Photo of Adam  Williams, Ph.D.

Adam Williams, Ph.D.

Assistant Professor, Jackson Laboratory for Genomic Medicine
Academic Office Location:
The Jackson Laboratory for Genomic Medicine
10 Discovery Lane
Farmington, CT 06032
Phone: (860) 837-2351
Fax: (860) 837-2398
Email: adam.williams@jax.org
Website(s):

Genetics and Developmental Biology Graduate Program

Williams Lab Page

Education
DegreeInstitutionMajor
B.S.Exeter CollegeChemistry
B.S.Cardiff UniversityBiochemistry
Ph.D.University College London, Laboratory of Dimitris KioussisMolecular Immunology

Awards
Name of Award/HonorAwarding Organization
K. S. Dodgson Memorial Prize, Best Performance by a BiochemistUniversity of Wales, Cardiff, South Glam
Scholarship for ExcellenceUniversity of Wales, Cardiff, South Glam

 


Not accepting students for Lab Rotations at this time

Journal Articles

  • Group 1 Innate Lymphoid Cell Lineage Identity Is Determined by a cis-Regulatory Element Marked by a Long Non-coding RNA.
    Mowel, Walter K; McCright, Sam J; Kotzin, Jonathan J; Collet, Magalie A; Uyar, Asli; Chen, Xin; DeLaney, Alexandra; Spencer, Sean P; Virtue, Anthony T; Yang, EnJun; Villarino, Alejandro; Kurachi, Makoto; Dunagin, Margaret C; Pritchard, Gretchen Harms; Stein, Judith; Hughes, Cynthia; Fonseca-Pereira, Diogo; Veiga-Fernandes, Henrique; Raj, Arjun; Kambayashi, Taku; Brodsky, Igor E; O'Shea, John J; Wherry, E John; Goff, Loyal A; Rinn, John L; Williams, Adam; Flavell, Richard A; Henao-Mejia, Jorge Immunity 2017 Sep;47(3):435-449.e8
  • Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity.
    Calabro, Samuele; Liu, Dong; Gallman, Antonia; Nascimento, Manuela Sales L; Yu, Zizi; Zhang, Ting-Ting; Chen, Pei; Zhang, Biyan; Xu, Lan; Gowthaman, Uthaman; Krishnaswamy, Jayendra Kumar; Haberman, Ann M; Williams, Adam; Eisenbarth, Stephanie C Cell reports 2016 Aug;16(9):2472-85
  • The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan.
    Kotzin, Jonathan J; Spencer, Sean P; McCright, Sam J; Kumar, Dinesh B Uthaya; Collet, Magalie A; Mowel, Walter K; Elliott, Ellen N; Uyar, Asli; Makiya, Michelle A; Dunagin, Margaret C; Harman, Christian C D; Virtue, Anthony T; Zhu, Stella; Bailis, Will; Stein, Judith; Hughes, Cynthia; Raj, Arjun; Wherry, E John; Goff, Loyal A; Klion, Amy D; Rinn, John L; Williams, Adam; Flavell, Richard A; Henao-Mejia, Jorge Nature 2016 Aug;537(7619):239-243
  • Bridging channel dendritic cells induce immunity to transfused red blood cells.
    Calabro, Samuele; Gallman, Antonia; Gowthaman, Uthaman; Liu, Dong; Chen, Pei; Liu, Jingchun; Krishnaswamy, Jayendra Kumar; Nascimento, Manuela Sales L; Xu, Lan; Patel, Seema R; Williams, Adam; Tormey, Christopher A; Hod, Eldad A; Spitalnik, Steven L; Zimring, James C; Hendrickson, Jeanne E; Stowell, Sean R; Eisenbarth, Stephanie C The Journal of experimental medicine 2016 May;
  • Editing the Mouse Genome Using the CRISPR-Cas9 System.
    Williams, Adam; Henao-Mejia, Jorge; Flavell, Richard A Cold Spring Harbor protocols 2016 Jan;2016(2):pdb.top087536
  • Generation of Genetically Modified Mice Using the CRISPR-Cas9 Genome-Editing System.
    Henao-Mejia, Jorge; Williams, Adam; Rongvaux, Anthony; Stein, Judith; Hughes, Cynthia; Flavell, Richard A Cold Spring Harbor protocols 2016 Jan;2016(2):pdb.prot090704
  • Coincidental loss of DOCK8 function in NLRP10-deficient and C3H/HeJ mice results in defective dendritic cell migration.
    Krishnaswamy, Jayendra Kumar; Singh, Arpita; Gowthaman, Uthaman; Wu, Renee; Gorrepati, Pavane; Sales Nascimento, Manuela; Gallman, Antonia; Liu, Dong; Rhebergen, Anne Marie; Calabro, Samuele; Xu, Lan; Ranney, Patricia; Srivastava, Anuj; Ranson, Matthew; Gorham, James D; McCaw, Zachary; Kleeberger, Steven R; Heinz, Leonhard X; Müller, André C; Bennett, Keiryn L; Superti-Furga, Giulio; Henao-Mejia, Jorge; Sutterwala, Fayyaz S; Williams, Adam; Flavell, Richard A; Eisenbarth, Stephanie C Proceedings of the National Academy of Sciences of the United States of America 2015 Mar;112(10):3056-61
  • The microRNA miR-181 is a critical cellular metabolic rheostat essential for NKT cell ontogenesis and lymphocyte development and homeostasis.
    Henao-Mejia, Jorge; Williams, Adam; Goff, Loyal A; Staron, Matthew; Licona-Limón, Paula; Kaech, Susan M; Nakayama, Maki; Rinn, John L; Flavell, Richard A Immunity 2013 May;38(5):984-97
  • Cutting edge: Nlrp10 is essential for protective antifungal adaptive immunity against Candida albicans.
    Joly, Sophie; Eisenbarth, Stephanie C; Olivier, Alicia K; Williams, Adam; Kaplan, Daniel H; Cassel, Suzanne L; Flavell, Richard A; Sutterwala, Fayyaz S Journal of immunology (Baltimore, Md. : 1950) 2012 Nov;189(10):4713-7
  • NLRP10 is a NOD-like receptor essential to initiate adaptive immunity by dendritic cells.
    Eisenbarth, Stephanie C; Williams, Adam; Colegio, Oscar R; Meng, Hailong; Strowig, Till; Rongvaux, Anthony; Henao-Mejia, Jorge; Thaiss, Christoph A; Joly, Sophie; Gonzalez, David G; Xu, Lan; Zenewicz, Lauren A; Haberman, Ann M; Elinav, Eran; Kleinstein, Steven H; Sutterwala, Fayyaz S; Flavell, Richard A Nature 2012 Apr;484(7395):510-3
  • CD8 locus nuclear dynamics during thymocyte development.
    Ktistaki, Eleni; Garefalaki, Anna; Williams, Adam; Andrews, Simon R; Bell, Donald M; Foster, Katie E; Spilianakis, Charalampos G; Flavell, Richard A; Kosyakova, Nadezda; Trifonov, Vladmir; Liehr, Thomas; Kioussis, Dimitris Journal of immunology (Baltimore, Md. : 1950) 2010 May;184(10):5686-95
  • The role of NOD-like Receptors in shaping adaptive immunity.
    Williams, Adam; Flavell, Richard A; Eisenbarth, Stephanie C Current opinion in immunology 2010 Feb;22(1):34-40
  • Chitin is a size-dependent regulator of macrophage TNF and IL-10 production.
    Da Silva, Carla A; Chalouni, Cécile; Williams, Adam; Hartl, Dominik; Lee, Chun G; Elias, Jack A Journal of immunology (Baltimore, Md. : 1950) 2009 Mar;182(6):3573-82
  • Generalized immune activation as a direct result of activated CD4+ T cell killing.
    Marques, Rute; Williams, Adam; Eksmond, Urszula; Wullaert, Andy; Killeen, Nigel; Pasparakis, Manolis; Kioussis, Dimitris; Kassiotis, George Journal of biology 2009 Jan;8(10):93
  • Position effect variegation and imprinting of transgenes in lymphocytes.
    Williams, Adam; Harker, Nicola; Ktistaki, Eleni; Veiga-Fernandes, Henrique; Roderick, Kathleen; Tolaini, Mauro; Norton, Trisha; Williams, Keith; Kioussis, Dimitris Nucleic acids research 2008 Apr;36(7):2320-9
  • Tyrosine kinase receptor RET is a key regulator of Peyer's patch organogenesis.
    Veiga-Fernandes, Henrique; Coles, Mark C; Foster, Katie E; Patel, Amisha; Williams, Adam; Natarajan, Dipa; Barlow, Amanda; Pachnis, Vassilis; Kioussis, Dimitris Nature 2007 Mar;446(7135):547-51
  • Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression
    Williams A*, Lee GR*, Spilianakis CG, Hwang SS, Eisenbarth SC, Flavell RA. (*Co-first authors) Proc Natl Acad Sci 2013 April 23 110
  • Interchromosomal association and gene regulation in trans
    Williams A, Spilianakis CG, Flavell RA. Trends Genet. 2010 Apr 26(4):188-197
  • Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens
    Wegmann F, Gartlan KH, Harandi AM, Brinckmann SA, Coccia M, Hillson WR, Kok WL, Cole S, Ho LP, Lambe T, Puthia M, Svanborg C, Scherer EM, Krashias G, Williams A, Blattman JN, Greenberg PD, Flavell RA, Moghaddam AE, Sheppard NC, Sattentau QJ. Nat Biotechnol 2012 Sep 30(9):883-888
  • Rac GTPases play critical roles in early T cell development
    Dumont C, Corsoni-Tadrzak A, Ruf S, de Boer J, Williams A, Turner M, Kioussis D, Tybulewicz VL. Blood. 2009 Apr 23 113(17):3990-3998
  • The role of CTCF in regulating nuclear organization
    Williams A, Flavell RA. J Exp Med. 2008 Apr 14 205(4):747-750
  • Topological organization of multichromosomal regions by the long intergenic noncoding RNA Firre
    Hacisuleyman E, Goff LA, Trapnell C, Williams A, Henao-Mejia J, Sun L, McClanahan P, Hendrickson DG, Sauvageau M, Kelley DR, Morse M, Engreitz J, Lander ES, Guttman M, Lodish HF, Flavell R, Raj A, Rinn JL. Nat Struct Mol Biol. 2014 21(2):198-206
  • Transgenic mice with hematopoietic and lymphoid specific expression of Cre
    de Boer J*. Williams A*. Skavdis G. Harker N. Coles M. Tolaini M. Norton T. Williams K. Roderick K. Potocnik AJ. Kioussis D. (*Co-first authors). Eur J Immunol. 2003 Feb 33(2):314-325

Reviews

  • miR-181 and metabolic regulation in the immune system
    Williams A*, Henao-Mejia J*, Harman CCD, Flavell RA. (*Co-first authors). Cold Spring Harbor Symposium. volume 78. In press