UCONN

HEALTH

Photo of Daniel W. Rosenberg, Ph.D.

Daniel W. Rosenberg, Ph.D.

Professor of Medicine
Investigator, Center for Molecular Medicine
Academic Office Location:
Medicine
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3101
Phone: 860-679-8704
Fax: 860-679-7639
Website(s):

Center for Molecular Medicine

Cell Biology Graduate Program

Genetics & Developmental Biology Graduate Program

Education
DegreeInstitutionMajor
B.S.SUNYBiochemistry
M.S.University of MichiganToxicology/Environmental Science
Ph.D.University of MichiganToxicology

Awards
Name of Award/HonorAwarding Organization
HealthNet Inc., Chair in Cancer BiologyUConn Health Center
Visiting Professor, NCCRI, Tokyo, Japan
R01CA125691 selected as an Exemplar of NCI-funded Translational Research (2008, 2009).
Golf Foundation
Patterson Trust
New Investigator AwardThe Donaghue Medical Research Foundation
NE-SOT Best Poster (1996, 1998, 2007);
New Investigator AwardAACP

 

 

Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Israel Cancer Research Foundation (ICRF)Study Sectiongrant reviewerOtherInternational20132013
NIH, Cancer Chemoprevention Study Section (CDP)Study SectionMemberExternalNational20102014
Carcinogenesis Session Chair, AACR Professional/Scientific OrganizationChairExternalNational2008
Archives Pharmacal ResearchEditorial BoardEditorial BoardExternalNational2000

My laboratory has a longstanding interest in the molecular events that accompany early gastrointestinal neoplasia. We apply powerful and exquisitely sensitive cutting-edge technologies to understand the earliest cellular changes that precede cancer, including NextGen sequencing, computational biology, analysis of the microbiome, proteomics and cell biology. We are also actively developing mouse genetic models to recapitulate human neoplasia, with a focus on colorectal and pancreatic cancers. A major effort of our laboratory is to develop natural products that may be used to interrupt the processes of cancer initiation and progression.

Accepting students for Lab Rotations: Summer '17, Fall '17, Spring '18


Lab Rotation Projects:


1. Understanding the molecular events associated with early neoplasia


2. Developing novel mouse genetic models of colorectal and pancreas cancers


3. Defining the role of the microbiome and metabolome in cancer pathogenesis


4. Applying an array of nextGen and bioinformatics approaches to understanding early precancerous changes


5. Using natural products (e.g. whole foods, PUFAs) for prevention of cancer


6. Using powerful whole genome approaches to define the epigenome of cancer initiation


7. Defining the role of the stromal microenvironment and proinflammatory cytokines in early stages of cancer

Journal Articles

Conference Papers

  • Gene deletion of mPGES-1 results in a significant reduction in tumor stage and burden in the BBN mouse model of bladder cancer. Highly Rated Abstract, Top 2%
    Nakanishi M, Choudhary S, Hegde P, Pilbeam C, Rosenberg D, Taylor JA. 2010 Jan;51596-597

Erratums

Reviews

Short Surveys

Title or AbstractTypeSponsor/EventDate/YearLocation
Nutritional Targets for Colon Cancer PreventionLectureNutrition Graduate Seminar Series2014Texas A&M
American Association of Clinical Endocrinology (AACE)LectureAACE2012New York, New York