Photo of Stephen M. King, Ph.D.

Stephen M. King, Ph.D.

Professor, Department of Molecular Biology and Biophysics
Academic Office Location:
Molecular, Microbial and Structural Biology
UConn Health
263 Farmington Avenue
Farmington, CT 06030-3305
Phone: 860-679-3347
Fax: 860-679-3408
Email: king@uchc.edu
Website(s):

Molecular Biology and Biochemistry Graduate Program

Education
DegreeInstitutionMajor
B.Sc.University of KentMicrobiology
Ph.D.University College LondonBotany and Microbiology

Post-Graduate Training
TrainingInstitutionSpecialty
PostdoctoralUniversity College LondonPostdoctoral Research Assistant

Awards
Name of Award/HonorAwarding Organization
Investigator of the Patrick and Catherine Weldon Donaghue Medical Research Foundation 2001-2006The Donaghue Foundation
Antarctic Service MedalU.S. Department of Defense
Name & DescriptionCategoryRoleTypeScopeStart YearEnd Year
Wellcome Trust Senior Investigator Awards, London, UKStudy SectionInterview Panel MemberExternalInternational20122012
National Institutes of Health (ZRG IMST-G 40 study section)Study SectionGrant ReviewerExternalNational20122012
Gordon Conference on Cilia, Mucus and Mucociliary Interactions, Ventura Beach, CA.OtherDiscussion LeaderExternalNational20112011
Symposium on the “New Biology of Cilia”, Albert Einstein College of Medicine, Bronx, NY.OtherDiscussion LeaderExternalNational20112011
2013 Gordon conference on Cilia, Mucus and Mucociliary Interactions, at Il Ciocco, Barga, Italy. OtherCorresponding ChairExternalInternational20112013
CytoskeletonEditorial BoardMemberExternalNational2010
Dyneins: Structure, Biology and DiseaseProfessional/Scientific JournalEditorExternalNational20102011
Senior Appointments and Promotions Committee, School of MedicineEducation CommitteeSecondary MemberUConn HealthUniversity20102013
Space Appeals CommitteeOtherMemberUConn HealthUniversity20102013
Course and Curriculum Evaluation Subcommittee, School of MedicineEducation CommitteeBasic Science MemberUConn HealthUniversity20102011
Genetics and Developmental Biology Graduate ProgramEducation CommitteeReview Board MemberUConn HealthUniversity20102010
National Institutes of Health (ZRG1 CB-Q study section)Study SectionGrant ReviewerExternalNational20102010
National Institutes of Health (ZRG1 CB-P study section)Study SectionGrant ReviewerExternalNational20102010
Central Electron Microscope FacilityProfessional/Scientific OrganizationDirectorUConn HealthUniversity2009
Special Review Board, School of MedicineEducation CommitteeMemberUConn HealthUniversity20092011
Molecular Biology & Biochemistry Graduate ProgramProfessional/Scientific OrganizationDirectorUConn HealthUniversity20092012
“Dynein as the Force Generator for Axonemal Beating” session. Dynein 2009. International Workshop on the Molecular Mechanisms of Axonemal and Cytoplasmic Dyneins. Kobe, Japan. OtherChairExternalInternational20092009
2011 Gordon conference on Cilia, Mucus and Mucociliary Interactions, Ventura, CA.OtherVice-chairExternalNational20092011
External Ph.D thesis examiner. Qasim Rasi, Department of Molecular Biology and Biochemistry, Simon Fraser University, Vancouver, BC, Canada.Education CommitteeExternal Ph.D Thesis ExaminerExternalInternational20092009
Methods in Cell Biology (Vol. 91. Cilia: Structure and Motility, Vol. 92. Cilia: Motors and Regulation, Vol. 93. Cilia: Model Systems and Intraflagellar Transport.)Professional/Scientific JournalEditor (with G.J. Pazour), ExternalNational20082009
Committee on Cell Biology, Human Systems, School of MedicineEducation CommitteeMemberUConn HealthUniversity20082008
National Science FoundationStudy SectionGrant ReviewerExternalNational20082008
French National Research Agency (ANR)Study SectionGrant ReviewerExternalInternational20082010
Senior Appointments and Promotions Committee, School of Medicine.Education CommitteeMemberUConn HealthUniversity20072010
Research CouncilResearch CommitteeMemberUConn HealthUniversity20072010
NMR Faculty Seach CommitteeOtherMemberUConn HealthUniversity20072008
“High Resolution Structure and Biochemistry of the Flagellum”, FASEB meeting on the Biology of Cilia and Flagella, Saxton’s River, VT.OtherSession ChairExternalNational20072007
External Ph.D thesis examiner. Yuqing Hou, Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA. Education CommitteeExternal Ph.D Thesis ExaminerExternalRegional20072007
Senior Appointments and Promotions Committee, School of Medicine.Education CommitteeSecondary ReviewerUConn HealthUniversity20062006
Education Committee, UCONN Partnership for Excellence in Structural BiologyEducation CommitteeMemberUConn HealthUniversity2006
Biophysics Core Oversight CommitteeAdvisory CommitteeMemberUConn HealthUniversity2006
Biophysics Core Oversight CommitteeAdvisory CommitteeMemberUConn HealthUniversity2006
Protein Folding Faculty Seach CommitteeOtherMemberUConn HealthUniversity20062006
MMSB Departmental Executive CommitteeAdvisory CommitteeMemberUConn HealthUniversity2006
External Ph.D thesis examiner. Vicki Kassouf, Westmead Institute, University of Sydney, Australia.Education CommitteeExternal Ph.D Thesis ExaminerExternalInternational20062006
French National Research Agency (ANR)Study SectionGrant ReviewerExternalInternational20062006
French Institute for Research on Rare Diseases (GIS-Institut des Maladies Rares)Study SectionGrant ReviewerExternalNational20062006
National Science Foundation (Antarctic Biology)Study SectionGrant ReviewerExternalNational20062006
Health Center Research Advisory CommitteeAdvisory CommitteeMemberUConn HealthUniversity20052011
National Institutes of Health (Nuclear Dynamics and Transport Study Section)Study SectionGrant ReviewerExternalNational20052008
National Institutes of Health “Nuclear Dynamics and Transport” Study SectionStudy SectionCharter MemberExternalNational20042008
Molecular Biology & Biochemistry Graduate ProgramEducation CommitteeAssociate DirectorUConn HealthUniversity20042009
Electron Microscope Facility Advisory CommitteeAdvisory CommitteeMemberUConn HealthUniversity2004
MMSB departmental retreat held on March 15th 2004Advisory CommitteeOrganizerUConn HealthUniversity20042004
Graduate School and MBB program Admissions CommitteesEducation CommitteeMemberUConn HealthUniversity2004
“Solution NMR”, New England Structure Symposium, University of Connecticut, Storrs, CTOtherSession ChairExternalRegional20042004
External Ph.D thesis examiner. Maureen Blomberg-Wirchell, Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA.Education CommitteeExternal Ph.D Thesis ExaminerExternalRegional20042004
External Ph.D thesis examiner. Mark Douglas, Westmead Institute, University of Sydney, Australia.Education CommitteeExternal Ph.D Thesis ExaminerExternalInternational20042004
National Institutes of Health (CDF-4 Study Section)Study SectionGrant ReviewerExternalNational20042004
Independent Research Group Proposal, Direction de l'Evaluation Scientifique, Institut Pasteur, Paris, France.Study SectionGrant ReviewerExternalInternational20042004
Northwest Health FoundationStudy SectionGrant ReviewerExternalNational20042004
Scientific Advisory Board, Solazyme Corporation, Palo Alto, CAAdvisory CommitteeMemberExternalNational20032003
NMR Spectroscopist Faculty Seach CommitteeOtherMemberUConn HealthUniversity20032003
External Ph.D thesis examiner. Diane Casey, Department of Cell Biology, University of Massachusetts Medical School, Worcester, MA. Education CommitteeExternal Ph.D Thesis ExaminerExternalRegional20032003
ZAR-1 IRG, NIAMSD, National Institutes of HealthStudy SectionAd hoc memberExternalNational20032003
National Institutes of Health (NIAMSD, ZAR-1 Review Committee)Study SectionGrant ReviewerExternalNational20032003
CDF-4 study section, NIH (October)Research CommitteeAd hoc memberExternalNational20022002
CDF-4 study section, NIH (October)Study SectionAd hoc memberExternalNational20022002
Biotechnology and Biological Sciences Research Council, UKStudy SectionGrant ReviewerExternalInternational20022004
CDF-4 study section, NIH (October)Study SectionAd hoc memberExternalNational20012001
GMBB Training Grant Application CommitteeEducation CommitteeChairUConn HealthUniversity20012001
Committee to revise Biochemistry I courseEducation CommitteeMemberUConn HealthUniversity20012001
Cell Motility and the CytoskeletonEditorial BoardMemberExternalNational20002009
Subcommittee on Cell Biology, Human Systems, School of Medicine.Education CommitteeChairUConn HealthUniversity20002000
CDF-4 study section, NIH (February & October)Study SectionAd hoc memberExternalNational20002000
Graduate Programs Committee.Education CommitteeMemberUConn HealthUniversity20002002
Genetics, Molecular Biology & Biochemistry Graduate ProgramEducation CommitteeDirectorUConn HealthUniversity20002002
Strategic Planning Committee for the Ph.D. Program in Biomedical ScienceEducation CommitteeMemberUConn HealthUniversity20002000
“Flagellar Biogenesis, Length Control and Mode of Action” Session, International Conference on the Cell and Molecular Biology of Chlamydomonas, Noordwijkerhout, NetherlandsOtherCo-convenerExternalInternational20002000
National Institutes of Health (CDF-4 Study Section)Study SectionGrant ReviewerExternalNational20002002
Review Board, Cellular & Molecular Pharmacology Graduate ProgramEducation CommitteeMemberUConn HealthUniversity19991999
National Science Foundation (Molecular and Cellular Biology)Study SectionGrant ReviewerExternalNational19991999
Methods (a companion volume to Methods in Enzymology)Professional/Scientific JournalEditor ExternalNational19982000
Cell Structural Dynamics Faculty Search CommitteeOtherMemberUConn HealthUniversity19981998
Neuroscience Chair Search Committee, School of Medicine.OtherMemberUConn HealthUniversity19981999
Vascular Biology Faculty Search CommitteeOtherMemberUConn HealthUniversity19981999
Molecular Biology & Biochemistry Graduate ProgramEducation CommitteeAssociate DirectorUConn HealthUniversity19982000
“Dynein Structure and Regulation” Session, International Conference on the Cell and Molecular Biology of Chlamydomonas, Tahoe City, CA.OtherChairExternalInternational19981998
HCRAC Equipment Grant Review Committee MemberOtherMemberUConn HealthUniversity19971998
Summer Internship Applications Committee, Grad. Student Affairs.Education CommitteeChairUConn HealthUniversity19971998
Search Committee for Director of Vascular Biology Center, School of MedicineOtherMemberUConn HealthUniversity19971998
Human Systems Implementation Committee, School of Medicine.Education CommitteeMemberUConn HealthUniversity19972003
GRB-5 Special Emphasis Panel, National Institutes of HealthStudy SectionAd hoc memberExternalNational19971997
Health Center Research Advisory Council, University of Connecticut Health CenterStudy SectionGrant ReviewerUConn HealthUniversity19972001
National Science Foundation (Developmental Neuroscience)Study SectionGrant ReviewerExternalNational19971997
National Institutes of Health (NIDDK, GRB-5 Review Committee)Study SectionGrant ReviewerExternalNational19971997
The Jeffress Memorial Trust, Commonwealth of VirginiaStudy SectionGrant ReviewerExternalNational19971997
Biology-2 Study Section, National Institutes of HealthStudy SectionMemberExternalNational19961996
External Ph.D thesis examiner. Angela Ramsey, Department of Biology, Northeastern University, Boston, MA.Education CommitteeExternal Ph.D Thesis ExaminerExternalRegional19962000
External Ph.D thesis examiner. Charlotte Vines, Department of Cell Biology, Harvard Medical School, Boston, MA.Editorial BoardExternal Ph.D Thesis ExaminerExternalRegional19961996
National Science Foundation (International Program)Study SectionGrant ReviewerExternalNational19961996
National Institutes of Health (Biology-2 Study Section)Study SectionGrant ReviewerExternalNational19961996
Summer Internship Applications Committee, Graduate Student AffairsEducation CommitteeMemberUConn HealthUniversity19951995
Committee on Undergraduate Dental Education, Dental Medicine CouncilEducation CommitteeMemberUConn HealthUniversity19951997
Biomaterials Center Faculty Search CommitteeOtherMemberUConn HealthUniversity19951996
Admissions Committee, Genetics, Mol. Biol. & Biochem. Graduate ProgramEducation CommitteeMemberUConn HealthUniversity19952002
Summer Internship Applications Committee, Graduate Student AffairsEducation CommitteeMemberUConn HealthUniversity19941994
School of Medicine CouncilEducation CommitteeAt-Large RepresentativeUConn HealthUniversity19941997
School of Dental Medicine CouncilEducation CommitteeAt-Large RepresentativeUConn HealthUniversity19941997
Biochemistry Department Faculty Search CommitteeOtherMemberUConn HealthUniversity19941995
Curriculum Committee, Genetics, Mol. Biol. & Biochem. Graduate ProgramEducation CommitteeMemberUConn HealthUniversity1994
Department of Biochemistry Seminar SeriesEducation CommitteeOrganizerUConn HealthUniversity19941995
National Science Foundation (Structural Basis of Cellular Organization)Study SectionGrant ReviewerUConn HealthUniversity19941996
National Institutes of Health (Reproductive Biology Section)Study SectionGrant ReviewerExternalNational19941994
Health Center Research Advisory Council, University of Connecticut Health CenterStudy SectionGrant ReviewerExternalNational19941995
American Society for Cell BiologyProfessional/Scientific OrganizationMemberExternalNational
Academic PressProfessional/Scientific JournalReviewerExternalNational
American Journal of PathologyProfessional/Scientific JournalReviewerExternalNational
Archives of Biophysics and BiochemistryProfessional/Scientific JournalReviewerExternalNational
Biochimica Biophysica ActaProfessional/Scientific JournalReviewerExternalNational
Cell Motility and the CytoskeletonProfessional/Scientific JournalReviewerExternalNational
CytoskeletonProfessional/Scientific JournalReviewerExternalNational
DevelopmentProfessional/Scientific JournalReviewerExternalNational
Developmental BiologyProfessional/Scientific JournalReviewerExternalNational
European Journal of BiochemistryProfessional/Scientific JournalReviewerExternalInternational
Human Molecular GeneticsProfessional/Scientific JournalReviewerExternalNational
Journal of Biological ChemistryProfessional/Scientific JournalReviewerExternalNational
Journal of Cell BiologyProfessional/Scientific JournalReviewerExternalNational
Journal of Eukaryotic MicrobiologyProfessional/Scientific JournalReviewerExternalNational
Journal of Cell ScienceProfessional/Scientific JournalReviewerExternalNational
Molecular Biology of the CellProfessional/Scientific JournalReviewerExternalNational
Molecular Cell BiologyProfessional/Scientific JournalReviewerExternalNational
Molecular MicrobiologyProfessional/Scientific JournalReviewerExternalNational
Nature Structural and Molecular BiologyProfessional/Scientific JournalReviewerExternalNational
Plant and Cell PhysiologyProfessional/Scientific JournalReviewerExternalNational
Plant CellProfessional/Scientific JournalReviewerExternalNational
Protein ScienceProfessional/Scientific JournalReviewerExternalNational
Protein ScienceProfessional/Scientific JournalReviewerExternalNational
Proceedings of the National Academy of ScienceProfessional/Scientific JournalReviewerExternalNational

Dyneins are microtubule-based molecular motors that power both ciliary/flagellar motility and a variety of essential intracellular motile events. In order for these massive enzymes to function correctly, they must be attached to the appropriate cargo and motor activity must be precisely regulated. Over the last few years we have identified a series of highly intriguing dynein components that appear to be involved in these regulatory activities. Current focus in the laboratory is on understanding the mechanisms which control motor function using a wide variety of techniques ranging from physiological measurements and genetic analyses to structural biology.

Accepting students for Lab Rotations: Summer '17, Fall '17, Spring '18


Lab Rotation Projects

The Role of WDR92 in Cytoplasmic Preassembly of Axonemal Dyneins

Cilia are required for organismal development and homeostasis.  The motility of these organelles is generated by dynein molecular motors.  These massive complexes are preassembled in the cytoplasm and over the last several years, multiple factors have been identified as being needed for this process.  Recently, we identified a component of a prefoldin-like co-chaperone complex as being required for the coordinate assembly of multiple ciliary components.  Furthermore, we have now obtained a Chlamydomonas null mutant which is able only to build very short (~0.5 micron) cilia.  This project will involve using biochemical, genetic and cell biological approaches to determine how WDR92 is specifically involved in building motile ciliary axonemes.


Curvature Sensing by Axonemal Dyneins

Axonemal dyneins must sense and respond to the curvature that they experience in order for regions of active microtubule sliding to oscillate across the structure and to propagate a wave of motor activity along the organelle generating a ciliary beat; both activities must occur at a rate consistent with the beat frequency (~60 Hz in Chlamydomonas).  For outer arm dyneins, we hypothesized that this mechano-switching involves a highly conserved leucine-rich repeat protein (LC1) that interacts directly with both MTs and the MT-binding domain of the outer arm g HC.  This project will utilize a newly available null mutant to rigorously test this concept by expressing mutant LC1 variants designed based on our previous biochemical and structural studies.  I anticipate that this will provide novel mechanistic insight into this fundamental feature of ciliary motility.


Peptide Amidation and the Control of Ciliogenesis (King and Eipper Laboratories)

Cilia are essential signaling and motile organelles that play key roles in development and homeostasis.  Defects in these microtubule-based structures lead to a broad array of phenotypes (including infertility, obesity, neurological disorders, polycystic kidneys, retinal degeneration, skeletal abnormalities and many others) collectively known as ciliopathies.  The enzyme peptidylglycine alpha-amidating monoxygenase (PAM) converts glycine-extended peptides into bioactive amidated products (e.g. oxytocin and vasopressin).  Although originally thought to have co-evolved with the nervous system, we recently found that PAM has deeper evolutionary roots and has been conserved in all organisms (even unicellular ones) that build sensory cilia.  Furthermore, using amiRNA knockdown strains of the green alga Chlamydomonas (the premier model system for analysis of cilia assembly and motility) we have now demonstrated that active PAM is not only present in cilia, but is actually essential for ciliogenesis, potentially through its effects on post-Golgi trafficking.  This project will focus on using biochemical, cell biological and molecular genetic approaches to further elucidate the mechanism(s) by which PAM activity impacts on cilia assembly and function. 


 

Journal Articles

Books

  • King SM (editor) Dyneins: Structure, Biology and Disease 2012 Jan;
  • King SM, Pazour GJ (editors) Methods in Cell Biology vol. 93 Cilia: Model Organisms and Intraflagellar Transport 2009 Jan;
  • King SM, Pazour GJ (editors) Methods in Cell Biology vol. 91 Cilia: Structure and Motility 2009 Jan;
  • King SM, Pazour GJ (editors), Methods in Cell Biology vol. 92 Cilia: Motors and Regulation 2009 Jan;
  • King, SM (editor) Methods vol. 22 Molecular Motors, 2000 Jan;

Abstracts

  • Dynein is regulated by a light chain that tethers one motor unit to tubulin
    Patel-King R, King SM Molecular Biology of the Cell 2008 Jan;19CD supplement
  • Regulated association of CrLis1 with the Chlamydomonas outer dynein arm
    Rompolas P, King SM Molecular Biology of the Cell 2008 Jan;19CD supplement
  • FAP133 is a dynein intermediate chain associated with the retrograde intraflagellar transport motor
    Rompolas P, Pedersen LB, Patel-King RS, King SM Molecular Biology of the Cell 2007 Jan;18CD supplement
  • Motor domain-mediated regulation of outer arm dynein
    Patel-King RS, King SM Molecular Biology of the Cell 2007 Jan;18CD supplement
  • Ca2+-dependent interaction of the heavy chain-associated LC4 light chain and intermediate chain 1 within Chlamydomonas outer arm dynein
    Sakato M, King SM Molecular Biology of the Cell 2006 Jan;17CD supplement
  • A Lis1-like protein is associated with axonemal outer arm dynein in Chlamydomonas
    Pedersen LB, Rosenbaum JL, King SM Molecular Biology of the Cell 2005 Jan;16279a
  • A member of the dynein light chain roadblock/LC7 family, Robl1, interacts differentially with Rab6A and Rab6A
    Wanschers B, van de Vorstenbosch R, King SM, Fransen J Molecular Biology of the Cell 2005 Jan;16370a
  • Alternative splicing as a mechanism to modulate the specificity of cytoplasmic dynein phosphorylation
    Tauhata S, Burke J, Joseph E, Lane WS, King SM, Pfister KK, Vaughan PS, Vaughan KT Molecular Biology of the Cell 2005 Jan;16265a
  • Cytoplasmic dynein phosphorylation changes subunit composition and regulates dynein localization during mitosis
    Whyte J, Lane WS, Pfister KK, King SM, Vaughan PS, Vaughan KT Molecular Biology of the Cell 2005 Jan;16264a
  • Identification of a third member of the LC8 family of dynein light chains in Chlamydomonas flagella
    Rompolas P, Patel-King RS, Gorbatyuk O, Wakabayashi K, Pazour GJ, King SM Molecular Biology of the Cell 2005 Jan;16263a
  • Proteins of the radial spoke, a mechanochemical signal transducer in 9+2 cilia and flagella
    Yang P, Diener DR, Yang C, Kohno T, Pazour GJ, Dienes J, Agrin N, King SM, Sale WS, Kamiya R, Rosenbaum JL, Witman GB Molecular Biology of the Cell 2005 Jan;16280a
  • A novel Tctex1-related light chain (LC9) associates with Chlamydomonas outer arm dynein
    DiBella LM, Gorbatyuk O, Wu H, Patel-King RS, King SM Molecular Biology of the Cell 2004 Jan;15224a
  • Association of the intermediate chains and light chains in the cytoplasmic dynein complex
    Lo KWH, Kogoy JM, King SM, Pfister KK Molecular Biology of the Cell 2004 Jan;15564a
  • Ca2+-dependent and -independent interactions between light chain 4 and the gamma heavy chain of Chlamydomonas outer arm dynein
    Sakato M, King SM Molecular Biology of the Cell 2004 Jan;15223a
  • Cytoplasmic dynein is regulated by multiple signaling pathways during mitosis
    Whyte J, Pfister KK, King SM, Lane WS, Vaughan PS, Vaughan KT Molecular Biology of the Cell 2004 Jan;15567a
  • Monitoring the in vivo redox state of Chlamydomonas flagellar proteins
    Wakabayashi K, King SM Molecular Biology of the Cell 2004 Jan;15224a
  • Analysis of proteins interacting with the outer dynein arm docking complex (ODA-DC) from Chlamydomonas flagella by chemical crosslinking
    Wakabayashi K, King SM, Kamiya K Molecular Biology of the Cell 2002 Jan;13184a
  • The Roadblock light chains of cytoplasmic dynein associate with Hepatitis B X-interacting protein
    Nikulina K, King SM Molecular Biology of the Cell 2002 Jan;13182a
  • Protein synthesis and the cell cycle: centrosome reproduction in sea urchin eggs is not under translational control.
    Sluder, G; Miller, F J; Cole, R; Rieder, C L The Journal of cell biology 1990 Jun;110(6):2025-32

Book Sections

  • Composition and assembly of axonemal dyneins
    King SM Dyneins: Structure, Biology and Disease 2012 Jan;209-243
  • Axonemal Dyneins: assembly, structure and force generation
    Wakabayashi K, Sakato M, King SM The Chlamydomonas Source Book volume 3: Cell Motility and Behavior 2009 Jan;131-208
  • Dynein motors: structure, mechanochemistry and regulation
    King SM Molecular Motors 2002 Jan;45-78
  • The biochemistry, genetics and molecular biology of flagellar dynein
    Witman GB, Wilkerson CG, King SM Microtubules 1994 Jan;229-249
  • The ATPases of Chlamydomonas outer arm dynein differ in their pH and cationic requirements
    Gatti JL, King SM, Witman GB Comparative Spermatology 20 Years After 1991 Jan;439-446
  • The intermediate chain / light chain complex: an important structural entity of outer arm dynein
    Witman GB, King SM, Moss AG, Wilkerson CG Comparative Spermatology 20 Years After 1991 Jan;439-446
  • The molecular structure of Chlamydomonas outer arm dynein
    King SM, Witman GB Cell Movement “The Dynein ATPases” Vol 1 1989 Jan;61-75

Conference Papers

  • The gamma heavy chain within outer arm dynein acts as a key regulatory node for ciliary/flagellar motility
    King SM 2009 Jan;
  • Land of the Rising Chlamy: a report of the 11th international meeting on the Cell and Molecular Biology of Chlamydomonas held in Kobe, Japan, from May 11--15, 2004.
    Vallon, Olivier; King, Stephen M Protist 2004 Dec;155(4):373-80
  • Flagellar radial spokes contain a Ca2+-stimulated nucleoside diphosphate kinase.
    Patel-King, Ramila S; Gorbatyuk, Oksana; Takebe, Sachiko; King, Stephen M Molecular biology of the cell 2004 Aug;15(8):3891-902
  • Design and regulation of the AAA+ microtubule motor dynein.
    Sakato, Miho; King, Stephen M Journal of structural biology 2004 Jan;146(1-2):58-71
  • Detection of proteins interacting with the outer dynein arm docking complex (ODA-DC) in Chlamydomonas flagella by chemical crosslinking
    King SM 2004 Jan;
  • Identification of a novel WD-repeat axonemal protein that specifically binds GTP
    King SM 2004 Jan;
  • LC7b, a novel light chain associated with both outer and inner dynein arms
    King SM 2004 Jan;
  • Monitoring the in vivo redox state of Chlamydomonas flagellar proteins
    King SM 2004 Jan;
  • Organization of AAA domains within the dynein motor unit and structure of the AAA domain-associated protein LC1
    King SM 2001 Jan;
  • Molecular organization of the dynein microtubule motor
    King SM 2000 Jan;
  • Methyl benzimidazol-2-yl carbamate-induced cell cycle arrest in Saccharomyces cerevisiae
    King SM 1983 Jan;
  • Conference on Microtubules in Microorganisms
    King SM 1981 Jan;

Editorials

  • Editorial
    King S.M. Methods 2000 Jan;22(4):283-284

Letters

Notes

Other

  • The unicellular biflagellated green alga Chlamydomonas reinhardtii. A response to “Whither model organism research?”
    Beck CF, Cerutti H, Cole DG, Goodenough U, Grossman A, Harris EH, Hegemann P, King SM, et. al. Science E-Letters 2005 Jan;
  • Movement of microtubules on flagellar dynein
    Paschal BM, King SM, Moss AG, Collins CA, Vallee RB, Witman GB Cell Motility and the Cytoskeleton Video Supplement 1990 Jan;2(52):47

Reviews

Short Surveys

Title or AbstractTypeSponsor/EventDate/YearLocation
Fertilization and Activation of DevelopmentTalkGordon Conference, Plymouth, NH1999