on Rapid Responses to Steroid Hormones2003Florence, Italy
The Quest For The Elusive Membrane Progesterone ReceptorTalkGabriel Bialy State-of-the-Art Lecture in Reproductive Physiology2003Carbondale, IL
Progesterone Regulation of Granulosa Cell Viability Through Membrane-initiated MechanismTalk36th Meeting of the Society for the Study of Reproduction2003Cincinnati, OH
Progesterone and ApoptosisTalkInternational Congress on Hormonal Steroids and Hormones and Cancer2002Fukuoka, Japan
Extracellular matrix and cell-cell contact as regulators of ovarian surface epithelial cell mitosis and apoptosisTalkSerono Symposium: XIII Ovarian Workshop2000Madison, WI
IP3R3 Expression and ROSE-179 cell ApoptosisTalkSerono Symposium: XII Ovarian Workshop1998Houston, TX
Placing progesterone in the apoptotic pathwayLecturePostgraduate Course: Apoptosis in the Reproductive System1997San Diego, CA
Cell contact inhibits granulosa cell and ovarian epithelial cell apoptosisTalkSerono Symposium: Cell Death in Reproductive Physiology1996Chicago, IL
Steroids as negative regulators of granulosa cell proliferation and differentiationTalkSchering Symposium: Cell Culture Models in Pharmaceutical Research1993Berlin, Germany
Regulation of follicular developmentTalkNIH Conference: Ovarian Follicular Selection and Atresia1992Bethesda, MD
Model systems used to study follicular atresia TalkIX Ovarian Workshop: Ovarian Cell Interactions1992Chapel Hill, NC
Alterations within oocytes which predicate abnormal preimplantation development TalkVII European Sterility Congress Symposium on Post Conception Failures in Reproduction1984Monte Carlo
Control of ovarian function in vitroTalkSerono Symposium: Development and Function of the Reproductive Tissues1984Rehovet, Israel