Zhao-Wen Wang, Ph.D.Professor of Neuroscience
Faculty in Neuroscience, Cell Biology and Genetics & Developmental Biology Graduate Programs
|M.S.||Third Military Medical University||Medicine and Physiology|
|Ph.D.||Michigan State University||Physiology/Neuroscience|
|Postdoctoral||University of Pennsylvania||Electrophysiology|
|Name of Award/Honor||Awarding Organization|
|National Research Service Award (Individual), 1996-1999|
|National Research Service Award (Institutional), 1995-1996|
|Name & Description||Category||Role||Type||Scope||Start Year||End Year|
|Genetic Society of American||Professional/Scientific Organization||Member||External||National||2005|
|Society for Neuroscience||Professional/Scientific Organization||Member||External||National||2002|
Regulation of neurotransmitter release by Ca2+ and Ca2+-sensitive proteins
Function and regulation of gap junctions
My lab uses the nematode Caenorhabditis elegans (C. elegans) as a model organism to study molecular mechanisms of neurotransmitter release, and the function and regulation of gap junctions. C. elegans is a very powerful model system for studying fundamental biological problems, which is highlighted by the award of two recent Noble prizes (Physiology or Medicine, 2002 and 2006) to scientists studying C. elegans.
Ca2+ plays key roles in neurotransmitter release. It triggers the release by directly binding to Ca2+ sensor(s) at the presynaptic site, and regulates the release by modulating the activities of several presynaptic proteins. We study the functions of presynaptic voltage-gated Ca2+ channels, ryanodine receptor (a Ca2+-releasing channel in the endoplasmic reticulum membrane), BK channel (a large-conductance Ca2+-activated K+ channel), and Ca2+/calmodulin-dependent protein kinase II (CaMKII) in neurotransmitter release, and try to determine whether and how these proteins interact at the presynaptic site. These research programs have the potential to significantly advance our understanding of the molecular mechanisms of synaptic transmission.
Gap junctions are intercellular channels that are almost ubiquitously expressed. However, their biological functions and regulations are still poorly understood. My lab was the first (so far the only one) to adapt the dual whole-cell voltage clamp technique to the analysis of electrical coupling in C. elegans. We use a combination of electrophysiological, genetic, and cell biological techniques to identify and characterize conserved mechanisms of gap junction assembly and regulation.
Accepting Lab Rotation Students: Summer '18, Fall '18, Spring '19