Gordon G. Carmichael, Ph.D.

Professor, Genetics and Developmental Biology
Academic Office Location:
Genetics & Developmental Biology
University of Connecticut Health Center
263 Farmington Avenue
Farmington, CT 06030-3301
Phone: 860-679-2259
Fax: 860-679-8345
Email: carmichael@nso2.uchc.edu
Website(s): Cell Biology Graduate Program
Genetics & Developmental Biology Graduate Program
Molecular Biology & Biochemistry Graduate Program

Education
DegreeInstitutionMajor
Ph.D.Harvard UniversityBiophysics
B.S.Duke UniversityPhysics

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralSwiss Institute for Experimental Cancer ResearchPostdoctoral Fellow in the Department of Virology, Laboratory of Dr. Bernhard Hirt
FellowshipHarvard Medical SchoolResearch Fellow in Pathology
PostdoctoralEstablished Investigator of the American Heart AssociationPostdoctoral Fellow of The Jane Coffin Childs Memorial Fund for Medical Research

Awards
Name of Award/HonorAwarding Organization
Faculty of 1000University of Connecticut Health Center
Osborn Biomedical Science Graduate Teaching Award Recipient Graduate Student Organization
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
MGB Study SectionStudy SectionReviewerExternalNational20132013
Review Panel, NSFStudy SectionReviewerExternalNational20102013
WIRES RNA This is a scientific journalEditorial BoardAssociate EditorExternalInternational2010
RNA SocietyProfessional/Scientific OrganizationmemberExternalInternational
UCHC Medical Selectives committeeEducation CommitteememberUConn Health CenterUniversity
The primary interests of my group are the molecular signals which control the expression and function of mRNA molecules. We study RNA polymerase II promoters and the mechanisms of splicing, polyadenylation and RNA export from the nucleus to the cytoplasm. A recent area of interest has been the mechanism of action of naturally-occurring antisense RNA regulation in mammalian cells. Our preferred model system is the mouse polyoma virus, but we are also using other systems, including histone genes, the HIV-1 virus and yeast.
Not Accepting Lab Rotation Students at this time We study the consequences of double strand RNA in cells, especially with regard to what happens in the nucleus. Our work includes studies on RNA editing, the nucleocytoplasmic transport of RNA molecules, and mechanisms by which dsRNAs can lead to gene silencing. Rotation projects would most likely involve molecular studies on proteins we have identified that play important roles in dsRNA metabolism.

Journal Articles

Books

  • Methods in Molecular Biology: RNA Silencing
    G.G. Carmichael (2005) Methods in Molecular Biology: RNA Silencing

Book Chapters

  • Nucleocytoplasmic mRNA transport
    Y. Huang and G.G. Carmichael (2001) Results and Problems in Cell Differentiation 140-155

Book Sections

  • A role for RNA editing in gene silencing
    J. Zhou, L. Chen and G.G. Carmichael (2008) Frontiers of RNA and DNA editing 190-202
  • Mechanism of action of antisense RNA in eukaryotic cells
    Z. Zhang and G.G. Carmichael (2003) Cancer Drug Discovery and development: Nucleic Acid Therapeutics in Cancer 89-104
  • Polyoma virus hr-t gene products
    T.L. Benjamin, B.S. Schaffhausen and G.G. Carmichael (1980) Animal Virus Genetics, ICN-UCLA Symposium on Molecular and Cellular Biology, vol. XVIII 295-308
  • Assay and partial purification of Epstein-Barr virus nuclear antigen
    D. Baron, W.C. Benz, G. Carmichael, R.R. Yocum and J.L. Strominger (1975) Epstein-Barr Virus, Production, Concentration, and Purification, IARC Internal Technical Report 257-262

Notes

Other

  • Bacterial RNA-binding proteins involved in Qβ RNA replication
    G.G. Carmichael (1975) Ph.D. Thesis, Harvard University

Reviews

Short Surveys

Title or AbstractTypeSponsor/EventDate/YearLocation
Recent RNA StoriesTalkHarvard University2013Boston, MA
Innate Immunity in Stem CellsTalkBedford Stem Cell Research Foundation2013Waltham, MA
Innate Immunity in Pluripotent CellsPosterCold Spring Harbor, Asia2013Suzhou, China
New Insights into Gene Expression from Deep SequencingTalkTufts University Medical School2012Tufts Medical School
New Insights into Gene Expression from Deep SequencingTalkAlbert Einstein College of Medicine2012Albert Einstein Medical School
New Insights into Gene Expression from Deep SequencingTalkOhio State University2012Ohio State University
A New Class of Intron-derived Long Noncoding RNAsTalkExperimental Biology Meeting2012San Diego
New Intron-derived Long Noncoding RNAsTalkGordon Research Conference2012GRC, Newport, RI
A New Class of Intron-derived Long Noncoding RNAsTalkRiboclub (Sherbrooke, Quebec, Canada)2012Riboclub, Sherbrooke, Canada
Long Noncoding RNAs with snoRNA EndsTalkCold Spring Harbor, Asia2012Suzhou, China
New Insights into Gene Expression from Deep SequencingTalkMedical School, Xian, China2012Xian, China