UCONN

HEALTH

Photo of Daniel W. Rosenberg, Ph.D.

Daniel W. Rosenberg, Ph.D.

Professor of Medicine and Health Net Inc., Endowed Chair in Cancer Biology
Director, Colon Cancer Prevention Program, Neag Comprehensive Cancer Center
Department of Medicine (primary); Department of Genetics and Developmental Biology (secondary); Department of Molecular and Cell Biology - Storrs Campus (adjunct faculty)
Academic Office Location:
Medicine
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3101
Phone: 860-679-8704
Fax: 860-679-7639
Website(s):

Center for Molecular Oncology

Cell Biology Graduate Program

Genetics and Developmental Biology Graduate Program

Curriculum Vitae:
Education
DegreeInstitutionMajor
B.S.SUNYBiochemistry
M.S.University of MichiganToxicology/Environmental Science
Ph.D.University of MichiganToxicology

Awards
Name of Award/HonorAwarding Organization
National Cancer Institute, Pre-cancer Atlas (PCA) Think Tank, NIH
2017 CICATS M1 Mentorship Award
External Advisory Committee of the Marshall University COBRE Program -- Member
HealthNet Inc., Chair in Cancer BiologyUConn Health Center
Connecticut Academy of Science and Engineering (CASE) Elected Member
Editor, Special Issue of Mutation Research, "Application of Genomic Technologies to the Study of Colon Cancer" NIH chemoprevention Study Section, Full member
Visiting Professor, NCCRI, Tokyo, Japan
R01CA125691 selected as an Exemplar of NCI-funded Translational Research (2008, 2009).
Golf Foundation
Patterson Trust
NE-SOT Best Poster (1997, 1999, 2007);
New Investigator AwardThe Donaghue Medical Research Foundation
New Investigator AwardAACP

 

 

Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Israel Cancer Research Foundation (ICRF)Study Sectiongrant reviewerOtherInternational20132013
NIH, Cancer Chemoprevention Study Section (CDP)Study SectionMemberExternalNational20102014
Carcinogenesis Session Chair, AACR Professional/Scientific OrganizationChairExternalNational2008
Archives Pharmacal ResearchEditorial BoardEditorial BoardExternalNational2000

My laboratory has a longstanding interest in the molecular events that accompany early gastrointestinal neoplasia. We apply powerful and exquisitely sensitive cutting-edge technologies to understand the earliest cellular changes that precede cancer, including NextGen sequencing, computational biology, analysis of the microbiome, proteomics and cell biology. We are also actively developing mouse genetic models to recapitulate human neoplasia, with a focus on colorectal and pancreatic cancers. A major effort of our laboratory is to develop natural products that may be used to interrupt the processes of cancer initiation and progression.

Accepting students for Lab Rotations: Summer '17, Fall '17, Spring '18


Lab Rotation Projects:


1. Understanding the molecular events associated with early neoplasia


2. Developing novel mouse genetic models of colorectal and pancreas cancers


3. Defining the role of the microbiome and metabolome in cancer pathogenesis


4. Applying an array of nextGen and bioinformatics approaches to understanding early precancerous changes


5. Using natural products (e.g. whole foods, PUFAs) for prevention of cancer


6. Using powerful whole genome approaches to define the epigenome of cancer initiation


7. Defining the role of the stromal microenvironment and proinflammatory cytokines in early stages of cancer

Journal Articles

Conference Papers

  • Gene deletion of mPGES-1 results in a significant reduction in tumor stage and burden in the BBN mouse model of bladder cancer. Highly Rated Abstract, Top 2%
    Nakanishi M, Choudhary S, Hegde P, Pilbeam C, Rosenberg D, Taylor JA. 2010 Jan;51596-597

Erratums

Reviews

Short Surveys

Title or AbstractTypeSponsor/EventDate/YearLocation
SNUCRI Cancer SymposiumLectureSNUCRI2014Mokpo, Korea
International Symposium on Microgenomics 2014Lecture2014Paris,France
Tel Aviv University Sackler School of MedicineLectureTel Aviv University2014Israel
Ichilov Hospital, Department of GastroenterologyLectureIchilov Hospital2014Tel Aviv, Israel
CSSI Science DayLectureNational Cancer Institute2014Bethesda, MD
SUNY Cancer CenterLectureSUNY2014Stony Brook, NY
Microgenomics Thought Leader SummitLectureThermo-Fischer2014South San Francisco, CA
Genomics Application Workshop PresentationLectureAmerican Society Human Genetics2014San Diego, CA
American Institute of Cancer Research Annual MeetingLectureAmerican Institute of Cancer Research2014Washington, DC
Nutritional Targets for Colon Cancer PreventionLectureNutrition Graduate Seminar Series2014Texas A&M
Obesity Research SymposiumLectureMarshall University School of Medicine2013Huntington, West VA
Proximal human aberrant crypt foci as surrogate markers of colorectal cancer riskPoster2013Wilmington, NC
Obesity as a risk factor for colorectal cancerPlenary LectureMarshall University Childhood Obesity Conference2013Huntington, West Virginia
American Association of Clinical Endocrinology (AACE)LectureAACE2012New York, New York
Kansas State UniversityLectureCOBRE Program2012Manhattan, KS
Seoul National University Cancer Research Institute SymposiumLecture2012Seoul, Korea
Center for Tumor MicroenvironmentLectureCollege of Pharmacy2012Seoul, Korea
California Walnut Commission Scientific Advisory Board MeetingLectureCWC2012Honolulu, Hawaii
University of Arizona Cancer CenterLecture2011Tucson, AZ
University of Tel AvivLecture2011Tel Aviv, Israel
Ichilov HospitalLecture2011Tel Aviv, Israel
New York Medical CollegeLecture2011Valhalla, NY
Berry Health Benefits SymposiumLecture2011West Lake Village, CA
Department of Chemical BiologyLectureRutgers University2011New Brunswick, NJ
University of New Mexico Cancer CenterLecture2010Albuquerque, NM
John Wayne Cancer InstituteLecture2010Santa Monica, CA
University of Kansas School of MedicineLectureCancer Center2010Kansas City, KA
Fox-Chase Cancer CenterLecture2010Philadelphia, PA
The International Cancer Research Symposium 2010: Defining and Translating Science Behind the DiseaseLecture2010Thiruvananthapuram, India
Lombardi Cancer CenterLectureGeorgetown University2009Washington, DC
Arizona Comprehensive Cancer CenterLectureUniversity of Arizona2009Tuscan, AZ
Sylvester Cancer CenterLectureUniversity of Miami2009Miami, FL
4th International Conference on Phospholipase A2 and Lipid MediatorsLecture2009Tokyo, Japan
Gifu UniversityLectureInstitute for Cancer Research2009Gifu, Japan
Lipid Signaling Pathways in CancerLectureFASEB Summer Research Conference2009Carefree, AZ
Weill-Cornell Medical CollegeLectureDepartment of Surgery2009New York, NY
Invited Plenary Lecture, Eighth Annual AARC Conference on Frontiers in Cancer Prevention ResearchLecture2009Houston, TX
American Association for Cancer Research (two oral presentations)Lecture2008San Diego, CA
Louisiana State University Cancer CenterLecture2008New Orleans, LA
American Association for Cancer ResearchLectureSession Chairman2008San Diego, CA
National Cancer Center Research InstituteLecture2008Tokyo, Japan
Tokyo Metropolitan Medical InstituteLecture2008Tokyo, Japan
Kyoto University School of MedicineLecture2008Kyoto, Japan
Kanazawa Medical UniversityLecture2008Kanazawa, Japan
NCI TranslatesLecture2008Washington, DC
Lombardi Cancer CenterLectureGeorgetown University2008Washington, DC
University of PittsburghLecture2008Pittsburgh, PA
University of ColoradoLecture2008Denver, CO
Oklahoma Medical Research FoundationLecture2007Oklahoma City, OK
Burnham InstituteLecture2007LaJolla, CA
FASEB Summer Conference on Bioactive Lipid MediatorsLectureFASEB2007Indian Wells, CA
Bioactive Lipids in Cancer, Inflammation and Related DiseasesLecture2007Montreal, Canada
International Symposium on Genetic, Pharmacologic and Nutritional Modulations of CarcinogenesisLecture2007Seoul, Korea
9th International Conference on Mechanisms of Anti-mutagenesis and Anti-carcinogenesisLecture2007Jeju Island, Korea
Department of Cell BiologyLectureAlbert Einstein College of Medicine of Yeshiva University2006Bronx, NY
Pathology Lecture SeriesLectureWayne State University School of Medicine2006Detroit, MI
Gene Expression in Tumors - Discovery and DiagnosticsLectureLongwood Medical Center2006Boston, MA
City of HopeLectureDivision of Biology2005Duarte, CA
American Association for Cancer ResearchLecture2005Anaheim, CA
STADY ConferenceLectureTel Aviv University2005Israel
STADY ConferenceLectureTel Aviv University2005Israel
Experts meeting on Toxicogenomics and PharmacogenomicsLectureBoeringher-Ingelheim2004New York, NY
Arcturus EngineeringLecture2004Palo Alto, CA
IPMCLectureSophia-Antipolis2004France
Phospholipase ConferenceLectureInternational PAF2004Berlin, Germany
Phospholipase ConferenceLectureInternational PAF2004Berlin, Germany
Cambridge Health Tech Institute 2nd Annual LCM SymposiumLectureCambrige Health Tech Institute2004Boston, MA
IHC Meeting, presentation and workshop on LCMLectureIHC2004San Diego, CA
ACF pathobiology and its implications for biomarker development related to colorectal cancer risk and preventive responseLectureNCI2004Rockville, MD
UCLALectureHarbor Medical Center2003Torrance, CA
University of Arizona Cancer CenterLecture2003Tucson, AZ
Genomic and Proteomic Sample Preparation Short Course (Co-Chair)Lecture2003Boston, MA
Liver Hepatoxicity Mini-SymposiumLectureBoeringher-Ingelheim2003Ridgefield, CT
Department of Pharmaceutical SciencesLectureUniversity of Pittsburgh2003Pittsburgh, PA
University of IllinoisLectureSchool of Veterinary Sciences2003Champagne-Urbana, IL
Environmental Protection AgencyLecture2003Research Triangle Park, NC
Huntsman Cancer InstituteLecture2002Salt Lake City, UT
University of Massachusetts School of MedicineLecture2002Worcester, MA
Symposium on the Effects of Oxidant Balance on Breast and Colon CancerLecture2002New York, NY
Keynote Lecture, 2nd Australian Microarray ConferenceLecture2002Courant Cove, Australia
Molecular Profiling of Normal Development and Pathology in Tissues: Integrating Laser Microdissection and MicroanalysisLectureNIH2002Bethesda, MD
Department of Environmental MedicineLectureNew York University2002Tuxedo, NY
Enabling Molecular Profiling with Cellular ResolutionLectureCambridge Health Tech Institute2002San Diego, CA
M.D. Anderson Cancer CenterLectureUniversity of Texas2001Science Park, TX
American Association of Cancer ResearchLectureMini-symposium2001New Orleans, LA
Department of Human GeneticsLectureUMDNJ at Rutgers University2000Piscataway, NJ
Department of PathologyLectureYale University School of Medicine2000New Haven, CT
National Institute of Environmental Health SciencesLecture1999Research Triangle Park, NC
Pathobiology Seminar SeriesLectureDepartment of Medical Oncology, Brown University1999Providence, RI
Department of Pharmacology and ToxicologyLectureMedical College of Virginia1999Richmond, VA
University of Puerto RicoLectureDepartment of Biochemistry1999San Juan, PR
Signal Transduction Seminar SeriesLectureParke-David Pharmaceutical Research1998Ann Arbor, MI
Starr Center for Human Genetics, HHMILectureRockefeller University1998NY, NY
1st Annual Meeting on Rodent Models in Modern Risk AssessmentLectureThe Jackson Laboratory1998Bar Harbor, ME