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Leia Shuhaibar, Ph.D.Assistant Professor, Department of Cell Biology
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Education
Post-Graduate Training
Awards
| Degree | Institution | Major |
|---|---|---|
| B.S. | University of Zulia (Universidad del Zulia) | Biology |
| M.S. | Florida Institute of Technology | Biological Science - Cell and Molecular |
| Ph.D. | University of Connecticut Health Center | Biomedical Sciences - Cell Biology |
Post-Graduate Training
| Training | Institution | Specialty |
|---|---|---|
| Postdoctoral | University of Connecticut Health Center | Postdoctoral Fellow |
Awards
| Name of Award/Honor | Awarding Organization |
|---|---|
| Poster award, 1st place. 31st Annual graduate student research day. University of Connecticut Health Center. Farmington, Connecticut | University of Connecticut Health Center |
| Honorific Mention for Undergraduate Thesis. | University of Zulia. Dept of Biology. Maracaibo, Venezuela |
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| Society for the Study of Reproduction (SSR) | Professional/Scientific Organization | Member | External | National | 2016 |
Journal Articles
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Phosphatase inhibition by LB-100 enhances BMN-111 stimulation of bone growth.
JCI insight 2021 May;6(9):e141426
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Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor.
eLife 2017 Dec;6
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Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis.
Biology of reproduction 2016 May;94(5):110
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Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase is required for rapid resumption of oocyte meiosis in response to luteinizing hormone.
Developmental biology 2015 Oct;409194-201
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Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles.
Proceedings of the National Academy of Sciences of the United States of America 2015 Mar;112(17):5527-32
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Dephosphorylation and inactivation of NPR2 guanylyl cyclase in granulosa cells contributes to the LH-induced decrease in cGMP that causes resumption of meiosis in rat oocytes.
Development (Cambridge, England) 2014 Sep;141(18):3594-604
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Luteinizing hormone reduces the activity of the NPR2 guanylyl cyclase in mouse ovarian follicles, contributing to the cyclic GMP decrease that promotes resumption of meiosis in oocytes.
Developmental biology 2012 Jun;366(2):308-16
Book Chapters
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Preparing for fertilization: Intercellular signals for oocyte maturation
Reproductive and Developmental Strategies 2018 Jan;535-548
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| FGF-inhibition of NPR2-mediated Cyclic GMP Production in Growth Plate Chondrocytes is Reversed by the Phosphatase Inhibitor LB-100 | Poster | 2018 meeting of the American Society for Bone and Mineral Research | 2018 | Montreal, CAN. |
| Prevention of guanylyl cyclase-B dephosphorylation increases the length and cortical content of long bones. | Poster | 8th Int'l Conf. on cGMP. cGMP: Generators, Effectors, Therap. Implications | 2017 | Bamberg, Germany |
| Hormonal control of meiosis by cyclic GMP: Live imaging of cGMP in mouse ovarian follicles. | Talk | Florida Institute of Technology | 2016 | Melbourne, Florida |
| Changes in the phosphorylation of guanylyl cyclase-B (GC-B) regulates bone growth in a mouse model. | Poster | ASBMR (American Society for Bone and Mineral Research) Annual Meeting | 2016 | Atlanta, Georgia |
| Phosphorylation of the cGMP phosphodiesterase PDE5 is required for the LH-induced increase in cGMP hydrolytic activity in mouse ovarian follicles. | Poster | 49th Annual Meeting: Society for the Study of Reproduction | 2016 | San Diego, California |
| Luteinizing hormone signaling via cyclic GMP diffusion through gap junctions | Talk | Oocyte maturation and fertilization meeting IV | 2015 | Asamushi, Japan |
| Dephosphorylation of juxtamembrane serines and threonines of the NPR2 guanylyl cyclase regulates oocyte meiotic resumption (Abstract published in BMC Pharmacology and Toxicology) | Poster | 7th Int. Conf. - cGMP. cGMP:Generators,Effectors,Therap.Implications | 2015 | Trier, Germany |
| Luteinizing hormone signaling rapidly reduces cyclic GMP levels in rat ovarian follicles by dephosphorylation of NPR2 and phosphorylation of PDE5A, leading to meiotic resumption. | Poster | Society for the Study of Reproduction Annual Meeting | 2015 | San Juan, Puerto Rico |
| Hormonal control of meiosis by cyclic GMP: Live imaging of cGMP in mouse ovarian follicles | Talk | MRC Laboratory of Molecular Biology | 2015 | Cambridge, United Kingdom |
| Luteinizing hormone restarts meiosis through dephosphorylation and inactivation of the NPR2 guanylyl cyclase in the surrounding granulosa cells | Poster | Northeast Regional Meeting of the Society for Developmental Biology | 2014 | Woods Hole, Massachusetts |
| Cyclic GMP-mediated intercellular communication in mammalian ovarian follicles. Presented at 6th International Conference on cGMP: Generators, Effectors and Therapeutic Implications (Abstract published in BMC Pharmacology and Toxicology) | Poster | 6th Int. Conf. on cGMP: Generators, Effectors and Therapeutic Implications | 2013 | Erfurt, Germany |
| Luteinizing hormone signaling decreases cyclic GMP production in rat ovarian follicles by rapidly dephosphorylating the NPR2 guanylyl cyclase and by slowly decreasing its agonist CNP | Poster | EMBO W.shop Oocyte mat. and fert.: Lessons from canonical+emerging models | 2013 | Banyuls-sur-Mer, France |
| Spatial and temporal dynamics of the LH-induced decrease in cGMP in mouse ovarian follicles. Presented at the | Poster | EMBO Wks. Oocyte mat. and fert.: Lessons from canonical and emerging models | 2013 | Banyuls-sur-Mer, France |
| Luteinizing hormone reduces guanylyl cyclase activity in the granulosa cells of the mouse ovary, leading to the resumption of meiosis in the oocyte | Poster | ASCB Annual Meeting | 2011 | Denver, Colorado |