Photo of Yanjiao  Zhou, M.D., Ph.D.

Yanjiao Zhou, M.D., Ph.D.

Assistant Professor of Medicine
Academic Office Location:
Medicine
UConn Health
263 Farmington Avenue
Farmington, CT 06030
Phone: 860-679-6381
Website(s):

Immunology Graduate Program

Education
DegreeInstitutionMajor
M.D.Zhangjiakou Medical CollegeMedicine
Ph.D.Tianjin Medical UniversityMicrobiology and Immunology

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralThe Rockefeller UniversityImmunology
PostdoctoralThe Genome Institute of Washington University School of MedicineMicrobiome and Bioinformatics

Awards
Name of Award/HonorAwarding Organization
Director Innovation AwardJackson Laboratory
Award for Institute of Clinical and Translational SciencesWashington University School of Medicine
1st Place Scholarship for Honored StudentZhangjiakou Medical School

The major research interest of our laboratory is to develop microbiome-based diagnostics and therapeutics for multiple sclerosis as well as other diseases, with a focus on how nutrition and microbial metabolites influence the gut-brain axis. By taking a multidisciplinary approach that includes bioinformatics and molecular biology, we are researching the following areas:

(1) Determine how intermittent fasting affects the gut microbiome and MS pathogenesis in mouse models and patients in collaboration with Washington University School of Medicine. We also work on different strategies to identify microbes, microbial genes and metabolites that modulate peripheral inflammation and neuroinflammation, which potentially permits the development of probiotic-based therapeutics for MS.

(2) Study nutritional induced alteration of the lung and gut microbiome and its influence on airway inflammation. We are testing how Boswellia, an herbal extract with anti-inflammatory properties ameliorate asthma through reconfiguration of the gut and lung microbiome.

(3) Develop a novel host-microbiome ontology resource. We are building a clustered and integrated host-microbiome interaction database that allows for effective microbial information retrieval and data modeling.

Accepting students for Lab Rotations: Summer '18, Fall '18, Spring '19

Journal Articles

Book Chapters

  • Acquisition of the Human Gut Microbiota
    Zhou Y, Warner B, Tarr PI WGO Handbook on Gut Microbes. 2014 May;18-22
  • Hypothesis testing of metagenomic data
    La Rosa PS, Zhou Y, Sodergren E, Weinstock G, Shannon WD. Metagenomics for Microbiology 2014 Jan;

Case Reports

  • Transferable vancomycin resistance in a community-associated MRSA lineage.
    Rossi, Flávia; Diaz, Lorena; Wollam, Aye; Panesso, Diana; Zhou, Yanjiao; Rincon, Sandra; Narechania, Apurva; Xing, Galen; Di Gioia, Thais S R; Doi, André; Tran, Truc T; Reyes, Jinnethe; Munita, Jose M; Carvajal, Lina P; Hernandez-Roldan, Alejandra; Brandão, Denise; van der Heijden, Inneke Marie; Murray, Barbara E; Planet, Paul J; Weinstock, George M; Arias, Cesar A The New England journal of medicine 2014 Apr;370(16):1524-31

Reviews