Photo of Anthony T. Vella, Ph.D.

Anthony T. Vella, Ph.D.

Professor and Chair
Boehringer Ingelheim Chair in Immunology
Associate Dean of Research Mentoring and Career Development
Academic Office Location:
Immunology
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3710
Phone: 860-679-4364
Fax: 860-679-8130
Website(s):

Immunology Graduate Program

Education
DegreeInstitutionMajor
B.A.Buffalo State CollegeBiology
M.S.Rensselaer Polytechnic InstituteBiology
Ph.D.Cornell UniversityImmunology

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralNational Jewish Center for Immunology and Respiratory MedicineImmunology
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Immunology Graduate Program at UConn HealthProfessional/Scientific OrganizationDirectorUConn HealthUniversity20072010

My laboratory focuses on several aspects of T cell and inflammation biology. Our aim is to uncover how T cells function so that we can guide and control behavior of these important immune cells. We believe that the outcome of this work will foster vaccine development, but also devise new ways to control unwanted immune responses. Our approach is to understand how adjuvants and costimulatory pathways influence the function of T cells, and define how cytokine networks impact immune cell behavior. A brief overview highlighting our goals are given below:


Vaccine Adjuvants: Commonly, vaccines are made up of antigen (Ag) and adjuvant. Antigens stimulate specific T and B cells through an Ag receptor, while adjuvants activate innate immune cells by triggering pattern recognition receptors. Without adjuvants vaccines would likely be ineffective. My lab studies several different adjuvants and one example is bacterial lipopolysaccharide, which stimulates innate immune cells such as macrophages through toll-like receptor-4 (TLR4). What’s striking is that the response emanating from TLR4 conditions Ag-stimulated T cells to survive. While the mechanism is largely unknown, our recent data suggest that a specific signaling pathway is key to survival. A goal is to uncover this process by using cellular approaches, biochemistry and proteomics.


T cell Costimulation: Costimulation of T cells provides an “on” signal that induces T cell growth, cytokine secretion, and programs survival and cytotoxic potential. Several years ago we discovered that a combination of costimulators fostered enhanced responses and reasoned that this combination would be useful in cancer treatment. In a collaborative study with Dr. Adam Adler (Department of Immunology, UCHC) and others, we tested this idea. Our recent data show that costimulating T cells through CD134 and CD137 induces both CD4 and CD8 T cells to become powerful effectors capable of killing tumor cells. This project is focused on understanding the mechanism of heightened T cell responsiveness with a goal of developing this approach for future use in cancer patients.


Pediatric Intestinal Inflammatory Diseases: A new collaborative research project with Dr. Francisco Sylvester, a pediatric gastroenterologist currently at The University of North Carolina at Chapel Hill (Chapel Hill, NC), is focused on studying the basis of ulcerative colitis, Crohn disease, and eosinophilic esophagitis in pediatric patients. This effort is comprised of a research team including clinicians and bioinformatics specialists that hope to bring basic observations from the clinic to the laboratory and back to the bedside. One idea we are working on is that specific cytokine networks determine disease state and severity. We believe that these cytokines networks are derived from changes in the microbiome of patients or byproducts of microbes, and postulate that understanding this process will help to develop new ways to divert active disease into remission.

Not accepting lab rotation students at this time

Journal Articles

Reviews

Title or AbstractTypeSponsor/EventDate/YearLocation
Department of Microbiology and ImmunologyVirginia Commonwealth University2015Richmond, VA
Immunology & InflammationBoehringer Ingelheim2014Ridgefield CT
Department of Microbiology and ImmunologyUniversity of Texas Health Sciences Center2013San Antonio, TX
School of MedicineVirginia Tech Carilion Research Institute2012Roanoke, VA
Department of Microbiology, Immunology and Cancer BiologyUniversity of Minnesota2011Minneapolis, MN
Departmental Seminar, Rocky Mountain National LabNIH2011Hamilton, MT
Connecticut Institute of Clinical and Translational Science (CICATS) First Translational SymposiumUniversity of Connecticut Health Center2010Farmington, CT
New England Immunology ConferenceUniversity of Connecticut Health Center2010Woods Hole, MA
Center for Biotechnology and Genomic MedicineMedical College of GA2010Augusta, GA
Pediatric Research DayConnecticut Children’s Medical Center2010Hartford, CT
Department of Molecular Biology and ImmunologyUniversity of North Texas Health Sciences Center2010Fort Worth, TX
Inflammation GroupAmgen Corp.2009Seattle, WA