UCONN

HEALTH

Photo of Thiruchandurai V. Rajan, M.D., Ph.D.

Thiruchandurai V. Rajan, M.D., Ph.D.

Professor, Pathology and Laboratory Medicine
Academic Office Location:
Pathology and Laboratory Medicine
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3105
Phone: 860-679-3221
Fax: 860-679-2936
Education
DegreeInstitutionMajor
B.S.All India Institute of Medical SciencesMedicine
OtherAll India Institute of Medical SciencesMedicine
Ph.D.Sue-Goding Graduate Divison of Medical Sciences, Yeshiva UniversityCell Biology

Awards
Name of Award/HonorAwarding Organization
Outstanding teacher awardMedical and Dental Classes of 2011
Annual Redway Award and MedalNew York State Medical Association
Biochemistry, Pharmacology, Pathology, and Microbiology. Awarded Merit Scholarships in I, II, and III M.B., B.S. examinations for standing first in the University.
Awarded the Dorab Tata and Catherine Freeman prizes.
Awarded the Gold Medal as the best outgoing graduate, Class of 1968.
Awarded the Lord Nuffield Fellowship
Chemistry, Physics, and Biology. Awarded a National Merit Scholarship by the Government of India for standing second in the UniversityGovernment of India
Chemistry and Mathematics. Awarded a National Merit Scholarship Government of India
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
senior appointments and promotions committeeAdvisory CommitteeMemberUConn HealthUniversity2009
committee on undergraduate medical educationEducation CommitteeMemberUConn HealthUniversity2009
education CouncilEducation CommitteeMemberUConn HealthUniversity2009
research misconduct committeeResearch CommitteeMemberUConn HealthUniversity2009
institutional review boardResearch CommitteeMemberUConn HealthUniversity2009
Academy of distinguished educatorsEducation CommitteeChairmanUConn HealthUniversity2008
admissions committee school of medicineEducation CommitteeMemberUConn HealthUniversity2008
course and curriculum evaluation subcommittee (CCESC)Education CommitteeChairmanUConn HealthUniversity2006
Academic advancement committeeEducation CommitteeChairUConn HealthUniversity2001
scientific advisory committee of the clinical research CenterAdvisory CommitteeCo-ChairUConn HealthUniversity1995
We focus our efforts on understanding the biology of human lymphatic filariasis, using Brugia malayi as a model and various deficient mice as hosts. We have found that a class of poly-unsaturated fatty acids, including linoleic, linolenic and arachidonic acids serve the nutritional/trophic needs of this organism. This result has been quite surprising to us, since we had initially anticipated that a protein might be the molecule that is required. We have since determined that inhibitors of leukotriene synthesis block molting, suggesting that B. malayi requires a leukotriene to complete its development. This observation opens novel avenues for therapy.

We have also been examining the factors determining host immunity against this parasite. Using targeted mutations that result in the lack of B lymphocytes, we have made the unexpected observation that B lymphocytes appear to play a central role in host defense. Reconstitution of SCID mice with purified peritoneal exudate cells, which are enriched for a certain subset of B lymphocytes known as the B1 B cells, we have demonstrated that this subset of B lymphocytes is able to mediate host protection. This observation opens the door to the identification of parasite derived molecules that may be playing critical role in host community.

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