Education

Degree	Institution	Major
BA	Williams College	Mathematics
PhD	Johns Hopkins University	Mechanical Engineering

Post-Graduate Training

Training	Institution	Specialty
Postdoctoral	University of Michigan	Neurology / Biophysics
Postdoctoral	University of Connecticut Health Center	MMSB

Awards

Name of Award/Honor	Awarding Organization
NIH Cancer Research Training Award Fellowship, Structural Glycobiology Section, LECB, NCI	NIH
NIH Cancer Research Training Award Fellowship, Molecular Structure Section, LECB, NCI	NIH
Elected to Sigma Xi	Williams College
Abel Wolman Fellowship: Awarded to an outstanding first-year doctoral candidate in Whiting School of Engineering	Johns Hopkins University

Name & Description	Category	Role	Type	Scope	Start Year	End Year
Molecular Biology and Biochemistry Graduate Program	Education Committee	Associate Director	UConn Health	University	2021	2024
NESS: North Eastern Structure Symposium	Workshop/Conference	Chair	External	Regional	2018	2018
Concepts in Magnetic Resonance A	Professional/Scientific Journal	guest editor, special issue	External	National	2017	2018
UConn Health Dental Senate	Advisory Committee	MBB representative	UConn Health	University	2017	2024
NUScon: Nonuniform sampling and reconstruction challenge in NMR spectroscopy	Professional/Scientific Organization	Chair	External	International	2017	2023
PESB: UConn Partnership for Excellence in Structural Biology	Professional/Scientific Organization	member	UConn Health	University	2014

Nonuniform Sampling of Multidimensional NMR.  Nonuniform sampling (NUS) approaches in multidimensional NMR (Nuclear Magnetic Resonance) enable dramatic reductions in experiment time, increases in sensitivity and enhancements in resolution. In order to access these benefits, complex theory and data processing workflows are required. Our work delivers quantitative methods for evaluating best practices, so that advanced NMR techniques become more broadly accessible and effective in addressing challenging problems in structural biology. 

NMRbox.  Computation is crucial for applications of NMR that provide insights into biomolecular structure, dynamics, interactions, and stability, and have translational applications including diagnostics and drug discovery. The amount of NMR software is exploding, making it more difficult to discover new software, and to support a full complement of software on a diverse set of computer platforms or maintain legacy packages. NMRbox is a National Center resource for biomolecular NMR (Nuclear Magnetic Resonance) software. It provides tools for finding the software you need, documentation and tutorials for getting the most out of the software, and cloud-based virtual machines for executing the software.

Accepting Lab Rotation Students: Fall Block 2024, Spring 1 and 2 Block 2025

Journal Articles

Book Chapters

Conference Papers

Letters

Title or Abstract	Type	Sponsor/Event	Date/Year	Location
NMRbox Summer Workshop	Other	NMRbox	2018	Farmington, CT
NMRbox Workshop @ The Scripps Research Institute	Other	The Scripps Research Institute	2017	San Diego, CA
NMRbox Summer Workshop	Other	NMRbox	2017	Farmington, CT
NMRbox Workshop @ University of Gothenburg	Other	University of Gothenburg	2017	Gothenburg, Sweden
NMRbox Workshop @ University of Maryland	Other	University of Maryland	2017	Rockville, MD
NMRbox Workshop @ The Weizmann Institute of Science	Other	Weizmann Institute of Science	2017	Rehovot, Israel
NMRbox: National Center for Biomolecular NMR Data Processing and Analysis	Poster	Experimental Nuclear Magnetic Resonance Conference	2016	Pittsburgh, PA
NMRbox: NATIONAL CENTER FOR BIOMOLECULAR NMR DATA PROCESSING AND ANALYSIS.	Poster	Biophysical Society Meeting	2016	Los Angeles, CA
Nonuniform sampling: theory and NMRbox tools	Talk	Chicago Area NMR Discussion Group Meeting	2016	Milwaukee, WI
A computational model of allosteric activation: insights into SOD1-linked ALS	Talk	UConn Health, Center for Cell Analysis and Modeling Department Seminar	2016	Farmington, CT
Partial-Component Nonuniform Sampling	Talk	New York Structural Biology Center	2015	New York, NY, USA
Ring Current Shifts: A geometric characterization and survey of the BMRB	Poster	Gordon Research Conference: Computational Aspects of Biomolecular NMR	2015	Il Ciocco, Italy
Hypercomplex Multidimensional NMR Employing Partial-Component Nonuniform Sampling	Talk	Experimental Nuclear Magnetic Resonance Conference	2014	Boston, MA
Molecular Modeling Reveals Molecular Function	Talk	University of Connecticut Health Center	2013	Farmington, CT
Characterizing Sensitivity for Hypercomplex Multidimensional NMR Employing Partial-Componentm Subsampling	Poster	GRC: Computational Aspects of Biomolecular NMR	2013	Mount Snow, Vermont
Characterizing Sensitivity for Hypercomplex Multidimensional NMR Employing Partial-Component Subsampling	Poster	Upstate NY NMR Symposium	2013	Troy, NY
Improved Metrics for Predicting Performance of Nonuniformly Sampled Schedules	Poster	Experimental Nuclear Magnetic Resonance Conference	2011	Pacific Grove, California
Binding Profiles Based on Normal Mode Analysis as a Foundation for a Unified Approach to Allosteric Activation of Prolactin Receptor	Poster	Biophysical Society Annual Meeting	2011	Baltimore, Maryland
Nonuniform Sampling for Improving Resolution in Multidimensional NMR	Poster	Experimental Nuclear Magnetic Resonance Conference	2010	Daytona Beach, Florida
Characterization and Optimization of Nonuniform Sampling for Multidimensional NMR Experiments	Poster	Biophysical Society Annual Meeting	2010	San Francisco, California
Computational Models of Allostery: Potential Mechanisms for Disease Control	Talk	University of Connecticut Health Center	2009	Farmington, Connecticut
Computational Models of Allostery: Potential Mechanisms for Disease Control	Talk	Boston University	2009	Boston, Massachusetts
Computational Methods for Predicting Sites of Functionally Important Dynamics	Talk	Biophysical Society Annual Meeting	2009	Boston, Massachusetts
Computational Analysis of Familial Amyotrophic Lateral Sclerosis Causing Mutations of Cu-Zn Superoxide Dismutase	Poster	American Neurological Association Annual Meeting	2008	Salt Lake City, Utah
Normal Mode Directed Exploration of Conformation Space as a Tool for Studying Macromolecular Interactions	Poster	Biophysical Society Annual Meeting	2008	Long Beach, California
Iterative Cluster Normal Mode Analysis (icNMA): A Tool for Traversing the Conformation Energy Landscape with an Application to ALS	Poster	Biophysical Society Annual Meeting	2007	Baltimore, Maryland
Biological Function Determined by Cluster-NMA on Very Large Structures	Talk	Johns Hopkins University	2004	Baltimore, Maryland
Efficient Determination of Low-Frequency Modes on Large Protein Structures by Cluster-NMA	Poster	Biophysical Society Annual Meeting	2004	Baltimore, Maryland
Cluster-NMA: A Computationally Efficient, Rigid-Body-Based, Normal Mode Analysis Tool	Poster	Institute for Biophysical Research Annual Meeting	2003	Linthicum Heights, Maryland
Protein Dynamics Modeling	Poster	The 7th Johns Hopkins Folding Meeting	2003	Berkeley Springs, West Virginia
A Dual Approach to Triangle Sequences: A Multidimensional Continued Fraction Algorithm	Talk	Joint Meetings of the MAA and AMS	1999	Providence Rhode Island