Photo of Yanjiao  Zhou, M.D., Ph.D.

Yanjiao Zhou, M.D., Ph.D.

Assistant Professor of Medicine
Academic Office Location:
Medicine
UConn Health
263 Farmington Avenue
Farmington, CT 06030-L3080
Phone: 860-679-6379
Website(s):

Immunology Graduate Program

Education
DegreeInstitutionMajor
M.D.Zhangjiakou Medical CollegeMedicine
M.S.Tianjin Medical UniversityImmunology
Ph.D.Tianjin Medical UniversityMicrobiology

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralThe Rockefeller UniversityImmunology
PostdoctoralThe Genome Institute of Washington University School of MedicineMicrobiome and Bioinformatics

Awards
Name of Award/HonorAwarding Organization
Award for Institute of Clinical and Translational SciencesWashington University School of Medicine
3rd class scholarship for honored student.Zhangjiakou Medical College
1st Place Scholarship for Honored StudentZhangjiakou Medical School
3rd class scholarship for honored student.Zhangjiakou Medical College

The major research interest of our laboratory is to develop microbiome-based diagnostics and therapeutics for multiple sclerosis as well as other diseases, with a focus on how nutrition and microbial metabolites influence the gut-brain axis. By taking a multidisciplinary approach that includes bioinformatics and molecular biology, we are researching the following areas:

(1) Determine how intermittent fasting affects the gut microbiome and MS pathogenesis in mouse models and patients in collaboration with Washington University School of Medicine. We also work on different strategies to identify microbes, microbial genes and metabolites that modulate peripheral inflammation and neuroinflammation, which potentially permits the development of probiotic-based therapeutics for MS.

(2) Study nutritional induced alteration of the lung and gut microbiome and its influence on airway inflammation. We are testing how Boswellia, an herbal extract with anti-inflammatory properties ameliorate asthma through reconfiguration of the gut and lung microbiome.

(3) Develop a novel host-microbiome ontology resource. We are building a clustered and integrated host-microbiome interaction database that allows for effective microbial information retrieval and data modeling.

Accepting Lab Rotation Students: Summer '19, Fall '19, Spring '20


 


Postdoctoral associate: Host-gut microbiome interaction in autoimmune disease 


The Laboratory of Microbiome Science at University of Connecticut Health Center is a new laboratory that is interested in developing microbiome-based diagnosis and therapeutics for human diseases. We are looking for a dedicated postdoctoral candidate to study host-gut microbiome interaction in multiple sclerosis, an autoimmune disease affecting central nervous system. By integrating experimental and multi-OMICS approaches, the postdoc associate will investigate how the gut microbiome modulates local gut immune response and affects neuroinflammations in an animal model of multiple sclerosis. The postdoc associate will have the opportunity to perform microbiome manipulation including fecal transplantation and anaerobic culturing, immune assays and bioinformatics. 


Minimal requirement:



  • Ph.D. degree in microbiology or immunology.

  • Have a good publication record


Skills and abilities:


- Have strong scientific credentials in the field of immunology or microbiology.


- Have the ability to design experiments and effectively perform experiments and trouble shooting.


- Experienced in animal work, cell culture, immune assay, or microbiology techniques including anaerobic culturing and bacterial engineering.


- Good written and verbal communication skills


- Bioinformatic skills are preferred but not required


Open date: 


Immediate


Special instructions to applicants:


Interested persons should submit a cover letter, curriculum vitae, and a list of 3 references to Dr. Yanjiao Zhou via yazhou@uchc.edu

Journal Articles

Book Chapters

  • Acquisition of the Human Gut Microbiota
    Zhou Y, Warner B, Tarr PI WGO Handbook on Gut Microbes. 2014 May;18-22
  • Hypothesis testing of metagenomic data
    La Rosa PS, Zhou Y, Sodergren E, Weinstock G, Shannon WD. Metagenomics for Microbiology 2014 Jan;

Case Reports

  • Transferable vancomycin resistance in a community-associated MRSA lineage.
    Rossi, Flávia; Diaz, Lorena; Wollam, Aye; Panesso, Diana; Zhou, Yanjiao; Rincon, Sandra; Narechania, Apurva; Xing, Galen; Di Gioia, Thais S R; Doi, André; Tran, Truc T; Reyes, Jinnethe; Munita, Jose M; Carvajal, Lina P; Hernandez-Roldan, Alejandra; Brandão, Denise; van der Heijden, Inneke Marie; Murray, Barbara E; Planet, Paul J; Weinstock, George M; Arias, Cesar A The New England journal of medicine 2014 Apr;370(16):1524-31

Reviews