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Liping Xiao, MD, PhDAssistant Professor of Medicine and Psychiatry
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Education
Post-Graduate Training
Awards
Degree | Institution | Major |
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MD | Hebei Medical University | Medicine |
PhD | Tianjin Medical University | Endocrinology and Metabolism |
MSc | UConn Health | Clinical Translational Research |
Post-Graduate Training
Training | Institution | Specialty |
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Residency | Tangshan Worker Hospital | Internal Medicine |
Fellowship | Tianjin Medical University | Endocrinology and Metabolism |
Postdoctoral | UConn Health | Endocrinology and Metabolism |
Awards
Name of Award/Honor | Awarding Organization |
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Patent: METHODS OF TREATING SICKLE CELL DISORDER AND RELATED CONDITIONS. | UConn Health |
ASBMR 2019 Mid-Career Faculty Travel Award | American Society for Bone and Mineral Research |
Lawrence G. Raisz Travel Grant Award | UConn Health |
Co-chair at Symposium “Thematic FGF Differences” | ASBMR annual meeting |
Invited speaker | Gordon Research Conference |
The Department of Medicine Scholars Awards | UConn Health |
Lawrence G. Raisz Fund for Musculoskeletal Research & Education ASBMR Travel Award | UConn Health |
Reviewer | Gene |
Reviewer | Cellular Physiology and Biochemistry |
Lawrence G. Raisz Fund for Musculoskeletal Research & Education ASBMR Travel Award | UConn Health |
Recipient | Lawrence G. Raisz Travel Grant Award |
Reviewer | International Journal of Medical and Health Sciences Research |
Reviewer | International Journal of Nanomedicine |
Reviewer | PLOS ONE |
Reviewer | International Journal of Medical and Health Sciences Research |
Recipient | Lawrence G. Raisz Travel Grant Award |
Recipient, Henry Christian Award | American Federation for Medical Research |
Volunteer Interpreter, Commitment Recognition Award | UConn Health |
Web Jee Young Investigator Award, | International Chinese Musculoskeletal Research Society |
Recipient, ICHTS Web Jee Young Investigator Award | International Chinese Hard Tissue Society |
Young Investigator Award | ASBMR annual meeting |
Recipient, Young Investor Award | American Society for Bone and Mineral Research |
Member | International Chinese Society for Bone and Mineral Research |
Federal Scholarship | Tianjin Medical University |
Member | American Society for Bone and Mineral Research |
Not accepting students for Lab Rotations at this time
Journal Articles
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Effects of GBT1118, a voxelotor analog, on bone disease in sickle cell disease mice.
Scientific reports 2024 Sep;14(1):22330
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Fibroblast Growth Factor 23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handling in Sickle Cell Disease Mice.
Endocrinology 2023 Nov;164(12):
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Bone loss is ameliorated by fecal microbiota transplantation through SCFA/GPR41/ IGF1 pathway in sickle cell disease mice.
Scientific reports 2022 Nov;12(1):20638
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FGF receptor inhibitor BGJ398 partially rescues osteoarthritis-like phenotype in older high molecular weight FGF2 transgenic mice via multiple mechanisms.
Scientific reports 2022 Sep;12(1):15968
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Fibroblast Growth Factor 2 High Molecular Weight Isoforms in Dentoalveolar Mineralization.
Calcified tissue international 2021 Jul;
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Gait disturbances and muscle dysfunction in fibroblast growth factor 2 knockout mice.
Scientific reports 2021 May;11(1):11005
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Automated Indentation Demonstrates Structural Stiffness of Femoral Articular Cartilage and Temporomandibular Joint Mandibular Condylar Cartilage Is Altered in FgF2KO Mice
Cartilage 2020 Oct;1947603520962565
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Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High Molecular Weight FGF2 Isoforms.
Endocrinology 2020 Jan;161(1):
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Depletion of Intestinal Microbiome Partially Rescues Bone Loss in Sickle Cell Disease Male Mice.
Scientific reports 2019 Jun;9(1):8659
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Ablation of low-molecular-weight FGF2 isoform accelerates murine osteoarthritis while loss of high-molecular-weight FGF2 isoforms offers protection.
Journal of cellular physiology 2019 Apr;2344418-4431
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Bone marrow neutrophil aging in sickle cell disease mice is associated with impaired osteoblast functions.
Biochemistry and biophysics reports 2018 Dec;16110-114
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FGF2 crosstalk with Wnt signaling in mediating the anabolic action of PTH on bone formation.
Bone reports 2018 Dec;9136-144
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FGF23 regulates Wnt/β-catenin signaling-mediated osteoarthritis in mice overexpressing high molecular weight FGF2.
Endocrinology 2018 Apr;1592386-2396
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FGF23 Neutralizing Antibody Partially Improves Bone Mineralization Defect of HMWFGF2 Isoforms Transgenic Female Mice.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2018 Mar;331347-1361
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Inhibition of FGFR Signaling Partially Rescues Hypophosphatemic Rickets in HMWFGF2 Tg Male Mice.
Endocrinology 2017 Oct;158(10):3629-3646
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Clinically Relevant Concentrations of Ketamine Inhibit Osteoclast Formation In Vitro in Mouse Bone Marrow Cultures.
Journal of cellular biochemistry 2016 Oct;118914-923
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FGF2 High Molecular Weight Isoforms Contribute to Osteoarthropathy in Male Mice.
Endocrinology 2016 Oct;1574602-4614
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FGF23 Neutralizing Antibody Ameliorates Hypophosphatemia and Impaired FGF Receptor Signaling in Kidneys of HMWFGF2 Transgenic Mice.
Journal of cellular physiology 2016 Jun;232610-616
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Loss of Bone in Sickle Cell Trait and Sickle Cell Disease Female Mice Is Associated with Reduced IGF-1 in Bone and Serum.
Endocrinology 2016 May;1573036-46
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Age-related changes in FGF-2, fibroblast growth factor receptors and β-catenin expression in human osteoblasts (mesenchyme-derived progenitor cells).
Journal of Cellular Biochemistry 2016 Mar;117(3):721-9
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FGFR Inhibitor Ameliorates Hypophosphatemia and Impaired Engrailed-1/Wnt Signaling in FGF2 High Molecular Weight Isoform Transgenic Mice.
Journal of cellular biochemistry 2016 Jan;1171991-2000
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Accelerated Fracture Healing in Transgenic Mice Overexpressing an Anabolic Isoform of Fibroblast Growth Factor 2.
Journal of cellular biochemistry 2015 Aug;117599-611
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Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis.
The Journal of biological chemistry 2014 Nov;289(52):36303-14
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Fibroblast growth factor-2 isoform (low molecular weight/18 kDa) overexpression in preosteoblast cells promotes bone regeneration in critical size calvarial defects in male mice.
Endocrinology 2014 Mar;155(3):965-974
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FGF-2 enhances Runx-2/Smads nuclear localization in BMP-2 canonical signaling in osteoblasts.
Journal of cellular physiology 2013 Nov;228(11):2149-58
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BMP-2 differentially modulates FGF-2 isoform effects in osteoblasts from newborn transgenic mice.
Endocrinology 2013 Aug;154(8):2723-33
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Nuclear fibroblast growth factor 2 (FGF2) isoforms inhibit bone marrow stromal cell mineralization through FGF23/FGFR/MAPK in vitro.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2013 Jan;28(1):35-45
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Fibroblast growth factor 2 stimulation of osteoblast differentiation and bone formation is mediated by modulation of the Wnt signaling pathway.
The Journal of biological chemistry 2011 Nov;286(47):40575-83
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The impaired bone anabolic effect of PTH in the absence of endogenous FGF2 is partially due to reduced ATF4 expression.
Biochemical and biophysical research communications 2011 Aug;412(1):160-4
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Disruption of the Fgf2 gene activates the adipogenic and suppresses the osteogenic program in mesenchymal marrow stromal stem cells.
Bone 2010 Aug;47(2):360-70
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Signaling pathways implicated in PGF2alpha effects on Fgf2+/+ and Fgf2-/- osteoblasts.
Journal of cellular physiology 2010 Aug;224(2):465-74
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Nuclear isoforms of fibroblast growth factor 2 are novel inducers of hypophosphatemia via modulation of FGF23 and KLOTHO.
The Journal of biological chemistry 2010 Jan;285(4):2834-46
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Fibroblast growth factor 2 positively regulates expression of activating transcription factor 4 in osteoblasts.
Biochemical and biophysical research communications 2010 Jan;391(1):335-9
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Exported 18-kDa isoform of fibroblast growth factor-2 is a critical determinant of bone mass in mice.
The Journal of biological chemistry 2009 Jan;284(5):3170-82
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Reduced expression and function of bone morphogenetic protein-2 in bones of Fgf2 null mice.
Journal of cellular biochemistry 2008 Apr;103(6):1975-88
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Impaired bone anabolic response to parathyroid hormone in Fgf2-/- and Fgf2+/- mice.
Biochemical and biophysical research communications 2006 Mar;341(4):989-94
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Over-expression of fibroblast growth factor-2 causes defective bone mineralization and osteopenia in transgenic mice.
Journal of cellular biochemistry 2005 May;95(1):83-94
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Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts.
The Journal of biological chemistry 2004 Jun;279(26):27743-52
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Effect of overexpressing fibroblast growth factor 2 protein isoforms in osteoblastic ROS 17/2.8 cells.
Journal of cellular biochemistry 2003 Aug;89(6):1291-301
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Automated Indentation Demonstrates Structural Stiffness of Femoral Articular Cartilage and Temporomandibular Joint Mandibular Condylar Cartilage Is Altered in FgF2KO Mice
Cartilage Oct 3
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Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High Molecular Weight FGF2 Isoforms
Endocrinology Jan 1;161(1)
Book Chapters
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Infiltrative Marrow Disorders and Osteoporosis
The ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism 2024 Jul;Chapter 72
Abstracts
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Abaloparatide Mediates Osteoblastogenesis through FGF2 and -Catenin/ Wnt Effectors
JBMR, Suppl, 2024.
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Conditional Knockout of Fgf2 in Cartilage Results in Osteoarthritis Development in Mice
JBMR Suppl2021
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Conditional Knockout of FGF2 in Osteocytes Results in Impaired Bone Formation and Increased Osteocytes Apoptosis in Mice
JBMR, Suppl, 2022.
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Effects of Voxelotor Analog GBT1118 on Bone in Sickle Cell Disease Mice.
JBMR, Suppl, 2023.
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Fecal Microbiota Transplantation Alleviates Bone Loss in Sickle Cell Disease Mice through Regulating SCFA Medicated IGF1 Production
JBMR Suppl2021
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FGF Receptor Inhibitor BGJ398 Reduces Osteoarthritis Phenotype in Hyp Mice via Modulation of Aberrant FGF2/FGF23/FGFR1 and Inflammasome Signaling in Hyp Knee Articular Cartilage
JBMR, Suppl, 2024
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FGF23 in crosstalk of bone, kidney, and hematopoiesis in sickle cell bone disease
J Bone Miner Res 2019, Suppl
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FGF23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handing in Sickle Cell Disease Mice.
JBMR, Suppl, 2023
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FGF23 Neutralizing Antibody Rescues Reduced Bone Nodule Formation in Bone Marrow Stromal Cell Cultures from Sickle Cell Disease Mice
J Bone Miner Res 2020, Suppl
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Fibroblast Growth Factor 23 Neutralizing Antibody Partially Rescues Bone Loss in Sickle Cell Disease Mice
JBMR, Suppl, 2024.
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Impaired PTH-stimulated periosteal proliferation, Wnt activity and fracture healing in Fgf2 knockout mice
J Bone Miner Res 2019, Suppl
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Inhibition of FGFR Signaling Partially Rescues Osteoarthritis in Mice Overexpressing High Molecular Weight FGF2 Isoforms
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Inhibition of FGFR signaling partially rescues osteoarthritis in mice overexpressing high-molecular-weight FGF2
J Bone Miner Res 2019, Suppl
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Inhibition of TLRs/NF-kB Signaling Pathway through FGFR Blocking Partially Rescues Osteoarthritis in HMWFGF2 Transgenic Mice
JBMR, Suppl, 2022.
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Mechanically Induced Knee Osteoarthritis Observed in Control Mice Via Activation of The Inflammasome was not Observed in Mice with Conditional Knockout of High Molecular Weight FGF2 in Articular Cartilage
JBMR, Suppl, 2024
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Muscle dysfunction in Female Fibroblast Growth Factor 2 Knockout Mice
J Bone Miner Res 2019, Suppl
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Probiotic Visbiome Partially Ameliorates Pain and Osteoarthritis in Sickle Cell Disease Mice.
JBMR, Suppl, 2024.
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Role of FGF Receptor, FGF23 Signaling in Enthesopathy of Achilles Tendon in High Molecular Weight FGF2 Transgenic Mice
J Bone Miner Res 2020, Suppl
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Systemic Administration of rhPRG4 Ameliorates Anemia and Osteoarthritis in Sickle Cell Disease Mice
JBMR Suppl(2021):2021
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Transplantation of the Gut Microbiota from Healthy Mice Ameliorates Bone Loss in Sickle Cell Disease Recipient Mice
J Bone Miner Res 2020, Suppl
Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
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Talk: FGF23 Neutralizing Antibody Ameliorates Abnormal Renal Phosphate Handing in Sickle Cell Disease Mice. | Talk | 2023 | ASBMR, Canada | |
Effects of Voxelotor Analog GBT1118 on Bone in Sickle Cell Disease Mice. | Poster | ASBMR annual meeting | 2023 | ASBMR, Canada |
Characterizing Craniofacial and Dentition Phenotype of Sickle Cell Trait Mice | Poster | 2023 | Portland, Oregon, USA | |
FGFR Inhibition Partially Rescues Osteoarthritis in Older Male HMWFGF2 Transgenic Mice via Modulation of IL-1/NF-kB Signaling | Poster | Gordon Research Conference | 2022 | Lucca (Barga), Italy |
Inhibition of TLRs/NF-kB Signaling Pathway through FGFR Blocking Partially Rescues Osteoarthritis in HMWFGF2 Transgenic Mice | Poster | 2022 | ASBMR | |
Conditional Knockout of FGF2 in Osteocytes Results in Impaired Bone Formation and Increased Osteocytes Apoptosis in Mice | Poster | 2022 | ASBMR | |
Fecal Microbiota Transplantation Alleviates Bone Loss in Sickle Cell Disease Mice through Regulating SCFA Medicated IGF1 Production | Talk | ASBMR annual meeting | 2021 | ASBMR |
Systemic Administration of rhPRG4 Ameliorates Anemia and Osteoarthritis in Sickle Cell Disease Mice | Poster | 2021 | ASBMR | |
Conditional Knockout of Fgf2 in Cartilage Results in Osteoarthritis Development in Mice | Poster | 2021 | ASBMR | |
Transplantation of the Gut Microbiota from Healthy Mice Ameliorates Bone Loss in Sickle Cell Disease Recipient Mice (Oral) | Talk | Annual meeting of the American Society for Bone and Mineral Research | 2020 | ASBMR, Virtual |
FGF23 Neutralizing Antibody Rescues Reduced Bone Nodule Formation in Bone Marrow Stromal Cell Cultures from Sickle Cell Disease Mice | Poster | Annual meeting of the American Society for Bone and Mineral Research | 2020 | ASBMR, Virtual |
Role of FGF Signaling in Enthesopathy of Achilles Tendon in High Molecular Weight FGF2 Transgenic Mice | Poster | Rare Disease Day Symposium | 2020 | RDD, North Haven, CT |
Role of FGF Signaling in Enthesopathy of Achilles Tendon in HMWFGF2 Transgenic Mice | Poster | UConn Musculoskeletal Institute Research Day | 2020 | UConn Musculoskeletal Institute Research Day, Farmington, CT |
High Molecular Weight FGF2 in Dentin and Alveolar Bone Mineralization | Poster | Rare Disease Day Symposium | 2020 | RDD, North Haven, CT |
FGF23 in crosstalk of bone, kidney, and hematopoiesis in sickle cell bone disease | Talk | Annual meeting of the American Society for Bone and Mineral Research | 2019 | Orlando, Florida |
Inhibition of FGFR signaling partially rescues osteoarthritis in mice overexpressing high-molecular-weight FGF2 | Talk | Annual meeting of the American Society for Bone and Mineral Research | 2019 | Orlando, Florida |
Impaired PTH-stimulated periosteal proliferation, Wnt activity and fracture healing in Fgf2 knockout mice | Poster | Annual meeting of the American Society for Bone and Mineral Research | 2019 | Orlando, Florida |
Muscle dysfunction in Female Fibroblast Growth Factor 2 Knockout Mice. Annual Meeting of the American Society for Bone & Mineral Research | Poster | Annual meeting of the American Society for Bone and Mineral Research | 2019 | Orlando, Florida |
Investigating the Role of Fibroblast Growth Factor 2 Isoforms in the Development of Alzheimer’s Disease Biomarkers in the Hippocampus of Female Mice | Poster | Partnership for Innovation and Education (PIE) INNOVATION RESEARCH DAY | 2019 | Farmington, CT |
BMP-2 enhances the bone healing effect of low molecular weight fgf-2 on calvarial defects in mice | Talk | American Federation for Medical Research Eastern Regional Meeting | 2013 | Washington, DC |
Effect of valproic acid on huntington’s disease affected human embryonic stem cells | Talk | The Department of Psychiatry Research Bonanza at UCHC | 2013 | Farmington, CT |
Exported 18kDa isoform of fibroblast growth factor-2 improved bone regeneration in critical size mice calvarial defects | Talk | Annual Research Day of the New England Musculoskeletal Institute | 2011 | Farmington, CT, June 2011 |
Targeted overexpression of the nuclear FGF2 isoforms in osteoblasts induces hypophosphatemia via modulation of FGF23 and Klotho in mice | Talk | American Society for Bone and Mineral Research | 2008 | Montreal, Quebec, CANADA |
Effect of overexpression of a FGF2 isoform on bone loss in ovariectomized mice | Talk | Center for Interdisciplinary Research in Women's Health | 2006 | Farmington, CT |
Transgenic mice expressing high molecular weight isoforms of FGF2 exhibit decreased bone mass and disturbed phosphate homeostasis | Talk | ASBMR annual meeting | 2006 | Philadelphia, PA |
The exported 18kDa isoform of FGF2 is a critical determinant of bone mass in mice | Talk | ASBMR annual meeting | 2004 | Seattle, Washington |
26th Annual Meeting of the American Society for Bone and Mineral Research | Lecture | American Society for Bone and Mineral Research | 2004 | Seattle, WA |
The transcription factor STAT-1 is a novel negative regulator of bone mass and bone formation | Talk | ASBMR annual meeting | 2003 | Minneapolis, Minnesota |
Oral Presentation | Lecture | 25th Annual Meeting of the American Society for Bone and Mineral Research | 2003 | Minneapolis, MN |